173 results on '"Yunpeng Xie"'
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2. Association of Preablation Plasma Corin Levels With Atrial Fibrillation Recurrence After Catheter Ablation: A Prospective Observational Study
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Yichang Zhao, Xiaoyang Yuan, Yunpeng Xie, Xiaomeng Yin, Ying Liu, Yuanjun Sun, Yue Gong, Jinqiu Liu, and Feifei Chen
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atrial fibrillation ,catheter ablation ,corin ,natriuretic peptides ,recurrence ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background We assessed the impact of pre‐ and postprocedural plasma corin levels on the recurrence of atrial fibrillation (AF) after catheter ablation (CA). Methods and Results This prospective, single‐center, observational study included patients undergoing their first CA of AF. Corin was measured before and 1 day after CA. The primary end point was recurrent AF between 3 and 12 months after ablation. From April 2019 through May 2021, we analyzed 616 patients with AF (59.09% men) with a mean age of 62.86±9.42 years. Overall, 153 patients (24.84%) experienced recurrent AF. In the recurrence group, the pre‐ and postprocedure corin concentrations were 539.14 (329.24–702.08) and 607.37 (364.50–753.80) pg/mL, respectively, which were significantly higher than the nonrecurrence group's respective concentrations of 369.05 (186.36–489.28) and 489.12 (315.66–629.05) pg/mL (both P494.85 pg/mL predicted AF recurrence at 1 year. An increase of 1 SD in corin concentrations before CA (264.94 pg/mL) increased the risk of recurrent AF by 54.3% after adjusting for confounding variables (hazard ratio, 1.465 [95% CI, 1.282–1.655]; P
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- 2024
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3. Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro
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Zhenyu Feng, Ningning Zhang, Jie Bai, Qiu-yue Lin, Yunpeng Xie, and Yun-long Xia
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Cardiac remodeling ,Biochanin A ,Inflammation ,Fibrosis ,Oxidative stress ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The heart undergoes pathological cardiac hypertrophy as an adaptive response to prolonged pathological stimulation, leading to cardiomyocyte hypertrophy, fibroblast proliferation, and an increase in extracellular matrix. Chinese medicine monomers are now receiving much attention for the treatment of cardiac hypertrophy and myocardial remodeling. Biochanin A (BCA) is a kind of flavonoid structural monomer, which has a certain therapeutic effect on bone thinning disease, aging syndrome, lung cancer, etc. Moreover, it exhibits hypoglycemic, anti-inflammatory, anti-oxidation, anti-bacteria and other pharmacological properties. It is still unknown whether BCA has an impact on the mechanism of TAC-induced cardiac hypertrophy. Here, cardiac remodeling was induced by TAC. BCA was injected intraperitoneally at 25 and 50 mg/kg/day one week in advance. Masson, WGA, DHE and other pathological staining and serum were used to detect the inhibitory effect of BCA on cardiac hypertrophy in mice. The anti-hypertrophic effect of BCA was demonstrated by studying the pathological manifestations of Neonatal rat cardiomyocytes (NRCMs) and cardiac fibroblasts (CFs) in vitro. The results showed that BCA significantly reduced TAC-induced fibrosis, inflammation, oxidative stress, and myocardial hypertrophy. BCA inhibited Ang II-induced cell hypertrophy and oxidative stress in NRCMs in vitro and Ang II-induced CF migration, proliferation, and collagen secretion. This suggests that BCA plays a key role in inhibiting the progression of myocardial remodeling, suggesting that BCA may be a promising agent for the treatment of myocardial hypertrophy and fibrosis.
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- 2024
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4. Effects of Acetazolamide on Collagen Metabolism in Keratoconus Fibroblasts
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Yunpeng XIE, Xuqin LEI, Jie SONG, Xiaona LI, Rui HE, Jizhong YANG, and Pengfei FENG
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acetazolamide ,keratoconus ,collagen ,oxidative stress ,Chemical engineering ,TP155-156 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Technology - Abstract
Keratoconus is characterized by the progressive thinning and protrusion of central cornea. Dysregulated collagen metabolism is one of the causes of this disease. In this study, the effect of acetazolamide on collagen synthesis in keratoconus fibroblasts and its mechanism were explored, which could provide a reference for the clinical treatment of keratoconus. The cultured keratoconus fibroblasts were treated with 100 μmol/L acetazolamide solution. The expression of collagen metabolism-related genes was then analyzed by qPCR. The collagen content was detected by ELISA and Western Blot. The intracellular ROS content was analyzed by fluorescent probe DCFH-DA. The changes of MDA content and the total antioxidant capacity were detected by spectrophotometry. It was suggested that after acetamide treatment, the expression of COLs and LOXs, of which coded enzymes paticipated in collagen synthesis and crosslinking, were significantly up-regulated, while the expression of collagen degradation genes including MMP2, MMP3, and MMP9 were significantly down-regulated. The contents of type I collagen and total collagens were both reduced by acetamide treatment. In addition, the total antioxidant capacity of cells and the expression of the antioxidant enzyme gene NQO-1 were significantly up-regulated, while the contents of ROS and MDA were significantly decreased. The results indicated that acetazolamide could induce the synthesis and inhibit the degradation of collagens in keratoconus fibroblasts by reducing the intracellular oxidative stress levels.
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- 2023
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5. Study on the Degradation Effect of Carbonaceous Shale under the Coupling Effect of Chemical Erosion and High Temperature
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Guangwei Xiong, Qiunan Chen, Yongchao He, Zhenghong Chen, Xiaocheng Huang, and Yunpeng Xie
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carbonaceous slate ,chemical erosion ,triaxial compression ,discrete element simulation ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
The southwest region of China has abundant groundwater and high-temperature geothermal energy. Carbonaceous shale, as one of the typical surrounding rocks in this region, often suffers from deterioration effects due to the coupled action of groundwater chemical erosion and high temperature, which affects the long-term stability of tunnel engineering. In order to investigate the deterioration effects of carbonaceous shale under the coupled action of chemical erosion and high temperature, carbonaceous shale from a tunnel of Lixiang Railway in Yunnan Province was taken as the research object. The microstructure and mineral composition of the samples before and after chemical erosion were obtained with a scanning electron microscope-energy dispersive spectrometer and an X-ray diffraction test. Then, triaxial compression tests were conducted on the samples under different time points and different temperature effects of chemical erosion, and the stress–strain curves and the deterioration laws under a single factor were obtained. An improved numerical simulation method based on the parallel bond model was developed, which can account for the coupled effects of chemical erosion and high temperature on the rock. By simulating the triaxial compression test of carbonaceous shale, the deterioration law of carbonaceous shale under the coupled action was discussed. The results show that chemical erosion has a significant deterioration effect on the triaxial compressive strength of carbonaceous shale, and the degree of deterioration is related to the erosion time. In the first 30 days of erosion, the triaxial compressive strength of carbonaceous shale decreased by 11.38%, which was the largest deterioration range. With the increase in erosion time, the deterioration rate gradually decreased; temperature had a significant threshold effect on the strength of carbonaceous shale, and a clear turning point appeared at about 200 °C. By simulating the deterioration effects of carbonaceous shale under the coupled action of chemical erosion and high temperature, it was found that the longer the duration of chemical erosion, the stronger the temperature sensitivity of carbonaceous shale, and the more serious the loss of compressive strength during the heating process. When the temperature was low, the strength of carbonaceous shale changed little, and some samples even showed an increase in strength; when the temperature was high, the strength of carbonaceous shale decreased significantly, showing deterioration characteristics. The numerical simulation method was compared and verified with the indoor test results, and it was found that the numerical calculation had a good agreement with the test results.
