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Accumulating evidence suggests that two chronic respiratory diseases, nontuberculous mycobacterium (NTM)-pulmonary disease (PD) and allergic asthma, are frequently present together and that they likely influence the disease development and progression of each other. However, their precise interactions regarding the pathogenesis of comorbid diseases versus that of individual diseases are not well understood. In this study, comorbid diseases (i.e., Mycobacteria avium (Mav) pulmonary infection (PI) (Mav-PI) and ovalbumin-induced allergic asthma) were established in mice in different orders and at different time periods. Individual disease-specific characteristics, including alterations in immune cell populations and antigen-specific immune responses, were analyzed and compared. To assess Mav-PI pathogenesis, lung inflammation and bacterial burden levels were also determined. Allergic asthma induction in the presence of Mav-PI markedly aggravated Mav-PI pathogenesis by increasing the bacterial burden and the severity of lung inflammation. Interestingly, the general outcome of allergic asthma with goblet cell hyperplasia was alleviated at a chronic stage in the comorbid mouse model. Overall, the increase in the number of Mav CFUs was inversely correlated with the Mav-specific Th17 response, as confirmed by comparing BALB/c and C57BL/6J mice. Overall, the pathogenesis of existing Mav-PI is more severely affected by allergen exposure than vice versa. This Mav-PI exacerbation is associated with disruption of Mav-specific Th17 responses. This study provides the first evidence that the Mav-specific Th17 response plays an important role in the control of Mav pathogenesis in the presence of allergic asthma, indicating that targeting the Th17 response has therapeutic potential for NTM-PD accompanied by allergic asthma.

PURPOSE: The purpose of this study was to investigate the effects of 3 dimensional exercises and Klapp’s exercise on parameters of scoliosis in subjects with non-structure scoliosis. METHOD: This study was performed on 24 subjects. Twenty-four subjects were divided into two groups; 3 dimensional exercise(n=12), Klapp’s exercise(n=12). Both of the group performed the exercise 3 times a week for 5 weeks. The data was analyzed by the Paired t-test for comparing before and after changes of factors in each group and the Independent t-test for comparing the between groups. RESULT: The result are as follows. There was statistically significant difference of before and after arthopometric parameters, trunk flexion, Cobb's angle in 3 dimensional exercise(p 0.05). CONCLUSION: As a result of this study, we found that the 3 dimensional exercise may be effective more than Klapp’s exercise.