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8 results on '"Yuriko Uchida"'

1. Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization

Author

Kyohei Yamaji, Hiroki Shiomi, Takeshi Morimoto, Yukiko Matsumura-Nakano, Natsuhiko Ehara, Hiroki Sakamoto, Yasuaki Takeji, Yusuke Yoshikawa, Ko Yamamoto, Eri T. Kato, Kazuaki Imada, Takeshi Tada, Ryoji Taniguchi, Ryusuke Nishikawa, Tomohisa Tada, Takashi Uegaito, Tatsuya Ogawa, Miho Yamada, Teruki Takeda, Hiroshi Eizawa, Nobushige Tamura, Keiichi Tambara, Satoru Suwa, Manabu Shirotani, Toshihiro Tamura, Moriaki Inoko, Junichiro Nishizawa, Masahiro Natsuaki, Hiroshi Sakai, Takashi Yamamoto, Naoki Kanemitsu, Nobuhisa Ohno, Katsuhisa Ishii, Akira Marui, Hiroshi Tsuneyoshi, Yasuhiko Terai, Shogo Nakayama, Kazuhiro Yamazaki, Mamoru Takahashi, Takashi Tamura, Jiro Esaki, Shinji Miki, Tomoya Onodera, Hiroshi Mabuchi, Yutaka Furukawa, Masaru Tanaka, Tatsuhiko Komiya, Yoshiharu Soga, Michiya Hanyu, Takenori Domei, Kenji Ando, Kazushige Kadota, Kenji Minatoya, Yoshihisa Nakagawa, Takeshi Kimura, Mitsuo Matsuda, Yuzo Takeuchi, Hirokazu Mitsuoka, Takashi Konishi, Seiji Ootani, Hisayoshi Fujiwara, Yoshiki Takatsu, Yukihito Sato, Kazuaki Kataoka, Ryuji Nohara, Kimisato Nakano, Syoichi Miyamoto, Nagai Kunihiko, Tomoyuki Murakami, Katsuya Ishida, Masakiyo Nobuyoshi, Hitoshi Yasumoto, Masashi Iwabuchi, Masayuki Kato, Ryozo Tatami, Ryuichi Hattori, Toru Kita, Yasuki Kihara, Hiroshi Kato, Takeshi Aoyama, Takahiro Sakurai, Masaki Kawanami, Tamaki Suyama, Eiji Tada, Tsukasa Inada, Hiroyasu Uzui, Akira Nakano, Jong-Dae Lee, Akinori Takizawa, Nawada Ryuzo, Eiji Shinoda, Masaaki Takahashi, Minoru Horie, Hiroyuki Takashima, Mamoru Toyofuku, Hajime Kotoura, Akira Miura, Yoshiki Matoba, Takuro Takumi, Chuwa Tei, Shuichi Hamasaki, Osamu Doi, Hirofumi Kambara, Satoshi Kaburagi, Kazuaki Mitsudo, Tetsu Mizoguchi, Yoshida Akira, Kazuhisa Kaneda, Hisao Ogawa, Koichi Sugamura, Seigo Sugiyama, Kiyoshi Doyama, Makoto Araki, Ryuzo Sakata, Tadashi Ikeda, Masahiko Onoe, Kazuo Yamanaka, Atsushi Iwakura, Keiichi Fujiwara, Kinji Soga, Tsutomu Matsushita, Noboru Nishiwaki, Yuichi Yoshida, Yukikatsu Okada, Michihiro Nasu, Tadaaki Koyama, Kuniyoshi Tanaka, Takaaki Koshiji, Koichi Morioka, Mitsuomi Shimamoto, Fumio Yamazaki, Masaki Aota, Hiroyuki Hara, Takafumi Tabata, Yutaka Imoto, Hiroyuki Yamamoto, Katsuhiko Matsuda, Masafumi Nara, Hiroyuki Nakajima, Michio Kawasuji, Syuji Moriyama, Sakiko Arimura, Yumika Fujino, Miya Hanazawa, Chikako Hibi, Risa Kato, Yui Kinoshita, Kumiko Kitagawa, Masayo Kitamura, Takahiro Kuwahara, Maeda Sachiko, Izumi Miki, Saeko Minematsu, Satoko Nishida, Naoko Okamoto, Asuka Saeki, Hitomi Sasae, Yuki Sato, Asuka Takahashi, Emi Takinami, Saori Tezuka, Marina Tsuda, Miyuki Tsumori, Yuriko Uchida, Yuko Yamamoto, Misato Yamauchi, Itsuki Yamazaki, Mai Yoshimoto, Mitsuru Abe, Masayuki Fuki, Mamoru Hayano, Eri Kato, Yoshihiro Kato, Tetsu Nakajima, Kenji Nakatsuma, Junichi Tazaki, Akihiro Tokushige, Hiroki Watanabe, Hidenori Yaku, Erika Yamamoto, and Yugo Yamashita