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- 2024
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6. Hyperhomocysteinaemia Promotes Doxorubicin-Induced Cardiotoxicity in Mice
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Rui Fan, Yao Wang, Jinjin Zhang, Xiangbo An, Shuang Liu, Jie Bai, Jiatian Li, Qiuyue Lin, Yunpeng Xie, Jiawei Liao, and Yunlong Xia
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hyperhomocysteinaemia ,homocysteine ,methionine ,doxorubicin ,cardiotoxicity ,folic acid ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Doxorubicin, a widely used chemotherapeutic drug in clinical oncology, causes a series of cardiac side effects referred to as doxorubicin-induced cardiotoxicity. Hyperhomocysteinaemia is an independent risk factor for multiple cardiovascular diseases. However, whether hyperhomocysteinaemia contributes to doxorubicin-induced cardiotoxicity is currently unknown. In this study, we explored the pathogenic effects of hyperhomocysteinaemia induced by dietary methionine supplementation (2% wt/wt in rodent chow) in a mouse model of doxorubicin-induced cardiotoxicity. Our data showed that methionine supplementation doubled serum homocysteine levels, inducing mild hyperhomocysteinaemia. Doxorubicin at a cumulative dosage of 25 mg/kg body weight led to significant weight loss and severe cardiac dysfunction, which were further exacerbated by methionine-induced mild hyperhomocysteinaemia. Doxorubicin-induced cardiac atrophy, cytoplasmic vacuolisation, myofibrillar disarray and loss, as well as cardiac fibrosis, were also exacerbated by methionine-induced mild hyperhomocysteinaemia. Additional folic acid supplementation (0.006% wt/wt) prevented methionine-induced hyperhomocysteinaemia and inhibited hyperhomocysteinaemia-aggravated cardiac dysfunction and cardiomyopathy. In particular, hyperhomocysteinaemia increased both serum and cardiac oxidative stress, which could all be inhibited by folic acid supplementation. Therefore, we demonstrated for the first time that hyperhomocysteinaemia could exacerbate doxorubicin-induced cardiotoxicity in mice, and the pathogenic effects of hyperhomocysteinaemia might at least partially correlate with increased oxidative stress and could be prevented by folic acid supplementation. Our study provides preliminary experimental evidence for the assessment of hyperhomocysteinaemia as a potential risk factor for chemotherapy-induced cardiotoxicity in cancer patients.
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- 2023
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7. Computing Power Network: Multi-Objective Optimization-Based Routing
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Yunpeng Xie, Xiaoyao Huang, Jingchun Li, and Tianhe Liu
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computing power network ,multi-objective optimization ,genetic algorithm ,NSGA-II ,reinforcement learning ,Chemical technology ,TP1-1185 - Abstract
This paper presents a novel routing planning method based on multi-objective optimization to tackle the routing problem in computing power networks. The proposed method aims to improve the performance and efficiency of routing by considering multiple objectives. In this study, we first model the computing power network and formulate the routing problem as a multi-objective optimization problem. To address this problem, we introduce a non-dominated sorting genetic algorithm incorporating a ratio parameter adjustment strategy based on reinforcement learning. Extensive simulations are conducted to evaluate the performance of the proposed routing algorithm. The results demonstrate significant client latency and cost reductions, highlighting the algorithm’s effectiveness. By providing a comprehensive solution to the routing problem in computing power networks, this work contributes to the field by offering improved performance and efficiency. The proposed method’s ability to optimize multiple objectives sets it apart from existing approaches, making it a valuable contribution to the research community.
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- 2023
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8. Investigation of Damage and Creep for Bedding’s Carbonaceous Slate with Chemical Erosion Effect
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Weihao Zeng, Zhenghong Chen, Yunpeng Xie, and Qiunan Chen
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carbonaceous slate ,bedding angle ,chemical erosion ,creep characteristic ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Tunnel projects in the southwestern mountainous area of China are in full swing. According to the tunnel burial depth, structural characteristics, and chemical erosion environments of the Lixiang railway tunnel, carbonaceous slate specimens obtained in the field were taken to experimentally investigate the physical, mechanical, and creep characteristics of the bedding’s slate specimens after chemical erosion. The results of scanning electron microscopy (SEM) indicate that chemical erosion leads to internal damage in the carbonaceous slate specimens, and the internal damages are increasing with the increase of erosion days. Moreover, the specimens’ ultrasonic test (UT) results prove that specimens with smaller bedding angles suffer a more serious erosion and induce more internal cracks. Under conventional triaxial compression conditions with 40 MPa of confining pressures, the conventional triaxial compressive strength (σs) decreases with the decrease of the bedding angle and the increase of erosion days, and the failure modes of the specimens are mainly controlled by oblique shear fractures and accompanied by the occurrence of slip dislocation fractures between the bedding inclination. Under creep conditions with 40 MPa of confining pressures, the final deformations of specimens are increasing with the increase of erosion days, which means the longer the erosion days, the greater the deformations. The failure modes of the specimens under creep conditions are controlled by shear fractures, and for the specimen with a 60° bedding angle and long-term erosion, there are block separations and many cavities along the shear planes. Therefore, more attention should be paid to prevent serious failure of the surrounding rock if the surrounding rock has a bedding angle of 60° or suffers long-term erosion.
