763 results on '"Yuxin, WU"'
Search Results
2. NK cell immunopotentiators-loaded nanoliposomes enhance ADCC effect for targeted therapy against HER2-positive breast cancer
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Ruoxin Du, Changqing Cao, Dong Fan, Guodong Li, Shuangpeng Pu, Xinyao Xu, Mengmeng Liu, Gege Shi, Yuxin Wu, Qiang Hao, Yuan Gao, Juliang Zhang, Huadong Zhao, and Cun Zhang
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HER2+ breast cancer ,Trastuzumab resistance ,Natural killer cell ,Antibody-dependent cell-mediated cytotoxicity ,Nanoliposomes ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Trastuzumab serves as a cornerstone of first-line therapy for HER2-positive (HER2+) breast cancer; however, a significant challenge arises due to the emergence of resistance within approximately one year of commencement of treatment, particularly in advanced cases with metastatic disease where its efficacy is limited. Our investigation into the tumor tissue from HER2+ breast cancer patients, employing single-cell sequencing and bioinformatics analysis, has elucidated a crucial mechanism underlying the reduced responsiveness of tumors to trastuzumab: the diminished infiltration and activity of natural killer (NK) cells within the tumor microenvironment (TME). To counteract this impediment, we meticulously selected two potent immune-modulating peptides TKD and IP-10p, which are known to recruit and enhance the activity of NK cells. Through in vitro experiments, we substantiated that bolstering the tumor infiltration and activity of NK cells can lead to an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) effect, thereby amplifying the anti-tumor activity of trastuzumab. Building upon this foundational discovery, we further designed HER2-targeted pH-sensitive nanoliposomes to encapsulate TKD and IP-10p peptides. The novel designed nanoliposomes were strategically employed in conjunction with NK cell supplement therapy within a HER2+ breast cancer model undergoing trastuzumab treatment, yielding a striking anti-tumor response and indicating that the combination strategy effectively reinvigorated the anti-tumor immune response. In essence, this study not only underscores a critical link between the diminished ADCC effect mediated by trastuzumab and the development of resistance in HER2+ breast cancer but also demonstrates leveraging HER2-targeted nanoliposomes to deliver NK cell immunopotentiators can significantly enhance the functional activity of NK cells and their infiltration within the TME, culminating in improved antitumor efficacy of trastuzumab through the augmentation of the ADCC effect. Graphical abstract more...
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- 2025
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3. Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles
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Cheng Zou, Xiao Liu, Weizhong Wang, Lei He, Anan Yin, Zhengcong Cao, Maorong Zhu, Yuxin Wu, Xiaolin Liu, Jiying Ma, Yalong He, Shuning Wang, Wangqian Zhang, Wei Liu, Yingqi Zhang, Jintao Gu, Wei Lin, Kuo Zhang, and Meng Li more...
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Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library corresponding to all disease-related immune genes, and performed an in vivo CRISPR knockout (KO) screen in syngeneic GBM mouse models. We demonstrated that the deletion of GDF15 in GBM cells ameliorated the immunosuppressive tumor microenvironment (TME) and enhanced the antitumor efficacy of immune checkpoint blockade (ICB) response. Moreover, we designed unique nanoparticles for efficient encapsulation of CRISPR-Cas9, noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe strategy for GDF15 gene therapy. The CRISPR-Cas9 nanoparticles, known as ANPSS (Cas9/sgRNA), are easily created by enclosing a single Cas9/sgRNA complex in a polymer shell that is sensitive to glutathione. This shell also contains a dual-action ligand that aids in crossing the blood‒brain barrier, targeting tumor cells, and selectively releasing Cas9/sgRNA. Our encapsulating nanoparticles demonstrated promising GBM targeting, resulting in high GDF15 gene editing efficiency within brain tumors while showing minimal off-target gene editing in high-risk tissues. Treatment with ANPSS (Cas9/sgGDF15) effectively halted tumor growth, reversed immune suppression, and enhanced the efficacy of ICB therapy. These results emphasize the potential role of GDF15 in modulating the immune microenvironment and enhancing the effectiveness of current immunotherapy strategies for GBM. Graphical Abstract more...
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- 2025
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4. Climate action contributor and carbon space appropriator: national image construction of China in dual-carbon commitment from Indian media’s perspective
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Yuxin Wu and Xiufeng Zhao
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History of scholarship and learning. The humanities ,AZ20-999 ,Social Sciences - Abstract
Abstract China’s commitment in 2020 to its dual-carbon goal, demonstrating its intention to participate in tackling climate crisis, drew the attention of international media, particularly the media of India, which tends to deem China a rival neighbour. Indian media continually reported this announcement and subsequent policies and actions in China, reflecting Indian cognition and attitude toward China’s commitment to climate change and the Sino-Indian relationship. Given that, the present study adopts the Discourse-Historical Approach (DHA), using corpus tools Sketch Engine (SkE) and KH Coder to identify and visualise the topics of the 127 reports collected from three mainstream English newspapers in India, namely The Times of India, The Indian Express, and Hindustan Times, analysing the major discursive strategies including nomination, predication, and perspectivization strategy, and explores the national images of China constructed by the reports and uncovers the hidden ideology. The study finds that Indian media are mainly concerned with China’s target, plan, and conditions of the dual-carbon commitment, resorting to specially designed references, negative evaluations, and perspectivization strategies like indirect speech to target China’s energy practice, casting doubt on China’s capability to realise its goal. As regards China’s national image, Indian media construct China as a significant contributor to global climate action while evaluating its international role as a carbon space ‘appropriator’, with ‘too ambitious’ carbon goals and ‘disappointing’ carbon practices. In general, such construction reflects, to some degree, India’s tension against China’s rapid rise in climate governance. In addition, the competition for discursive rights in international carbon politics can also provide an account of the negative construction. The present study visualises the topics and the semantic features, promoting further integration of critical discourse analysis with corpus linguistics. Meanwhile, this analysis contributes to China-related international and regional media studies. more...
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- 2025
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5. Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade
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Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, and Wei Lin more...
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Glioblastoma ,Immunotherapy ,CRISPR/Cas9 ,Gene editing ,All-in-one ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches to combat GBM. Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy. Our approach involved the use of genetic engineering to the long-lasting production of PD-1 and the brain-specific peptide angiopep-2 on the surface of EVs. These modified EVs were then utilized to rejuvenate exhausted CD8+ T cells blocking PD-L1, resulting in significant therapeutic benefits for GBM treatment. Furthermore, the EVs contained Cas9 protein and sgRNA for precise and minimally invasive gene therapy, which addressing the key barriers associated with in vivo CRISPR‒Cas9 gene editing treatment. The multigene editing of EVs resulted in efficient intratumor multisite gene editing (PLK1: 58.6%, VEGF: 52.7%), leading to the successful apoptosis of tumor cells in vivo and demonstrating an antiangiogenic effect. This research introduces a promising universal platform for combining immune checkpoint blockade therapy with gene editing treatment. Graphical Abstract more...
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- 2025
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6. Study on the foam production characteristics of air self-suction foam generator by jet
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Caiyuan Lu, Yuxin Wu, Di Zhu, and Yuntao Liang
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Confined space fires ,Foam generator ,FER ,Air self-suction ,Range ,Medicine ,Science - Abstract
Abstract Confined space fires could easily cause serious casualties and property damage, and foam is an effective means of preventing confined space fires. The existing foam generator does not have both momentum and foam expansion rate (FER) and is poorly suited to confined spaces. In order to develop a foam generator suitable for confined space fire protection, an in-depth analysis of the physical foaming characteristics of self-suction foam is required, and the structure of the foam generator is optimized accordingly. For this reason, this paper analyzes the foaming characteristics and forming principle of air self-suction foam generator, and simulates and studies the over-current ratio of rectifying orifice plate with the help of Fluent software, $$\varphi$$ (the ratio of the area of the fluid that can pass through the rectifier disk to the vertical cross-sectional area of the fluid flow), the distribution patterns of flow field, pressure, and turbulence intensity inside the foaming machine are determined by the nozzle cavity spacing and mixing cavity diameter. The study demonstrates that water flow is the most effective means of entraining air, and that the contact between the fluid and foam network is most thorough when the overflow ratio of the fan disc ( $$\varphi$$ ) is 0.455, the distance between nozzle cavities $$\mu$$ (the distance between the nozzle and the closest end face of the foam chamber vertically.) is 200 mm, and the diameter of the mixing chamber ( $${d}$$ ) is 260 mm. These conditions are optimal for the foam generator. Experimental verification shows that the device has the strongest air entrainment capability at $$\varphi$$ 0.455. The foam mesh number ( $${m}$$ ), foam mesh spacing ( $${\ell}$$ ), and number of layers of foam mesh ( $${n}$$ ) significantly impact the air self-solution foaming of the jet. These factors influence FER, range (L), foam stacking thickness ( $$\sigma$$ ), and unfoamed liquid separation rate (γ, Foam solution not involved in the foaming process.), but the magnitude of their effect varies. Considering the four factors affecting foam production performance, the optimal effect is achieved when the foam mesh of 16, the foam mesh spacing of 3 cm, the foam mesh of 2 layers, the distance between the foam mesh and the nozzle is 22 cm and $$\varphi$$ is 0.455. Under these conditions, the foaming ratio (FER) of the jet self-suction foaming machine is 42 times, with L at 13 m, σ at 7 cm, and γ at 0.15 L/s. A device has been developed for long-distance and high FER air self-suction of foam generator, which can significantly assist in fire prevention and extinguishing in confined spaces. more...
