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2 results on '"Yunfei Li Song"'

1. Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending

Author

Maarten Jaspers, Florian Tegel, Timo P. Roelofs, Fabian Starsich, Yunfei Li Song, Bernhard Meir, Richard Elkes, and Bastiaan H.J. Dickhoff

Subjects
Mini-Blending, Process intensification, Powder blending, Continuous direct compression, Continuous Processing, Pharmacy and materia medica, RS1-441
Abstract

Process intensification involves the miniaturization of equipment while retaining process throughput and performance. The pharmaceutical industry can benefit from this approach especially during drug product development, where the availability of active pharmaceutical ingredients (API) is often limited. It reduces the need for process scale up, as equipment used during product development and commercial production is identical. However, applications of process intensification for processing pharmaceutical powders are limited so far. Here we show that semi-continuous mini-blending can be utilized for process intensification of blending of API and excipients. Uniform blending at commercially relevant throughputs was achieved through mini-blends with a volume of less than ten liters. Our results demonstrate that blending speed, cycle time and blender fill level can be optimized without compromising blending performance. Acceptable blend uniformity is obtained over a broad range of operating parameters, by choosing the right excipients. The optimized throughput of the mini-blending process is in line with the desired throughput of a commercial Continuous Direct Compression (CDC) process.

Published
2024
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2. Catalytic hydrogenation of: N -4-nitrophenyl nicotinamide in a micro-packed bed reactor

Author

Andrew R. Teixeira, Stephen C. Born, Yunfei Li Song, Yanxiang Shi, Cuixian Yang, Benjamin Martin, Maryam Peer Lachegurabi, Hongkun Lin, Berthold Schenkel, Klavs F. Jensen, Li Song, Yunfei [0000-0002-6138-9000], Apollo - University of Cambridge Repository, Massachusetts Institute of Technology. Department of Chemical Engineering, Yang, Cuixian, Teixeira, Andrew, Shi, Yanxiang, Born, Stephen C, Lin, Hongkun, Peer Lachegurabi, Maryam, and Jensen, Klavs F

Subjects
Packed bed, Active ingredient, 34 Chemical Sciences, 010405 organic chemistry, Chemistry, Dimer, Condensation, 010402 general chemistry, Residence time (fluid dynamics), 01 natural sciences, Pollution, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Chemical engineering, Mass transfer, Environmental Chemistry, Amine gas treating
Abstract

Recent advancements in micro-flow technologies and a drive toward more efficient, greener and safer processes have led to a renaissance in flow-chemistry for pharmaceutical production. In this work, we demonstrate the use of a stabilized Pd nanoparticle-organic-silica catalyst to selectively catalyze the hydrogenation of N-4-nitrophenyl nicotinamide, a functionalized active pharmaceutical ingredient (API) surrogate. Extensive catalyst and reactor characterization is provided to establish an in-depth understanding of the unique multiphase dynamics within the micro-packed bed reactor, including the identification of a large liquid holdup (74-84%), rapid multiphase mass transfer (kma > 1 s-1), and liquid residence time distributions. A kinetic analysis has revealed that the surface catalyzed hydrogenation progresses through a condensation mechanism whereby an azo dimer intermediate is formed and rapidly consumed. Finally, a parametric study was performed at various pressures, temperatures, residence times and flow regimes to achieve quantitative chemoselective conversion of the nitroarene to the corresponding primary amine.

Published
2018

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