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Microwave-assisted magnetic Pb(II)-imprinted-poly(schiff base-co-Methacrylic acid) (MA/Fe3O4@Pb(II)-IIP) was prepared by inverse emulsion-suspension polymerization using lead ion as template ion, m...

OBJECTIVE: To demonstrate the ability of achieving low dose and high-quality head CT images for children with acute head trauma using 100 kVp and adaptive statistical iterative reconstruction (ASIR-V) algorithm in single rotation on a 16 cm wide-detector system. MATERIALS AND METHODS: We retrospectively analyzed the CT dose index (CTDI) and image quality of 104 children aged 0–6 years with acute head trauma (1 hour –3 days) in two groups: Group 1(n = 50) on a 256-row CT with single rotation at a reduced-dose of 100 kVp/240 mA and reconstructed using ASIR-V at 70%level; Group 2(n = 54) on a 64-row CT with multiple rotations at a standard dose of 120 kVp/ 180mA and reconstructed using a conventional filtered back-projection (FBP). Both groups used the 0.5 s/r axial scan mode. CT dose index (CTDI) and quantitative image quality measurements were compared using the Student t test; qualitative image quality comparison was carried out using Mann-Whitney rank test and the inter-reviewer agreement was evaluated using Kappa test. RESULTS: The exposure time was 0.5 s for Group 1 and 3.27±0.29 s for Group 2. The CTDI in Group 1 was 9.74±0.86mGy, 36.38%lower than the 15.31mGy in Group 2 (p < 0.001). Group 1 and Group 2 had similar artifact index (2.06±1.06 vs. 2.37±1.18) in the cerebellar hemispheres, and similar contrast-to-noise ratio (2.32±0.83 vs. 1.69±0.68), (1.47±0.72 vs. 1.10±0.43) respectively for cerebellum and thalamus (p > 0.05). Image quality was acceptable for diagnosis, and motion artifacts were reduced in Group 1 (p < 0.001). CONCLUSION: Single rotation CT with 100 kVp and 70%ASIR-V on 16 cm wide-detector CT reduces radiation dose and motion artifacts for children with acute head trauma without compromising diagnostic quality as compared with standard dose protocol. Thus, it provides a novel imaging method in management of pediatric acute head trauma.

Copper is an important strategic resource for the national economy and social security of China. Water use is a significant component of copper production. However, water shortages and water pollution are two global crises in water resource management. In this study, a copper production industry in China was studied from the perspective of water footprint (WF) and ecological industry (eco-industry). A WF inventory was built by accounting for the entire production and supply chain process, including mining, ore dressing, transportation, smelting, and electrolysis. An index system comprising target, criterion, and variable layers was established to evaluate the sustainable utilization of water resources. It was observed that the studied industry showed a good sustainability for water resource utilization. Only 65.67 tons of freshwater per ton of product was inputted in the entire process due to virtual water (VW) and the use of reclaimed water. However, the WF of each ton of cathode copper product was 162.58 t, and the imported VW of the eco-industry accounted for 92.45%. Increasing the VW import and reducing the VW export can alleviate water shortages. A detailed WF analysis showed that the effects of evaporation and different types of losses on the blue WF (BWF) were significant and should be considered. Upstream water consumption of electricity and other energy sources were also observed to be an important part of the BWF. Regardless of whether freshwater or recycled water was used, the WF can be reduced only by effectively reducing water consumption.

Background RING finger protein 135 (RNF135) has an important role in the occurrence of many cancers, however, the regulation and function of RNF135 in hepatocellular carcinoma (HCC) remains unknown. Methods The promoter methylation status and mRNA expression of RNF135 were evaluated by methylation-specific PCR and real-time PCR in HCC cell lines and tissues, and further analyzed from The Cancer Genome Atlas database. Transwell migration, wound healing assay, cell viability, and colony formation assay were performed to investigate the function of RNF135. GSEA analysis, TIMER database and ESTIMATE algorithm were used to decipher the associated pathway and immune infiltration. The survival analysis was applied to assess the prognostic value of RNF135. Results RNF135 expression was downregulated in 5 of 8 HCC cell lines and HCC tissues, and was negatively correlated with its promoter hypermethylation. Demethylating regent decitabine restored RNF135 expression on the cellular level. Knockdown of RNF135 expression enhanced the migration of HCC cells, while RNF135 overexpression repressed cell migration. Bioinformatics analysis revealed a positive relationship between RNF135 expression and six immune cell infiltrates (B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells). Survival analysis disclosed that RNF135 hypermethylation is independently associated with poor clinical outcomes in HCC. Conclusions Decreased RNF135 expression driven by promoter hypermethylation is frequently occurred in HCC and associated with prognosis of HCC. RNF135 functions as a tumor suppressor and involves in tumor immune microenvironment in HCC.