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- 2025
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7. Prevalence of Disability in Older Adults with Chronic Disease in China: a Meta-analysis
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HE Yuxin, WU Yixin, YANG Shan, XIN Bo, LI Mengchi, JIANG Wenhui
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chronic disease ,disability ,older adults ,meta-analysis ,china ,Medicine - Abstract
Background As global population continues to age, disability has become one of the most prominent health problems in the aging population. Chinese older adults with chronic diseases often diagnosed with multi-morbidities resulting in increased risks for disability. However, previous evidence on disability rates in this population have been inconsistent. Objective To systematically evaluate the prevalence of disability in older adults with chronic diseases in China. Methods We searched databases including PubMed, Embase, Web of Science, Cochrane Library, Scopus, CNKI, Wanfang Data, VIP, CBM and China Medical Journal Full-text Database up until August 2023 for publications on disability prevalence in Chinese older adults with chronic diseases. Literature screening, quality appraisal and data extraction were performed independently by two researchers. Meta-analysis was conducted using Stata 16.0 software. Results A total of 32 publications (34 studies) were included. Sample sizes ranged from 221 to 16 566 cases with a disability rate of 6.9%-82.8%. Meta-analysis showed that the prevalence of disability in Chinese older adults with chronic diseases was 43.2% (95%CI=32.9%-53.5%). Subgroup analyses showed: disability rate was higher in female (36.6%, 95%CI=27.0%-46.2%) than in male (33.9%, 95%CI=23.9%-43.9%) ; disability prevalence increased with age (60-69 years old: 24.2%, 95%CI=14.3%-34.0%; 70-79 years old: 34.9%, 95%CI=24.1%-45.7%; ≥80 years old: 47.7%, 95%CI=36.3%-59.1%) ; compared to other chronic diseases, individuals with dementia/Parkinson's disease (56.3%, 95%CI=40.9%-71.7%), mental illness (53.9%, 95%CI=46.0%-61.7%), and cerebrovascular disease (49.2%, 95%CI=33.5%-64.8%) had the highest prevalence of disability; and the prevalence of disability increased with the number of comorbidities (1 disease: 33.1%, 95%CI=20.8%-45.3%; 2 diseases: 36.3%, 95%CI=22.6%-50.0%; ≥3 diseases: 49.7%, 95%CI=31.3%-68.0%) . Conclusion The prevalence of disability among Chinese older adults with chronic diseases is high and can be impacted by both the type of chronic disease and the number of comorbidities. It is recommended to strengthen chronic disease monitoring and management efforts to prevent and eliminate disability and promote healthy aging in this population. more...
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- 2025
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8. Bioactive constituents of amphibious Rotala rotundifolia at different growth stages and response surface optimization for flavonoid extraction
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Shuyi Chu, Zhijun Shi, Jibo Xiao, and Yuxin Wu
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Rotala rotundifolia ,Amphibious plant ,Response surface methodology ,Ultrasonic-assisted extraction ,Flavonoids ,Medicine ,Science - Abstract
Abstract Rotala rotundifolia is an amphibious aquatic plant that can live in submerged and emergent forms. It is superior in nitrogen and phosphorus removal and has been used as a traditional medicine in China for over a hundred years. In this study, the bioactive constituents from different tissues of submerged and emergent R. rotundifolia at different growth periods were investigated. The response surface method was used to optimize the flavonoids extraction condition. The amount of flavonoids and triterpenoids from different tissues of R. rotundifolia were much higher than tannins and alkaloids. The highest total flavonoids amount from the leaves of submerged R. rotundifolia was 270.92 ± 13.34 mg/g at day 30 (phyllomorphosis finished), 1.8 times that of the emergent form (150.45 ± 15.11 mg/g). The highest triterpenoids content from the submerged and emergent forms was 242.20 ± 11.51 and 163.09 ± 14.87 mg/g at days 90 and 150 (flowering stage), respectively. The optimal flavonoid extraction conditions were: extraction time 50 min, ultrasonic power 333 W, ethanol concentration 79.3%, and a solid–liquid ratio of 1:60. The LC-MS/MS analysis showed that the extracts from submerged and emergent R. rotundifolia contained 26 and 22 flavonoids, respectively. This study provides phytochemical evidence for the further utilization of R. rotundifolia. more...
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- 2024
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9. Data-driven prediction framework of surrounding rock pressure in a fully mechanized coal face with temporal-spatial correlation
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Yang Song, Yinhui Feng, Weidong Wang, Yuhan Fan, Yuxin Wu, and Ziqi Lv
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Surrounding rock pressure ,Hydraulic support ,Data-driven ,Temporal-spatial fusion ,Medicine ,Science - Abstract
Abstract Surrounding rock pressure prediction for fully mechanized coal face (FMCF) roof management and control is of great significance. The key challenge is to effectively combine various factors to evolve the surrounding rock pressure trend with high temporal-spatial correlation and heterogeneity. The hydraulic support load is an important indicator that reflects the change in the surrounding rock pressure. Inspired by the research on 'support-surrounding rock’ and the massive data collected by sensors, this paper proposes a data-driven prediction framework for surrounding rock pressure in FMCFs. The framework includes the multidimensional working condition matrix (MWCM) building module, the hydraulic support group temporal-spatial feature fusion (HTSFF) network, and the adaptive deployment strategy (ADS). The MWCM generating methods of hydraulic support in combination with the mining process and the data quality and quantity requirements of the conventional supervised learning method are weakened by the treatment of missing data adapting to the working conditions. The HTSFF network focuses on capturing the spatial correlation of the surrounding rock pressure along the mining direction and the temporal periodicity along the advancing direction of the FMCF and fully considers the dependencies between them. ADS aims to solve the problem of missing data in model deployment and reduce the interference of abnormal data in the model prediction process by adaptively generating MWCM. The rationality and practicability of various designs of the proposed framework were verified on our dataset. Quantitative experiments show that the average error of the surrounding rock pressure prediction is 1.2406 MPa, and the accuracy, precision, and recall rate of periodic pressure prediction are all above 95%. This method can effectively assist FMCF roof management and control. Although the method is effective, it may require further fine-tuning of the model to adapt to different geological conditions and varying sensor quality, ensuring broader applicability. more...
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- 2024
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10. Prediction of the early hepatocellular carcinoma development in patients with chronic hepatitis B virus infection using gadoxetic acid-enhanced magnetic resonance imaging
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Mimi Tang, Danyang Xu, Huilin Jin, Chenyu Song, Xiaoqi Zhou, Huasong Cai, Lujie Li, Meicheng Chen, Yuxin Wu, Yanji Luo, Yuying Chen, and Shi-Ting Feng
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Non-hypervascular hypointense nodules ,Hepatocellular carcinoma ,Radiomics ,Magnetic resonance imaging ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Non-hypervascular hypointense nodules (NHHNs) can transform into hypervascular hepatocellular carcinoma (HCC) during the long-term follow-up. However, the risk factors for NHHN hypervascular transformation in chronic hepatitis B virus (HBV)-infected populations are unknown. This study assessed the predictive value of gadoxetic acid-enhanced magnetic resonance imaging (MRI) for HCC development in patients with chronic HBV infection. Methods A total of 86 patients with HBV infection who underwent gadoxetic acid-enhanced MRI at the First Affiliated Hospital of Sun Yat-sen University between January 2011 and July 2019 and were followed up for 2 years were retrospectively reviewed. Imaging features, including cirrhosis, steatosis, and NHHNs, were collected. Radiomics features were extracted from the entire liver. The HCC development predictive models were built based on each patient’s clinical data, MRI features, and radiomic features. We then collected the qualitative and quantitative features of each NHHN and investigated the risk factors of hypervascular transformation. Results Thirteen patients developed HCC within two years. The risk factors for HCC development in patients with chronic HBV infection included older age, cirrhosis, and NHHNs. The MRI, radiomics, and integrated models developed all had an area under the curve (AUC) above 0.8. The potential risk factors for hypervascular transformation of NHHNs were the diameter of the NHHN (OR = 1.69, 95% CI:1.23, 2.32, P = 0.001) and the signal intensity (SI) ratio of the NHHN to the liver in the hepatobiliary phase (HBP SI ratio*10, OR = 0.36, 95% CI:0.11, 0.85, P = 0.044). The AUC of the hypervascular transformation model was 0.846 (95% CI:0.719, 0.972). Conclusion In chronic HBV infection population, patients with older age, cirrhosis and NHHNs are more likely to develop HCC within two years. Models based on these factors or radiomic features can effectively predict HCC development. The diameter of the NHHNs and the signal intensity ratio of NHHN to the liver in the hepatobiliary phase are potential risk factors for the hypervascular transformation of NHHNs. more...
