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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. miR-484 is previously reported to be a crucial modulator during the process from precancerous lesion to cancer. Tumour suppressor candidate 5 (TUSC5) is a potential tumour suppressor, but its expression and function in HCC are obscure. In this study, we aimed to explore the roles of miR-484 and TUSC5 in HCC, and clarify the relationship between them. We demonstrated that miR-484 was significantly up-regulated in HCC, while TUSC5 was down-regulated. TUSC5 was validated as the target gene of miR-484 and both of them were associated with the prognosis of HCC patients. miR-484 mimics markedly promoted the malignant phenotypes while TUSC5 plasmid had the opposite effect. In conclusion, miR-484/TUSC5 is potential diagnostic biomarkers and therapy targets for HCC.

For the purpose of studying the influence of evaporation temperature on system efficiency and turbine efficiency of ocean thermal energy conversion (OTEC) Rankine cycle in different temperature differences. The 15kW OTEC experiment system has been designed and built. By maintaining hot seawater and turbine parameters, OTEC Rankine cycle has been experimentally studied. The results showed that the system efficiency and turbine efficiency increase with the increase of seawater temperature difference, and when the temperature difference is 19.7°C, matching the design conditions: turbine efficiency is 73%, output power is 15kW. The system efficiency and turbine efficiency show a tendency of rising first and then decreasing with the increase of evaporating temperature at given temperature difference.