Acoustic black hole (ABH) effects can be obtained via proper structural tailoring to induce a gradual reduction of the flexural wave velocity, thus creating high energy density structural areas. The wave energy focalization effect shows promising features for establishing novel vibration energy harvester configurations in terms of the high energy level and broadband characteristics. In this study, an energy harvesting structure with ABH features which ensures the structural strength as well as enhances the harvesting performance is proposed and investigated. Considering the wavelength compression in ABHs, piezoelectric patches bonded on the surfaces of ABHs are sliced into micro arrays to convert the mechanical energy effectively, which make sure that the positive and negative electric charge generated on the surfaces of harvesters won’t be neutralized. Each of the transducers is shunted with a resistor impedance. Fully coupled numerical models which consist of vibrational structures and electrical circuits are built to assess the energy harvesting performance of ABH-feature beam and uniform beam under both steady state and transient excitations. Experiments are also conducted to verify the significant performance enhancement in the ABH beam as compared that in the uniform beam. It is shown that the ABH structural tailoring can be used for broadband vibration energy harvesting and boost the harvested power by more than one order of magnitude.

The growing interest in deep learning approaches to video surveillance raises concerns about the accuracy and efficiency of neural networks. However, fast and reliable detection of abnormal events is still a challenging work. Here, we introduce a two-stream approach that offers an autoencoder-based structure for fast and efficient detection to facilitate anomaly detection from surveillance video without labeled abnormal events. Furthermore, we present post hoc interpretability of feature map visualization to show the process of feature learning, revealing uncertain and ambiguous decision boundaries in the video sequence. Experimental results on Avenue, UCSD Ped2, and Subway datasets show that our method can detect abnormal events well and explain the internal logic of the model at the object level.

Background: As global healthcare system is overwhelmed by novel coronavirus disease (COVID-19), early identification of risks of adverse outcomes becomes the key to optimize management and improve survival. This study aimed to provide a CT-based pattern categorization to predict outcome of COVID-19 pneumonia.Methods: One hundred and sixty-five patients with COVID-19 (91 men, 4–89 years) underwent chest CT were retrospectively enrolled. CT findings were categorized as Pattern 0 (negative), Pattern 1 (bronchopneumonia pattern), Pattern 2 (organizing pneumonia pattern), Pattern 3 (progressive organizing pneumonia pattern), and Pattern 4 (diffuse alveolar damage pattern). Clinical findings were compared across different categories. Time-dependent progression of CT patterns and correlations with clinical outcomes, i.e.„ discharge or adverse outcome (admission to ICU, requiring mechanical ventilation, or death), with pulmonary sequelae (complete absorption or residuals) on CT after discharge were analyzed.Results: Of 94 patients with outcome, 81 (86.2%) were discharged, 3 (3.2%) were admitted to ICU, 4 (4.3%) required mechanical ventilation, 6 (6.4%) died. 31 (38.3%) had complete absorption at median day 37 after symptom onset. Significant differences between pattern-categories were found in age, disease severity, comorbidity and laboratory results (all P < 0.05). Remarkable evolution was observed in Pattern 0–2 and Pattern 3–4 within 3 and 2 weeks after symptom-onset, respectively; most of patterns remained thereafter. After controlling for age, CT pattern significantly correlated with adverse outcomes [Pattern 4 vs. Pattern 0–3 [reference]; hazard-ratio [95% CI], 18.90 [1.91–186.60], P = 0.012]. CT pattern [Pattern 3–4 vs. Pattern 0–2 [reference]; 0.26 [0.08–0.88], P = 0.030] and C-reactive protein [>10 vs. ≤ 10 mg/L [reference]; 0.31 [0.13–0.72], P = 0.006] were risk factors associated with pulmonary residuals.Conclusion: CT pattern categorization allied with clinical characteristics within 2 weeks after symptom onset would facilitate early prognostic stratification in COVID-19 pneumonia.

