157 results on '"Yukio Nishiguchi"'
Search Results
2. Impact of a robotic system on intra‐abdominal infectious complications after minimally invasive gastrectomy in patients with gastric cancer: A propensity score matching analysis regarding visceral obesity
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Naoshi Kubo, Katsunobu Sakurai, Tsuyoshi Hasegawa, Yutaka Tamamori, Yasuhito Iseki, Takafumi Nishii, Sadatoshi Shimizu, Toru Inue, Yukio Nishiguchi, and Kiyoshi Maeda
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gastric cancer ,robotic gastrectomy ,visceral obesity ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background The efficacy of robotic gastrectomy (RG) on postoperative complications in patients with gastric cancer (GC) is unclear in terms of the volume of intra‐abdominal fat tissue. Patients and Methods We enrolled 403 patients with GC who had minimally invasive surgery between January 2015 and July 2022. During this time, 197 RG and 206 laparoscopic gastrectomies (LG) were performed on the study participants. According to the computed tomography scan, patients were defined as having or not having visceral obesity based on the visceral fatty area (VFA). In each high and low VFA group, we compared short‐term outcomes between the RG group and LG group. Results After PS matching for patients with high VFA, the two groups were well matched, with 71 cases in both the RG and LG groups. The median surgical time in the RG group was significantly longer (420 vs. 365 min, p
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- 2024
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3. Glycated hemoglobin level on admission associated with progression to severe disease in hospitalized patients with non‐severe coronavirus disease 2019
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Ryutaro Numaguchi, Masafumi Kurajoh, Yoshikazu Hiura, Takumi Imai, Tomoaki Morioka, Mika Saito, Satoshi Shiraishi, Masanori Emoto, and Yukio Nishiguchi
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COVID‐19 ,Glycated hemoglobin ,Severe progression ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims/Introduction Poor glycemic control is known to be associated with severe infection development. This retrospective observational study examined whether glycemic control before coronavirus disease 2019 (COVID‐19) onset contributes to progression from non‐severe to severe COVID‐19. Materials and Methods Glycated hemoglobin (HbA1c) was measured on hospital admission in 415 patients with non‐severe COVID‐19. The outcome was determined from time of hospital admission to severe progression, based on clinical practice guidelines for COVID‐19 in Japan. Results The median value for HbA1c on admission was 6.1%, with diabetes present in 138 patients (33.3%). Among the total cohort, 93 (22.4%) progressed to severe COVID‐19 with a median (interquartile range) time of 4 days (3–7 days), whereas 322 (77.6%) were discharged after 13 days (10–17 days). A multivariable Cox proportional hazards regression model showed that HbA1c level on admission was independently associated with progression to severe COVID‐19 (hazard ratio for 1% increase 1.237, 95% confidence interval 1.037–1.475; P = 0.018), with findings consistent among several sensitivity analyses. In subgroup analyses, such an association was significant in patients with diabetes, as well as older age, current smoking habit, lower estimated glomerular filtration rate, higher C‐reactive protein level, moderate II COVID‐19, dyslipidemia and chronic respiratory disease, with no remarkable inconsistency among the subgroups. Finally, higher HbA1c level (≥7%) was more strongly associated with severe COVID‐19 progression than diabetes. Conclusions The results suggest that poor glycemic control before COVID‐19 onset contributes to progression from non‐severe to severe COVID‐19, even in patients with severe COVID‐19 risk factors regardless of the presence of diabetes.
