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168 results on '"Yun, Sin Weon"'

14. Association between body mass index and fecal calprotectin levels in children and adolescents with irritable bowel syndrome

Author

Kim, Jun Hwan, primary, Yi, Dae Yong, additional, Lee, Yoo Min, additional, Choi, You Jin, additional, Kim, Ju Young, additional, Hong, Yong Hee, additional, Park, Ji Young, additional, Kim, Su Yeong, additional, Lee, Na Mi, additional, Yun, Sin Weon, additional, Chae, Soo Ahn, additional, Lim, In Seok, additional, Choi, Eung Sang, additional, and Jeong, In Sook, additional

Published
2022
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19. Reference levels of blood mercury and association with metabolic syndrome in Korean adults

Author

Eom, Sang-Yong, Choi, Sun-Hee, Ahn, Su-Ju, Kim, Dong-Kyeong, Kim, Dong-Won, Lim, Ji-Ae, Choi, Byung-Sun, Shin, Hye-Jung, Yun, Sin-Weon, Yoon, Hae-Jung, Kim, Yu-Mi, Hong, Young-Seoub, Yun, Yong-Woon, Sohn, Seok-Joon, Kim, Heon, Park, Kyung-Su, Pyo, Hee-Soo, Kim, Ho, Oh, Se-Young, Kim, Jeongseon, Lee, Sang-Ah, Ha, Mina, Kwon, Ho-Jang, and Park, Jung-Duck

Published
2014
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25. A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

Author

Kim, Jae-Jung, Hong, Young Mi, Sohn, Saejung, Jang, Gi Young, Ha, Kee-Soo, Yun, Sin Weon, Han, Myung Ki, Lee, Kyung-Yil, Song, Min Seob, Lee, Hyoung Doo, Kim, Dong Soo, Lee, Jong-Eun, Shin, Eun-Soon, Jang, Ji-Hyun, Lee, Yeon-Su, Kim, Sook-Young, Lee, Jong-Young, Han, Bok-Ghee, Wu, Jer-Yuarn, Kim, Kwi-Joo, Park, Young-Mi, Seo, Eul-Joo, Park, In-Sook, Lee, Jong-Keuk, and Korean Kawasaki Disease Genetics Consortium

Published
2011
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34. Neuro-Behcet's Syndrome with Miliary Tuberculosis Presenting with Features Mimicking Acute Tuberculous Meningitis

Author

Yi Dae Yong, Choi Eung Sang, Yun Sin Weon, Lim In Seok, Chae Soo Ahn, and Lee Na Mi

Subjects
Miliary tuberculosis, medicine.medical_specialty, S syndrome, Tuberculosis, business.industry, Neuro behcet, medicine.disease, Dermatology, Tuberculous meningitis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, business, 030217 neurology & neurosurgery
Published
2016

38. Assessment of the Clinical Heterogeneity of Kawasaki Disease Using Genetic Variants ofBLKandFCGR2A

Author

Sim, Bo Kyung, primary, Park, Hyein, additional, Kim, Jae-Jung, additional, Yun, Sin Weon, additional, Yu, Jeong Jin, additional, Yoon, Kyung Lim, additional, Lee, Kyung-Yil, additional, Kil, Hong-Ryang, additional, Kim, Gi Beom, additional, Han, Myung-Ki, additional, Song, Min Seob, additional, Lee, Hyoung Doo, additional, Ha, Kee Soo, additional, Sohn, Sejung, additional, Hong, Young Mi, additional, Jang, Gi Young, additional, and Lee, Jong-Keuk, additional

Published
2019
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40. Epidemiology of Demyelinating Diseases in Korean Pediatric Patients.

Author

Yoon, Hye Hyun, Park, Ji Young, Kim, Su Yeong, Lee, Na Mi, Yi, Dae Yong, Yun, Sin Weon, Lim, In Seok, and Chae, Soo Ahn

Subjects
DEMYELINATION, GUILLAIN-Barre syndrome, CHILD patients, EPIDEMIOLOGY, MULTIPLE sclerosis, NEUROMYELITIS optica
Abstract

The epidemiology of demyelinating diseases in the Korean pediatric population has not been reported to date. This study aimed to identify the epidemiology of demyelinating diseases in Korean children by using big data. The subjects were children (0-17 years old) diagnosed with acute-disseminated encephalomyelitis, multiple sclerosis, neuromyelitis optica, and Guillain-Barré syndrome enrolled in the Korean Health Insurance Review and Assessment Service (HIRA) from January 2010 to December 2017. Of 1722 enrolled children, 553 (32.1%) had acute-disseminated encephalomyelitis, 170 (9.9%) had multiple sclerosis, 68 (3.9%) had neuromyelitis optica, and 931 (54.1%) had Guillain-Barré syndrome. The male-female ratios were 1.47:1 in acute-disseminated encephalomyelitis, 1.43:1 in Guillain-Barré syndrome, 1:1.66 in multiple sclerosis, and 1:1.62 in neuromyelitis optica. Demyelinating diseases were most prevalent in summer. The prevalence differed by region, with 545 (31.6%) in Seoul and 298 (17.3%) in Gyeonggi. This study is the first to identify the incidence of demyelinating diseases in South Korea. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Association of an IGHV3-66gene variant with Kawasaki disease