ObjectiveAs a pandemic, a most-common pattern resembled organizing pneumonia (OP) has been identified by CT findings in novel coronavirus disease (COVID-19). We aimed to delineate the evolution of CT findings and outcome in OP of COVID-19.Materials and Methods106 COVID-19 patients with OP based on CT findings were retrospectively included and categorized into non-severe (mild/common) and severe (severe/critical) groups. CT features including lobar distribution, presence of ground glass opacities (GGO), consolidation, linear opacities and total severity CT score were evaluated at three time intervals from symptom-onset to CT scan (day 0-7, day 8-14, day>14). Discharge or adverse outcome (admission to ICU or death), and pulmonary sequelae (complete absorption or lesion residuals) on CT after discharge were analyzed based on the CT features at different time interval.Results79(74.5%) patients were non-severe and 103(97.2%) were discharged at median day 25 (range, day 8-50) after symptom-onset. Of 67 patients with revisit CT at 2-4 weeks after discharge, 20(29.9%) had complete absorption of lesions at median day 38 (range, day 30-53) after symptom-onset. Significant differences between complete absorption and residuals groups were found in percentages of consolidation (1.5% vs. 13.8%, P=0.010), number of involved lobe >3 (40.0% vs. 72.5%, P=0.030), CT score >4 (20.0% vs. 65.0%, P=0.010) at day 8-14.ConclusionsMost OP cases had good prognosis. Approximately one-third of cases had complete absorption of lesions during 1-2 months after symptom-onset while those with increased frequency of consolidation, number of involved lobe>3, and CT score >4 at week 2 after symptom-onset may indicate lesion residuals on CT.

To delineate the evolution of CT findings in patients with mild COVID-19 pneumonia. CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia, a baseline CT, and at least one follow-up CT were retrospectively reviewed. CT features including lobar distribution and presence of ground glass opacities (GGO), consolidation, and linear opacities were analyzed on per-patient basis during each of five time intervals spanning the 3 weeks after disease onset. Total severity scores were calculated. Of patients, 85.2% had travel history to Wuhan or known contact with infected individuals. The most common symptoms were fever (84.1%) and cough (56.8%). The baseline CT was obtained on average 5 days from symptom onset. Four patients (4.5%) had negative initial CT. Significant differences were found among the time intervals in the proportion of pulmonary lesions that are (1) pure GGO, (2) mixed attenuation, (3) mixed attenuation with linear opacities, (4) consolidation with linear opacities, and (5) pure consolidation. The majority of patients had involvement of ≥ 3 lobes. Bilateral involvement was more prevalent than unilateral involvement. The proportions of patients observed to have pure GGO or GGO and consolidation decreased over time while the proportion of patients with GGO and linear opacities increased. Total severity score showed an increasing trend in the first 2 weeks. While bilateral GGO are predominant features, CT findings changed during different time intervals in the 3 weeks after symptom onset in patients with COVID-19. • Four of 88 (4.5%) patients with COVID-19 had negative initial CT. • Majority of COVID-19 patients had abnormal CT findings in ≥ 3 lobes. • A proportion of patients with pure ground glass opacities decreased over the 3 weeks after symptom onset.