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- 2024
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11. The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions
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Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, and Evgeni Ponimaskin
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G protein-coupled receptor (GPCR) ,Receptor oligomerization ,Serotonin receptor 7 (5-HT7R) ,Hyaluronan receptor CD44 ,Fluorescence Resonance Energy Transfer (FRET) ,Bioluminescence Resonance Energy Transfer (BRET) ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Background Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R), a class A GPCR, and the cell adhesion molecule CD44. However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic. Methods Using a quantitative FRET (Förster resonance energy transfer) approach, we determined the affinities for the formation of homo- and heteromeric complexes of 5-HT7R and CD44. The impact of heteromerization on 5-HT7R-mediated cAMP signaling was assessed using a cAMP responsive luciferase assay and a FRET-based cAMP biosensor under basal conditions as well as upon pharmacological modulation of the 5-HT7R and/or CD44 with specific ligands. We also investigated receptor-mediated G protein activation using BRET (bioluminescence resonance energy transfer)-based biosensors in both, homo- and heteromeric conditions. Finally, we analyzed expression profiles for 5-HT7R and CD44 in the brain during development. Results We found that homo- and heteromerization of the 5-HT7R and CD44 occur at similar extent. Functionally, heteromerization increased 5-HT7R-mediated cAMP production under basal conditions. In contrast, agonist-mediated cAMP production was decreased in the presence of CD44. Mechanistically, this might be explained by increased Gαs and decreased GαoB activation by 5-HT7R/CD44 heteromers. Unexpectedly, treatment of the heteromeric complex with the CD44 ligand hyaluronic acid boosted constitutive 5-HT7R-mediated cAMP signaling and receptor-mediated transcription, suggesting the existence of a transactivation mechanism. Conclusions Interaction with the hyaluronan receptor CD44 modulates both the constitutive activity of 5-HT7R as well as its agonist-mediated signaling. Heteromerization also results in the transactivation of 5-HT7R-mediated signaling via CD44 ligand. more...
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- 2024
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12. Unsupervised anomaly detection in shearers via autoencoder networks and multi-scale correlation matrix reconstruction
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Yang Song, Weidong Wang, Yuxin Wu, Yuhan Fan, and Xuan Zhao
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Shearer ,Unsupervised learning ,Autoencoder networks ,Anomaly detection ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Abstract As the main equipment of coal mining production, the anomaly detection of shearer is important to ensure production efficiency and coal mine safety. One key challenge lies in the limited or even absence of labeled monitoring data for the equipment, coupled with the high costs associated with manual annotation. Another challenge stems from the complex structure of the mining machines, making it difficult to reflect the overall operational state through local anomaly detection. Consequently, the application of decoupled local anomaly detection for mining machines in practical production remains challenging. This paper presents an unsupervised learning-based method for detecting anomalies in shearer. The method includes a module for constructing a Multi-scale Correlation Matrix (MSCM) of mining machine operating conditions, as well as the CNN-ConvLSTM Autoencoder (C-CLA) network. The module for constructing an MSCM enhances the representation of interrelationships between various features of the equipment from different perspectives using multiple correlation analysis methods. The C-CLA network integrates convolutional and convolutional recurrent neural networks, with the convolutional structure extracting local spatial features and the ConvLSTM structure further capturing information from different time scales and feature scales, thereby enhancing the model’s perceptual capabilities towards changes in equipment status. Finally, shearer anomaly detection is achieved through the analysis of reconstructed residual matrices. The rationality and practicality of the proposed method have been validated on our dataset, and the model’s generalization capability has been verified through repeated experiments in similar scenarios. However, due to variations in the working environment of different mining faces and differences in equipment models, implementing detection on other mining faces often requires retraining the model with new data. Furthermore, we compared our method with other anomaly detection techniques, and our detection efficiency was superior by approximately 3%. This method effectively detects anomalies in the shearer. more...
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- 2024
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13. Spartina alterniflora invasion significantly alters the assembly and structure of soil bacterial communities in the Yellow River Delta
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Pengyuan Sun, Yuxin Wu, Pengcheng Zhu, Jingfeng Wang, Xiaona Yu, and Weihua Guo
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assembly process ,bacterial community ,coastal wetlands ,co-occurrence network ,Spartina alterniflora invasion ,Microbiology ,QR1-502 - Abstract
Soil microbial communities are integral to almost all terrestrial biogeochemical cycles, which are essential to coastal wetland functioning. However, how soil bacterial community assembly, composition, and structure respond to native and non-native plant invasions in coastal wetlands remains unclear. In this study of the coastal wetlands of the Yellow River Delta in China, the assembly, community composition, and diversity of soil bacterial communities associated with four wetland plant species (Phragmites australis, Spartina alterniflora, Suaeda salsa, and Tamarix chinensis) and four soil depths (0–10 cm, 10–20 cm, 20–30 cm, and 30–40 cm) were characterized using high-throughput sequencing. Plant species identity, as well as environmental factors, rather than soil depth, was found to play predominant roles in shaping the diversity and structure of wetland soil bacterial communities. S. alterniflora invasion altered bacterial community structure and increased bacterial diversity. Phragmites australis-associated bacterial communities were enriched with sulfate-reducing bacteria such as Desulfurivibrio and Desulfuromonas. In comparison, S. alterniflora-associated bacterial communities were enriched with both sulfate-reducing bacteria (SEEP-SRB1) and sulfate-oxidizing bacteria (Sulfurimonas), which maintained a dynamic balance in the local sulfur-cycle, and thereby enhanced S. alterniflora growth. In addition, stochastic processes dominated the assembly of soil bacterial communities associated with all four plant species, but were most important for the S. alterniflora community. The S. alterniflora-associated bacterial community also showed stronger interactions and more extensive connections among bacterial taxa; a co-occurrence network for this community had the greatest average clustering coefficient, average degree, modularity, and number of links and nodes, but the lowest average path length. Altogether, individual plant species had distinct effects on soil bacterial community assembly and structure, with the invasive species having the strongest impact. These results provide insights into microbial ecology and inform management strategies for coastal wetland restoration. more...
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- 2025
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14. A venturi device for stable addition of foaming agent to self‐suction liquid at high flow rates
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Caiyuan Lu, Yuxin Wu, Mujun Chen, and Yuntao Liang
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cavitation ,pressure ,self‐suction liquid ,suction liquid ratio ,Venturi ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract To achieve a stable addition of foaming agent under high flow rates, an independently designed venturi structure with self‐suction of liquid to add foaming agent was numerically simulated. We simulated the effects of different self‐suction liquid structures' diameters (diameter of the tube in which the liquid is sucked in), contraction angles, throat length, and position on the suction liquid ratio (ratio of venturi self‐suction liquid flow rate to total flow rate), compared and analyzed the data, and determined the optimal self‐suction liquid structures parameters. The suction liquid ratio shows a tendency to first stabilize and then decrease as the outlet pressure increases. When the outlet pressure in range of 0.30–0.45 MPa, the suction liquid ratio remains stable at 1.14%. However, as the outlet pressure increases, the ability of the venturi structure to add foaming agent through the self‐suction liquid decreases under high flow rates, causing the suction liquid ratio to rapidly decrease to a minimum value of 0.60 MPa. We have conducted a detailed analysis of the process and flow field of suction liquid. As the outlet pressure increases, the high‐speed area of the throat gradually shrinks, and the flow field in the diffusion section fluctuates. When the outlet pressure is 0.6 MPa and the velocity field shifts toward the upper part of the diffusion section, the cavitation area will gradually disappear and lose its liquid suction ability. more...