Author

Johnson, Todd A., Mashimo, Yoichi, Wu, Jer-Yuarn, Yoon, Dankyu, Hata, Akira, Kubo, Michiaki, Takahashi, Atsushi, Tsunoda, Tatsuhiko, Ozaki, Kouichi, Tanaka, Toshihiro, Ito, Kaoru, Suzuki, Hiroyuki, Hamada, Hiromichi, Kobayashi, Tohru, Hara, Toshiro, Chen, Chien-Hsiun, Lee, Yi-Ching, Liu, Yi-Min, Chang, Li-Ching, Chang, Chun-Ping, Hong, Young-Mi, Jang, Gi-Young, Yun, Sin-Weon, Yu, Jeong-Jin, Lee, Kyung-Yil, Kim, Jae-Jung, Park, Taesung, Lee, Jong-Keuk, Chen, Yuan-Tsong, and Onouchi, Yoshihiro

Abstract

In a meta-analysis of three GWAS for susceptibility to Kawasaki disease (KD) conducted in Japan, Korea, and Taiwan and follow-up studies with a total of 11,265 subjects (3428 cases and 7837 controls), a significantly associated SNV in the immunoglobulin heavy variablegene (IGHV) cluster in 14q33.32 was identified (rs4774175; OR = 1.20, P= 6.0 × 10−9). Investigation of nonsynonymous SNVs of the IGHVcluster in 9335 Japanese subjects identified the C allele of rs6423677, located in IGHV3-66, as the most significant reproducible association (OR = 1.25, P= 6.8 × 10−10in 3603 cases and 5731 controls). We observed highly skewed allelic usage of IGHV3-66, wherein the rs6423677 A allele was nearly abolished in the transcripts in peripheral blood mononuclear cells of both KD patients and healthy adults. Association of the high-expression allele with KD strongly indicates some active roles of B-cells or endogenous immunoglobulins in the disease pathogenesis. Considering that significant association of SNVs in the IGHVregion with disease susceptibility was previously known only for rheumatic heart disease (RHD), a complication of acute rheumatic fever (ARF), these observations suggest that common B-cell related mechanisms may mediate the symptomology of KD and ARF as well as RHD.

Published
2021
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47. Association of the IL16Asn1147Lys polymorphism with intravenous immunoglobulin resistance in Kawasaki disease

Author

Kim, Hea-Ji, Kim, Jae-Jung, Yun, Sin Weon, Yu, Jeong Jin, Yoon, Kyung Lim, Lee, Kyung-Yil, Kil, Hong-Ryang, Kim, Gi Beom, Han, Myung-Ki, Song, Min Seob, Lee, Hyoung Doo, Ha, Kee Soo, Hong, Young Mi, Jang, Gi Young, and Lee, Jong-Keuk

Abstract

Kawasaki disease (KD) is an acute, self-limited vasculitis, mainly affecting children younger than 5 years old, with accompanying fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) is the standard treatment for KD; however, ~15% of patients are resistant to IVIG treatment. To identify protein coding genetic variants influencing IVIG resistance, we re-analyzed our previous genome-wide association study (GWAS) data from 296 patients with KD, including 101 IVIG non-responders and 195 IVIG responders. Five nonsynonymous SNPs (nsSNPs) in five immune-related genes, including a previously reported SAMD9LnsSNP (rs10488532; p.Val266Ile), were associated with IVIG non-response (odds ratio [OR] = 1.89–3.46, P= 0.0109–0.0035). In a replication study of the four newly-identified nsSNPs, only one in the interleukin 16 (IL16) gene (rs11556218, p.Asn1147Lys) showed a trend of association with IVIG non-response (OR = 1.54, P= 0.0078). The same IL16nsSNP was more significantly associated with IVIG non-response in combined analysis of all data (OR = 1.64, P= 1.25 × 10−4). Furthermore, risk allele combination of the IL16CT and SAMD9LTT nsSNP genotypes exhibited a very strong effect size (OR = 9.19, P= 3.63 × 10−4). These results implicate IL16 as involved in the mechanism of IVIG resistance in KD.

Published
2020
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48. Identification of SAMD9Las a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis

Author

Kim, Jae-Jung, Yun, Sin Weon, Yu, Jeong Jin, Yoon, Kyung Lim, Lee, Kyung-Yil, Kil, Hong-Ryang, Kim, Gi Beom, Han, Myung-Ki, Song, Min Seob, Lee, Hyoung Doo, Ha, Kee Soo, Sohn, Sejung, Ebata, Ryota, Hamada, Hiromichi, Suzuki, Hiroyuki, Ito, Kaoru, Onouchi, Yoshihiro, Hong, Young Mi, Jang, Gi Young, and Lee, Jong-Keuk

Abstract

Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10–20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P=1.39 × 10−5). The same SNP in the SAMD9Llocus was tested in the Japanese population, and it revealed a more significant association in a meta-analysis with Japanese data (OR = 4.30, P=5.30 × 10−6). These results provide new insights into the mechanism of IVIG response in KD.

Published
2020
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