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Quercetin is a flavonoid with strong antioxidant capacities. Recent studies indicate that quercetin can protect eye cells from oxidative damage. Lipid nanocarriers can protect the lipophilic drugs, achieving greater physical and chemical stability and controlling the release. Two potential nanocarriers including nanoemulsions (NE) and solid lipid nanoparticles (SLNs) are chosen as vehicles for quercetin encapsulation. Biocompatible surfactants Tween and Span were combined to develop oil in water interfaces to stabilize the quercetin. The size distribution of lipid nanocarriers was around 150–345 nm by using dynamic light scattering or transmission electron microscopy. The ocular quercetin delivery was confirmed by using confocal microscopy and ex vivo porcine eyes. The quercetin loaded solid lipid nanoparticles had the highest flux of 158 μg cm−2 on cornea after 24 hours. In addition, SLNs had the lowest cytotoxicity for cornea and retinal ganglion cells, and the value of half maximal inhibitory concentration were 268.85 and 211.3 μg ml−1, respectively. Quercetin loaded SLNs could efficiently protect cornea and retinal ganglion cells from H2O2-induced oxidative damages. Taken together, our results help to shed light on the complex interplay between the quercetin, the carrier composition, the ocular tissues and the antioxidant activities.

Proposed three modeling methods for the numerical calculation of the foam material, the method of single cell deposition modeling is simple, but the assumptions of the foam cell structure become complicated, which don’t reflect the position and shape of the bubble holes adequately; the method of three dimensional reconstruction can truly reflect the shape of the foam material’s microstructure only for sliced section foam material, and it involves multiple softwares which leads to become difficult to accomplish; the method of programming enables cell distribute within the foam matrix material anywhere and be able to control the bubble shape of the hole, and it can also control the porosity by the program.

To study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer.Rat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer.The thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P0.01 or P0.05).WTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.