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- 2023
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9. Research progress on the role of ferroptosis in cardiovascular disease
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Han Li, Li Lin, Yun-Long Xia, Yunpeng Xie, and Xiaolei Yang
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ferroptosis ,cardiovascular disease ,iron overload ,lipid peroxidation ,arrhythmia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The cardiovascular disease pathogenesis is extremely complex and seriously threatens human health. Cardiomyocyte death plays a significant role in cardiovascular disease occurrence and development. In addition to the previously revealed modes of cell death (apoptosis, autophagy, and pyroptosis), ferroptosis is highly related to the development of cardiovascular diseases, including arrhythmia, atherosclerosis, and myocardial ischemia/reperfusion. Ferroptosis is a novel cell death pathway driven by lipid peroxidation and iron overload. Lipid, amino acid, and iron metabolism regulate the ferroptosis pathway. Small molecule compounds (iron chelators, antioxidants, and ferroptosis inhibitors) and genetic programming can alleviate or prevent cardiovascular disease by inhibiting the ferroptosis pathway. Ferroptosis plays a key role in various cardiovascular disease occurrence and development, and inhibiting ferroptosis in cardiomyocytes is expected to become a feasible treatment method. In this mini-review, we systematically summarize the molecular mechanisms of ferroptosis in different cardiovascular diseases, delineate the regulatory network between ferroptosis and cardiovascular diseases, and highlight its potential therapeutic targets.
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- 2022
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10. Sustainability Analysis of the Water Environment Carrying Capacity of Harbin City Based on an Optimized Set Pair Analysis Posture-Deviation Coefficient Method Evaluation Model
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Nan Sun, Zhongbao Yao, Yunpeng Xie, Tianyi Wang, Jinzhao Yang, Xinyu Li, and Qiang Fu
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water environment carrying capacity ,set pair analysis posture evaluation method ,bias coefficients method ,Harbin ,weight optimization ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
To scientifically measure the water environment carrying capacity of Harbin City and its change trend, based on analysis of the implications of the sustainability of the urban water environment’s carrying capacity, an evaluation index system for the sustainability of the water environment carrying capacity of Harbin City was constructed. Most existing evaluation methods rely on static data to construct correlation functions between research objects and rank criteria, while the dynamic nature of the information is not considered enough. In this paper, we use hierarchical analysis (analytic hierarchy process, AHP) to determine the weights of each index of the system and then apply the projection tracing method (projection pursuit, PP) to optimize the determined weights. Combining the set pair analysis posture evaluation method and bias coefficients method to explore the dynamic balance mechanism between different index factor levels, a sustainability evaluation model for water environment carrying capacity integrating informational evolution is constructed. Finally, the applicability of the optimization model is tested by comparing the confidence criterion judging method. The model realizes quantitative evaluation of the carrying capacity of the urban water environment. It provides a new and effective means for accurate and reasonable determination of the coefficient of variance and the number of links and dynamic analysis of the water environment carrying capacity system and judgment of its sustainable development trend. The results show that the weight for water resource quality is 0.55, which is the subsystem with the greatest overall impact on the carrying capacity of the water environment in Harbin. The evaluation level of the set-to-potential eigenvalue for 2010–2017 is biased positive 2, and the rest of the years are quasi 2. The reduced value of the coefficient of oppositeness corresponding to the years 2010–2017 is more significant. The maximum value of the dynamic evolution of the load-carrying capacity level is nearly −0.35. From the vertical comparison of different levels, it is found that the water environment carrying capacity of Harbin City gradually recovered to the normal loadable level over time. This overall shows an improving trend.
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- 2023
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11. Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1
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Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, and Deshi Dong
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doxorubicin ,apoptosis ,oxidative stress ,inflammation ,Naringin ,ECHS1 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Doxorubicin (DOX) leads to myocardial cell damage and irreversible heart failure, which limits the clinical application of DOX. Naringin has biological functions of inhibiting inflammation, oxidative stress and apoptosis. Our aim was to investigate whether Naringin could prevent DOX-related cardiotoxicity in mice. Naringin was administered by gavage and mice were intraperitoneally injected with doxorubicin (1 mg/kg/day) for 15 days. H&E, Masson, TUNEL and others experiments were examined. NRVMs and H9C2 cells were treated with Naringin and DOX in vitro. Using IF, ELISA and Western Blot to detect the effect of Naringin and ECHS1 on cells. The results showed that Naringin could prevent DOX related cardiac injury, inhibit cardiac oxidative stress, inflammation and apoptosis in vivo and in vitro. Inhibition of ECHS1 could interfere the effect of Naringin on DOX-induced myocardial injury. Naringin may provide a new cardiac protective tool for preventing the cardiotoxicity of anthracycline drugs.
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- 2022
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12. Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice
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Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, and Jiawei Liao
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Diets rich in polyphenols are known to be beneficial for cardiovascular health. Gallic acid (GA) is a plant-derived triphenolic chemical with multiple cardio-protective properties, such as antiobesity, anti-inflammation, and antioxidation. However, whether GA could protect against atherosclerotic cardiovascular diseases is still not defined. Here, we investigated the effects of low-dose GA administration on diet-induced metabolic disorders and atherosclerosis in the atherosclerosis-prone apolipoprotein E (Apoe) knockout mice fed on a high-fat Western-type diet (WTD) for 8 weeks. Our data showed that GA administration by oral gavage at a daily dosage of 20 mg/kg body weight did not significantly ameliorate WTD-induced hyperlipidemia, hepatosteatosis, adipogenesis, or insulin resistance; furthermore, GA administration did not significantly ameliorate WTD-induced atherosclerosis. In conclusion, our data demonstrate that low-dose GA administration does not elicit significant health effect on diet-induced metabolic disorders or atherosclerosis in the Apoe knockout mice. Whether GA could be beneficial for atherosclerotic cardiovascular diseases therefore needs further exploration.
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- 2022
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13. Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro
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Ningning Zhang, Xiangbo An, Pingping Lang, Feng Wang, and Yunpeng Xie
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Ginsenoside Rd ,Hypertrophy ,Oxidative stress ,Fibrosis ,Inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cardiac hypertrophy are the major health challenges in the whole world. Ginsenoside Rd is an important component of cell growth and tumorigenesis, but the role and mechanism of ginsenoside Rd in pressure overload induced cardiac dysfunction and remodeling are still not fully illuminated. Here, cardiac hypertrophic remodeling and dysfunction were induced by pressure overload in mice. Myocardial histology was detected by Masson's trichrome staining and hematoxylin-eosin staining (H&E). Western blot was used to detect protein levels of signal mediators. Cardiac function was evaluated by echocardiography, and qPCR analysis was used to detect mRNA expression of hypertrophy and fibrosis markers. Cardiomyocyte size was detected by Wheat germ agglutinin (WGA) staining. Dihydroethidine (DHE) staining was used to detect oxidative stress. We also detected the influence of Ginsenoside Rd on rat neonatal cardiac myocytes (NRCMs) treated by Phenylephrine (PE). Our results showed that Ginsenoside Rd significantly improved pressure overload induced contractile dysfunction, fibrosis, cardiac hypertrophy, inflammation and oxidative stress in mice. Moreover, protein levels of AKT, calcineurin A, ERK1/2 and TGF-β1 were significantly decreased in the Ginsenoside Rd-treated hearts as compared to control. Ginsenoside Rd treated in cardiomyocytes inhibited PE-induced cardiomyocyte hypertrophy. These results revealed that ginsenoside Rd improved cardiac dysfunction and remodeling induced by pressure overload, which is related to the inhibition of a variety of signaling pathways.