Published
2022
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3. Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture

Author

Fengming Yue, Kanji Hirashima, Hiroyuki Kanno, Daihachiro Tomotsune, Mikiko Kobayashi, Shunsuke Nakamura, Tadayuki Yokoyama, Katsunori Sasaki, Ken Matsumoto, Sakiko Takizawa-Shirasawa, and Yuriko Uchida

Subjects
0301 basic medicine, Histology, Induced Pluripotent Stem Cells, Mice, SCID, Biology, Pathology and Forensic Medicine, Kruppel-Like Factor 4, 03 medical and health sciences, 0302 clinical medicine, SOX2, Cancer stem cell, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, CD90, RNA, Messenger, Induced pluripotent stem cell, Cell Biology, Cellular Reprogramming, Xenograft Model Antitumor Assays, 030104 developmental biology, KLF4, Cell culture, Colonic Neoplasms, Cancer cell, Neoplastic Stem Cells, Cancer research, Reprogramming, 030217 neurology & neurosurgery
Abstract

Cancer stem cells (CSCs) are specific targets for therapeutic applications, but the rarity of CSCs within tumors makes the isolation of CSCs difficult. To overcome these problems, we generated CSCs in vitro using established reprogramming techniques. We transduced four previously established reprogramming factors, Oct3/4, Sox2, Klf4, and L-myc, into the colon cancer cell lines LoVo and OUMS-23, and investigated the biological characteristics of these lines. Tra-1-60+ cells were obtained from reprogrammed induced pluripotent stem (iPS) cell-like colonies and showed CSC properties, including colony formation, maintenance of colonies by repeated passages, and feeder cell dependency, as well as increased expressions of CSC markers such as CD133 and ALDH1. The CSC-like cells showed increased chemoresistance to 5-fluorouracil and elevated tumorigenicity upon transplantation into kidneys of immune-deficient mice. These tumors shifted to a poorly differentiated stage with many atypical cells, cytoplasmic mucin, and focal papillary components, with demonstrated dedifferentiation. The principal component analysis from DNA microarrays showed that though both cell lines moved to iPS cells after reprogramming, they were not completely identical to iPS cells. Significantly elevated gene expression of Decorin and CD90 was observed in CSC-like cells. Together, these results show that reprogramming of cancer cells produced not pluripotent stem cells but CSC-like cells, and these findings will provide biological information about genuine CSCs and help establish new CSC-targeted therapies.

Published
2018
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7. Clinical Efficacy of Thrombus Aspiration on 5-Year Clinical Outcomes in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Author

Hiroki Watanabe, Hiroki Shiomi, Kenji Nakatsuma, Takeshi Morimoto, Tomohiko Taniguchi, Yutaka Furukawa, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura, Ryuzo Sakata, Akira Marui, Mitsuo Matsuda, Hirokazu Mitsuoka, Masahiko Onoe, Kazuo Yamanaka, Hisayoshi Fujiwara, Yoshiki Takatsu, Nobuhisa Ohno, Ryuji Nohara, Tomoyuki Murakami, Teruki Takeda, Masakiyo Nobuyoshi, Masashi Iwabuchi, Michiya Hanyu, Ryozo Tatami, Tsutomu Matsushita, Manabu Shirotani, Noboru Nishiwaki, Toru Kita, Yukikatsu Okada, Hiroshi Kato, Hiroshi Eizawa, Katsuhisa Is, Masaru Tanaka, Shogo Nakayama, Jong‐Dae Lee, Akira Nakano, Takaaki Koshiji, Koichi Morioka, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Masaaki Takahashi, Junichiro Nishizawa, Hiroyuki Takashima, Takashi Tamura, Masaki Aota, Mamoru Takahashi, Takafumi Tabata, Chuwa Tei, Shuichi Hamasaki, Yutaka Imoto, Hiroyuki Yamamoto, Hirofumi Kambara, Osamu Doi, Katsuhiko Matsuda, Masafumi Nara, Kazuaki Mitsudo, Kazushige Kadota, Tatsuhiko Komiya, Shinji Miki, Tetsu Mizoguchi, Hiroyuki Nakajima, Hisao Ogawa, Seigo Sugiyama, Michio Kawasuji, Syuji Moriyama, Ryuichi Hattori, Takeshi Aoyama, Makoto Araki, Satoru Suwa, Keiichi Tanbara, Kumiko Kitagawa, Misato Yamauchi, Naoko Okamoto, Yumika Fujino, Saori Tezuka, Asuka Saeki, Miya Hanazawa, Yuki Sato, Chikako Hibi, Hitomi Sasae, Emi Takinami, Yuriko Uchida, Yuko Yamamoto, Satoko Nishida, Mai Yoshimoto, Sachiko Maeda, Izumi Miki, Saeko Minematsu, Mitsuru Abe, Tomohisa Tada, Junichi Tazaki, Yoshihiro Kato, Mamoru Hayano, Akihiro Tokushige, Masahiro Natsuaki, and Tetsu Nakajima