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- 2022
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4. Survey Regarding Gastrointestinal Stoma Construction and Closure in Japan
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Yoshiko Ando, Arata Takahashi, Makoto Fujii, Hiroshi Hasegawa, Toshimoto Kimura, Hiroyuki Yamamoto, Tetsuya Tajima, Yukio Nishiguchi, Yoshihiro Kakeji, Hiroaki Miyata, and Yuko Kitagawa
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colostomy ,enterostomy ,gastrointestinal stoma closure ,gastrointestinal stoma construction ,national clinical database ,ostomy surgery ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background and Aim In Japan, the actual number of stoma constructions and stoma closures is not known. The aim of this study was to conduct a survey to determine the number of gastrointestinal stoma constructions and closures in Japan. Methods Enrolled participants comprised patients undergoing selected gastrointestinal surgeries who were recorded in the National Clinical Database. This database uses the “Common Items for Gastrointestinal Surgeons.” These procedures were formulated by the Japanese Society of Gastroenterological Surgery during 2013–2018. Results According to the National Clinical Database, a total of 154,323 gastrointestinal stomas were constructed between January 1, 2013 and December 31, 2018. By procedure, there were 78,723 cases of stoma construction, 39,653 of abdominoperineal resection, 2470 total pelvic exenteration procedures, and 33,572 Hartmann's procedures. The ratio of stoma closures to stoma constructions increased annually in patients under 70 y of age but not in older patients. Approximately 35% of total colectomies, 60% of proctocolectomies, and 20% of low anterior resections were accompanied by stoma construction. The number of patients with rectal cancer who underwent colostomy increased gradually during the study period and the number who underwent stoma construction increased among older patients. Conclusion The number of cases of gastrointestinal stoma construction has increased gradually in Japan, and the proportion of older patients is increasing each year. The purposes and surgical techniques for stoma construction are diverse and are expected to increase in Japan, a super‐aged society.
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- 2022
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5. Inflammation Related to Association of Low Uric Acid and Progression to Severe Disease in Patients Hospitalized for Non-Severe Coronavirus Disease 2019
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Masafumi Kurajoh, Yoshikazu Hiura, Ryutaro Numaguchi, Yasutaka Ihara, Takumi Imai, Tomoaki Morioka, Masanori Emoto, and Yukio Nishiguchi
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uric acid ,antioxidants ,inflammation ,COVID-19 ,disease progression ,Biology (General) ,QH301-705.5 - Abstract
Uric acid has antioxidant properties. To examine whether a low uric acid level is associated with severe coronavirus disease 2019 (COVID-19) progression via inflammation, alveolar damage, and/or coagulation abnormality, a retrospective observational study of 488 patients with non-severe COVID-19 and serum uric acid level ≤7 mg/dL at admission was conducted. Serum C-reactive protein (CRP), serum Krebs von den Lungen 6 (KL-6), and plasma D-dimer levels were also measured as markers of inflammation, alveolar damage, and coagulation abnormality, respectively. Median values for uric acid, CRP, KL-6, and D-dimer at admission were 4.4 mg/dL, 3.33 mg/dL, 252.0 U/mL, and 0.8 µg/mL, respectively. Among the total cohort, 95 (19.5%) progressed to severe COVID-19 with a median (interquartile range) time of 7 (4–14) days. Multivariable Cox proportional hazards regression analysis showed that low uric acid level was associated with a higher rate of severe COVID-19 progression. However, uric acid level was inversely associated with CRP level, and the association between the level of uric acid and severe COVID-19 progression was significantly different with and without CRP level inclusion. In contrast, no such association was found for KL-6 or D-dimer level. Low uric acid may contribute to severe COVID-19 progression via increased inflammation in subjects without hyperuricemia.
