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Fault slip rates are critical for understanding the evolution of active faults, earthquake recurrence, and crustal deformation. Yet variations in slip rate along the Haiyuan Fault Zone (HYFZ), a large-scale sinistral strike-slip fault in the northeastern margin of the Tibetan Plateau, remain disputed. Here, we investigate in detail late Quaternary and present-day fault slip rates for several segments across the HYFZ based on previously published geologic and geodetic (i.e. GNSS and InSAR) estimates. Our results reveal that the strike-slip rates increase from ~1.6±0.4–1.8±0.3 mm/a on the Halahu (HLH) fault to ~5.2±1.3–6.2±0.9 mm/a on the Lenglongling (LLL) and Jinqianghe (JQH) faults, then decrease to ~3.9±0.8–4.6±0.3 mm/a on the Maomaoshan (MMS) and Laohushan (LHS) faults, subsequently remain relatively constant (i.e. ~4.6±0.8–4.8±0.7 mm/a) on the Haiyuan (HY) fault (in narrow sense), and finally decrease to ~1.3±0.1–1.5±0.3 mm/a on the Liupanshan (LPS) fault, from west to east. These results indicate that the strike-slip rates on the LLL and JQH faults are highest and decrease toward fault tips along the HYFZ, approximating an asymmetrical bell-shaped distribution. Furthermore, geodetic (short-term) and geologic (long-term) slip rates are in general agreement, indicating that the slip rates were relatively constant in the recent geologic history. Despite the shallow creep on the LHS fault, the Tianzhu Seismic Gap, Tuolaishan (TLS), LLL, and LPS faults have a large locking depth, strain accumulation, and/or long seismic quiescence period, underscoring the substantial seismic hazard in these areas. Our study contributes to characterizing the total slip rate budget across the HYFZ and provides insight into further understanding of seismic hazard and regional crustal deformation.

2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) is a widely used brominated flame retardant belonging to persistent organic pollutants (POPs). After being released into the marine environment, BDE-47 can cause a range of toxic effects on marine organisms through bioaccumulation, biomagnification, and intergenerational transmission. These effects include lethality, impaired motility, photosynthetic toxicity, immune damage, liver toxicity, developmental impairments, and reproductive toxicity. This article reviews the latest research progress on the toxic effects and molecular mechanisms of BDE-47 mentioned above. The primary mechanisms underlying its toxicity include oxidative stress, DNA damage, cellular apoptosis, impaired metabolism, and activation of the MAPK signaling cascade.

Abstract Articular cartilage damage is often caused by joint disease, trauma, and aging in everyday life. Cartilage damage usually refers to some changes in the normal structure and a gradual loss of function. Local discomforts, such as slight swelling or pain, may occur. Due to the lack of blood vessels and nerves in articular cartilage, articular cartilage damage is difficult to repair, making the detection and repair of articular cartilage damage difficult. New detection and repair technologies are urgently needed. The existing treatment methods are often used to monitor the internal environment and repair cartilage by implanting stents. Due to its high precision and simulation, 3D printing has shown great potential in carrier drug refinement and detection sensing and has become one of the more ideal technologies in the biomedical field. This article reviews the mitigation measures of bone injury, 3D printing technology, and treatment strategies for bone injury based on 3D printing technology. In addition, some challenges and possible solutions are also put forward for the treatment of bone injuries, as well as some possible development directions in the future.

Adventitious root formation is a bottleneck during vegetative proliferation. Potassium (K+) is an essential macronutrient for plants. K+ accumulation from the soil and its distribution to the different plant organs is mediated by K+ transporters named K+ transporter (KT), K+ uptake (KUP), or high-affinity K+ (HAK). This study aimed to identify members of the HAK gene family in apples and to characterize the effects of K+ supply on adventitious root formation and on the expression of HAK genes and the genes that putatively control auxin transport, signaling, and cell fate during adventitious root formation. In this study, 34 HAK genes (MdHAKs) were identified in the apple (Malus × domestica ‘Golden Delicious’) genome. A phylogenetic analysis divided MdHAKs into four clusters (I, II, III, and IV), comprising 16, 1, 4, and 13 genes, respectively. The syntenic relationships revealed that 62.5% of the total MdHAK genes arise from genomic duplication events. Chromosome location, domain structure, motif analysis, and physico-chemical characteristics were subsequently investigated. Furthermore, the application of K+ indicated the emergence of adventitious roots at 8 d and produced more adventitious roots at 16 d than the K+-free control (CK) treatment. In addition, various MdHAKs showed root-specific expression in B9 apple rootstock stem cuttings and enhanced expression during the initiation and emergence stages of adventitious root formation in response to K+ treatment. Additionally, K+ treatment enhanced the expression levels of MdPIN1, MdPIN2, and MdAUX1. Further data indicated that a higher expression of MdWOX11, MdLBD16, and MdLBD29 and of cell cycle-related genes contributed to the auxin-stimulated adventitious root formation in response to K+.

Rice is a primary food source, and height is a crucial parameter affecting its growth status. Consequently, high-precision, real-time monitoring of quantitative changes in crop height are required for improved crop production. Polarimetric interferometric SAR (PolInSAR) has both polarization and interferometric observation capabilities. Due to the short height of crops and rapid growth changes, the large spatial and short temporal baselines of PolInSAR data are essential for effective crop height inversion; however, relevant satellite-borne SAR and airborne SAR data are currently limited. This study presents a PolInSAR rice height inversion algorithm that uses the oriented volume over ground (OVoG) mode with PolInSAR 0-time and controllable spatial baseline data from a LAMP microwave anechoic chamber. Exploiting the advantages of microwave anechoic chamber measurement data, which includes continuous frequency bands, multiple baselines, and varied incidence angles, the influences of incident angles, baseline length, number of baselines, and baseline combinations are assessed. The highest accuracy rice plant height inversion has a root mean square deviation (RMSE) of 0.1093 m and is achieved with an incidence angle of 35–55°, baseline length of 0.25°, and three to four baselines. Furthermore, an imaging geometric equivalence analysis provides reliable foundation data to guide research into new earth observation SAR systems. The results indicate that, under simulated observations from the GF3 satellite at an altitude of 755 km, the optimal spatial baseline ranges for various frequency bands are as follows: L-band: 10.93–42.59 km; S-band: 4.10–15.97 km; C-band: 2.48–9.64 km; X-band: 1.36–5.32 km; Ku-band: 0.87–3.40 km. Notably, the measurement modes corresponding to the C, X, and Ku bands are ultimately identified as the most suitable for PolInSAR rice height inversion.