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- 2024
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15. Effects of hypoxia and reoxygenation on energy metabolism, immune response, and apoptosis in orange-spotted grouper (Epinephelus coioides)
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Yuxin Wu, Yiran Lin, Bing Lin, Yukun Huang, Zhide Yu, Yonghao Ma, Yuwei Feng, Qiaoyi Chen, Along Gao, and Hu Shu
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Epinephelus coioides ,hypoxia ,reoxygenation ,energy metabolism ,immune response ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Hypoxia is an unfavorable environmental condition that produces diverse negative effects in fish. High-density cultures of Epinephelus coioides are more likely to experience hypoxic conditions than those in natural environments. To assess the effects of hypoxia on E. coioides, we examined the related enzyme activities and gene expression after 48 h of hypoxia and 24 h of dissolved oxygen (DO) recovery. Under hypoxic stress (DO: 1.2 ± 0.1 mg/L), the energy supply mode of fish changed from aerobic metabolism to anaerobic metabolism, and the serum glucose content and lactate dehydrogenase activity were significantly upregulated. Total protein, hepatic glycogen, and two key regulatory enzymes (i.e., hexokinase and pyruvate kinase) were differentially expressed in the liver, and mRNA expression of three genes (i.e., LDHA, GLUT1, and MCT2) also showed a high expression trend. In serum, three immune-related enzymes (i.e., alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) were found to be involved in regulation by hypoxia and showed different levels of changing patterns. Expression of inflammatory genes (i.e., IL-8, IFNγ, MyD88, and NF-kB) were significantly regulated in liver. With prolongation of hypoxic stress, high expression of apoptotic genes (i.e., p53, Bax, Bcl-2, and Caspase-9) was closely related to the degree of apoptosis in the liver. Our investigation of the changes in energy metabolism, immune response, and apoptosis of E. coioides under hypoxia and reoxygenation (DO, 6.0 ± 0.1 mg/L) provides a theoretical bases for healthy aquaculture and selection of varieties with tolerance to hypoxia. more...
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- 2024
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16. Application of three Transformer neural networks for short-term photovoltaic power prediction: A case study
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Jiahao Wu, Yongkai Zhao, Ruihan Zhang, Xin Li, and Yuxin Wu
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Photovoltaic power ,Time series prediction (TSP) ,Transformer neural network ,Renewable energy sources ,TJ807-830 - Abstract
In order to solve the potential safety hazards caused by the fluctuation of photovoltaic (PV) power generation, it is necessary to predict it in advance and take countermeasures as soon as possible. Based on the three models of vanilla Transformer, Informer, and Autoformer, this paper considers three prediction scenarios: zero-cost prediction, low-cost prediction, and high-cost prediction, and realizes the power prediction under two prediction horizons of 4 h and 24 h for a matrix of a centralized PV power station in Hubei Province, China. The results of some configurations meet the industry-recommended metric requirements, and the overall performance of the vanilla Transformer is better than Informer and Autoformer. After comparing the three models and different prediction intervals, and considering the practical industrial demand, this paper gives recommended configurations for both 4 h and 24 h predictions. The practical rolling prediction performance of the recommended configurations demonstrates the applicability and flexibility of the proposed methods. more...
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- 2024
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17. Quantitative phenotyping of crop roots with spectral electrical impedance tomography: a rhizotron study with optimized measurement design
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Valentin Michels, Chunwei Chou, Maximilian Weigand, Yuxin Wu, and Andreas Kemna
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Beans ,Complex resistivity ,Induced polarization ,Maize ,Phenotyping ,Rhizotron ,Plant culture ,SB1-1110 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Root systems are key contributors to plant health, resilience, and, ultimately, yield of agricultural crops. To optimize plant performance, phenotyping trials are conducted to breed plants with diverse root traits. However, traditional analysis methods are often labour-intensive and invasive to the root system, therefore limiting high-throughput phenotyping. Spectral electrical impedance tomography (sEIT) could help as a non-invasive and cost-efficient alternative to optical root analysis, potentially providing 2D or 3D spatio-temporal information on root development and activity. Although impedance measurements have been shown to be sensitive to root biomass, nutrient status, and diurnal activity, only few attempts have been made to employ tomographic algorithms to recover spatially resolved information on root systems. In this study, we aim to establish relationships between tomographic electrical polarization signatures and root traits of different fine root systems (maize, pinto bean, black bean, and soy bean) under hydroponic conditions. Results Our results show that, with the use of an optimized data acquisition scheme, sEIT is capable of providing spatially resolved information on root biomass and root surface area for all investigated root systems. We found strong correlations between the total polarization strength and the root biomass ( $$R^2 = 0.82$$ R 2 = 0.82 ) and root surface area ( $$R^2 = 0.8$$ R 2 = 0.8 ). Our findings suggest that the captured polarization signature is dominated by cell-scale polarization processes. Additionally, we demonstrate that the resolution characteristics of the measurement scheme can have a significant impact on the tomographic reconstruction of root traits. Conclusion Our findings showcase that sEIT is a promising tool for the tomographic reconstruction of root traits in high-throughput root phenotyping trials and should be evaluated as a substitute for traditional, often time-consuming, root characterization methods. more...
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- 2024
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18. Climate chamber investigation of the effect of indoor thermal histories on thermal adaptation in different seasons
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Yuxin Wu, Angchen Jiang, Hong Liu, Baizhan Li, and Risto Kosonen
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Skin temperature ,Thermal experience ,Thermal comfort ,Cold acclimation ,Hot summer and cold winter ,Environmental technology. Sanitary engineering ,TD1-1066 ,Building construction ,TH1-9745 - Abstract
The indoor thermal history of residents in the hot summer and cold winter climate zone in China have undergone a significant change in recent years, which also changes their seasonal thermal adaptations and this has formed feed-back effects to the increasing usage of air conditioning units in this area. To study the seasonal variations of thermal adaptation, the thermal comfort experiments were conducted on two groups of participants. Each groups included 20 participants who had indoor history mainly with natural ventilation (NV group) and air-conditioning (AC group), respectively. The results demonstrated that the thermal sensation vote (TSV) in warm environments did not differ between AC and NV subjects in summer. However, the TSV of AC subjects were much lower than that of NV subjects in the same standard effective temperature and skin temperature in a cold environment in winter. Overall, the participants who spent most of their time in AC space in winter showed a low level of thermal adaptation with a narrower acceptable skin temperature range of 32.6 – 33.5 °C. Thus, this study presents the basic information regarding the seasonal effects on human thermal adaptation due to different long-term indoor thermal histories. more...
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- 2024
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19. Design of rescue robot system based on multi-sensor information fusion.
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Hongmei Zhao, Jun Zhang, Yuxin Wu, and Jisong Chen
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- 2024
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20. Assessment of spatial and socioeconomic disparities in urban green space accessibility based on a Physical Activity Diversity Index (PADI)
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Yunjing Hou, Yiming Liu, Yuxin Wu, and Bo Zhang
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Urban green space ,Physical activity promotion ,Diversity ,Accessibility ,Socioeconomic disparities ,Ga2SFCA method ,Ecology ,QH540-549.5 - Abstract
Urban green spaces (UGS) contribute to residents’ health by promoting physical activity. However, there are significant spatial and socioeconomic disparities in UGS accessibility, leading to unequal access to UGS benefits among residents. Current assessments of UGS accessibility often overlook the role of UGS in promoting physical activity. Additionally, the consideration of UGS components typically focuses on their quantity rather than diversity. In light of this, our study proposes an evaluation method for the Physical Activity Diversity Index (PADI) of UGS and revises the supply scale parameter in the Gaussian two-step floating catchment area (Ga2SFCA) model based on this index. Taking Harbin, China as an example, we measure UGS accessibility and explore its association with residents’ income levels using the bivariate Moran’s I and multiple linear regression models. Our findings indicate that a higher PADI can partially compensate for insufficient UGS area, thereby increasing accessibility in certain areas and alleviating the relative disadvantage of low-income groups in accessing UGS. Considering PADI can more accurately identify underserved areas, providing more precise guidance for urban planning. This study highlights the importance of considering the diversity of UGS components in accessibility assessments and offers feasible solutions to mitigate spatial and socioeconomic disparities in UGS accessibility. more...
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- 2024
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21. A noval Dual-Parameter Structural Model with Enhanced traffic flow representations.
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Yuxin Wu, Xudong Zhang, and Haina Tang
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- 2025
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22. Data informativity for tracking control of learning systems: Test and design conditions.
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Yuxin Wu and Deyuan Meng
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- 2025
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23. RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
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Yue Yu, Zhihua Xu, Hao Zhou, Ruyan Xu, Jia Xu, Wenjun Liu, Yuxin Wu, Yue Qiu, Guangbo Zhang, Xue Huang, and Yan Chen
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Breast cancer ,RBP7 ,Prognosis ,Fatty acid metabolism ,Nomogram ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Background Increasing evidence proves that RBP7 plays a significant role in breast cancer (BC). The present study was aimed to investigate the mechanism of RBP7. Methods Western Blotting and qRT-PCR were performed for evaluating the expression levels. CCK8, colony forming, xenograft mouse model, wound healing and transwell assays were conducted to examine cell ability of proliferation, invasion and migration. Nile red staining and Oil red O staining were used for testing the lipid. Results RBP7 was related to overall survival (OS) in patients with HR + BC. RBP7 protein was significantly decreased in HR + BC tissues and cells. RBP7 suppressed HR + BC cell proliferation in vitro and in vivo, and inhibited migration and invasion. RBP7 reduced fatty acid in HR + BC cells by inhibiting the AKT/SREBP1 pathway. Conclusions RBP7 may function as a tumor suppressor in HR + BC by inhibiting the AKT/SREBP1 pathway and reducing fatty acid. more...
