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27 results on '"Yulia, Angela"'

1. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial

Author

Ahuja, Ashwin, Alexander, Hazel, Arya, Rita, Bahl, Rachna, Bapir, Mihraban, Barry, Natalie, Basak, Sambita, Bishop, Linda, Biswas, Chandrima, Campbell, Deniesha, Chados, Nikolaos, Davies, Sarah, Davison, Jessica, Dudgeon, Lucy, Ferry, Orla, Ficquet, Jo, Girling, Jo, Gowans, Sharon, Hewitt, Lesley, Hinshaw, Kim, Holt, Siobhan, Jack, Elaine, Jennings, Jacqui, Maher, Martin, McBean, Mel, McDonnell, Sian, Mehta, Anku, Morris, Katie, O'Brien, Clare, Obiozo, Chinwe, Peers, Beth, Pickering, Francis, Regan, Maeve, Rich, Mel, Roughley, Lindsay, Ryan, Grace, Sharp, Andrew, Smart, Brittany, Smith, Annabel, Stirrat, Laura, Thompson, Hilary, Trepte, Lauren, Verghese, Lynda, Willson, Seren, Yulia, Angela, Hurrell, Alice, Webster, Louise, Sparkes, Jenie, Battersby, Cheryl, Brockbank, Anna, Clark, Katherine, Duhig, Kate E, Gill, Carolyn, Green, Marcus, Hunter, Rachael M, Seed, Paul T, Vowles, Zoe, Myers, Jenny, Shennan, Andrew H, and Chappell, Lucy C

Published
2024
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2. Malpresentation

Author

Yulia, Angela, Maksym, Kasia, Lack, Nicola, Fernando, Roshan, editor, Sultan, Pervez, editor, and Phillips, Sioned, editor

Published
2022
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3. Induction of Labour

Author

Yulia, Angela, Mayers, Kate, Maksym, Kasia, Lack, Nicola, Fernando, Roshan, editor, Sultan, Pervez, editor, and Phillips, Sioned, editor

Published
2022
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4. Molecular mechanisms of the interactions involving cyclic AMP in the myometrium during pregnancy

Author

Yulia, Angela, Johnson, Mark R., and Terzidou, Vasso

Subjects
618.3
Abstract

Preterm labour is the most important cause of perinatal mortality. Our ability to prevent preterm labour has been hindered by poor understanding of the factors that initiate human parturition. cAMP is a second messenger which plays significant role in respiratory, cardiovascular, and reproductive systems. The role of cAMP-signalling pathway in the maintenance of pregnancy has been investigated. My results suggest that during pregnancy, high cAMP levels repress OTR via PKA-dependent pathway and this repression may contribute to myometrial quiescence. My results also suggest that as pregnancy advances, the activity of cAMP/PKA pathway declines and, in contrast, the levels of Epac1, rise. This pattern may be associated with an increase in OTR expression, which may contribute to uterine contractions. The ability of cAMP to repress inflammation in human myometrial cells was explored. My results show that cAMP repress the expression of inflammation related genes and pro-inflammatory cytokines. These results suggest that high cAMP/PKA tone in pregnancy may exert an anti-inflammatory effect and a reduction of cAMP/PKA tone may contribute to the pro-inflammatory effects of labour. AKIP1 has been identified to act as a molecular switch, determining cAMP/PKA action towards NFκB activity in various cell types. To date, no study was done to investigate the role played by AKIP1 in myometrial cells. My results suggest that in myometrial cells, low AKIP1 levels, helps to promote the anti-inflammatory effects of cAMP/PKA. The ability of cAMP in enhancing myometrial response to progesterone was tested. The results suggest that cAMP enhanced progesterone responsive genes via PKA. Furthermore, the ability of progesterone to repress IL-1β-induced inflammation may be enhanced by cAMP. Knockdown studies using siRNA, suggest that cAMP acts via PKA to enhance the anti-inflammatory action of progesterone. Overall, these data support a novel role for cAMP which may help in the prevention of preterm labour.