Dual-polarization division multiplexing (DPDM) is considered to be a potential method to boost the secure key rate (SKR) of the continuous-variable quantum key distribution (CV-QKD) system. In this article, we propose a pilot alternately assisted local local oscillator (LLO) CV-QKD scheme based on multi-dimensional multiplexing, where time division multiplexing and frequency division multiplexing are combined with dual-polarization multiplexing techniques to dramatically isolate the quantum signal from the pilot tone. We establish a general excess noise model for the LLO CV-QKD system to analyze the influence mechanism of various disturbances (e.g., time-domain diffusion, frequency-domain modulation residual, and polarization perturbation) on the key parameters, such as the channel transmittance and excess noise. Specifically, the photon leakage noise from the reference path to the quantum path and that between quantum signals with two different polarization paths are simultaneously analyzed in the dual-polarization LLO CV-QKD scheme for the first time. Furthermore, a series of simulations are established to verify the performance of the proposed scheme. The results show that the maximal isolation degree achieves 84.0 dB~90.4 dB, and the crosstalk between pilot tones and quantum signals can be suppressed to a very small range. By optimizing the system parameters (e.g., modulation variance and repetition frequency), the SKR with 12.801 Mbps@25 km is achieved under the infinite polarization extinction ratio (PER) and 30 dB residual ratio of the frequency modulation in the nanosecond-level pulse width. Moreover, the performance of the proposed DPDM CV-QKD scheme under relatively harsh conditions is simulated; the results show that the SKR with 1.02 Mbps@25 km is achieved under a relatively low PER of 17 dB with the nanosecond-level pulse width and 20 dB residual ratio of the frequency modulation. Our work lays an important theoretical foundation for the practical DPDM LLO CV-QKD system.

With the continuous development of metropolitan broadband and network, the need of secure and faster transmission also increases. The authors demonstrate a single-carrier four-state continuous-variable quantum key distribution (CVQKD) with sub-Gbps key rate within metropolitan area and secure transmissions up to 25 km

Abstract Currently, tumor-infiltrating lymphocytes (TILs) in invasive breast cancers are assessed solely on the basis of their number, whereas their spatial distribution is rarely investigated. Therefore, we evaluated TILs in 579 patients with invasive breast cancer of no special type (IBC-NST) with a focus on their spatial distributions in tumor center (TC) and invasive margin (IM). We also assessed a new factor, namely para-tumor infiltrating lymphocytes (PILs) in the para-tumor lobular area (Para). Five immunoarchitectural patterns (IPs) were observed, which were significantly associated with clinicopathological features, especially molecular subtypes, histological grades, clinical stages, and programmed death-ligand 1 (PD-L1) expression. High-TIL density (IP1/2) correlated with favorable disease-free survival (DFS) in TNBC patients (p = 0.04), but opposite results were observed for luminal B subtype patients (both the lowest TIL and PIL densities (IP5) correlated with good DFS, p = 0.013). Luminal B patients with high TILs in the IM and low TILs in the TC (IP3) exhibited the worst DFS, whereas those with low TILs (similar to IP5) and high PILs (IP4) exhibited poor DFS. We also identified TIL subpopulations with significantly different IPs. Our findings suggest that IP can be a potential prognostic factor for tumor immunity in IBC.

The drought resistance of eight commonly used apple rootstocks under natural drought conditions was examined to provide clues for the selection, promotion, and utilization of drought-resistant apple rootstocks. The ultrastructural differences and physiological and biochemical characteristics of the leaves of eight apple rootstocks under drought stress were observed. The index changes were used to rank drought resistance by the membership function method comprehensively. The results showed that the leaf thickness, palisade tissue thickness, sponge tissue thickness, net photosynthetic rate, and chlorophyll content were significantly higher in 'Fupingqiuzi' than those of other rootstocks at various stress conditions. The leaf water content and water use efficiency of 'Qingzhen 1' were significantly higher than those of other rootstocks under different stress conditions. The root vigor of 'B.9' was significantly higher than that of other rootstocks. The results of membership function analysis showed that the drought resistance of different rootstocks was in the order: 'Fupingqiuzi' > 'Qingzhen 1' > 'B.9' > 'MM.111' > 'GM256' > 'MM.106' > 'M.26' > 'M.9-Nic29'. 'Fupingqiuzi' had the strongest drought resistance, and 'Qingzhen 1' and 'B.9' were also relatively drought-resistant. These rootstocks can be used as raw materials for drought-resistant apple rootstock breeding and are propagated and utilized in arid areas.

Anthocyanins, a categories of metabolites derived from flavonoid biosynthesis pathway, are responsible for the red color of peach. Anthocyanin metabolism is modulated by a complicated regulatory network. In this study, our results demonstrated that PpNAC25 was a component of anthocyanin regulatory network in peach. PpNAC25 showed a closed relationship with the well-known ripening-related gene NOR (no-ripening) and was highly expressed in peach fruit. Overexpression of PpNAC25 in poplar resulted in a redder shoot tips compared with EV control. PpNAC25 overexpression upregulated the anthocyanin biosynthetic and transportation genes in transcript levels and then increased anthocyanin contents. In Y1H and Luc/Ren assay, PpNAC25 bound to the promoter of the anthocyanin-activator PpMYB10.1 and PpMYB10.2 and activated its transcript. Moreover, PpNAC25 formed a heterodimer with PpNAC1, an anthocyanin-regulator. Our researches provide evidence that PpNAC25 may be a positive regulator of anthocyanin biosynthesis in peach fruit.

The diversity and community assembly mechanisms of eukaryotic plankton in coastal waters is so far not clear. In this study, we selected the coastal waters of Guangdong-Hong Kong-Macao Greater Bay Area, which is a highly developed region in China, as the research area. By use of high-throughput sequencing technologies, the diversity and community assembly mechanisms of eukaryotic marine plankton were studied in which a total of 7,295 OTUs were obtained, and 2,307 species were annotated by doing environmental DNA survey of 17 sites consist of surface and bottom layer. Ultimately, the analysis reveals that the species abundance of bottom layer is, by and large, higher than that in the surface layer. In the bottom, Arthropoda is the first largest group, accounting for more than 20% while Arthropoda and Bacillariophyta are dominant groups in surface waters accounting for more than 40%. It is significant of the variance in alpha-diversity between sampling sites, and the difference of alpha-diversity between bottom sites is greater than that of surface sites. The result suggests that the environmental factors that have significant influence on alpha-diversity are total alkalinity and offshore distance for surface sites, and water depth and turbidity for bottom sites. Likewise, the plankton communities obey the typical distance-decay pattern. Analysis about community assembly mechanisms reveals that, overall, dispersal limitation is the major pattern of community formation, which accounts for more than 83% of the community formation processes, suggesting that stochastic processes are the crucial assembly mechanism of the eukaryotic plankton community in the study area.