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- 2019
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14. Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway
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Yajuan Lin, Yunpeng Xie, Zhujing Hao, Hailian Bi, Yang Liu, Xiaolei Yang, and Yunlong Xia
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Uric acid is an effective antioxidant. Oxidized low-density lipoprotein (ox-LDL) is derived from circulating LDL and promotes atherosclerosis. The Keap1-Nrf2-ARE pathway is a key body pathway involved in protection against internal and external oxidative damages. The role of uric acid on vascular endothelial function damaged by ox-LDL, and its effect on the Keap1-Nrf2-ARE pathway has not been fully explored. HUVECs were treated with different concentrations of uric acid and ox-LDL to explore the effect of uric acid in vitro. Cell phenotype was determined by cytometry and Western blot. Nuclear translocation of Nrf2 was determined by immunofluorescence. Coimmunoprecipitation was used to determine the level of Nrf2 ubiquitination. A microfluidic device was used to mimic the vascular environment in the body, and the level of mRNA levels of inflammatory factors was determined by RT-PCR. The findings of this study show that suitable uric acid can significantly reduce endothelial damage caused by ox-LDL, such as oxidative stress, inflammation, and increased adhesion. In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. Interestingly, the effects of UA were significantly inhibited by administration of Brusatol, an inhibitor of Nrf2. In summary, suitable concentrations of uric acid can alleviate the oxidative stress level of endothelial cells through Nrf2 nuclear translocation and further protect cells from damage.
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- 2021
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15. Corrigendum to 'Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro' [Biomed. Pharmacother. 109 (2019) 1016–1023]
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Ningning Zhang, Xiangbo An, Pingping Lang, Feng Wang, and Yunpeng Xie
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Therapeutics. Pharmacology ,RM1-950 - Published
- 2020
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16. Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice
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Jiawei Liao, Xiangbo An, Xiaolei Yang, Qiu-Yue Lin, Shuang Liu, Yunpeng Xie, Jie Bai, Yun-Long Xia, and Hui-Hua Li
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immunoproteasome ,LMP10 ,diet ,atherosclerosis ,macrophage ,inflammation ,Biology (General) ,QH301-705.5 - Abstract
Macrophage polarization and inflammation are key factors for the onset and progression of atherosclerosis. The immunoproteasome complex consists of three inducible catalytic subunits (LMP2, LMP10, and LMP7) that play a critical role in the regulation of these risk factors. We recently demonstrated that the LMP7 subunit promotes diet-induced atherosclerosis via inhibition of MERTK-mediated efferocytosis. Here, we explored the role of another subunit of LMP10 in the disease process, using ApoE knockout (ko) mice fed on an atherogenic diet (ATD) containing 0.5% cholesterol and 20% fat for 8 weeks as an in vivo atherosclerosis model. We observed that ATD significantly upregulated LMP10 expression in aortic lesions, which were primarily co-localized with plaque macrophages. Conversely, deletion of LMP10 markedly attenuated atherosclerotic lesion area, CD68+ macrophage accumulation, and necrotic core expansion in the plaques, but did not change plasma metabolic parameters, lesional SM22α+ smooth muscle cells, or collagen content. Myeloid-specific deletion of LMP10 by bone marrow transplantation resulted in similar phenotypes. Furthermore, deletion of LMP10 remarkably reduced aortic macrophage infiltration and increased M2/M1 ratio, accompanied by decreased expression of pro-inflammatory M1 cytokines (MCP-1, IL-1, and IL-6) and increased expression of anti-inflammatory M2 cytokines (IL-4 and IL-10). In addition, we confirmed in cultured macrophages that LMP10 deletion blunted macrophage polarization and inflammation during ox-LDL-induced foam cell formation in vitro, which was associated with decreased IκBα degradation and NF-κB activation. Our results show that the immunoproteasome subunit LMP10 promoted diet-induced atherosclerosis in ApoE ko mice possibly through regulation of NF-κB-mediated macrophage polarization and inflammation. Targeting LMP10 may represent a new therapeutic approach for atherosclerosis.
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- 2020
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17. Quercetin Dihydrate inhibition of cardiac fibrosis induced by angiotensin II in vivo and in vitro
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Liang Wang, Aiping Tan, Xiangbo An, Yunlong Xia, and Yunpeng Xie
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Quercetin Dihydrate ,Hypertrophy ,Fibrosis ,Inflammation ,Proliferation ,Angiotensin II ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cardiac fibroblasts play a key role in the process of myocardial remodeling and myocardial fibrosis, which will eventually lead to heart failure. Quercetin Dihydrate has been studied in cardiovascular disease, but its effect on myocardial fibrosis is not clear. Here, cardiac remodeling was induced by infusion of Ang II (1000 ng/kg/min) for 2 weeks in mice. Quercetin Dihydrate was injected intraperitoneally for 25 mM/kg body weight (BW) once two days. We found that Quercetin Dihydrate significantly reduced cardiac contractile function, fibrosis, inflammation and myocardial hypertrophy induced by Ang II. Quercetin Dihydrate could inhibit the expression of Collagen I and Collagen III, which are the markers of fibroblast differentiation. We also verified the inhibitory effect of Quercetin Dihydrate on the proliferation and differentiation of fibroblasts induced by angiotensin II in vitro. Our results show that quercetin dihydrate plays a key role in the progression of myocardial fibrosis and suggests that Quercetin Dihydrate may be a promising drug for the treatment of myocardial fibrosis.
