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This study was conducted to evaluate whether sildenafil effectively treats necrotizing enterocolitis (NEC).

Aim: The objective of the present research was to compare the nutritional status, weight gain, length of hospital stay, and the development of some complications in very low birth-weight (VLBW) infants who received and those who did not receive olive oil supplementation enterally. Materials and Methods: This study was a single-blind, randomized controlled trial with 96 VLBW infants (intervention: 48, control: 48) in a neonatal intensive care unit. In this study, those infants who met the inclusion criteria for the study were divided into two groups by using a random number table. The same feeding protocol (breast milk and/or formula milk) was applied to the infants in both groups. From the seventh day of life (after starting to take 25-30 mL/kg/day orally), 0.5 cc/30 mL of olive oil was added to the milk at each feeding of those infants in the intervention group. Results: In comparison with the control group, the infants in the intervention group had a higher daily weight gain rate in the first month and a higher weight on the tenth day, a shorter transition time to full enteral feeding, a higher amount of calories on the day of transition to full enteral feeding, and a shorter length of hospital stay (p<0.05). Furthermore, the need for rectal enema and the prevalence of sepsis, gastrointestinal system intolerance, and bronchopulmonary dysplasia were significantly lower in the intervention group in comparison with the control group (p<0.05). Conclusion: These findings suggest that olive oil supplementation administered enterally to preterm infants can be recommended since it positively affects the development of infants. Trial registration: This study was registered in ClinicalTrials.gov with the following ID: NCT05815849. This study was retrospectively registered on the 14th of April, 2023. [ABSTRACT FROM AUTHOR]

Background/aim: The development of postoperative adhesion after abdominal surgery is sometimes a severe problem. Our study investigates the effectiveness of exogenous surfactant application in preventing adhesion development in the experimental adhesion model. Materials and methods: This randomized-controlled interventional study was carried out in the animal laboratory of Kahramanmaraş Sütçü İmam University between March 1 and March 31, 2020. An experimental intra-abdominal adhesion model was established in 24 adult female rats by cecal abrasion. Rats were randomly divided into four groups. Groups I, II, and III were taken intraperitoneally as beractant, poractant, and calfactant applied groups, respectively. Group IV was the control group. Relaparotomy was performed in all groups on the 15th postoperative day, and intra-abdominal adhesions were scored macroscopically according to the Canbaz scoring system. In addition, the cecal regions were evaluated microscopically and scored according to the Zühlke microscopic classification system. The scores of the groups were compared statistically. Results: The Zühlke adhesion development score was significantly lower in the exogenous surfactant applied groups. In addition, when the surfactant-applied groups were compared among themselves, it was seen that the adhesion score in the beractant group was significantly better than the other surfactant types (p < 0.01). Conclusion: Our study results showed that prophylactic intraperitoneal surfactant application significantly reduced postoperative adhesion development, particularly beractant. [ABSTRACT FROM AUTHOR]

Aim: Pulmonary hemorrhage is an important cause of morbidity and mortality in premature infants. There are few studies on pulmonary hemorrhage and associated morbidities observed in premature. The aim of this study was to investigate the possible relationship between pulmonary hemorrhage and respiratory problems in premature infants. Material and method: Premature infants aged 25–32 weeks who were born between January 2014 and January 2018 in the neonatal intensive care unit were included to the study. Of these premature infants, 28 were patients diagnosed as pulmonary hemorrhage and 56 were control cases with the same demographic characteristics without pulmonary hemorrhage. From the medical records of infants; clinical course characteristics such as duration of ventilation, duration of oxygen supplementation, hospital stay were detailed. The data was analyzed statistically. Results: The duration of mechanical ventilation was significantly longer in the pulmonary bleeding group than in the control group (p: .001). There was a significant difference between the groups in terms of moderate and severe bronchopulmonary dysplasia (BPD) and the rate of BPD in the pulmonary hemorrhage group was higher than in the control group (17.2%-53.6%; p: .001). In addition, pulmonary hemorrhage group had significant patent ductus arteriosus (PDA) and preterm retinopathy (ROP) rate compared with control group. Discussion: This study implicated that, pulmonary hemorrhage is related with respiratory morbidities in preterm infants such as BPD and prolonged respiratory support. At the same time, the other morbidities such as ROP prolonged hospitalization are higher in infants with pulmonary hemorrhage. Conclusion: In the follow-up of patients with pulmonary hemorrhage, defining respiratory problems and treatment and prophylaxis of comorbid conditions may be planned sooner. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)