Objectives To delineate the evolution of CT findings in patients with mild COVID-19 pneumonia outside of Wuhan.Methods CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia outside of Wuhan, a baseline and at least one follow-up CT were retrospectively reviewed. CT features including lobar distribution and presence of ground glass opacities (GGO), consolidation, and linear opacities, were analyzed on per patient basis during each of five time intervals spanning the three weeks after disease onset. Total severity scores were calculated.Results 85.2 % of patients had travel history to Wuhan or known contact with infected individuals. The most common symptoms were fever (84.1%) and cough (56.8%). The baseline CT was obtained on average 5 days from symptom onset. Four patients (4.5%) had negative initial CT. Significant differences were found among the time intervals in the proportion of pulmonary lesions that are 1) pure GGO, 2) mixed attenuation, 3) mixed attenuation with linear opacities, 4) consolidation with linear opacities, and 5) pure consolidation. The majority of patients had involvement of ≥ 3 lobes. Bilateral involvement was more prevalent than unilateral involvement. The proportions of patients observed to have pure GGO or GGO and consolidation decreased over time while proportion of patients with GGO and linear opacities increased. Total severity score showed an increasing trend in the first two weeks. Conclusions While bilateral GGO are predominant features, CT findings changed during different time intervals in the three weeks after symptom onset in patients with COVID-19.

Background As a pandemic, a most-common pattern resembled organizing pneumonia (OP) has been identified by CT findings in novel coronavirus disease (COVID-19). We aimed to delineate the evolution of CT findings and outcome in OP of COVID-19. Materials and methods 106 COVID-19 patients with OP based on CT findings were retrospectively included and categorized into non-severe (mild/common) and severe (severe/critical) groups. CT features including lobar distribution, presence of ground glass opacities (GGO), consolidation, linear opacities and total severity CT score were evaluated at three time intervals from symptom-onset to CT scan (day 0–7, day 8–14, day > 14). Discharge or adverse outcome (admission to ICU or death), and pulmonary sequelae (complete absorption or lesion residuals) on CT after discharge were analyzed based on the CT features at different time interval. Results 79 (74.5%) patients were non-severe and 103 (97.2%) were discharged at median day 25 (range, day 8–50) after symptom-onset. Of 67 patients with revisit CT at 2–4 weeks after discharge, 20 (29.9%) had complete absorption of lesions at median day 38 (range, day 30–53) after symptom-onset. Significant differences between complete absorption and residuals groups were found in percentages of consolidation (1.5% vs. 13.8%, P = 0.010), number of involved lobe > 3 (40.0% vs. 72.5%, P = 0.030), CT score > 4 (20.0% vs. 65.0%, P = 0.010) at day 8–14. Conclusion Most OP cases had good prognosis. Approximately one-third of cases had complete absorption of lesions during 1–2 months after symptom-onset while those with increased frequency of consolidation, number of involved lobe > 3, and CT score > 4 at week 2 after symptom-onset may indicate lesion residuals on CT.

In this work, biochar-supported nano zero-valent iron/nickel bimetallic composite (BC@nZVI/Ni) was synthesized using liquid phase reduction method and used to activate persulfate (PS) to degrade norfloxacin (NOR) in water. The synthesized BC@nZVI/Ni was characterized using scanning electron microscope (SEM), X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS). The effects of various reaction parameters, such as mass ratio of nZVI/Ni to BC, PS concentration, initial pH value, temperature, humic acid and the inorganic anions on NOR degradation were investigated using the system of nZVI/Ni/PS. The results showed that the system of nZVI/Ni/PS showed the higher degradation efficiency. The quenching experiments and EPR analysis manifested that SO4− was the predominant radical species in acidic and neutral conditions, while OH played an important role in alkaline environment. Matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) analysis illustrated that NOR can be degraded through multiple routes, such as decarboxylation, defluorination and cleavage of piperazine ring in the presence of SO4− and OH. These results demonstrated that nZVI/Ni/PS process was a promising strategy for treating norfloxacin-containing wastewater.

The acoustic black hole (ABH) in thin-walled structures allows the reduction of phase velocity of flexural waves, producing high energy density within structural areas which offers excellent potential for vibration based energy harvesting. The broadband characteristic of the ABH effect is beneficial to increase the operational frequency range of vibration energy harvesters. In this paper, finite element models of a beam with embedded ABHs and its full coupling with piezo-transducers bonded on its surface are analyzed. The size of piezoelectric patches is designed to be relatively smaller than the wavelengths of ABH features in order to make sure that the positive and negative electric charge generated on the surface of harvesters won't be neutralized. The performances of energy harvesters in the ABH structure are investigated and compared with those of the uniform beam under steady state in numerical simulations. The results show that the ABH features are much more effective for vibration energy harvesting than conventional uniform structures.