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- 2020
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18. Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice
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Jiawei Liao, Xiaolei Yang, Qiuyue Lin, Shuang Liu, Yunpeng Xie, Yunlong Xia, and Hui-Hua Li
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Background. Ubiquitin-like modifier activating enzyme 1 (UBA1) is the first and major E1 activating enzyme in ubiquitin activation, the initial step of the ubiquitin-proteasome system. Defects in the expression or activity of UBA1 correlate with several neurodegenerative and cardiovascular disorders. However, whether UBA1 contributes to atherosclerosis is not defined. Methods and Results. Atherosclerosis was induced in apolipoprotein E-knockout (Apoe-/-) mice fed on an atherogenic diet. UBA1 expression, detected by immunohistochemical staining, was found to be significantly increased in the atherosclerotic plaques, which confirmed to be mainly derived from lesional CD68+ macrophages via immunofluorescence costaining. Inactivation of UBA1 by the specific inhibitor PYR-41 did not alter the main metabolic parameters during atherogenic diet feeding but suppressed atherosclerosis development with less macrophage infiltration and plaque necrosis. PYR-41 did not alter circulating immune cells determined by flow cytometry but significantly reduced aortic mRNA levels of cytokines related to monocyte recruitment (Mcp-1, Vcam-1, and Icam-1) and macrophage proinflammatory responses (Il-1β and Il-6). Besides, PYR-41 also suppressed aortic mRNA expression of NADPH oxidase (Nox1, Nox2, and Nox4) and lesional oxidative stress levels, determined by DHE staining. In vitro, PYR-41 blunted ox-LDL-induced lipid deposition and expression of proinflammatory cytokines (Il-1β and Il-6) and NADPH oxidases (Nox1, Nox2, and Nox4) in cultured RAW264.7 macrophages. Conclusions. We demonstrated that UBA1 expression was upregulated and mainly derived from macrophages in the atherosclerotic plaques and inactivation of UBA1 by PYR-41 suppressed atherosclerosis development probably through inhibiting macrophage proinflammatory response and oxidative stress. Our data suggested that UBA1 might be explored as a potential pharmaceutical target against atherosclerosis.
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- 2020
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19. Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4
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Ningning Zhang, Yunpeng Xie, Yidi Tai, Yingying Gao, Wei Guo, Wendan Yu, Jia Li, Xu Feng, Jiaojiao Hao, Yue Gao, Xinrui Zhao, Yina Liao, Wei Jiang, Ge Liu, Wuguo Deng, and Xiaonan Cui
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hTERT ,CPSF4 ,Proliferation ,Apoptosis ,Migration ,Bufalin ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
Background/Aims: Bufalin can induce apoptosis in certain human cancer cell lines, but bufalin has not yet been thoroughly evaluated in colorectal cancer cells. Cleavage and polyadenylation specific factor 4 (CPSF4) and human telomerase reverse transcriptase (hTERT) play important roles in colorectal cancer growth. The aim of this study was to investigate the roles and interactions of bufalin, CPSF4 and hTERT and the effects of bufalin in human colorectal cancer. Methods: We treated LoVo and SW620 cells with bufalin to investigate the effect of bufalin on proliferation, apoptosis and migration. We verified the relationship between CPSF4 and hTERT using pulldown assays, luciferase reporter assays and chromatin immunoprecipitation (ChIP) assays. Results: Bufalin inhibited the proliferation and migration of and induced apoptosis in LoVo and SW620 cells. We identified CPSF4 as an hTERT promoter-binding protein in colorectal cancer cells. Conclusion: Our study identified bufalin as a potential small molecule inhibitor for cancer therapy.
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- 2016
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20. miR-196b inhibits cell migration and invasion through targeting MAP3K1 in hydatidiform mole
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Zhenzhen Guo, Linlin Sui, Jia Qi, Qiannan Sun, Yuefei Xu, Na Zou, Yunpeng Xie, and Ying Kong
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miR-196b ,MAP3K1 ,Hydatidiform mole ,Human choriocarcinoma cell ,Migration ,Invasion ,Therapeutics. Pharmacology ,RM1-950 - Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNAs that are closely associated with carcinogenesis. Accumulating data indicate that miR-196b participates in the development of various types of cancers. However, the role of miR-196b in the formation of hydatidiform mole (HM) is still unclear. Our previous studies have demonstrated that miR-196b levels were decreased in JAR and BeWo cells and in HM tissue samples, as demonstrated by RT-PCR analysis. Furthermore, we discovered that overexpression of miR-196b in JAR and BeWo cells inhibited cellular proliferation, migration and invasion, as shown by Cell counting kit-8 (CCK-8) and transwell assays, respectively. Subsequently, we explored the interaction of miR-196b with its target gene in human choriocarcinoma cell lines. MAP3K1 is a target gene predicted by bioinformatic analysis that was previously shown to exhibit reduced expression levels following treatment with miR-196b in JAR and BeWo cells. We demonstrated that MAP3K1 was a direct target of miR-196b using the dual-luciferase reporter assay in Hela cells. In summary, the present study demonstrated that miR-196b suppressed proliferation, migration and invasion of human choriocarcinoma cells by inhibiting its transcriptional target MAP3K1. miR-196b and MAP3K1 may be considered potential targets for the clinical treatment of HM.
- Published
- 2019
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21. Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling
- Author
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Yinghua Li, Yunpeng Xie, Dan Cui, Yanni Ma, Linlin Sui, Chenyang Zhu, Hui Kong, and Ying Kong
- Subjects
Endometrial cancer ,Migration ,Invasion ,EMT ,Osteopontin ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
Background/Aims: Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer. Methods: The proliferation, migration and invasion ability of HEC-1A cells were detected by Cell Counting Kit-8 (CCK-8), Wound scratch assay and transwell. Western blots were employed to detect the expression of Matrix metalloproteinase-2 (MMP-2) and epithelial-mesenchymal transition (EMT)-related factors in HEC-1A cells treated with rhOPN. Results: rhOPN promotes cell proliferation, migration and invasion in HEC-1A cells. rhOPN influenced EMT-related factors and MMP-2 expression in HEC-1A cells. rhOPN promoted HEC-1A cells migration, invasion and EMT through protein kinase B (PKB/AKT) and Extracellular regulated protein kinases (ERK1/2) signaling pathway. Conclusions: These results may open up a novel therapeutic strategy for endometrial cancer: namely, rhOPN have important roles in controlling growth of endometrial of cancer cells and suggest a novel target pathway for treatment of this cancer.
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- 2015
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22. OPN Induces FoxM1 Expression and Localization through ERK 1/2, AKT, and p38 Signaling Pathway in HEC-1A Cells
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Yunpeng Xie, Yinghua Li, and Ying Kong
- Subjects
FoxM1 ,OPN ,proliferation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Mammalian embryo implantation is an extremely complex process and requires endometrial receptivity. In order to establish this receptivity, sequential proliferation and differentiation during the menstrual cycle is necessary. Forkhead box M1 (FoxM1) is described as a major oncogenic transcription factor in tumor initiation, promotion and progression. According to these functions, we believe that FoxM1 should also play an essential role in embryo implantation. Osteopontin (OPN), an adhesion molecule, has been studied extensively in reproduction. In this study, we observed the expression and distribution of FoxM1 during the proliferative-phase and secretory-phase human endometrium and the pre-implantation mouse uterus firstly. Then we observed the relationship between OPN and FoxM1. Our results showed that FoxM1 was mainly distributed in glandular epithelium. OPN increased the expression of FoxM1 in the human uterine epithelial cell line HEC-1A cells in a time- and concentration-dependent manner. OPN regulates FoxM1 to influence HEC-1A cell proliferation through extracellular regulated protein kinases (ERK 1/2), protein kinase B (PKB, AKT), and the p38 mitogen activated protein kinases (p38MAPK, p38) signaling pathway. Inhibition of ERK 1/2, AKT and p38 suppressed OPN-induced FoxM1 expression and location. Our data indicate that FoxM1 might be regulated by OPN to influence endometrial proliferation to establish endometrial receptivity.