ObjectivesThis study aims to evaluate the diagnostic value of real-time four-dimensional transesophageal echocardiography (RT4D-TEE) for implant-related thrombus (IRT).MethodsWe collected 1,125 patients with atrial fibrillation from May 2019 to February 2022 in our hospital. All patients accepted transesophageal echocardiography (TEE) examination to exclude any thrombi before the LAAC procedure.ResultsThere were 760 patients with LAAC, 66 patients with CIED, and 299 patients without any implantations. A total of 40 patients with an established diagnosis of IRT were further analyzed. The accurate detection rate of IRT by RT4D-TEE was 4.8% (40/826), which was higher than 3.8% (31/826) by 2D-TEE (P = 0.004). No IRT was found on TEE in the rest of the 786 patients. These 40 patients were divided into LAAC (n = 23) and CIED (n = 17) groups according to the results of RT4D-TEE. In the LAAC group, IRT distributed on different parts of the LAA occluder surface, 91.3% (21/23) with clumps of thrombi, and 8.7% (2/23) with a thin layer of thrombi covering the surface of the occluder. In the CIED group, thrombi were seen attached to the leads in the right atrium and right ventricle. The thrombi were beaded in 17.6% (3/17), corded in 17.6% (3/17), and clotted in the remaining 64.7% (11/17) of cases. After adjusting the anticoagulant dosage and following up for 6 months, 20% (8/40) of cases were successfully resolved, 67.5% (27/40) became smaller, and 12.5% (5/40) showed no changes.ConclusionThe accurate detection rate of IRT by RT4D-TEE was significantly higher than that by 2D-TEE. 2D-TEE has limitations, but RT4D-TEE can be used as an effective complementary method. Imaging and some clinical features differ significantly between IRT on occluder and IRT on CIED lead.

Anthropogenic activities have dramatically increased nitrogen (N) and phosphorous (P) enrichments in terrestrial ecosystems. However, it is still unclear on how bacterial and fungal communities would respond to the simultaneously increased N and P enrichment. In this study, we used a field experiment to simulate N and P input, and examined the effects of N and P additions on the abundance, alpha-diversity, and community composition of soil bacteria and fungi in a riparian forest. Six nutrient-addition treatments, including low N (30 kg N ha–1 year–1), high N (150 kg N ha –1 year–1), low P (30 kg P2O5 ha–1 year–1), high P (150 kg P2O5 ha –1 year–1), low N+P, high N+P, and a control (CK) treatment were set up. We found that the N and P additions significantly affected bacterial abundance, community composition, but not the alpha diversity. Specifically, 16S, nirK, and nirS gene copy numbers were significantly reduced after N and P additions, which were correlated with decreases in soil pH and NO-3-N, respectively; Co-additions of N and P showed significantly antagonistic interactions on bacterial gene copies; Nutrient additions significantly increased the relative abundance of Proteobacteria while reduced the relative abundance of Chloroflexi. Mantel’s test showed that the alteration in bacterial composition was associated with the changes in soil pH and NO-3-N. The nutrient additions did not show significant effects on fungal gene copy numbers, alpha diversity, and community composition, which could be due to non-significant alterations in soil C/N and total P concentration. In conclusion, our results suggest that soil bacteria are more sensitive than fungi in response to N and P enrichment; the alterations in soil pH and NO-3-N explain the effects of N and P enrichment on bacterial communities, respectively; and the co-addition of N and P reduces the negative effects of these two nutrients addition in alone. These findings improve our understanding of microbial response to N and P addition, especially in the context of simultaneous enrichment of anthropogenic nutrient inputs.

The world’s largest macroalgae bloom (also known as green tide) has been reported since the 29th Olympic Games in 2008, which is verified as the fast reproduction of floating green macroalgae (Ulva prolifera). It is helpful to assess the biomass of macroalgae for the government of marine environment protection. In this study, the synchronization cruise experiment was firstly introduced, which aimed to investigate the biomass evaluation of Ulva prolifera in the Yellow Sea of China. The Floating Algae Index by Polarimetric SAR image (FAIPS) was then proposed. Finally, the floating algae biomass evaluation model was demonstrated and verified, which showed an exponential relationship between FAIPS and wet biomass per area (kg/m2) of macroalgae. The model proposed in this paper can be used in the biomass assessment of floating algae in the presence of polarimetric SAR images, regardless of daylight and cloud coverage over the sea surface.

Abstract It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led to dysfunction of tumor-infiltrating CD8+ T immune cells due to increasing the production of adenosine. However, the role of tumor expressed-CD38 on neoplastic formation and progression remains elusive. In the present study, we aimed to delineate the molecular and biochemical function of the tumor-associated CD38 in lung adenocarcinoma progression. Our clinical data showed that the upregulation of tumor-originated CD38 was correlated with poor survival of lung cancer patients. Using multiple in vitro assays we found that the enzymatic activity of tumor expressed-CD38 facilitated lung cancer cell migration, proliferation, colony formation, and tumor development. Consistently, our in vivo results showed that inhibition of the enzymatic activity or antagonizing the enzymatic product of CD38 resulted in the similar inhibition of tumor proliferation and metastasis as CD38 gene knock-out or mutation. At biochemical level, we further identified that cADPR, the mainly hydrolytic product of CD38, was responsible for inducing the opening of TRPM2 iron channel leading to the influx of intracellular Ca2+ and then led to increasing levels of NRF2 while decreasing expression of KEAP1 in lung cancer cells. These findings suggested that malignant lung cancer cells were capable of using cADPR catalyzed by CD38 to facilitate tumor progression, and blocking the enzymatic activity of CD38 could be represented as an important strategy for preventing tumor progression.

Black-necked crane (Grus nigricollis, BNC), facing serious threats from human activities and habitat variations, is an endangered species classified as vulnerable under the revised IUCN Red List. In this article, we investigated and analyzed the population and nesting microhabitat of BNCs in the Longbao National Nature Reserve (NNR) from 1978 to 2016, and found the number of BNCs increased from 24 in 1978 to 216 in 2016. This establishment of the Longbao NNR represented the activities of protecting endangered animal species are effective. However, the land cover classification results of Landsat images showed that the marsh wetland, which was the BNC’s primary habitat, decreased during 1978–2016, while artificial buildings increased, which affected the habitat of BNCs. The increase in average temperature over the past 40 years has also had an impact on the number of BNCs. BNCs preferred to nest in marsh wetlands or on islands with open water or star-like distributions through observation. The results of the principal component analysis showed that the nearest distance between nests and habitat type were the primary factors influencing nesting site selection. To protect BNC, we suggest decreasing wetland fragmentation, reducing habitat degradation and providing an undisturbed habitat.

Soil salinization is a critical and global environmental problem. Effectively mapping and monitoring the spatial distribution of soil salinity is essential. The main aim of this work was to map soil salinity in Shandong Province located on the Yellow River Delta of China using Sentinel-1/2 remote sensing data and digital elevation model (DEM) data, coupled with soil sampling data, and combined with four regression models: support vector regression (SVR), stepwise multi-regression (SMR), partial least squares regression (PLSR) and random forest regression (RFR). For these purposes, 60 soil samples were collected during the field survey conducted from 9 to 14 October 2019, corresponding to the Sentinel-1/2 and DEM data. Then we established a soil salinity and feature dataset based on the sampled data and the features extracted from Sentinel-1/2 and DEM data. This study adopted the feature importance of the RF model to screen all features. The results showed that the CRSI index made the greatest contribution in retrieving soil salinity in this region. In this paper, 18 sampling points were used to validate and compare the performance of the four models. The results reveal that, compared with the other regression models, the PLSR model has the best performance (R2 = 0.66, and RMSE = 1.30). Finally, the PLSR method was used to predict the spatial distribution of soil salinity in the Yellow River Delta. We concluded that the model can be used effectively for the quantitative estimation of soil salinity and provides a useful tool for ecological construction.

