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2. Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer

Author

Neeroa, Bibi Noorheen Haleema Mooneerah, Anuar, Nurshafida Adzlin Shamsul, Brianna, Yusefi, Mostafa, Shameli, Kamyar, Teow, Sin-Yeang, Rezaei, Nima, Series Editor, Ahmed, Atif A., Editorial Board Member, Aguiar, Rodrigo, Editorial Board Member, Ambrosio, Maria R., Editorial Board Member, Artac, Mehmet, Editorial Board Member, Augustine, Tanya N., Editorial Board Member, Bambauer, Rolf, Editorial Board Member, Bhat, Ajaz Ahmad, Editorial Board Member, Bertolaccini, Luca, Editorial Board Member, Bianchini, Chiara, Editorial Board Member, Cavic, Milena, Editorial Board Member, Chakrabarti, Sakti, Editorial Board Member, Cho, William C. S., Editorial Board Member, Czarnecka, Anna M., Editorial Board Member, Domingues, Cátia, Editorial Board Member, Eşkazan, A. Emre, Editorial Board Member, Fares, Jawad, Editorial Board Member, Fonseca Alves, Carlos E., Editorial Board Member, Fru, Pascaline, Editorial Board Member, Da Gama Duarte, Jessica, Editorial Board Member, García, Mónica C., Editorial Board Member, Gener, Melissa A.H., Editorial Board Member, Estrada Guadarrama, José Antonio, Editorial Board Member, Hargadon, Kristian M., Editorial Board Member, Holvoet, Paul, Editorial Board Member, Jurisic, Vladimir, Editorial Board Member, Kabir, Yearul, Editorial Board Member, Katsila, Theodora, Editorial Board Member, Kleeff, Jorg, Editorial Board Member, Liang, Chao, Editorial Board Member, Tan, Mei Lan, Editorial Board Member, Li, Weijie, Editorial Board Member, Prado López, Sonia, Editorial Board Member, Macha, Muzafar A., Editorial Board Member, Malara, Natalia, Editorial Board Member, Orhan, Adile, Editorial Board Member, Prado-Garcia, Heriberto, Editorial Board Member, Pérez-Velázquez, Judith, Editorial Board Member, Rashed, Wafaa M., Editorial Board Member, Sanguedolce, Francesca, Editorial Board Member, Sorrentino, Rosalinda, Editorial Board Member, Shubina, Irina Zh., Editorial Board Member, de Araujo, Heloisa Sobreiro Selistre, Editorial Board Member, Torres-Suárez, Ana Isabel, Editorial Board Member, Włodarczyk, Jakub, Editorial Board Member, Yeong, Joe Poh Sheng, Editorial Board Member, Toscano, Marta A., Editorial Board Member, Wong, Tak-Wah, Editorial Board Member, Yin, Jun, Editorial Board Member, and Yu, Bin, Editorial Board Member

Published
2023
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3. Preparation and Characterization of Cross-Linked Chitosan/Cellulose Bionanohybrids

Author

Yusefi, Mostafa, Shameli, Kamyar, Chan Zhe, Justin, Bin Che Sidik, Nor Azwadi, Cavas-Martínez, Francisco, Editorial Board Member, Chaari, Fakher, Series Editor, di Mare, Francesca, Editorial Board Member, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Editorial Board Member, Ivanov, Vitalii, Series Editor, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Ismail, Muhammad Yusri, editor, Mohd Sani, Mohd Shahrir, editor, Kumarasamy, Sudhakar, editor, Hamidi, Mohd Adnin, editor, and Shaari, Mohd Shamil, editor

Published
2023
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12. Green synthesis of gold nanoparticles via Artocarpus odoratissimus peel extract for potential applications of optical filter and catalytic degradation

Author

Dayana Mohamed Isa, Eleen, primary, Rahmah Aid, Siti, additional, Rasit Ali, Roshafima, additional, Asako, Yutaka, additional, Shameli, Kamyar, additional, Farhana Arissa Jonny, Nur, additional, Hiyama Zazuli, Aina, additional, Husnaa Mohd Taib, Siti, additional, and Yusefi, Mostafa, additional

Published
2024
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14. Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity.