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- 2014
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23. Modeling and Optimization for Computing Power Resource-Aware in CPN.
- Author
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Jiacong Li, Hang Lv 0006, Bo Lei, and Yunpeng Xie
- Published
- 2023
24. Communication and Computing Integration: Characteristic of Computing Power Network towards 6G.
- Author
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Qianying Zhao, Min Wei, Yunpeng Xie, and Bo Lei
- Published
- 2023
- Full Text
- View/download PDF
25. A new network infrastructure architecture arising from the multimedia service evolution.
- Author
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Jing Tang, Fujia Liu, Xiaoting Ma, Bo Lei, and Yunpeng Xie
- Published
- 2023
- Full Text
- View/download PDF
26. Research and Design of Broadband Intelligent Internet for Cloud-Network Convergence.
- Author
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Yunpeng Xie, Jing Tang, Xiaoting Ma, Bo Lei, and Jiacong Li
- Published
- 2023
- Full Text
- View/download PDF
27. Integrated solution for industrial Internet based on edge computing.
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Jing Tang, Fujia Liu, Xiaoting Ma, Bo Lei, and Yunpeng Xie
- Published
- 2023
- Full Text
- View/download PDF
28. A Multicast Scheduling Method Based on EVPN-VXLAN Extension in Data Center Networks.
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Nan Wu, Guozhen Dong, Wenjuan Xing, Shizhong Nie, and Yunpeng Xie
- Published
- 2023
- Full Text
- View/download PDF
29. Shape adjustment of the 'FAST' active reflective surface.
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Xiaoyu Miao, Yunpeng Xie, and Fanqi Xu
- Published
- 2022
- Full Text
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30. A Consensus Approach for SDN Controllers based on Blockchain.
- Author
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Jiacong Li, Hang Lv 0006, Bo Lei, and Yunpeng Xie
- Published
- 2022
- Full Text
- View/download PDF
31. A Hierarchical Routing Mechanism for Service in CPN.
- Author
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Jiacong Li, Hang Lv 0006, Bo Lei, and Yunpeng Xie
- Published
- 2023
- Full Text
- View/download PDF
32. A Security Mapping Approach between Multi Tenant and Computing Routing Nodes in CPN.
- Author
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Jiacong Li, Hang Lv 0006, Bo Lei, and Yunpeng Xie
- Published
- 2023
- Full Text
- View/download PDF
33. A Computing Power Resource Modeling Approach for Computing Power Network.
- Author
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Jiacong Li, Hang Lv 0006, Bo Lei, and Yunpeng Xie
- Published
- 2022
- Full Text
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34. Anthracycline-Induced Atrial Structural and Electrical Remodeling Characterizes Early Cardiotoxicity and Contributes to Atrial Conductive Instability and Dysfunction
- Author
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Ruopeng Tan, Tao Cong, Guiwen Xu, Zhujing Hao, Jiawei Liao, Yunpeng Xie, Yajuan Lin, Xiaolei Yang, Qingsong Li, Yang Liu, and Yun-Long Xia
- Subjects
Antibiotics, Antineoplastic ,Physiology ,Clinical Biochemistry ,Breast Neoplasms ,Atrial Remodeling ,Cell Biology ,Biochemistry ,Antioxidants ,Cardiotoxicity ,Mice ,Doxorubicin ,Atrial Fibrillation ,Animals ,Humans ,General Earth and Planetary Sciences ,Anthracyclines ,Female ,Dexrazoxane ,Reactive Oxygen Species ,Molecular Biology ,General Environmental Science - Published
- 2022
35. Crystallographic Characterization of <scp> Lu 2 O </scp> @ C s (6)‐ <scp> C 82 </scp> and <scp> Er 2 O </scp> @ C s (6)‐ <scp> C 82 </scp> : The Role of Metal Species on Cluster Configuration †
- Author
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Pengwei Yu, Haocheng Mei, Shuaifeng Hu, Changwang Pan, Wangqiang Shen, Pengyuan Yu, Kun Guo, Yunpeng Xie, Takeshi Akasaka, Lipiao Bao, and Xing Lu
- Subjects
General Chemistry - Published
- 2023
36. Concurrent topology optimization of multiple components sharing partial design domain based on distance regularized parameterized level set method
- Author
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Zhongqi Sheng, Qunyi Hu, and Yunpeng Xie
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Numerical Analysis ,Applied Mathematics ,General Engineering - Published
- 2023
37. Application of lattice anchor rod in high and steep slope support
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Shuijiang Li, Hongbo Liu, Yongkang Ye, and Yunpeng Xie
- Published
- 2023
38. Development and Application of Chiral Nematic Cellulose Nanocrystalline Iridescent Films
- Author
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Yunpeng Xie, Qi Zhu, and Guangxue Chen
- Published
- 2023
39. Steering Lu3N clusters in C76–78 cages: cluster configuration dominated by cage transformation
- Author
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Pengwei Yu, Shuaifeng Hu, Xinyue Tian, Wangqiang Shen, Pengyuan Yu, Kun Guo, Yunpeng Xie, Lipiao Bao, and Xing Lu
- Subjects
General Materials Science - Abstract
How cage transformation interacts with cluster configuration has been elucidated by three designed metallofullerenes, namely Lu3N@Cs(17 490)-C76, Lu3N@C2(22 010)-C78, and Lu3N@D3h(5)-C78, with an easy-to-compare cluster configuration and cage arrangement.