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- 2024
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24. MILD pulverized combustion technology: The latest research progress and key scientific issues
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Junfu LÜ, Lele FENG, Yuxin WU, and Hai ZHANG
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moderate or intense low-oxygen dilution (mild) combustion ,high-speed jet ,coal combustion ,pollutant ,turbulence ,Geology ,QE1-996.5 ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The MILD combustion is a combustion mode that occurs in a moderate or extremely low oxygen environment, combining the advantages of high combustion heat utilization and very low NOx emissions, and is considered by the international combustion field to be one of the cleaner combustion technologies with great potential for application. Since the relevant research began around 1990, the technology for achieving a MILD combustion of gas fuels has been relatively mature, while the research on the MILD combustion mechanism and implementation conditions of solid fuels such as coal powder and biomass is still relatively lacking. Based on the high momentum oxidizer jet, internal recirculation is achieved, eliminating the need for external high-temperature preheating to establish MILD combustion, greatly expanding the application range of MILD combustion. This paper provides an overview of the basic characteristics of MILD powder fuel combustion from the aspects of particle dispersion, heating, ignition, combustion, and pollutants. Due to the uneven dispersion and reaction of particles, the MILD combustion process of carbon-based solid fuels such as coal powder is more complex than that of gas fuels. High speed jet MILD combustion not only increases ignition delay but also expands ignition and reaction zones, requiring systematic research on the characteristics and mechanisms of each combustion stage. This paper introduces the research achievements in the theoretical design and equipment development of solid fuel MILD combustion. It is recommended to improve the existing coal-fired boiler burner, adjust the process parameters to match the MILD combustion mode, increase the residence time of coke particles to improve combustion efficiency, improve combustion stability, and suppress various pollutant emissions, including fine particulate matter, through high-precision numerical simulation. Based on the overall approach of interconnected energy systems, the coupling research between MILD combustion and various new combustion technologies should be promoted, especially strengthening the research on the co-combustion characteristics of coal powder, biomass and hydrogen, ammonia and other combustible gases, and assisting in energy transformation. Exploring the characteristics of turbulent two-phase flow, turbulent interphase heat transfer, and turbulent chemical coupling in the powder MILD combustion is crucial for deepening the understanding of powder MILD combustion. It involves multivariate analysis and high-precision simulation, which will be the focus and difficulty of future research. more...
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- 2024
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25. Analysis on hot briquetting mechanism of biomass fuel pellets
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Shouyu ZHANG, Jiantian HUANG, Sen LANG, Xingjia ZHANG, Xuyang CHEN, Ning LIANG, Bangyong LÜ, Chuke YANG, Nan HU, Yuxin WU, and Junfu LÜ
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biomass ,briquetting ,intermolecular forces ,mechanical interlocking ,bridging ,Geology ,QE1-996.5 ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Under the carbon peaking and carbon neutrality strategy, biomass has attracted much attention due to its characteristics of regeneration, low pollution and zero carbon emissions. The imperfects of biomass, such as the loose structure and low energy density, can be effectively solved by briquetting, and the resulted fuel pellets can be used as a substitute for fossil fuels, which is of great significance for the construction of new energy system. In the paper, the influencing factors of the hot briquetting process of biomass were summarized, and the evolution behavior and binding mechanism of biomass particles during the hot briquetting process were analyzed and discussed. Biomass briquetting process mainly includes cold briquetting and hot briquetting. Compared with cold briquetting process of biomass, hot briquetting with lower energy consumption can produce the biomass fuel pellets with higher quality. The moisture content (4%−15%) of the raw biomass has greater influence, the briquetting temperature (70−150 ℃) has relatively smaller effect on the density of the fuel pellets, and the briquetting pressure (60−130 MPa) and the particle size ( < 2.5 mm) of the raw material show the different impact on the density of the fuel pellets from different biomass. During the hot process, cellulose mainly plays the role of supporting skeleton, hemicellulose and lignin play the role of binder. In the microcosmic process of hot briquetting process, the inertia movement and subsequent viscoelastic-plastic deformation of the biomass particles occur and the mechanical interlock is formed between the particles. The brittle particles are broken and the natural viscous components are released, and thus, the bridge linkage between the particles is formed under the integrated effects of moisture, temperature and pressure. Mechanical interlocking and bridging reduce the distance between biomass molecules and promote the generation of intermolecular forces. Based on the above-mentioned mechanism of the hot briquetting of biomass, the quality of the resulted fuel pellets can be improved by biomass component adjustment, biomass blending or hydrothermal pretreatment. In the future, the molecular dynamics simulation method will be used to investigate the biomass briquetting process to obtain the molecular bonding mechanism of biomass components, which is conducive to further exploring the hot briquetting mechanism of biomass, and provide important guiding significance for the preparation of fuel pellets and molding materials from biomass. more...
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- 2024
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26. Dual-Functional UAV-Empowered Space-Air-Ground Networks: Joint Communication and Sensing.
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Xiangdong Zheng, Yuxin Wu, Lisheng Fan, Xianfu Lei, Rose Qingyang Hu, and George K. Karagiannidis
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- 2024
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27. Synchronizability-Based Distributed Learning Control for Multi-Agent Systems.
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Yuxin Wu and Deyuan Meng
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- 2024
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28. Resilient Machine Learning-Based Semantic-Aware MEC Networks for Sustainable Next-G Consumer Electronics.
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Yuxin Wu, Shunpu Tang, Lianhong Zhang, Lisheng Fan, Xianfu Lei, and Xiang Chen 0007
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- 2024
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29. Scoring Aided Federated Learning on Long-Tailed Data for Wireless IoMT Based Healthcare System.
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Lianhong Zhang, Yuxin Wu, Lunyuan Chen, Lisheng Fan, and Arumugam Nallanathan
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- 2024
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30. Priority-Aware Resource Allocation for RIS-assisted Mobile Edge Computing Networks: A Deep Reinforcement Learning Approach.
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Jing Ling, Chao Li, Lianhong Zhang, Yuxin Wu, Maobin Tang, and Fusheng Zhu
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- 2024
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31. Pediatric WNT medulloblastoma predisposition in intraoperative blood loss: a retrospective observational cohort study
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Zaiyu Zhang, Yuxin Wu, Xueling Zhao, Wenyuan Ji, Lusheng Li, Xuan Zhai, Ping Liang, Yuan Cheng, and Jianjun Zhou
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blood loss ,hemorrhage ,medulloblastoma ,molecular subgroup ,wingless ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionMolecular subgroups influence the vascular architecture within medulloblastomas, particularly the wingless (WNT) subgroup, which contributes to its propensity for primary tumor hemorrhage. Whether this mechanism affects intraoperative blood loss remains unknown. This study aimed to assess the association between WNT medulloblastoma and the predisposition for blood loss.MethodsThis was a retrospective observational study using data from a neuro-oncology center comprising molecular data on patients treated between December 31, 2014, and April 30, 2023. Differences between WNT and other subgroups in the risk of primary outcome-intraoperative blood loss were assessed using multivariable-adjusted linear regression.ResultsOf the 148 patients included in the analysis, 18 patients (12.2%) had WNT, 42 (28.4%) had sonic hedgehog (SHH) TP53-wildtype, 7 (4.7%) had SHH TP53-mutant, and 81 (54.7%) were non-WNT/ non-SHH. The WNT subgroup more frequently underwent primary intratumoral hemorrhage (22% vs. 3.8%; p = 0.011). The median intraoperative blood loss was 400.00 (interquartile range [IQR] 250, 500) mL for WNT and 300.00 [200, 400] mL for the other subgroups (p = 0.136), with an adjusted β of 135.264 (95% confidence intervals [CI], 11.701–258.827; p = 0.032). Similar results were observed in both midline and noninfiltrative margin medulloblastoma.DiscussionWNT medulloblastoma is typically associated with primary intratumoral hemorrhage and intraoperative blood loss. The validity of determining the surgical approach based on predicted molecular subtypes from imaging data is questionable. However, attempting to engage in risk communication with patients in a molecular-specific way is worthwhile to validate. more...