Author

Hamrayev, Hemra, Jazayeri, Seyed Davoud, Yusefi, Mostafa, Brianna, Teow, Sin‐Yeang, Wu, Yuan Seng, Anwar, Ayaz, Korpayev, Serdar, Kartouzian, Aras, and Shameli, Kamyar

Subjects
TRANSMISSION electron microscopy, CYTOTOXINS, SCANNING electron microscopy, NANOPARTICLE size, INFRARED spectroscopy
Abstract

In this study, zinc oxide nanoparticles (ZnO‐NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO‐NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO‐NPs are produced through a sintering process at temperatures ranging from 300 to 700 °C. The most effective nanoparticles are obtained at 600 °C, as determined by X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO‐NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 µg mL−1, the Cs/ZnO‐NPs demonstrate significantly higher cancer cell toxicity compared to ZnO‐NPs alone, while remaining non‐toxic to normal cells. This indicates that Cs/ZnO‐NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO‐NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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15. How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

Author

Yusefi,Mostafa, Shameli,Kamyar, Jahangirian,Hossein, Teow,Sin-Yeang, Afsah-Hejri,Leili, Mohamad Sukri,Siti Nur Amalina, and Kuča,Kamil

Subjects
International Journal of Nanomedicine
Abstract

Mostafa Yusefi,1,2 Kamyar Shameli,3 Hossein Jahangirian,4 Sin-Yeang Teow,5 Leili Afsah-Hejri,6 Siti Nur Amalina Mohamad Sukri,1 Kamil Kuča1,7,8 1Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia; 2Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia; 3Institute of Virology, School of Medicine, Technical University of Munich, Munich, 81675, Germany; 4CaroGen Corporation, Farmington, CT, USA; 5Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang Province, 325060, People’s Republic of China; 6Department of Food Safety and Quality, School of Business, Science and Technology, Lakeland University Plymouth, WI 53073, USA; 7Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic; 8Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicCorrespondence: Kamyar Shameli; Hossein Jahangirian, Tel +4917646555701 ; +16178608429, Email kamyarshameli@gmail.com; kamran.jahangirian@gmail.comAbstract: Chemotherapy is the most prominent route in cancer therapy for prolonging the lifespan of cancer patients. However, its non-target specificity and the resulting off-target cytotoxicities have been reported. Recent in vitro and in vivo studies using magnetic nanocomposites (MNCs) for magnetothermal chemotherapy may potentially improve the therapeutic outcome by increasing the target selectivity. In this review, magnetic hyperthermia therapy and magnetic targeting using drug-loaded MNCs are revisited, focusing on magnetism, the fabrication and structures of magnetic nanoparticles, surface modifications, biocompatible coating, shape, size, and other important physicochemical properties of MNCs, along with the parameters of the hyperthermia therapy and external magnetic field. Due to the limited drug-loading capacity and low biocompatibility, the use of magnetic nanoparticles (MNPs) as drug delivery system has lost traction. In contrast, MNCs show higher biocompatibility, multifunctional physicochemical properties, high drug encapsulation, and multi-stages of controlled release for localized synergistic chemo-thermotherapy. Further, combining various forms of magnetic cores and pH-sensitive coating agents can generate a more robust pH, magneto, and thermo-responsive drug delivery system. Thus, MNCs are ideal candidate as smart and remotely guided drug delivery system due to a) their magneto effects and guide-ability by the external magnetic fields, b) on-demand drug release performance, and c) thermo-chemosensitization under an applied alternating magnetic field where the tumor is selectively incinerated without harming surrounding non-tumor tissues. Given the important effects of synthesis methods, surface modifications, and coating of MNCs on their anticancer properties, we reviewed the most recent studies on magnetic hyperthermia, targeted drug delivery systems in cancer therapy, and magnetothermal chemotherapy to provide insights on the current development of MNC-based anticancer nanocarrier.Keywords: magnetic nanoparticles, polymer-based magnetic nanocomposites, hyperthermia, external magnetic field, targeted cancer treatments

Published
2023

19. The Potential Anticancer Activity of 5-Fluorouracil Loaded in Cellulose Fibers Isolated from Rice Straw

Author

Yusefi,Mostafa, Shameli,Kamyar, Jahangirian,Hossein, Teow,Sin-Yeang, Umakoshi,Hiroshi, Saleh,Bahram, Rafiee-moghaddam,Roshanak, and Webster,Thomas J