Subjects
Male, Acute coronary syndrome, medicine.medical_specialty, Thrombus aspiration, medicine.medical_treatment, Myocardial Infarction, Kaplan-Meier Estimate, Revascularization, Corrections, acute coronary syndrome, Coronary artery disease, Coronary thrombosis, Japan, Internal medicine, Medicine, ST segment, Humans, In patient, Clinical efficacy, Myocardial infarction, Registries, cardiovascular diseases, Stroke, Aged, Proportional Hazards Models, Thrombectomy, Original Research, business.industry, Coronary Thrombosis, percutaneous coronary intervention, Percutaneous coronary intervention, Correction, medicine.disease, thrombus aspiration, Treatment Outcome, Conventional PCI, Cardiology, Female, no reflow, Cardiology and Cardiovascular Medicine, business, coronary artery disease
Abstract

Background Adjunctive thrombus aspiration ( TA ) during primary percutaneous coronary intervention ( PCI ) was reported to promote better coronary and myocardial reperfusion. However, long‐term mortality benefit of TA remains controversial. The objective of this study is to investigate the clinical impact of TA on long‐term clinical outcomes in patients with ST ‐segment elevation myocardial infarction (STEMI) undergoing primary PCI . Methods and Results The CREDO ‐Kyoto AMI Registry is a large‐scale cohort study of acute myocardial infarction patients undergoing coronary revascularization in 2005–2007 at 26 hospitals in Japan. Among 5429 patients enrolled in the registry, the current study population consisted of 3536 patients who arrived at the hospital within 12 hours after the symptom onset and underwent primary PCI . Clinical outcomes were compared between the 2 patient groups with or without TA . During primary PCI procedures, 2239 out of 3536 (63%) patients underwent TA ( TA group). The cumulative 5‐year incidence of all‐cause death was significantly lower in the TA group than in the non‐ TA group (18.5% versus 23.9%, log‐rank P TA group was not significantly lower than that in the non‐ TA group (hazard ratio: 0.90, 95% CI : 0.76 to 1.06, P =0.21). The adjusted risks for cardiac death, myocardial infarction, stroke, and target‐lesion revascularization were also not significantly different between the 2 groups. Conclusions Adjunctive TA during primary PCI was not associated with better 5‐year mortality in STEMI patients.

Published
2015

8. Project on Changing the Negative Image of Girl Students Concerning Science Courses

Author

Shinko Sasaki, Jyunya Kobayashi, Naoyuk Fujita, Yuriko Uchida, Kyoji Komatsu, and Syozo Himuro

Subjects
Medical education, Engineering, Negative, business.industry, media_common.quotation_subject, Agency (sociology), Factory (object-oriented programming), Girl, Negative perception, business, media_common, Web site
Abstract

“Rikeigokoro no Susume project” , which is one of “the Support Projects for Girl Students to Choose the Science Course” promoted by the Japan Science and Technology Agency (JST) , is conducted by Nara, Hakodate, Sendai, Kure, Kagawa, and Ariake national colleges of technology. The aim of this project is to change the negative image ordinary junior high school and high school girl students have about becoming an engineer or scientist. To interest girl students in the science course, we made a poster, a leaflet and web site and held science events such as lectures and a factory tour. Almost all the participating girl students changed their negative perception of becoming an engineer or scientist to a positive one.

Published
2011
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