1. Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches
- Author
-
Yusri Mohd Yunus, Khalijah Awang, Geoffrey A. Cordell, Rohaya Ahmad, El Hassane Anouar, Moses K. Langat, and Fatimah Salim
- Subjects
Pharmacology ,Quantum chemical ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Absolute configuration ,Pharmaceutical Science ,Data interpretation ,Time-dependent density functional theory ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Uncaria ,Complementary and alternative medicine ,Computational chemistry ,Drug Discovery ,Molecular Medicine ,Density functional theory - Abstract
The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.
- Published
- 2019
- Full Text
- View/download PDF