Controlling the tree size of fruit species such as peach can reduce the amount of labor and input needed for orchard management. The phytohormone gibberellin (GA) positively regulates tree size by inducing degradation of the GA signaling repressor DELLA. The N-terminal DELLA domain in this protein is critical for its GA-dependent interaction with the GA receptor GID1 and the resulting degradation of the DELLA protein, which allows for growth-promoting GA signaling. In this study, a DELLA family member, PpeDGYLA, contains a DELLA domain but has amino acid changes in three conserved motifs (DELLA into DGYLA, LEQLE into LERLE, and TVHYNP into AVLYNP). In the absence or presence of GA3, the PpeDGYLA protein did not interact with PpeGID1c and was stable in 35S-PpeDGYLA peach transgenic callus. The overexpression of PpeDGYLA in both polar and Arabidopsis showed an extremely dwarfed phenotype, and these transgenic plants were insensitive to GA3 treatment. PpeDGYLA could interact with PpeARF6-1 and -2, supposed growth-promoting factors. It is suggested that the changes in the DELLA domain of PpeDGYLA may, to some extent, account for the severe dwarf phenotype of poplar and Arabidopsis transgenic plants. In addition, our study showed that the DELLA family contained three clades (DELLA-like, DELLA, and DGLLA). PpeDGYLA clustered into the DGLLA clade and was expressed in all of the analyzed tissues. These results lay the foundation for the further study of the repression of tree size by PpeDGYLA.

Lateral roots (LRs) are critical for absorbing water, minerals, and nutrients. Nitrate is a vital signaling molecule for regulating LR growth. However, understanding how nitrate interacts with endogenous hormones and genes to coordinate LR development is a bottleneck. In this study, B9 apple rootstock nursery plants were cultured hydroponically and treated with different nitrate treatments (Control; T1, 2.25 mM L−1; T2, 9 mM L−1; T3, 18 mM L−1; T4, 36 mM L−1; and T5, 72 mM L−1), where T5 outperformed the other treatments. Nursery plants were subsequently treated with control and T5 to explore the underlying physiological and molecular mechanisms by which nitrate promoted LR growth. Plant height, stem diameter, root morphological parameters, endogenous hormones, and gene expression levels were measured. Results showed that T5 promoted LR growth by increasing the endogenous contents of indole-3-acetic acid (IAA) and gibberellic acid (GA), and by decreasing the contents of abscisic acid (ABA), jasmonic acid (JA), and zeatin riboside (ZR) at most time points. Furthermore, the relative expression levels of nitrate transporter genes were upregulated in the control group, and nitrate assimilation genes were upregulated in T5 nursery plants at various time points. In addition, the transcript abundances of auxin-related genes were higher in T5 nursery plants, which increased auxin contents. MdSHR, MdGATA1, and MdSCR1 expressions were induced, hence increasing LR growth. In contrast, higher auxin content raised MdWOX11 expression, which enhanced the MdLBD16 and MdLBD29 expression levels, thus prompting the transcripts of cell cycle-related genes: MdCYCD1;1 and MdCYCP4;1. Overall, the changes in hormonal content and gene expression levels followed superior LR growth by T5.

There is heterogeneity in cancer patients’ responses to immune checkpoint inhibitors (ICIs), including hyperprogression, which is very rapid tumor progression following immunotherapy, and pseudoprogression, which is an initial increase followed by a decrease in tumor burden or in the number of tumor lesions. This heterogeneity complicates clinical decisions because either premature withdrawal of the treatment or prolonged ineffective treatment harms patients. We presented two patients treated with ICIs with heterogeneous responses. One patient had Merkel cell carcinoma in the right thigh, and the other had nasopharyngeal squamous carcinoma. The first patient was treated with sintilimab and the second with sintilimab combined with abraxane. In the first patient, subcutaneous lesions grew substantially after the first cycle of treatment with sintilimab. In the second patient, subcutaneous lesions grew gradually after the second cycle of treatment with sintilimab combined with abraxane. In both cases, biopsy examination confirmed that newly emerged lesions were metastases of the primary tumor. These two cases remind clinicians that when subcutaneous nodules appear after treatment with ICIs, pathological biopsy is needed to determine the nature—pseudoprogression or rapid progression—of the disease course.

Study region: Lop Nur, Xinjiang Province, China Study focus: Lop Nur has been a vast playa which was a historic lake in eastern Tarim Basin, northwest China. The lake's catchment played a significant role in the development of oasis states in the early Common Era, such as the ancient Loulan Kingdom. However, the history of lake dynamics remains unclear, and its potential linkage to the decline of Loulan Kingdom has been not well-examined. This paper aims to reconstruct the lake-level changes in Lop Nur over the last 2000 years using synthetic aperture radar (SAR) data, optically stimulated luminescence (OSL) dating of lacustrine and aeolian sediments, and radiocarbon (14C) dating of ancient bio-remains. Furthermore, the relationships between Lop Nur' fluctuation and the decline of ancient Loulan Kingdom were discussed New hydrological insights for the region: The results suggest that Lop Nur once covered an area more than 11, 602 km2 and that lake-level reduced gradually during 360–470 C.E. Subsequently, the lake experienced a few stages of lake-level fluctuation which never reached the upper-most shorelines. Also, the historical changes in the lake level were temporal coincided with the ancient Loulan Kingdom's collapse, showing that the dynamics of hydrological conditions in catchment may have a direct influence on the fall of human settlement in drylands.

The continuous emergence of SARS-coronavirus 2 (SARS-CoV-2) variants, especially the variants of concern (VOC), exacerbated the impact of the coronavirus disease 2019 (COVID-19) pandemic. As the key of viral entry into host cells, the spike (S) protein is the major target of therapeutic monoclonal antibodies (mAbs) and polyclonal antibodies elicited by infection or vaccination. However, the mutations of S protein in variants may change the infectivity and antigenicity of SARS-CoV-2, leading to the immune escape from those neutralizing antibodies. To characterize the mutations of S protein in newly emerging variants, the proteolytic property and binding affinity with receptor were assessed, and the vesicular stomatitis virus (VSV)-based pseudovirus system was used to assess the infectivity and immune escape. We found that some SARS-CoV-2 variants have changed significantly in viral infectivity; especially, B.1.617.2 is more likely to infect less susceptible cells than D614G, and the virus infection process can be completed in a shorter time. In addition, neutralizing mAbs and vaccinated sera partially or completely failed to inhibit host cell entry mediated by the S protein of certain SARS-CoV-2 variants. However, SARS-CoV-2 variant S protein-mediated viral infection can still be blocked by protease inhibitors and endocytosis inhibitors. This work provides a deeper understanding of the rise and evolution of SARS-CoV-2 variants and their immune evasion.