Subjects
International Journal of Nanomedicine
Abstract

Mostafa Yusefi,1 Kamyar Shameli,1 Hossein Jahangirian,2 Sin-Yeang Teow,3 Hiroshi Umakoshi,4 Bahram Saleh,2 Roshanak Rafiee-Moghaddam,2 Thomas J Webster2 1Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur 54100, Malaysia; 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA 02115, USA; 3Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Selangor Darul Ehsan 47500, Malaysia; 4Bio-Inspired Chemical Engineering Laboratory, Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Osaka 560-8531, JapanCorrespondence: Kamyar Shameli; Hossein Jahangirian Tel +60173443492; +1 6178608429Email kamyarshameli@gmail.com; kamran.jahangirian@gmail.comIntroduction: Green-based materials have been increasingly studied to circumvent off-target cytotoxicity and other side-effects from conventional chemotherapy.Materials and Methods: Here, cellulose fibers (CF) were isolated from rice straw (RS) waste by using an eco-friendly alkali treatment. The CF network served as an anticancer drug carrier for 5-fluorouracil (5-FU). The physicochemical and thermal properties of CF, pure 5-FU drug, and the 5-FU-loaded CF (CF/5-FU) samples were evaluated. The samples were assessed for in vitro cytotoxicity assays using human colorectal cancer (HCT116) and normal (CCD112) cell lines, along with human nasopharyngeal cancer(HONE-1)and normal (NP 460) cell lines after 72-hours of treatment.Results: XRD and FTIR revealed the successful alkali treatment of RS to isolate CF with high purity and crystallinity. Compared to RS, the alkali-treated CF showed an almost fourfold increase in surface area and zeta potential of up to − 33.61 mV. SEM images illustrated the CF network with a rod-shaped structure and comprised of ordered aggregated cellulose. TGA results proved that the thermal stability of 5-FU increased within the drug carrier. Based on UV-spectroscopy measurements for 5-FU loading into CF, drug loading encapsulation efficiency was estimated to be 83 ± 0.8%. The release media at pH 7.4 and pH 1.2 showed a maximum drug release of 79% and 46%, respectively, over 24 hours. In cytotoxicity assays, CF showed almost no damage, while pure 5-FU killed most of the both normal and cancer cells. Impressively, the drug-loaded sample of CF/5-FU at a 250 μg/mL concentration demonstrated a 58% inhibition against colorectal cancer cells, but only a 23% inhibition against normal colorectal cells. Further, a 62.50 μg/mL concentration of CF/5FU eliminated 71% and 39% of nasopharyngeal carcinoma and normal nasopharyngeal cells, respectively.Discussion: This study, therefore, showed the strong potential anticancer activity of the novel CF/5-FU formulations, warranting their further investigation.Keywords: rice straw, cellulose fibers, 5-fluorouracil, drug delivery, cytotoxicity assays, cancer treatment

Published
2020

20. Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Author

Yusefi,Mostafa, Shameli,Kamyar, Su Yee,Ong, Teow,Sin-Yeang, Hedayatnasab,Ziba, Jahangirian,Hossein, Webster,Thomas J, Kuča,Kamil, Yusefi,Mostafa, Shameli,Kamyar, Su Yee,Ong, Teow,Sin-Yeang, Hedayatnasab,Ziba, Jahangirian,Hossein, Webster,Thomas J, and Kuča,Kamil

Abstract

Mostafa Yusefi,1 Kamyar Shameli,1 Ong Su Yee,1 Sin-Yeang Teow,2 Ziba Hedayatnasab,3,4 Hossein Jahangirian,5 Thomas J Webster,5 Kamil Kuča1,6 1Department of Chemical and Environmental Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur, 54100, Malaysia; 2Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Selangor Darul Ehsan, 47500, Malaysia; 3Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; 4Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, 11155-9465, Iran; 5Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, 02115, USA; 6Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech RepublicCorrespondence: Kamyar Shameli; Kamil Kuča Email kamyarshameli@gmail.com; kamil.kuca@uhk.czIntroduction: Fe3O4 nanoparticles (Fe3O4 NPs) with multiple functionalities are intriguing candidates for various biomedical applications.Materials and Methods: This study introduced a simple and green synthesis of Fe3O4 NPs using a low-cost stabilizer of plant waste extract rich in polyphenols content with a well-known antioxidant property as well as anticancer ability to eliminate colon cancer cells. Herein, Fe3O4 NPs were fabricated via a facile co-precipitation method using the crude extract of Garcinia mangostana fruit peel as a green stabilizer at different weight percentages (1, 2, 5, and 10 wt.%). The samples were analyzed for magnetic hyperthermia and then in vitro cytotoxicity assay was performed.Results: The XRD planes of the samples were corresponding to the standard magnetite Fe3O4 with high crystallinity. From TEM analysis, the green synthesized NPs were spherical with an average size of 13.42± 1.58 nm and displayed diffraction rings of the Fe3O4 phase, which was in good a