- Published
- 2022
40. Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress
- Author
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Rui Fan, Xiangbo An, Yao Wang, Jinjin Zhang, Shuang Liu, Jie Bai, Jiatian Li, Qiuyue Lin, Yunpeng Xie, Yunlong Xia, and Jiawei Liao
- Subjects
Cell Biology ,Molecular Biology - Published
- 2023
41. Steering Lu
- Author
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Pengwei, Yu, Shuaifeng, Hu, Xinyue, Tian, Wangqiang, Shen, Pengyuan, Yu, Kun, Guo, Yunpeng, Xie, Lipiao, Bao, and Xing, Lu
- Abstract
While the strong interaction between the internal unit and the fullerene cage inside metallofullerenes is widely acknowledged, how the cage transformation interacts with the cluster configuration remains elusive. For this purpose, we herein synthesized three metallofullerene molecules with an easy-to-compare cluster configuration and cage arrangement, namely Lu
- Published
- 2022
42. Copper(I) Alkynyl Clusters with Crystallization-Induced Emission Enhancement
- Author
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Xing Lu, Chen Liu, Yang-Lin Shen, Jun-Jie Fang, Yunpeng Xie, and Zheng Liu
- Subjects
Infrared spectroscopy ,chemistry.chemical_element ,Crystal structure ,Phosphate ,Copper ,law.invention ,Amorphous solid ,Inorganic Chemistry ,chemistry.chemical_compound ,Crystallography ,chemistry ,law ,Cluster (physics) ,Physical and Theoretical Chemistry ,Crystallization ,Luminescence - Abstract
Four copper(I) alkynyl complexes incorporating phosphate ligands, namely, [Cu16(tBuC≡C)12(PhOPO3)2]n (1; PhOPO3 = phenyl phosphate), [Cu16(tBuC≡C)12(1-NaphOPO3)2]n (2; 1-NaphOPO3 = 1-naphthyl phosphate), [VO4@Cu25(tBuC≡C)19(1-NaphOPO3)](PF6)0.5(F)0.5 (3), and [PO4@Cu25(tBuC≡C)19(1-NaphOPO3)](PF6)0.5(F)0.5 (4), were solvothermally synthesized and well-characterized by IR spectroscopy, powder X-ray diffraction, and single-crystal X-ray diffraction. Single-crystal X-ray analysis revealed that the Cu16 cluster-based coordination chain polymers 1 and 2 are formed by assembly during crystallization, while 3 and 4 contain high-nuclearity copper(I) composite clusters enclosing orthovanadate and phosphate template ions, respectively, that are supported by ROPO32- ligands. Complexes 1-4 exhibit crystallization-induced emission enhancement. Their crystalline state shows strong luminescence, in striking contrast to the weak emission of the amorphous state and solution phase. A detailed investigation of the crystal structure suggests that well-arranged C-H···π and π···π interactions between the ligands are the major factors for this enhanced emission. Clusters 3 and 4 also exhibit photocurrent responses upon visible-light illumination.
- Published
- 2021
43. Effect of stroke etiology on endovascular treatment in patients with acute basilar artery occlusion.
- Author
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Tian TIAN, Zhongzhen LI, Miao YU, Yunpeng XIE, Wenhao SUN, Jia DU, and Shaoya YIN
- Published
- 2023
- Full Text
- View/download PDF
44. Construction of Silver Clusters Capped by Zwitterionic Ethynide Ligands
- Author
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Yang-Lin Shen, Yunpeng Xie, Jian-Lin Shi, Jun-Ling Jin, Xing Lu, Jun-Jie Fang, and Zheng Liu
- Subjects
Inorganic Chemistry ,Crystallography ,Thermogravimetric analysis ,chemistry.chemical_compound ,010405 organic chemistry ,Ligand ,Chemistry ,Cluster (physics) ,Physical and Theoretical Chemistry ,010402 general chemistry ,Propyne ,01 natural sciences ,0104 chemical sciences - Abstract
A zwitterionic ligand 3-(triethylammonio)propyne (TAP) has been employed to construct nine silver ethynide compounds for the first time. Single-crystal X-ray analyses reveal that compounds 1 and 2 are silver ethynide assemblies based on the Ag3 subunits and clusters 3-8 are small discrete clusters of Ag3, Ag6, Ag8, and Ag12, respectively, ligated by the bulky TAP ligand with different auxiliary ligands. In addition, upon acquiring the tripod-like tBuPO32-, a unprecedented 80 nuclei silver ethynide cluster was isolated and determined to be [(CF3CO2)5@Ag80(TAP)14(tBuPO3)16(CF3CO2)24]19+ by crystallography and thermogravimetric analysis. The C1 symmetry of Ag80 was deconstructed to be two [Ag40(TAP)7(tBuPO3)8(CF3CO2)12]12+ secondary building subunits arranged in a cross way, with five CF3CO2- trapped in the center. These results highlight that the elaborate selection of ethynide ligands is of great importance in the synthesis of novel silver ethynide clusters.
- Published
- 2021
45. Controllable synthesis of porous tubular carbon by a Ag+-ligand-assisted Stöber-silica/carbon assembly process
- Author
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Jun-Ling Jin, Ting Xu, Xing Lu, Ning Chen, Yang-Lin Shen, Yunpeng Xie, and Peng Ju Li
- Subjects
Materials science ,Nanostructure ,chemistry.chemical_element ,Resorcinol ,Catalysis ,Tetraethyl orthosilicate ,Metal ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,visual_art ,visual_art.visual_art_medium ,General Materials Science ,Porosity ,Mesoporous material ,Carbon - Abstract
Herein, in this study, we utilized Ag+-ligand interactions for critically regulating the morphology of carbon by the Stober-silica/carbon co-assembly method for the first time. Tetraethyl orthosilicate (TEOS) and resorcinol/formaldehyde (RF) assemble upon dictation by Ag+ and pyridyl-functionalized surfactants, producing porous carbon tubes (RF1) with a high surface area of 696 m2 g-1 and accessible mesopores ∼15 nm in size. Furthermore, when using tetrapropyl orthosilicate (TPOS) with a slower hydrolysis rate than that of TEOS, carbon tubes (RF2) with enhanced uniformity and a surface area as high as 2112 m2 g-1 are generated. Additionally, when using dopamine hydrochloride instead of RF as a carbon precursor, tubular polydopamine (TDA) with lengths of tens of microns is fabricated, which exhibits excellent catalytic activity toward oxygen reduction reactions in alkaline solutions due to its unique structural feature, a high surface area of 1350 m2 g-1, metallic silver remains of 8.3 wt%, and a rich nitrogen content of 3.6 wt%. This work sheds light on the engineering of a micellar soft template and synthesizing novel nanostructures by the extension of the Stober method.