Rice is a staple food for nearly half the world's population. Therefore, rice yield estimation has far-reaching significance for food security. As the population continues to expand, rice is often in short supply. Timely and accurate data on rice production is crucial for governments and markets. Traditional rice yield estimation techniques cannot meet the current demand. With its ability to penetrate clouds and rain and the advantage of abundant remote sensing information, spaceborne synthetic aperture radar (S-SAR) can be used in the application of rice yield measurement. In this paper, the history and recent developments of rice yield measurement (1988-2018) based on spaceborne synthetic aperture radar are introduced, and the application prospect and technical development of rice yield monitoring are sought.

The backscattering coefficient σ0 of a rice field is closely related to the amplitude, power, and phase of its radar backscattered signals. An investigation of the statistics of indoor full-polarization scatterometric and synthetic aperture radar (SAR) measurements on rice fields in the Laboratory of Target Microwave Properties (LAMP) is implemented in terms of the amplitude, power, and phase difference of backscattered signals. The validity and accuracy of LAMP measured data are studied and confirmed for the first time. The Rayleigh fading model and phase difference statistical model are both validated by the experimental data. Continuous microwave spectrum is obtained after spatial and frequency averaging over N independent scatterometric samples and full-polarization images are generated by applying a focusing algorithm to the SAR data. Comparisons between scatterometric results and SAR images with three resolutions of rice field scene are conducted with respect to amplitude and co-pol phase difference (CPD) statistics, as well as backscattering coefficients. The results show that the measured statistics of a rice field scene are in good agreement with those calculated by theoretical formulas. Spatial and frequency averaging of scatterometric data can increase N and thus improve the estimation accuracy of the backscattering coefficients. SAR images show a shift to the near range due to the intrinsic height of the rice plants and the probable existence of the double bounce scattering between vertical rice stems and the water surface considering the measurement geometry. The measured amplitude statistics of the SAR images approach a Rayleigh distribution with reduction of the resolution cell size while the size has little effect on the CPD statistics. The differences between backscattering coefficients extracted from the scatterometric data and SAR images confirm a 1-dB calibration accuracy in power of the LAMP measurement system.

SARS-coronavirus 2 (SARS-CoV-2), pathogen of coronavirus disease 2019 (COVID-19), is constantly evolving to adapt to the host and evade antiviral immunity. The newly emerging variants N501Y.V1 (B.1.1.7) and N501Y.V2 (B.1.351), first reported in the United Kingdom and South Africa respectively, raised concerns due to the unusually rapid global spread. The mutations in spike (S) protein may contribute to the rapid spread of these variants. Here, with a vesicular stomatitis virus (VSV)-based pseudotype system, we demonstrated that the pseudovirus bearing N501Y.V2 S protein has higher infection efficiency than pseudovirus with wildtype (WT) and D614G S protein. Moreover, pseudovirus with N501Y.V1 or N501Y.V2 S protein has better thermal stability than WT and D614G, suggesting these mutations of variants may increase the stability of SARS-CoV-2 S protein and virion. However, the pseudovirus bearing N501Y.V1 or N501Y.V2 S protein has similar sensitivity to inhibitors of protease and endocytosis with WT and D614G. These findings could be of value in preventing the spread of virus and developing drugs for emerging SARS-CoV-2 variants.

Earthquakes cause a huge number of landslides and alter the regional landslide risk distribution. As a result, after a significant earthquake, the landslide susceptibility maps (LSMs) must be updated. The study goal was to create seismic landslide susceptibility maps containing landslide causative variables which are adaptable to great changes in susceptibility after the Jiuzhaigou earthquake (MS 7.0) and to perform a rapid update of the LSM after the earthquake by means of the distributed scatterer interferometric synthetic aperture radar (DS-InSAR) technique. We selected the territory of Jiuzhaigou County (southwestern China) as the study region. Jiuzhaigou is a world-renowned natural heritage and tourist area of great human and ecological value. For landslide susceptibility mapping, we examined the applicability of three models (logistic regression, support vector machine, and random forest) for landslide susceptibility mapping and offered a strategy for updating seismic landslide susceptibility maps using DS-InSAR. First, using logistic regression, support vector machine, and random forest techniques, susceptibility models of seismic landslides were built for Jiuzhaigou based on twelve contributing variables. Second, we obtained the best model parameters by means of a Bayesian network and network search, while using five-fold cross-validation to validate the optimized model. According to the receiver operating characteristic curve (ROC), the SVM model and RF model had excellent prediction capability and strong robustness over large areas compared with the LR models. Third, the surface deformation in Jiuzhaigou was calculated using DS-InSAR technology, and the deformation data were adopted to update the landslide susceptibility model using the correction matrix. The correction of deformation data resulted in a susceptibility class transition in 4.87 percent of the research region. According to practical examples, this method of correcting LSMs for the continuous monitoring of surface deformation (DS-InSAR) was effective. Finally, we analyze the reasons for the change in the revised LSM and point out the help of ecological restoration in reducing landslide susceptibility. The results show that the integration of InSAR continuous monitoring not only improved the performance of the LSM model but also adapted it to track the evolution of future landslide susceptibility, including seismic and human activities.

Apigenin, a natural compound in celery, is found to have pro-osteogenesis capacity by screening in our previous work. This study is focused on its pro-osteogenesis mechanism evaluation. The pro-osteogenesis effect of apigenin (50 mg/kg/day), was evaluated in skull defected (SD) mice by monitoring changes in bone histomorphometry index, formation of new osteoblasts from MSCs and changes in the synthesis of pro-osteogenic cytokines. Signal pathways were investigated by QPCR, Western blot and immunofluorescence. Apigenin has significant pro-osteogenesis effect in vivo, which can promote osteoblasts formation, the expression of osteoblasts-specific marker genes and osteoblasts marker protein in vitro. From the perspective of molecular biology, apigenin promotes osteoblasts formation and the activation of Wnt pathway as well as the induction and nuclei translocation of β-catenin. Driven by the results of this study, celery might be a useful alternative functional food in helping bone defects regeneration.

Synthetic aperture radar (SAR) is an effective and important technique in monitoring crop and other agricultural targets because its quality does not depend on weather conditions. SAR is sensitive to the geometrical structures and dielectric properties of the targets and has a certain penetration ability to some agricultural targets. The capabilities of SAR for agriculture applications can be organized into three main categories: crop identification and crop planting area statistics, crop and cropland parameter extraction, and crop yield estimation. According to the above concepts, this paper systematically analyses the recent progresses, existing problems and future directions in SAR agricultural remote sensing. In recent years, with the remarkable progresses in SAR remote sensing systems, the available SAR data sources have been greatly enriched. The accuracies of the crop classification and parameter extraction by SAR data have been improved progressively. But the development of modern agriculture has put forwarded higher requirements for SAR remote sensing. For instance, the spatial resolution and revisiting cycle of the SAR sensors, the accuracy of crop classification, the whole phenological period monitoring of crop growth status, the soil moisture inversion under the condition of high vegetation coverage, the integrations of SAR remote sensing retrieval information with hydrological models and/or crop growth models, and so on, still need to be improved. In the future, the joint use of optical and SAR remote sensing data, the application of multi-band multi-dimensional SAR, the precise and high efficient modeling of electromagnetic scattering and parameter extraction of crop and farmland composite scene, the development of light and small SAR systems like those onboard unmanned aerial vehicles and their applications will be active research areas in agriculture remote sensing. This paper concludes that SAR remote sensing has great potential and will play a more significant role in the various fields of agricultural remote sensing.