Published
2021

27. Performance of cow dung reinforced biodegradable poly (lactic acid) biocomposites for structural applications

Author

Yusefi, Mostafa, Khalid, Mohammad, Md Yasin, Faizah, Abdullah, Luqman Chuah, Ketabchi, Mohammad Reza, Walvekar, Rashmi Gangasa, Yusefi, Mostafa, Khalid, Mohammad, Md Yasin, Faizah, Abdullah, Luqman Chuah, Ketabchi, Mohammad Reza, and Walvekar, Rashmi Gangasa

Abstract

In this work, performance of cow dung (CD) reinforced poly(lactic acid) (PLA) biocomposites was investigated for the potential use in load bearing application. CD of average 4 mm size was blended with PLA at different CD ratios (0–50 wt%) and their effects on the biocomposite properties were studied. The results showed an improvement in the flexural properties, while the tensile and impact strength dropped by 20 and 28% with the addition of 50% CD. The decline in the tensile and impact strength was due to micro-cracking and voids formation at higher CD content. Also, the incorporation of CD slightly decreased the thermal stability of the biocomposite. However, dynamic mechanical properties of the biocomposites generally improved. SEM analysis of tensile and impact fractured surfaces indicated that the CD had a reasonable adhesion with matrix. Moreover, the SEM micrographs of soil burial studies showed an accelerated degradation of higher CD wt% biocomposites.

Published
2018

28. Physico-mechanical properties of poly(lactic acid) biocomposites reinforced with cow dung

Author

Yusefi, Mostafa, Khalid, Mohammad, Md Yasin, Faizah, Ketabchi, Mohammad Reza, Hajalilou, Abdollah, Abdullah, Luqman Chuah, Yusefi, Mostafa, Khalid, Mohammad, Md Yasin, Faizah, Ketabchi, Mohammad Reza, Hajalilou, Abdollah, and Abdullah, Luqman Chuah

Abstract

The aim of this work is to investigate the reinforcing effects of cow dung (CD) on poly(lactic acid) (PLA) properties. The PLA/CD biocomposite blends with different CD ratios (0–50 wt.%) were prepared using an internal Brabender mixer followed by compression molding. The results showed an enhancement in flexural properties and an acceptable drop in tensile and impact strength with increasing CD loading. Incorporation of CD also led to an overall decline in thermal stability of the biocomposites. However, an improvement in dynamic mechanical properties of the biocomposites was recorded. For PLA based biocomposites, above Tg (60–65 °C), a difference in the dynamic modulus becomes more pronounced as the polymer shifts from glassy to rubbery state. SEM micrographs displayed an increase in the voids and surface roughness of biocomposites with increasing CD content. It was demonstrated that high strength, high modulus PLA/CD biocomposites can be fabricated with effective stress transfer even at 50 wt.% CD loading.

