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The rapid progress in cultivated meat research has engendered considerable attention towards the edible scaffolding biomaterials employed in the production. Cellulose has the advantages in availability, edibility, animal-free origin, etc., which show its potential in wide fields. This review begins by presenting the fundamental physical and chemical properties of cellulose from different sources, including plant and bacterial cellulose. Subsequently, we summarize the application of cellulose especially in cultivated meat and tissue engineering. Furthermore, we explore various methods for preparing cellulose-based scaffolds for cultivated meat, encompassing five specific structural variations. In the end, associated with utilizing cellulose in cultivated meat production, we address several primary challenges surrounding to cell adhesion, scaling up, processibility and mechanical properties, and provide potential innovations. This review underscores the potential of cellulose as a versatile biomaterial in the cultivated meat industry and provides insight into addressing critical challenges for its integration.

A method of employing high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling was developed in this study to investigate the effects of alcohol exposure on lipid homeostasis at the white adipose tissue (WAT)-liver axis in a mouse model of alcoholic fatty liver. In order to differentiate the liver lipids synthesized from the fatty acids that were transported back from adipose tissue and the lipids synthesized from other sources of fatty acids, a two-stage mouse feeding experiment was performed to incorporate deuterium into metabolites. Hepatic lipids extracted from mouse liver, epididymal white adipose tissue (eWAT) and subcutaneous white adipose tissue (sWAT) were analyzed. It was found that 13 and 10 triacylglycerols (TGs) incorporated with a certain number of deuterium were significantly increased in alcohol induced fatty liver at two and four weeks of alcohol feeding periods, respectively. The concentration changes of these TGs ranged from 1.7 to 6.3-fold increase. A total of 14 deuterated TGs were significantly decreased in both eWAT and sWAT at the two and four weeks and the fold-change ranged from 0.19 to 0.77. The increase of deuterium incorporated TGs in alcohol-induced fatty liver and their decrease in both eWAT and sWAT indicate that alcohol exposure induces hepatic influx of fatty acids which are released from WATs. The results of time course analysis further indicate a mechanistic link between adipose fat loss and hepatic fat gain in alcoholic fatty liver.