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- 2024
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32. Effect of product recommendation type and focal goal importance on consumer purchase intention
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Libin Chen, Shuo Wang, Ke Ma, and Yuxin Wu
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set recommendation ,separate recommendation ,focal goal ,purchase intention ,perceived incompleteness ,cognitive load. ,Management. Industrial management ,HD28-70 ,Business ,HF5001-6182 - Abstract
Purpose: The product recommendation type is attracting attention from both the retail and academic communities. However, there is no consensus on the effectiveness of set recommendation versus separate recommendation. This research investigates the interaction effect of product recommendation type and consumer’s focal goal importance on initial product purchase intention and cross-buying intention. Design/methodology/approach: Four studies were used to examine the hypotheses, including three experimental studies with general participants and a field study with student participants. Findings/results: An empirical analysis confirms an interaction relationship between product recommendation style and focal goal importance on enhancing purchase. When focal goal importance is high, set recommendation has a more positive effect on purchase intention. When focal goal importance is low, the separate recommendation has a more positive effect on purchase intention. Practical implications: Research findings provide guidance for sellers on which product recommendation type to use with different customers. Sellers should be flexible in determining different product recommendation types through different consumers’ focal goals. Originality/value: Findings reveal the congruency effect between product recommendation type and consumer’s focal goal importance, which indicates an interaction effect on initial product purchase intention and cross-buying intention. In addition, this research expands the application of regulatory focus theory and analyses the underlying mechanism by exploring the role of perceived incompleteness and cognitive load. more...
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- 2024
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33. Electrical Resistivity Changes During Heating Experiments Unravel Heterogeneous Thermal‐Hydrological‐Mechanical Processes in Salt Formations
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Hang Chen, Jiannan Wang, Linqing Luo, Shawn Otto, Jon Davis, Kristopher L. Kuhlman, and Yuxin Wu
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electrical resistivity tomography ,radioactive waste ,THM processes ,rock salt ,hydrogeophysics ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract Rock salt is considered a suitable medium for the permanent disposal of heat‐generating radioactive waste due to its isolation properties. However, excavation damage and heating induce complex and heterogeneous thermal‐hydrological‐mechanical (THM) processes across different zones. Quantifying this heterogeneity is crucial for accurate long‐term performance assessment models, but traditional methods lack the necessary resolution. This study employs 4D electrical resistivity tomography (ERT) monitoring during controlled heating experiments in a salt formation to unravel the spatiotemporal dynamics of THM processes. Advanced time‐lapse inversion and clustering analysis quantify subsurface properties and map the heterogeneity of THM dynamics. The ERT results can estimate subsurface properties and delineate the damaged and intact zones, enabling appropriate parameterization and representation of processes for long‐term modeling. This approach may be used in further improving the predictive models and ensuring the safe long‐term disposal of radioactive waste in rock salt. more...
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- 2024
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34. Physical exercise and mental health among older adults: the mediating role of social competence
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Bin Hou, Yuxin Wu, and Yuqi Huang
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physical exercise ,mental health ,social competence ,older adults ,mediating role ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundHealthy aging is crucial to the quality of life of older adults, of which mental health is an essential part. Physical exercise strongly affects their mental health and can alleviate psychological problems to a certain extent. Nevertheless, the correlation between physical exercise and the mental health of older adults individuals, as well as the underlying mechanism by which physical exercise impacts mental health, remains rather ambiguous.MethodsWe utilized multiple linear regression models to investigate the relationship between physical activity and mental health in 3,240 persons aged 60 and up. The propensity score matching (PSM) method was used to assess the robustness of the regression results. In addition, sequential recursive models were employed to investigate the mediating role of social competence in the link between physical activity and mental health.Results and discussionWe discovered a strong favorable association between physical exercise and mental health, which was mediated by social competence. Furthermore, the effect of physical exercise on mental health differed across older persons from various socioeconomic backgrounds.ConclusionOlder adults should strengthen their understanding of the role of physical exercise. Sports organizations that serve older adults by providing resources and services to help them maintain physical fitness and by hosting sports activities and competitions according to their needs should be established. more...
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- 2024
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35. The Importance of Accounting for Landscape Position When Investigating Grasslands: A Multidisciplinary Characterisation of a California Coastal Grassland
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Mike C. Rowley, Nicola Falco, Elaine Pegoraro, Baptiste Dafflon, Cynthia Gerlein‐Safdi, Yuxin Wu, Cristina Castanha, Jasquelin Peña, Peter S. Nico, and Margaret S. Torn
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critical‐zone approach ,landscape cluster analysis ,soil carbon dioxide fluxes ,NDVI ,soil organic carbon content ,soil moisture content ,Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
Abstract Grasslands are one of the most common land‐cover types, providing important ecosystem services globally, yet few studies have examined grassland critical‐zone functioning throughout hillslopes. This study characterised a coastal grassland over a small hillslope at Point Reyes National Seashore, California, using multidisciplinary techniques, combining remotely‐sensed, geophysical, plant, and soil measurements. Clustering techniques delineated the study area into four landscape zones, up‐, mid‐, and down‐slope, and a bordering riparian ecotone, which had distinct environmental properties that varied spatially across the site, with depth, and time. Soil moisture increased with depth and down slope towards a bordering riparian zone, and co‐varied with soil CO2 flux rates both spatially and temporally. This highlighted three distinct controls of soil moisture on soil respiration: CO2 fluxes were inhibited by high moisture content in the down‐slope during the wet winter months, and converged across landscape positions in the dry summer months, while also displaying post‐rain pulses. The normalised difference vegetation index (NDVI) ranged from 0.32 (September)–0.80 (April) and correlated positively with soil moisture and aboveground biomass, moving down slope. Yet, NDVI, aboveground biomass, and soil moisture were not correlated to soil organic carbon (SOC) content (0.4%–4.5%), which was highest in the mid‐slope. The SOC content may instead be linked to shifts in dominant grassland species and their rhizosphere properties with landscape position. This multidisciplinary characterisation highlighted significant heterogeneity in grassland properties with landscape position, and demonstrated an approach that could be used to characterise other critical‐zone environments on hillslopes. more...
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- 2024
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36. The mediating role of dynamic capability between sustainable development and competitive advantage in tourism enterprises in Henan Province (China)
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Yuxin Wu, Mohd Hizam-Hanafiah, and Yin Zhang
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sustainable development ,competitive advantage ,dynamic capability ,tourism enterprises ,Industries. Land use. Labor ,HD28-9999 - Abstract
Objective: This study explores the structural relationships between sustainable development and competitive advantage in tourism enterprises, along with the mediating role of dynamic capability, especially following the impact of COVID-19. Design/Method/Approach: An online questionnaire survey was conducted to collect 430 valid primary data sets from middle and senior managers in Henan tourism enterprises. Covariance-based structural equation modeling was utilized to test the direct effect, while the bootstrap method was used for testing mediating effects. Findings: The results reveal that sustainable development has a significant impact on the competitive advantage of tourism enterprises from three sustainability dimensions: economic, environmental and social. Meanwhile, dynamic capabilities represented by adaptive, absorptive and innovative capacities play a mediating role between them. Conclusions/Recommendation: The reshaping of the tourism industry by COVID-19 requires practitioners to take dynamic capability seriously in an uncertain environment. The higher demand for sustainability from tourists after the pandemic also suggests that improvements are a viable way for tourism enterprises to restore and cultivate competitive advantage. Originality/ Value: This study focuses on public health emergencies which are scarce in tourism crisis research (Duan et al., 2021). In addition, it is designed to help managers identify elements that can be used as internal drivers (Wang, 2021) showing how firms can incorporate sustainable development into strategic management, as this is still lacking (Zhang et al., 2020) in practice. more...
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- 2024
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37. Rapid Determination of Mebendazole and Its Metabolites in Cattle and Sheep Products by Captiva EMR-Lipid Technology Combined with UPLC-MS/MS
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Jiaming YE, Shihuan ZHONG, Leihai YE, Yuxin WU, and Jing WANG
- Subjects
mebendazole (mbz) ,hydroxy-mebendazole (mbz-oh) ,amino-mebendazole (mbz-nh2) ,liquid chromatography-tandem mass spectrometry (lc-ms/ms) ,solid phase extraction (spe) ,Food processing and manufacture ,TP368-456 - Abstract
A method for detecting mebendazole and its metabolites in cattle and sheep products was established by EMR-Lipid-ultra-performance liquid chromatography-tandem mass spectrometry. The samples were first extracted by oscillation with 0.2% ammoniated acetonitrile solution, then freeze centrifugation, purified by Captiva EMR-Lipid column and directly analyzed by LC-MS/MS. The 3 kinds of mebendazole drugs were separated by SB-C18 column (2.1 mm×100 mm, 1.8 μm) and gradiently eluted with acetonitrile and 0.1% formic acid water solution as mobile phase. The detection of mebendazole drugs was performed by tandem mass spectrometry in electrospray ionization under multiple reactions monitoring (MRM) mode. Matrix matching standard working curve and internal standard method were used for quantification. The calibration curves for target compounds were linear over the range of 0.2~50 ng/mL with correlation coefficients larger than 0.999. The detection limits (S/N>3) of 3 kinds of mebendazole drugs were 0.3 μg/kg. The recoveries of the 3 kinds of mebendazole drugs at three added levels were between 80.5% and 108.0%.The relative standard deviations were 1.1%~5.8%. The method overcame the current shortcomings of cumbersome preprocessing and long detection cycle, and it was simple in operation and accurate in results. The method was applicable to the rapid detection of mebendazole and its metabolites residues in cattle and sheep products. more...