- Published
- 2021
46. Nestlike Silver(I) Thiolate Clusters with Tunable Emission Color Templated by Heteroanions
- Author
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Guang-Xiong Duan, Yunpeng Xie, Pengyuan Yu, Jun-Ling Jin, Yang-Lin Shen, and Xing Lu
- Subjects
010405 organic chemistry ,Hexafluoroacetylacetone ,Organic Chemistry ,General Chemistry ,Template synthesis ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Metal ,chemistry.chemical_compound ,Crystallography ,Template ,chemistry ,visual_art ,visual_art.visual_art_medium ,Luminescence - Abstract
Four silver thiolate clusters, [H3 O][(Ag3 S3 )(BF4 )@Ag27 (tBuS)18 (hfac)6 H2 O]⋅H2 O (1; hfac = hexafluoroacetylacetone), [(Ag3 S3 )(CF3 CO2 )@Ag30 (tBuS)16 (CF3 CO2 )9 (CH3 CN)4 ]⋅CF3 CO2 ⋅4 CH3 CN (2), [(Ag3 S3 )(MoO4 )@Ag30 (tBuS)16 (CF3 CO2 )9 (CH3 CN)4 ]⋅2 CH3 CN (3), and [(Ag3 S3 )(CrO4 )@Ag30 (tBuS)16 (CF3 CO2 )9 (CH3 CN)4 ]⋅4 CH3 CN (4), were isolated. They have similar nestlike structures assembled by an [Ag3 S3 ]3- template together with one of the BF4 - , CF3 CO2 - , MoO4 2- , or CrO4 2- anions. Interestingly, the solid-state emissions of 2-4 are dependent on the templating anions and are tunable from green to orange and then to red by changing the template from CF3 CO2 - to MoO4 2- and to CrO4 2- , and this may be correlated to the charge transfer between these templates to metal atoms. This work helps to understand the templating role of heteroanions and the relationship between structure and properties.
- Published
- 2020
47. miR-302e Suppresses Glioma Progression by Targeting VEGFA
- Author
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Xin Liu, Tiemin Hu, Weixing Wang, and Yunpeng Xie
- Subjects
0301 basic medicine ,Biology ,medicine.disease ,medicine.disease_cause ,03 medical and health sciences ,Vascular endothelial growth factor A ,030104 developmental biology ,0302 clinical medicine ,Real-time polymerase chain reaction ,Oncology ,Apoptosis ,030220 oncology & carcinogenesis ,Glioma ,microRNA ,medicine ,Cancer research ,Gene silencing ,Signal transduction ,Carcinogenesis - Abstract
Background MiRNA can be involved in regulating tumor genesis and development by regulating the expression of specific genes and regulating corresponding signaling pathways. In this study, we explored the function and mechanisms of miR-302e in glioma progression. Methods Experimental methods include the following: real-time quantitative PCR, Western Blot Analysis, CCK8 assay and detection of apoptosis. Results MiR-302e was down-regulated in cancer tissues and cell lines, and the expression of miR-302e was negatively correlated with the tumor grade, which indicated poor prognosis in glioma patients. Followed functional analysis showed overexpression of miR-302e inhibited proliferation, migration and invasion but promoted apoptosis of glioma cells, while silencing miR-302e showed the opposite effects. Mechanistic studies have shown that VEGFA was a directed target of miR-302e. Forced expression of VEGFA removed the inhibiting impact of miR-302e on glioma development. In vivo tumorigenesis experiments showed that miR-302e suppressed glioma development by targeting VEGFA. Conclusion Present study emphasized miR-302e suppressed glioma development by targeting VEGFA, which might be a valuable target for glioma treatment.
- Published
- 2020
48. Machining scheme of aviation bearing bracket based on additive and subtractive hybrid manufacturing
- Author
-
Yunpeng Xie, Zhongqi Sheng, Jianbin Tong, and Yuqiang Fu
- Subjects
0209 industrial biotechnology ,Subtractive color ,Bearing (mechanical) ,Computer science ,Aviation ,business.industry ,Mechanical Engineering ,Machinability ,Bracket ,Process (computing) ,Mechanical engineering ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,02 engineering and technology ,law.invention ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,0203 mechanical engineering ,Machining ,Mechanics of Materials ,law ,Range (aeronautics) ,business - Abstract
Aviation bearing bracket is an important part of aircraft and other aviation products. In this paper, based on additive and subtractive hybrid manufacturing technology with high manufacturing flexibility and high machining accuracy, a machining scheme of aviation bearing bracket is designed. First, milling simulation was carried out to obtain the influence law of different cutting parameters on machining deformation, so as to guide the selection of reasonable finish machining parameters in the subsequent process planning. Then, the temperature field distribution of workpiece in the additive manufacturing was simulated, and the influence of different additive manufacturing parameters on the results was analyzed to determine the parameter selection range. Finally, considering the material utilization rate, machining accuracy, machining efficiency and machinability in the machining process of aviation bearing bracket, and proceeding from additive, subtractive and alternating manufacturing methods, the manufacturing process arrangement and process planning for aviation bearing bracket were designed.
- Published
- 2020
49. An integrated review of automation and robotic technologies for structural prefabrication and construction
- Author
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Mehrdad Arashpour, Cheav Por Chea, Yunpeng Xie, Yu Bai, and Xuebei Pan
- Subjects
0209 industrial biotechnology ,9. Industry and infrastructure ,Computer science ,business.industry ,020101 civil engineering ,02 engineering and technology ,Automation ,Construction engineering ,0201 civil engineering ,Prefabrication ,020901 industrial engineering & automation ,Control and Systems Engineering ,Safety, Risk, Reliability and Quality ,business ,Engineering (miscellaneous) - Abstract
Building construction has developed from the use of primitive tools to that of machinery, with a tendency toward automation. Automation of processes and robotics can improve efficiency, accuracy and safety in construction. On the other hand, structural prefabrication for construction is increasingly being adopted worldwide to enhance productivity and to alleviate the environmental impact of conventional construction processes. The combination and application of automation and prefabrication technologies may therefore introduce new developments to the construction industry. This paper provides a comprehensive review of the use of automation technology for structural prefabrication and construction, including recent developments, challenges and future trends. Five stages following the sequence of construction are proposed: design, construction management, robotic manufacturing, autonomous transportation and automatic structural assembly. The paper concludes that the widespread use of automation technology is preferable to structural prefabrication for construction, and that the design for robotic construction introduced through connection innovations may be beneficial as a means of avoiding complex operations and thus improving the efficiency of robotic assembly processes.
- Published
- 2020
50. Crystallographic Characterization of Er2C2@C80–88: Cluster Stretching with Cage Elongation
- Author
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Shuaifeng Hu, Yunpeng Xie, Masahiro Ehara, Xing Lu, Pei Zhao, Takeshi Akasaka, and Wangqiang Shen
- Subjects
Inorganic Chemistry ,Crystallography ,010405 organic chemistry ,Chemistry ,Cluster (physics) ,Physical and Theoretical Chemistry ,Elongation ,010402 general chemistry ,Cage ,01 natural sciences ,0104 chemical sciences ,Carbide ,Characterization (materials science) - Abstract
Six dierbium carbide endohedral metallofullerenes have been synthesized and chromatographically isolated. Single-crystal X-ray diffractometry unambiguously ascertains their structures as Er2C2@C2v(...
- Published
- 2020
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