Published
2017

31. Fabrication of PLA/COW dung-based biocomposite

Author

Yusefi, Mostafa and Yusefi, Mostafa

Abstract

Various environmental drawbacks such as reduction in land fill space and nonbiodegradability lead to systematically investigate the replacing of synthetic composites by using biocomposites. Biocomposites possess suitable characterizations such as light weight, combustible, nontoxic, and biodegradability behavior. However, the final product of the biocomposites carries certain drawbacks in terms of mechanical, physical and thermal properties. In order to determine their characteristic, this research aided to figure out the possibility of applying cow dung (CD) as filler to prepare polylactic acid (PLA) biocomposite. The main objective of this research is to obtain a suitable composition ratio based on the filler and the hosting polymer. The CD of two different sizes, namely 4.00 mm and 0.5 mm were blended with PLA. PLA/CD biocomposites with different CD ratios (0-60 wt.%) were fabricated using an internal Brabender mixer (W50EHT-3zones) followed by a 40 tones hydraulic compression moulding. The results showed that the addition of CD led to improve flexural properties compared to tensile and impact strength. Biocomposites with 4.00 mm CD (bigger filler) mainly showed higher mechanical properties than those of 0.5 mm CD (smaller filler). Scanning electron microscopy (SEM) of tensile and impact fractured surfaces indicated that the bigger fillers had stronger adhesion and bonding with the matrix. Moreover, the cavities and rough surface of biocomposites increased with the filler content addition. This led to lower mechanical and physical properties of the biocomposites and increased water uptake during water absorption test accordingly. Dynamic mechanical analysis (DMA) technique was also followed to determine both storage and loss modulus of the samples. Neat PLA indicted the lowest storage modulus, while the filler content addition generally improved the storage modulus. Results of hermogravimetric analysis (TGA) indicated that the addition of the filler content prolo

Published
2015

32. Green Synthesis of Fe 3 O 4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities.

Author

Yusefi M, Shameli K, Su Yee O, Teow SY, Hedayatnasab Z, Jahangirian H, Webster TJ, and Kuča K

Subjects
Antioxidants pharmacology, Cell Death drug effects, Cell Line, Tumor, Cell Survival drug effects, Dynamic Light Scattering, Humans, Hydrodynamics, Inhibitory Concentration 50, Magnetite Nanoparticles ultrastructure, Particle Size, Spectrometry, X-Ray Emission, Spectroscopy, Fourier Transform Infrared, Temperature, X-Ray Diffraction, Antineoplastic Agents pharmacology, Fruit chemistry, Garcinia mangostana chemistry, Green Chemistry Technology methods, Hyperthermia, Induced, Magnetite Nanoparticles chemistry, Plant Extracts chemistry
Abstract

Introduction: Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) with multiple functionalities are intriguing candidates for various biomedical applications., Materials and Methods: This study introduced a simple and green synthesis of Fe 3 O 4 NPs using a low-cost stabilizer of plant waste extract rich in polyphenols content with a well-known antioxidant property as well as anticancer ability to eliminate colon cancer cells. Herein, Fe 3 O 4 NPs were fabricated via a facile co-precipitation method using the crude extract of Garcinia mangostana fruit peel as a green stabilizer at different weight percentages (1, 2, 5, and 10 wt.%). The samples were analyzed for magnetic hyperthermia and then in vitro cytotoxicity assay was performed., Results: The XRD planes of the samples were corresponding to the standard magnetite Fe 3 O 4 with high crystallinity. From TEM analysis, the green synthesized NPs were spherical with an average size of 13.42±1.58 nm and displayed diffraction rings of the Fe 3 O 4 phase, which was in good agreement with the obtained XRD results. FESEM images showed that the extract covered the surface of the Fe 3 O 4 NPs well. The magnetization values for the magnetite samples were ranging from 49.80 emu/g to 69.42 emu/g. FTIR analysis verified the functional groups of the extract compounds and their interactions with the NPs. Based on DLS results, the hydrodynamic sizes of the Fe 3 O 4 nanofluids were below 177 nm. Furthermore, the nanofluids indicated the zeta potential values up to -34.92±1.26 mV and remained stable during four weeks of storage, showing that the extract favorably improved the colloidal stability of the Fe 3 O 4 NPs. In the hyperthermia experiment, the magnetic nanofluids showed the acceptable specific absorption rate (SAR) values and thermosensitive performances under exposure of various alternating magnetic fields. From results of in vitro cytotoxicity assay, the killing effects of the synthesized samples against HCT116 colon cancer cells were mostly higher compared to those against CCD112 colon normal cells. Remarkably, the Fe 3 O 4 NPs containing 10 wt.% of the extract showed a lower IC 50 value (99.80 µg/mL) in HCT116 colon cancer cell line than in CCD112 colon normal cell line (140.80 µg/mL)., Discussion: This research, therefore, introduced a new stabilizer of Garcinia mangostana fruit peel extract for the biosynthesis of Fe 3 O 4 NPs with desirable physiochemical properties for potential magnetic hyperthermia and colon cancer treatment., Competing Interests: The authors declare no conflicts of interest for this work., (© 2021 Yusefi et al.)

Published
2021
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