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- 2024
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38. Thermal sensation and percentage of dissatisfied in thermal environments with positive and negative vertical air temperature differences
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Yuxin Wu, Sheng Zhang, Hong Liu, and Yong Cheng
- Subjects
Vertical air temperature difference ,Thermal sensation ,Thermal comfort ,Percentage of dissatisfied ,Air distribution ,Environmental technology. Sanitary engineering ,TD1-1066 ,Building construction ,TH1-9745 - Abstract
Considering the percentage of dissatisfied due to local thermal sensation (PDLTSV), a vertical air temperature difference (ΔTd) threshold of about 3 °C was recommended in standards. However, some novel air distribution methods might create large positive (which means the head warmer than the feet, vice versa) or negative ΔTd, with no suitable proved criteria to be used. In this study, sixteen subjects were seated in a climatic box placed in a climate chamber to evaluate thermal sensation and percentage of dissatisfied with negative and positive ΔTd in different whole-body thermal conditions. Air temperatures were controlled independently at the upper and lower body parts, with 13 different air temperature sets combined with 22 °C, 25 °C, 28 °C, and 31 °C (i.e. -9 °C ≤ ΔTd ≤ 9 °C). Results showed that subjects were more thermally sensitive at the upper body and with positive ΔTd than at the lower body or with negative ΔTd. The 80% acceptable ΔTd range is about -8 to 7 °C in overall neutral (TSV = 0), -7 °C to 6 °C in slightly cool (TSV = -0.5) conditions, which is wider than -3 to 3 °C in slightly warm conditions (TSV = +0.5). By considering the factors of both TSV and ΔTd, a new overall percentage of dissatisfied index (OPDP) was proposed. Case studies show that the new OPDP index is more precise and suitable for the evaluations of different air distributions to predict overall percentage of dissatisfied in thermal environments with vertical air temperature difference. more...
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- 2023
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39. Research Progress on Antioxidant Peptides from Fish By-Products: Purification, Identification, and Structure–Activity Relationship
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Xinru Liu, Qiuyue Hu, Yafang Shen, Yuxin Wu, Lu Gao, Xuechao Xu, and Guijie Hao
- Subjects
oxidative stress ,amino acid types ,molecular weight ,structure–activity ,fish by-product ,purification and identification ,Microbiology ,QR1-502 - Abstract
Background/Objectives: Excessive reactive oxygen species (ROS) can lead to oxidative stress, which has become an urgent problem requiring effective solutions. Due to the drawbacks of chemically synthesized antioxidants, there is a growing interest in natural antioxidants, particularly antioxidant peptides. Methods: By reviewing recent literature on antioxidant peptides, particularly those extracted from various parts of fish, summarize which fish by-products are more conducive to the extraction of antioxidant peptides and elaborate on their characteristics. Results: This article summarizes recent advancements in extracting antioxidant peptides from fish processing by-products, Briefly introduced the purification and identification process of antioxidant peptides, specifically focusing on the extraction of antioxidant peptides from various fish by-products. Additionally, this article comprehensively reviews the relationship between amino acid residues that compose antioxidant peptides and their potential mechanisms of action. It explores the impact of amino acid types, molecular weight, and structure–activity relationships on antioxidant efficacy. Conclusions: Different amino acid residues can contribute to the antioxidant activity of peptides by scavenging free radicals, chelating metal ions, and modulating enzyme activities. The smaller the molecular weight of the antioxidant peptide, the stronger its antioxidant activity. Additionally, the antioxidant activity of peptides is influenced by specific amino acids located at the C-terminus and N-terminus positions. Simultaneously, this review provides a more systematic analysis and a broader perspective based on existing research, concluded that fish viscera are more favorable for the extraction of antioxidant peptides, providing new insights for the practical application of fish by-products. This could increase the utilization of fish viscera and reduce the environmental pollution caused by their waste, offering valuable references for the study and application of antioxidant peptides from fish by-products. more...
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- 2024
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40. Evolution and Functional Dynamics of TCP Transcription Factor Gene Family in Passion Fruit (Passiflora edulis)
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Munsif Ali Shad, Songguo Wu, Muhammad Junaid Rao, Xiaoying Luo, Xiaojin Huang, Yuxin Wu, Yuhong Zhou, Lingqiang Wang, Chongjian Ma, and Lihua Hu
- Subjects
passion fruit ,TCP transcription factors ,cold stress ,GFP subcellular localizations ,miRNA319s ,Botany ,QK1-989 - Abstract
Passion fruit is a valued tropical fruit crop that faces environment-related growth strains. TCP genes are important for both growth modulation and stress prevention in plants. Herein, we systematically analyzed the TCP gene family in passion fruit, recognizing 30 members. Genes exhibiting closer phylogenetic relationships exhibited similar protein and gene structures. Gene members of the TCP family showed developmental-stage- or tissue-specific expression profiles during the passion fruit life cycle. Transcriptome data also demonstrated that many PeTCPs showed induced expression in response to hormonal treatments and cold, heat, and salt stress. Based on transcriptomics data, eight candidate genes were chosen for preferential gene expression confirmation under cold stress conditions. The qRT-PCR assays suggested PeTCP15/16/17/19/23 upregulation, while PeTCP1/11/25 downregulation after cold stress. Additionally, TCP19/20/29/30 exhibited in silico binding with cold-stress-related miRNA319s. GFP subcellular localization assays exhibited PeTCP19/1 were localized at the nucleus. This study will aid in the establishment of novel germplasm, as well as the further investigation of the roles of PeTCPs and their cold stress resistance characteristics. more...
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- 2024
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41. Evaluation and Optimization of Landscape Spatial Patterns and Ecosystem Services in the Northern Agro-Pastoral Ecotone, China
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Yuxin Wu, Xiuwen Peng, Guodong Jia, Xinxiao Yu, and Honghong Rao
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InVEST model ,landscape spatial patterns ,ecosystem services ,ecological restoration ,optimization allocation ,Agriculture - Abstract
The alteration of landscape spatial patterns (LSPs) and ecosystem services (ESs) in watersheds can have detrimental effects on the local environment and community. However, a comprehensive understanding of the current state of LSPs and ESs in watersheds around Winter Olympic venues in China is limited. Here, we assessed current LSPs and ESs and developed optimization strategies for the Xigou watershed around Winter Olympic venues in the northern agro-pastoral ecotone of China. The results indicated that the main land use type was grassland in the Xigou watershed, and landscape types were relatively homogenous. All three ESs (water yield, sediment retention, and carbon storage) generally improved from 2004 to 2020. For ESs, there was the lowest total volume of water yield in 2004 (637.44 × 104 m3). But sediment retention (10.54 × 106 t, 18.13 × 106 t, 13.28 × 106 t, and 16.85 × 106 t) had an upward, then downward, then upward trend before and after ERP. Carbon storage grew steadily. Correlation analysis suggested that the three ESs were closely related to the landscape spatial indices of average patch area (AREA_MN), contagion index (CONTAG), and Shannon’s evenness index (SHEI). AREA_MN, CONTAG, and SHEI in the eastern part of the study area promoted sediment retention and carbon storage, while in the southwestern part of the study area, they inhibited water yield and sediment retention. The results suggest that improving sediment retention by optimizing land use and cover change (LUCC) and LSPs is the main approach to further enhance ESs in the study area. Our study suggests that the inclusion of multiple landscape pattern indices can provide a more comprehensive representation of regional ecosystem service. more...