Published
2016
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5. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial

Author

Hurrell, Alice, primary, Webster, Louise, additional, Sparkes, Jenie, additional, Battersby, Cheryl, additional, Brockbank, Anna, additional, Clark, Katherine, additional, Duhig, Kate E, additional, Gill, Carolyn, additional, Green, Marcus, additional, Hunter, Rachael M, additional, Seed, Paul T, additional, Vowles, Zoe, additional, Myers, Jenny, additional, Shennan, Andrew H, additional, Chappell, Lucy C, additional, Ahuja, Ashwin, additional, Alexander, Hazel, additional, Arya, Rita, additional, Bahl, Rachna, additional, Bapir, Mihraban, additional, Barry, Natalie, additional, Basak, Sambita, additional, Bishop, Linda, additional, Biswas, Chandrima, additional, Campbell, Deniesha, additional, Chados, Nikolaos, additional, Davies, Sarah, additional, Davison, Jessica, additional, Dudgeon, Lucy, additional, Ferry, Orla, additional, Ficquet, Jo, additional, Girling, Jo, additional, Gowans, Sharon, additional, Hewitt, Lesley, additional, Hinshaw, Kim, additional, Holt, Siobhan, additional, Jack, Elaine, additional, Jennings, Jacqui, additional, Maher, Martin, additional, McBean, Mel, additional, McDonnell, Sian, additional, Mehta, Anku, additional, Morris, Katie, additional, O'Brien, Clare, additional, Obiozo, Chinwe, additional, Peers, Beth, additional, Pickering, Francis, additional, Regan, Maeve, additional, Rich, Mel, additional, Roughley, Lindsay, additional, Ryan, Grace, additional, Sharp, Andrew, additional, Smart, Brittany, additional, Smith, Annabel, additional, Stirrat, Laura, additional, Thompson, Hilary, additional, Trepte, Lauren, additional, Verghese, Lynda, additional, Willson, Seren, additional, and Yulia, Angela, additional

Published
2024
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6. Fetal Lung Lesions

Author

Cook, James, primary, Yulia, Angela, additional, Wallis, Colin, additional, and Pandya, Pranav P., additional

Published
2020
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7. List of Contributors

Author

Acharya, Ganesh, primary, Aertsen, Michael, additional, Afshar, Yalda, additional, Ananth, Cande V., additional, Ashworth, Michael, additional, Au, Patrick, additional, Bakalis, Spyros, additional, Benoist, Guillaume, additional, Bilancia, Colleen G., additional, Bilardo, Caterina M., additional, Bryant, Louise D., additional, Butler, Colin R., additional, Van Calenbergh, Frank, additional, Caritis, Steve N., additional, Chitty, Lyn S., additional, Collins, Patricia, additional, Cook, James, additional, Cuckle, Howard, additional, David, Anna L., additional, De Catte, Luc, additional, De Coppi, Paolo, additional, de Jong-Pleij, Elisabeth, additional, De Keersmaecker, Bart, additional, Deprest, Jan, additional, Devlieger, Roland, additional, de Wert, Guido M., additional, Dickinson, Jan E., additional, Dilworth, Mark, additional, Dondorp, Wybo J., additional, Dunk, Caroline E., additional, Everett, Thomas R., additional, Fisher, Jane, additional, Galan, Henry L., additional, Ganapathi, Mythily, additional, Gardiner, Helena M., additional, Gotherstrom, Cecilia, additional, Harding, Richard, additional, Hewison, Jenny, additional, Hewitt, Richard J., additional, Hiersch, Liran, additional, Hill, Melissa, additional, Hillman, Sara L., additional, Hindryckx, An, additional, Hooper, Stuart B., additional, Huppertz, Berthold, additional, Hutchinson, J. Ciaran, additional, Hyett, Jon, additional, Joyeux, Luc, additional, Jurkovic, Davor, additional, Kingdom, John C., additional, Langlois, Sylvie, additional, Lemon, Lara S., additional, Leruez-Ville, Marianne, additional, Lewi, Liesbeth, additional, Levy, Brynn, additional, Loke, Y.W., additional, Lopriore, Enrico, additional, Macones, George A., additional, Malone, Fergal D., additional, Martirosian, Anahit, additional, McAuliffe, Fionnuala, additional, McDougall, Annie R.A., additional, Moise, Kenneth J., additional, Moffett, Ashley, additional, Müllers, Sieglinde M., additional, Neiger, Ran, additional, Newnham, John P., additional, Obican, Sarah G., additional, Odibo, Anthony O., additional, Oepkes, Dick, additional, Pandya, Pranav P., additional, Platt, Lawrence D., additional, Pratt, Rosalind, additional, Rajah, Kuhan, additional, Rao, Rashmi, additional, Richter, Jute, additional, Rosenbloom, Joshua I., additional, Russo, Francesca Maria, additional, Scialli, Anthony R., additional, Sebire, Neil J., additional, Sharkey, Andrew, additional, Shelmerdine, Susan C., additional, Sibley, Colin, additional, Snowise, Saul, additional, Steggerda, Sylke, additional, Su, Emily J., additional, Tang, Mary, additional, Te Pas, Arjan B., additional, Tita, Alan T., additional, Ushakov, Fred, additional, Van den Veyver, Ignatia B., additional, van Klink, Jeanine M., additional, Venkataramanan, Raman, additional, Ville, Yves, additional, Walkiewicz, Magdalena, additional, Wallis, Colin, additional, Walther-Jallow, Lilian, additional, Wapner, Ronald J., additional, Westgren, Magnus, additional, White, Scott W., additional, Wilson, Louise C., additional, Wilson, R. Douglas, additional, Winkelhorst, Dian, additional, Winyard, Paul J.D., additional, Wohlmuth, Christoph, additional, Wou, Karen, additional, Yaron, Yuval, additional, Leung, Kwok Yin, additional, and Yulia, Angela, additional