The estimation of phase noise of continuous-variable quantum key distribution protocol with a local local oscillator (LLO CVQKD), as a major process in quantifying the secret key rate, is closely relevant to the intensity of the phase reference. However, the transmission of the phase reference through the insecure quantum channel is prone to be exploited by the eavesdropper (Eve) to mount attacks. Here, we introduce a polarization attack scheme against the phase reference. Presently, in a practical LLO CVQKD system, only part of the phase reference pulses are measured to compensate for the polarization drift of the quantum signal pulses in a compensation cycle due to the limited polarization measurement rate, while the other part of the phase reference pulses are not measured. We show that Eve can control the phase noise by manipulating the polarization direction of the unmeasured phase reference to hide her attack on the quantum signal. Simulations show that Eve can obtain partial or total key rates information shared between Alice and Bob as the transmission distance increases. Improving the polarization measurement rate to 100% or monitoring the phase reference intensity in real-time is of great importance to protect the LLO CVQKD from polarization attack.

Background: Work-related stress among healthcare professionals poses a serious economic and healthcare burden. This study aimed to investigate the prevalence of burnout as well as anxiety, depression, and stress in medical residents from different majors, and assess the effects of an online psychological intervention on the mental health status of medical residents with a high degree of burnout.Methods: We conducted an online survey that collected information on the demographics, mental health, and burnout conditions of medical residents from Shengjing Hospital. The mental health condition was assessed by the Depression, Anxiety, and Stress Scale (DASS)−21. Further, burnout was assessed by the Maslach Burnout Inventory (MBI). Medical residents with a total MBI score between 50 and 75 were selected to receive online psychological intervention for 3 months.Results: Two-hundred and ten medical residents completed the questionnaire, of whom, 63 residents with an MBI score between 50 and 75 received the 3-month online psychological intervention. Anesthesia residents showed the highest level of depression, anxiety, and stress, and presented with a lower sense of personal accomplishment, higher emotional exhaustion, and higher depersonalization. Furthermore, pediatric residents had the second highest DASS and MBI scores following anesthesia residents. Following the online psychological intervention, negative emotional states and burnout levels were significantly lower among anesthesia and pediatric residents. There were no differences in the level of stress and sense of personal accomplishment pre- and post-online psychological intervention among the different majors.Conclusion: Our findings revealed high levels of burnout, as well as depression, anxiety, and stress symptoms in medical residents, with marked differences among different majors. The online psychological intervention effectively improved emotional exhaustion, and depersonalization, and relieved the psychological problems such as anxiety and depression in medical residents.

Adventitious root (AR) formation is required for the vegetative propagation of economically important horticultural crops, such as apples. Asexual propagation is commonly utilized for breeding programs because of its short life cycle, true-to-typeness, and high efficiency. The lack of AR formation from stem segments is a barrier to segment survival. Therefore, understanding the AR regulatory mechanisms is vital for the prolonged and effective use of biological resources. Several studies have been undertaken to comprehend the molecular and physiological control of AR, which has greatly extended our knowledge regarding AR formation in apples and other crops. Auxin, a master controller of AR formation, is widely used for inducing AR formation in stem cutting. At the same time, cytokinins (CKs) are important for cell division and molecular reprograming, and other hormones, sugars, and nutrients interact with auxin to control excision-induced AR formation. In this review, we discuss the present understandings of ARs’ formation from physiological and molecular aspects and highlight the immediate advancements made in identifying underlying mechanisms involved in the regulation of ARs. Despite the progress made in the previous decades, many concerns about excision-induced AR formation remain unanswered. These focus on the specific functions and interactions of numerous hormonal, molecular, and metabolic components and the overall framework of the entire shoot cutting in a demanding environment.

Time-series observations from Sentinel-1 A/B InSAR spanning November 2014 to July 2021 were used to study the late post-seismic deformation velocity field arising from the Kokoxili earthquake. The deformation velocity caused by the interseismic slip along the major active faults in Tibet was first simulated. Comparing the simulated deformation velocity with the observed one, the maximum ratio of the simulated deformation velocity to the observed one was found to be 42%, indicating continuity in the viscoelastic relaxation caused by the 2001 Kokoxili earthquake. Subsequently, the rheological structure of the Kokoxili region was explored using a mixed model comprising the viscoelastic relaxation mechanism and the buried elastic dislocation model. The best estimated viscosities for the lower crust and upper mantle were ηlc=1−0.44+0.78×1019 Pas and ηum=1+0+0.78×1020 Pas, respectively. The results obtained in this study were compared with those of previous studies that used the early post-seismic displacement ranging from 0 to 6.5 years following the earthquake. The obtained value was largely the same as the previously estimated steady-state viscosity, which means that the viscosities of the viscoelastic layer beneath the Kokoxili regions have almost reached their stable state. Furthermore, the effective lower crustal viscosity of the Kokoxili region exhibited a logarithmic trend with time.

Because transmitting polarization can be an arbitrary elliptical wave, and theoretically, there are numerous possibilities of hybrid dual-pol modes, therefore, it is necessary to explore the feature recognition and classification ability of compact polarimetric (CP) parameters under different transmitting and receiving modes to different ground objects. In this paper, we first simulated, extracted, and analyzed the scattering intensity of two types of rice of six temporal CP synthetic aperture radar (SAR) data under three transmitting modes. Then, during different phenology stages, the optimal parameters for distinguishing transplanting hybrid rice (T–H) and direct-sown japonica rice (D–J) were acquired. Finally, a decision tree classification model was established based on the optimal parameters to carry out the fine classification of the two types of rice and to verify the results. The results showed that this strategy can obtain a high classification accuracy for the two types of rice with an overall classification accuracy of more than 95% and a kappa coefficient of more than 0.94. In addition, and importantly, we found that the CP parameters in the 1103 period (harvest stage) were the best CP parameters to distinguish the two types of rice, followed by the 0730 (seedling–elongation stage), 0612 (seedling stage), and 0916 (heading–flowering stage) periods.