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- 2024
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42. Short-term power load forecasting for integrated energy system based on a residual and attentive LSTM-TCN hybrid network
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Hongyi Li, Shenhao Li, Yuxin Wu, Yue Xiao, Zhichong Pan, and Min Liu
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short-term power load forecasting ,integrate energy system ,long short-term memory ,temporal convolutional network ,attention mechanism ,General Works - Abstract
In the context of Integrated Energy System (IES), accurate short-term power demand forecasting is crucial for ensuring system reliability, optimizing operational efficiency through resource allocation, and supporting effective real-time decision-making in energy management. However, achieving high forecasting accuracy faces significant challenges due to the inherent complexity and stochastic nature of IES’s short-term load profiles, resulting from diverse consumption patterns among end-users and the intricate coupling within the network of interconnected energy sources. To address this issue, a dedicated Short-Term Power Load Forecasting (STPLF) framework for IES is proposed, which relies on a newly developed hybrid deep learning architecture. The framework seamlessly combines Long Short-Term Memory (LSTM) with Temporal Convolutional Network (TCN), enhanced by an attention mechanism module. By merging these methodologies, the network leverages the parallel processing prowess of TCN alongside LSTM’s ability to retain long-range temporal information, thus enabling it to dynamically concentrate on relevant sections of time series data. This synergy leads to improved prediction accuracy and broader applicability. Furthermore, the integration of residual connections within the network structure serves to deepen its learning capabilities and enhance overall performance. Ultimately, results from a real case study of a user-level IES demonstrate that the Mean Absolute Percentage Error (MAPE) of the proposed framework on the test set is 2.35%. This error rate is lower than the averages of traditional methods (3.43%) and uncombined single submodules (2.80%). more...
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- 2024
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43. Comparative study of imaging and pathology of primary mucinous adenocarcinoma with different imaging manifestations
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Jun Han, Jie Gao, Demei Chen, Mou Du, Yuxin Wu, Xidong Ma, Mei Xie, Hua Han, Chongchong Wu, and Xinying Xue
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adenocarcinoma ,gene ,imaging ,mucus ,pathological manifestation ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Pulmonary mucinous adenocarcinoma is a special type of lung cancer. Its imaging manifestations are diverse, which brings challenges to clinical diagnosis. However, its formation mechanism is unclear. Objective The objective of this study is to analyse the relevant mechanisms of the formation of pulmonary mucinous adenocarcinoma by observing its different imaging and pathological manifestations. Data and methods Retrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically. Results Forty‐three patients had pulmonary mucinous adenocarcinoma with a solitary nodule/mass, 41 patients with localized pneumonia and 19 patients with diffuse pneumonia. Their CT manifestations included ‘falling snowflake sign’, ground‐glass opacity close to the heart, vacuous signs/honeycombing and withered tree branches. Under the microscope, all the three types of pulmonary mucinous adenocarcinoma had visibly formed mucus lakes but were made of tumour cells with totally different shapes, which included the goblet‐like shape (tall column‐like shape) and quasi‐circular shape. Tall column‐shaped tumour cells were negative or weakly positive for thyroid transcription factor‐1 (TTF‐1) and strongly positive for ALK mutation, whereas quasi‐circular tumour cells were positive for TTF‐1 and less positive for ALK mutation. Conclusion The different imaging manifestations of mucinous adenocarcinoma are possibly due to the different amounts or viscosity of mucus produced, and the mechanisms of its formation may include (1) tumour cells in different shapes have different abilities to produce mucus; (2) tumours in different stages produce different amounts or viscosity of mucus; and (3) the TTF‐1 and ALK genes affect the production of mucus. more...
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- 2024
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44. Privacy Protection Technology for Internet of Vehicles.
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Mo Wang, Yi Zheng, Chongze Lin, Yan Cui, Yuxin Wu, and Shuping Wang
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- 2023
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45. Trackability-Based Distributed Learning Control for Multi-Agent Systems Under Switching Topologies.
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Yuxin Wu, Deyuan Meng, and Jing Wang
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- 2023
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46. Layer Importance and Hallucination Analysis in Large Language Models via Enhanced Activation Variance-Sparsity.
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Zichen Song, Sitan Huang, Yuxin Wu, and Zhongfeng Kang
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- 2024
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47. AVSS: Layer Importance Evaluation in Large Language Models via Activation Variance-Sparsity Analysis.
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Zichen Song, Yuxin Wu, Sitan Huang, and Zhongfeng Kang
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- 2024
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48. FlamePINN-1D: Physics-informed neural networks to solve forward and inverse problems of 1D laminar flames.
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Jiahao Wu, Su Zhang, Yuxin Wu, Guihua Zhang, Xin Li, and Hai Zhang
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- 2024
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49. Research progress of moderate or intense low-oxygen dilution (MILD) combustion of pulverized coal in high-speed jet
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Wenshi HUANG, Yuxin WU, Hai ZHANG, and Junfu LÜ
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moderate or intense low-oxygen dilution (mild) combustion of pulverized ,high-speed jets ,flameless combustion ,coal combustion ,particle dispersion ,Geology ,QE1-996.5 ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Developing a cleaner and more efficient combustion technology of pulverized coal is an important way to deal with the increasingly serious environmental pollution. Moderate or intense low-oxygen dilution (MILD) combustion of pulverized coal is regarded as a new combustion technology with great potential due to its advantages of reducing NOx emission and improving the uniformity of heat flux in the furnace. More importantly, the pulverized coal MILD technology combined with the oxy-fuel combustion technology will be an important path to reduce carbon emission in the process of coal utilization in the future. The history, characteristics and current research status of the MILD combustion of pulverized coal worldwide are summarized, and the key issues and research challenges of the MILD combustion technology of pulverized coal with a low preheating temperature are put forward. The MILD combustion technology of pulverized coal originates from that of gaseous fuels, which strengthen the entrainment of high-temperature flue gas and then dilute the reactants to make the flame become blurred or even invisible. Under the MILD conditions, the peak temperature in the combustion region is reduced and the uniformity of temperature distribution is improved, therefore significantly inhibiting the generation of thermal NOx and fuel NOx. The MILD combustion of pulverized coal can be realized by preheating air to high temperatures or increasing the jet velocity greatly, and the second way is more economical and feasible. However, the mechanisms and characteristics of the MILD combustion of pulverized coal under the condition of strong shear and turbulent mixing, when the jet velocity is as high as around 100 m/s, still need to be further investigated. Under the strong shear and entrainment of high-speed jets, the dispersion of coal particles, which is directly related to the achievement of the MILD combustion mode, is quite different from that in the conventional coal combustion. In addition, a strong turbulent mixing will affect the heating, devolatilization and char combustion of pulverized coal, therefore changing the ignition delay, the flame structure and the generation of pollutants. Based on the in-depth understanding of the above key issues and combined with the research on the MILD combustion of gaseous fuels, a systematic and accurate criterion for the MILD combustion of pulverized coal can be further developed, so as to better guide the application of the MILD combustion technology of pulverized coal. more...
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- 2023
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50. Experimental study on combustion optimization to alleviate fouling on heating surface of a Zhundong coal Boiler
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Dafu MA, Shouyu ZHANG, Xiang HE, Xu ZHAO, Weizhi LU, and Yuxin WU
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zhundong coal ,four-corner tangential boiler ,heating surface ,combustion temperature ,fouling improvement ,Mining engineering. Metallurgy ,TN1-997 - Abstract
In 2021, the price of most of the domestic coal skyrocketed, affecting the stable supply of electric power supply in some regions, while the price of Xinjiang Zhundong coal remains stable at a low level. Thus, the study of safe and stable large-scale combustion of Zhundong coal in boilers is more and more important for the energy supplyHowever, fouling and slagging often occur on the heating surfaces of the boiler due to the characteristics of Zhundong coal and the high temperature of the flue gas. The effects of the operating parameters, including the primary air velocity, operating oxygen content, air staging and coal fineness on the combustion temperature and NOx emission were investigated on a four-corner tangentially fired boiler of 660 MW capacity, which burned 95% Zhundong coal to get the relevant control criterion. Based on the research, the improvement of control function for contamination of heating surfaces was implemented under steady and dynamic working conditions. Finally, the influence of the improvement on the contamination of the heating surfaces was proved by the method of the contamination monitoring of heated surfaces. The results show that, at 660 MW load condition, the operating oxygen content had the most obvious influence on the flue gas temperature at the outlet of the furnace. The flue gas temperature decreased 99 °C when it increased from 2.0% to 3.5%. The reduction of the operating oxygen content and the local mean stoichiometric ratio of the main combustion zone could lead to a significant reduction of NOx emission and the change of the coal fineness had no obvious effect on NOx emission. After the improved control function was implemented, the rate of flue gas temperature decreased from 6.18 to 4.26 °C min−1 during the load increase process, the maximum temperature decreased from 1104 to 1023 °C under 660 MW. The heat absorption ratio of the platen superheater, low-temperature superheater and low-temperature reheater increased by 0.6%, 1.6% and 0.9%, respectively, indicating that the fouling and slagging was significantly reduced. At 330 MW load condition, increasing the coal fineness R90 to around 4.9% of the uppermost mill could effectively reduce the flue gas temperature near the bottom of the high-temperature reheater, reduce the deposition of combustible matter and fly ash, and inhibit the formation of fouling and slagging. more...
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- 2023
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