Published
2020
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9. Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: A multicentre retrospective cohort study

Author

Cauldwell, Matthew, primary, Bredaki, Emma, additional, Dassan, Pooja, additional, Dhanjal, Mandish K., additional, Kaler, Mandeep, additional, Madipola, Nissanka, additional, Mahmud, Mohammad, additional, Paviour, Dominic, additional, Senvar, Naz, additional, de Silva, Rajith, additional, Watt‐Coote, Ingrid, additional, Williams, David, additional, Yulia, Angela, additional, and Steer, Philip J., additional

Published
2021
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12. Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: A multicentre retrospective cohort study.

Author

Cauldwell, Matthew, Bredaki, Emma, Dassan, Pooja, Dhanjal, Mandish K., Kaler, Mandeep, Madipola, Nissanka, Mahmud, Mohammad, Paviour, Dominic, Senvar, Naz, de Silva, Rajith, Watt‐Coote, Ingrid, Williams, David, Yulia, Angela, and Steer, Philip J.

Abstract

Objective: To determine maternal, obstetric and neonatal outcomes in a cohort of women with cerebrovascular malformations (CVMs) that include arterial venous malformations (AVMs) and cavernomas. Design: Retrospective cohort study. Setting: Six specialist centres managing pregnant women with neurological disorders. Population: Sixty‐three women with CVMs in 83 pregnancies of ≥20 completed weeks' gestation. Methods: Retrospective case notes review. Main outcome measures: Neurological outcomes including rates of acute cerebral bleeding in pregnancy and reported seizures during pregnancy. Maternal outcomes included number of women with a livebirth and the proportion of women being delivered by caesarean section. Results: Most women had a good pregnancy outcome with high rates of vaginal delivery (73%) at term. There were no maternal deaths. Six women had an acute cerebral bleed, all of whom were delivered by planned caesarean section. In total, ten women had seizures in pregnancy (of whom four also had a bleed). Six (7%) babies were admitted to a neonatal unit. There was no significant difference in outcomes between women with AVMs and those with cavernomas. Conclusion: In the majority of cases, pregnancy outcomes were favourable, with most women having a vaginal delivery. All cases of cerebral bleeds that occurred were at a remove from the peripartum period. Women with cerebrovascular malformations have high rates of vaginal delivery. Women with cerebrovascular malformations have high rates of vaginal delivery. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: A multicentre retrospective cohort study.

Author

Cauldwell M, Bredaki E, Dassan P, Dhanjal MK, Kaler M, Madipola N, Mahmud M, Paviour D, Senvar N, de Silva R, Watt-Coote I, Williams D, Yulia A, and Steer PJ

Subjects
Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome epidemiology, Retrospective Studies, Seizures etiology, Cesarean Section, Delivery, Obstetric
Abstract

Objective: To determine maternal, obstetric and neonatal outcomes in a cohort of women with cerebrovascular malformations (CVMs) that include arterial venous malformations (AVMs) and cavernomas., Design: Retrospective cohort study., Setting: Six specialist centres managing pregnant women with neurological disorders., Population: Sixty-three women with CVMs in 83 pregnancies of ≥20 completed weeks' gestation., Methods: Retrospective case notes review., Main Outcome Measures: Neurological outcomes including rates of acute cerebral bleeding in pregnancy and reported seizures during pregnancy. Maternal outcomes included number of women with a livebirth and the proportion of women being delivered by caesarean section., Results: Most women had a good pregnancy outcome with high rates of vaginal delivery (73%) at term. There were no maternal deaths. Six women had an acute cerebral bleed, all of whom were delivered by planned caesarean section. In total, ten women had seizures in pregnancy (of whom four also had a bleed). Six (7%) babies were admitted to a neonatal unit. There was no significant difference in outcomes between women with AVMs and those with cavernomas., Conclusion: In the majority of cases, pregnancy outcomes were favourable, with most women having a vaginal delivery. All cases of cerebral bleeds that occurred were at a remove from the peripartum period., Tweetable Abstract: Women with cerebrovascular malformations have high rates of vaginal delivery., (© 2021 John Wiley & Sons Ltd.)

Published
2022
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