Adventitious root (AR) formation is a bottleneck for the mass propagation of apple rootstocks, and water stress severely restricts it. Different hormones and sugar signaling pathways in apple clones determine AR formation under water stress, but these are not entirely understood. To identify them, GL-3 stem cuttings were cultured on polyethylene glycol (PEG) treatment. The AR formation was dramatically decreased compared with the PEG-free control (CK) cuttings by increasing the endogenous contents of abscisic acid (ABA), zeatin riboside (ZR), and methyl jasmonate (JA-me) and reducing the indole-3-acetic acid (IAA) and gibberellic acid 3 (GA3) contents. We performed a transcriptomic analysis to identify the responses behind the phenotype. A total of 3204 differentially expressed genes (DEGs) were identified between CK and PEG, with 1702 upregulated and 1502 downregulated genes. Investigation revealed that approximately 312 DEGs were strongly enriched in hormone signaling, sugar metabolism, root development, and cell cycle-related pathways. Thus, they were selected for their possible involvement in adventitious rooting. However, the higher accumulation of ABA, ZR, and JA-me contents and the upregulation of their related genes, as well as the downregulation of sugar metabolism-related genes, lead to the inhibition of ARs. These results indicate that AR formation is a complicated biological process chiefly influenced by multiple hormonal signaling pathways and sugar metabolism. This is the first study to demonstrate how PEG inhibits AR formation in apple plants.

To verify the performance of the high-resolution fully polarimetric synthetic aperture radar (SAR) sensor carried by the Xinzhou 60 remote-sensing aircraft, we used corner reflectors to calibrate the acquired data. The target mechanism in high-resolution SAR images is more complex than it is in low-resolution SAR images, the impact of the point target pointing error on the calibration results is more obvious, and the target echo signal of high-resolution images is more easily affected by speckle noise; thus, more accurate extraction of the point target position and the response energy is required. To solve this problem, this paper introduces image context information and proposes a method to precisely determine the integration region of the corner reflector using sliding windows based on the integral method. The validation indicates that the fully polarimetric SAR sensor on the Xinzhou 60 remote-sensing aircraft can accurately reflect the radiometric characteristics of the ground features and that the integral method can obtain more stable results than the peak method. The sliding window allows the position of the point target to be determined more accurately, and the response energy extracted from the image via the integral method is closer to the theoretical value, which means that the high-resolution SAR system can achieve a higher radiometric calibration accuracy. Additionally, cross-validation reveals that the airborne SAR images have similar quality levels to Sentinel-1A and Gaofen-3 images.

This paper assesses the capability of Compact Polarized (CP) Synthetic Aperture Radar (SAR) to classify multi-sea-surface characteristics (defined as typical sea surface suspended sediments, such as oil spills algal look-alikes and algal blooms). CP reconstruction is carried out on two C-band RADARSAT-2 quad-polarized (QP) SAR images using Nord's algorithm. The accuracies of the reconstructed polarized signatures of the multi-sea-surface characteristics of open water, oil spills and algal blooms derived from QP original quad-polarized data (quad-pol) and CP reconstructed approximate quad-polarized data (namely pseudo quad-pol) are then compared and analyzed. In addition, 10 types of polarization parameters are chosen in order to investigate the accuracy of the reconstruction for open water, oil spills and algal blooms. A comparison of the results shows that, of the chosen parameters, the reconstruction accuracies for σ0HH, σ0VV, ρ, l1, l2 and α are the highest whereas the accuracies obtained for σ0HV, l3, H and A are unsatisfactory. The influence of reconstructed CP polarization parameters on the classification of multi-sea-surface characteristics is also assessed. Based on an assessment of this classification, it is concluded that the hybrid polarization (CTLR) mode should be adopted for the reconstruction of σ0HH, σ0VV, l1, H and α whereas the π/4 mode should be used for the reconstruction of σ0HV, ρ, l2 and l3.

We investigated the soil microbiologic characteristics, and the yield and sustainable production of winter wheat, by conducting a long-term fertilization experiment. A single application of N, P and K (NPK) fertilizer was taken as the control (CK) and three organic fertilization treatments were used: NPK fertilizer+pig manure (T1), NPK fertilizer+straw return (T2), NPK fertilizer+pig manure+straw return (T3). The results showed that all three organic fertilization treatments (T1, T2 and T3) significantly increased both soil total N (STN) and soil organic carbon (SOC) from 2008 onwards. In 2016, the SOC content and soil C/N ratios for T1, T2 and T3 were significantly higher than those for CK. The three organic fertilization treatments increased soil microbial activity. In 2016, the activity of urease (sucrase) and the soil respiration rate (SRS) for T1, T2 and T3 were significantly higher than those under CK. The organic fertilization treatments also increased the content of soil microbial biomass carbon (SMBC) and microbial biomass nitrogen (SMBN), the SMBC/SMBN ratio and the microbial quotient (qMB). The yield for T1, T2 and T3 was significantly higher than that of CK, respectively. Over the nine years of the investigation, the average yield increased by 9.9, 13.2 and 17.4% for T1, T2 and T3, respectively, compared to the initial yield for each treatment, whereas the average yield of CK over the same period was reduced by 6.5%. T1, T2, and T3 lowered the coefficient of variation (CV) of wheat yield and increased the sustainable yield index (SYI). Wheat grain yield was significantly positively correlated with each of the soil microbial properties (P

A microwave scattering model is a powerful tool for determining relationships between vegetation parameters and backscattering characteristics. The crown shape of the vegetation canopy is an important parameter in forestry and affects the microwave scattering modeling results. However, there are few numerical models or methods to describe the relationships between crown shapes and backscattering features. Using the Modified Tor Vergata Model (MTVM), a microwave scattering model based on the Matrix Doubling Algorithm (MDA), we quantitatively characterized the effects of crown shape on the microwave backscattering coefficients of the vegetation canopy. FEKO was also used as a computational electromagnetic method to make a complement and comparison with MTVM. In a preliminary experiment, the backscattering coefficients of two ideal vegetation canopies with four representative crown shapes (cylinder, cone, inverted cone and ellipsoid) were simulated: MTVM simulations were performed for the L (1.2 GHz), C (5.3 GHz) and X (9.6 GHz) bands in fully polarimetric mode, and FEKO simulations were carried out for the C (5.3 GHz) band at VV and VH polarization. The simulation results show that, for specific input parameters, the mean relative differences in backscattering coefficients due to variations in crown shape are as high as 127%, which demonstrates that the crown shape has a non-negligible influence on microwave backscattering coefficients of the vegetation canopy. In turn, this also suggests that investigation on effects of plant crown shape on microwave backscattering coefficients may have the potential to improve the accuracy of vegetation microwave scattering models, especially in canopies where volume scattering is the predominant mechanism.

Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases.

