1. Non-invasive diagnosis strategy of hepatocellular carcinoma in low-risk population
- Author
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Zonglin Xie, Zhenpeng Peng, Yujian Zou, Han Xiao, Bin Li, Qian Zhou, Shuling Chen, Lixia Xu, Jingxian Shen, Yunxian Mo, Sui Peng, Ming Kuang, Jianting Long, and Shi-Ting Feng
- Subjects
Hepatocellular carcinoma ,LI-RADS ,Diagnosis ,Low-risk ,Non-invasive ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Aims With prevalence of hepatocellular carcinoma (HCC) in low-risk population (LRP), establishing a non-invasive diagnostic strategy becomes increasingly urgent to spare unnecessary biopsies in this population. The purposes of this study were to find characterisics of HCC and to establish a proper non-invasive method to diagnose HCC in LRP. Methods A total of 681 patients in LRP (defined as the population without cirrhosis, chronic HBV infection or HCC history) were collected from 2 institutions. The images of computed tomography (CT) and magnetic resonance imaging (MRI) were manually analysed. We divided the patients into the training cohort (n = 324) and the internal validating cohort (n = 139) by admission time in the first institution. The cohort in the second institution was viewed as the external validation (n = 218). A multivariate logistic regression model incorporating both imaging and clinical independent risk predictors was developed. C-statistics was used to evaluate the diagnostic performance. Results Besides the major imaging features of HCC (non-rim enhancement, washout and enhancing capsule), tumor necrosis or severe ischemia (TNSI) on imaging and two clinical characteristics (gender and alpha fetoprotein) were also independently associated with HCC diagnosis (all P
- Published
- 2022
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