Urbanization has greatly changed the underlying surface roughness characteristics to a great extent and has great influence on the environment and climate. The Beijing-Tianjin-Hebei region is an important political and economic center in China and also one of the regions with the most rapid urbanization speed in the world. However, in recent years, haze contamination with extremely high Particulate Matter 2.5 concentration has occurred very frequently in this region. In this article, the extraction method for urban built-up area was proposed jointly using ALOS PALSAR data and nighttime light data, and then urbanization expansion in the study area from 2007 to 2011 was analyzed. At the same time, the wind velocity variation in the region was analyzed using observation data from meteorological stations. Using these two kinds of data, the effect of the roughness variation on wind velocity was investigated. The results showed that average wind velocities in the northern and western parts of the Beijing-Tianjin-Hebei region have been increasing, but the average wind velocity, the wind velocity in the prevailing wind direction, and the average north wind velocity in the southern cities, have all declined significantly except the seaside city, which is induced by the rapid expansion of built-up areas in this region.

Bread wheat is one of the most important crops in the world. However, osmotic stress significantly inhibits wheat growth and development, and reduces crop yield and quality. Plants respond to osmotic stress mainly through abscisic acid (ABA)-dependent and -independent pathways. In this study, root transcriptome profiles of wheat seedlings exposed to osmotic stress and exogenous ABA were analysed to identify osmotic-responsive genes belonging to the ABA-dependent or -independent pathways. We found that osmotic stress promoted proline biosynthesis in the ABA-dependent pathway, and trehalose biosynthesis is likely promoted among soluble sugars to maintain protein bioactivity under osmotic stress. In wheat roots subjected to osmotic stress, calcium ions, and glutathione exert their functions mainly through calcium-binding protein (CaM/CML) and glutathione-S-transferase, respectively, depending on both pathways. In addition, a complex relationship among phytohormones signal transduction was observed in response to osmotic stress. The findings of this study deepen our understanding of the molecular mechanisms of osmotic-stress resistance, and provide several candidate osmotic-responsive genes for further study.

The NAC genes, a large plant-specific family of transcription factors, regulate a wide range of pathways involved in development and response to biotic and abiotic stress. In this study, the NAC transcription factors were identified in 27 green plants, and the results showed that NAC transcription factors in plants undergo an appearance stage from water to land and a number expansion stage from gymnosperm to angiosperm. Investigating the evolutionary process of the NAC transcription factors from diploid species to hexaploid wheat revealed that tandem replications during the polyploidization process is an important event for increasing the number of NAC transcription factors in wheat. Then, the molecular characteristics, phylogenetic relationships, and expression patterns of 462 NAC transcription factors of hexaploid wheat (TaNACs) were analyzed. The protein structure results showed that TaNAC was relatively conservative at the N-terminal that contains five subdomains. All these TaNACs were divided into Group I and Group II by phylogenetic analysis, and the TaNACs in Group I should undergo strong artificial selection based on single nucleotide polymorphism (SNP) analysis. Through genome synteny and phylogenetic analysis, these TaNACs were classified into 88 groups and 9 clusters. The biased expression results of these TaNACs showed that there are 24 groups and 67 groups of neofunctionalization genes under biotic and abiotic stress, respectively, and 16 groups and 59 groups of subfunctionalization genes. This shows that neofunctionalization plays an important role in coping with different stresses. Our study provides new insights into the evolution of NAC transcription factors in hexaploid wheat.

Lodging, a commonly occurring rice crop disaster, seriously reduces rice quality and production. Monitoring rice lodging after a typhoon event is essential for evaluating yield loss and formulating suitable remedial policies. The availability of Sentinel-1 and Sentinel-2 open-access remote sensing data provides large-scale information with a short revisit time to be freely accessed. Data from these sources have been previously shown to identify lodged crops. In this study, therefore, Sentinel-1 and Sentinel-2 data after a typhoon event were combined to enable monitoring of lodging rice to be quickly undertaken. In this context, the sensitivity of synthetic aperture radar (SAR) features (SF) and spectral indices (SI) extracted from Sentinel-1 and Sentinel-2 to lodged rice were analyzed, and a model was constructed for selecting optimal sensitive parameters for lodging rice (OSPL). OSPL has high sensitivity to lodged rice and strong ability to distinguish lodged rice from healthy rice. After screening, Band 11 (SWIR-1) and Band 12 (SWIR-2) were identified as optimal spectral indices (OSI), and VV, VV + VH and Shannon Entropy were optimal SAR features (OSF). Three classification results of lodging rice were acquired using the Random Forest classification (RFC) method based on OSI, OSF and integrated OSI–OSF stack images, respectively. Results indicate that an overall level of accuracy of 91.29% was achieved with the combination of SAR and optical optimal parameters. The result was 2.91% and 6.05% better than solely using optical or SAR processes, respectively.

Reliable data congestion analytics in crowdsourced eHealth networks becomes particularly important, especially in big data era, because of wide adaption of ubiquitous crowdsourced healthcare participants. Since a crowdsourced eHealth network has intermittent connectivity to its remote healthcare provider, researchers usually use some well-studied networks to model the novel network, but data congestion analytics is still a big problem in most intermittent connecting networks. In most cases, data congestion analytics may be realized by fixing the number of forwarded copies, but sometimes, it cannot suit the changing network environments well. This problem could be solved by modifying packet forwarding conditions dynamically through detecting real-time network environment. Based on this idea, in this paper, an optimized routing algorithm named RSW (reduced variable neighborhood search-based spray and wait) is proposed. In the algorithm, nodes will exchange and store each other's buffer status during their communication, based on which, current network environments will be evaluated and quantified as a real-time threshold. Then, spray and wait adapts the threshold for data congestion control. Simulation shows that the proposed algorithm increases data packet delivery probability, and optimize the overhead ratio dramatically, which can be up to ten times lower than that of standard algorithm.

Five kinds of new homo-polymer and copolymers of methacrylate containing a fluorine ester group were synthesized and used for the binder of pressure-sensitive paint (PSP)to ensure the good compatibility between luminophore (Pt(II) meso-tetra (pentafluorophenyl) porphine (PtTFPP)) and polymer binder. In the work, we were concerned with how the structure of thesepolymers containing fluorine, especially the various ester group structure, affects the response frequency of PSP using oscillating sound wave technique. The results showed that the pressure sensitivities (Sp) of these PSP samples containing different polymers, exhibit some difference. The length of ester chain on the methacrylatepolymer affects the response frequency of PSP sensor layer composed of the polymer. The longer the chain length of the ester group, the higher the response frequency of the PSP sensor layer quenching by oxygen.

We use 2018–2020 Sentinel-1 InSAR time series data to study post-seismic deformation processes following the 2017 Mw 7.3 Kermanshah, Iraq earthquake. We remove displacements caused by two large aftershock sequences from the displacement field. We find that for a six month period the response is dominated by afterslip along the up-dip extension of the coseismic rupture zone, producing up to 6 cm of radar line-of-sight displacements. The moment magnitude of afterslip is Mw 5.9 or 12% of the mainshock moment. After that period, the displacement field is best explained by viscoelastic relaxation and a lower crustal viscosity of η l c = 1 − 0.4 + 0.8 × 10 19 Pas . The viscosity of the uppermost mantle is not constrained by the data, except that it is larger than 0.6 × 10 19 Pas . The relatively high lower crustal and uppermost mantle viscosities are consistent with a cold and dry lithosphere of the Zagros region.