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- 2023
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6. Percutaneous transesophageal gastro-tubing for the management of anastomotic leakage after upper GI surgery: a report of two clinical cases
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Yutaka Tamamori, Katsunobu Sakurai, Naoshi Kubo, Ken Yonemitsu, Yasuhiro Fukui, Junya Nishimura, Kiyoshi Maeda, and Yukio Nishiguchi
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Percutaneous transesophageal gastro-tubing ,Anastomotic leakage ,Upper GI surgery ,Transnasal drainage ,Double-lumen feeding tube ,Surgery ,RD1-811 - Abstract
Abstract Background Anastomotic leakage is a serious, sometimes critical complication of upper gastrointestinal (GI) surgery. The cavity and target drainage tubes are difficult to reach; therefore, a nasogastric tube (NGT) and fasting are required for an extended period. We successfully treated and managed two patients with anastomotic leakage using percutaneous transesophageal gastro-tubing (PTEG). Case presentation In case 1, a 79-year-old man with gastric cancer underwent total gastrectomy; 1 week later, he underwent emergent open laparotomy due to panperitonitis attributed to anastomotic leakage-related jejunojejunostomy. We resected the portion between esophagojejunostomy and jejunojejunostomy and reconstructed it using the Roux-en-Y technique. On postoperative day (POD) 9, anastomotic leakage was diagnosed at the esophagojejunostomy site and jejunotomy staple line. After using a circular stapler for jejunojejunostomy, a stapled jejunal closure was added. We inserted an NGT and performed aspiration for bowel decompression. As he did not improve within 2 weeks, we decided to perform PTEG to free him of the NGT. We kept performing intermittent aspiration; leakage stopped shortly after, due to effective inner drainage. The PTEG catheter was removed after oral intake was restarted. In case 2, an 81-year-old man with esophagogastric junction cancer underwent resection of the distal esophagus and proximal stomach. After shaping the remnant stomach, esophagogastrostomy was performed under the right thoracotomy. On POD 11, anastomotic leakage was identified, along with a mediastinal abscess. We inserted an NGT into the abscess cavity through the anastomotic leakage site. On POD 25, we performed PTEG and inserted a drainage tube, instead of an NGT. Although the abscess cavity disappeared, anastomotic leakage persisted as a fistula. We exchanged the PTEG with a double elementary diet (W-ED) tube with jejunal extension, with the side hole located near the anastomosis. The anastomotic fistula disappeared after treatment. Dysphagia persisted due to disuse atrophy of swallowing musculature; PTEG was useful for enteral feeding, even after the leakage occurred. Conclusion Patients are sometimes forced to endure pain for a long time for transnasal inner drainage. Using PTEG, patients will be free of sinus pain and discomfort; PTEG should be helpful for patients withstanding NGT.
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- 2020
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7. Successful surgical treatment for nonocclusive mesenteric ischemia of a wide area of the intestine accompanied by gastric conduit necrosis after esophagectomy for esophageal cancer: a case report and review of the literature
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Kotaro Miura, Naoshi Kubo, Katsunobu Sakurai, Yutaka Tamamori, Akihiro Murata, Takafumi Nishii, Shintaro Kodai, Akiko Tachimori, Sadatoshi Shimizu, Akishige Kanazawa, Toru Inoue, Yukio Nishiguchi, and Kiyoshi Maeda
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Mesenteric ischemia ,Postoperative complications ,Esophagectomy ,Surgery ,RD1-811 - Abstract
Abstract Background Nonocclusive mesenteric ischemia (NOMI) has been reported to be a life-threating disease. Gastric conduit necrosis is known as a critical postoperative complication after esophagectomy for esophageal cancer. We encountered a rare case of NOMI of a wide area of the intestine accompanied by gastric conduit necrosis after esophagectomy, which was successfully treated with an emergency operation. Case presentation A 67-year-old man presented with dysphagia. He was diagnosed with middle thoracic advanced esophageal cancer. After neoadjuvant chemotherapy, he underwent subtotal esophagectomy with lymphadenectomy and gastric conduit reconstruction. On postoperative day (POD) 2, he had diarrhea, high fever, and low blood pressure, which were treated with catecholamines. Laboratory data revealed acidosis and severe sepsis with multi-organ failure, including the kidneys. Although enhanced computed tomography did not exhibit definite findings of bowel ischemia, upper gastrointestinal endoscopy revealed necrotic mucosal changes in the whole gastric conduit. Therefore, we made a diagnosis of septic shock caused by gastric conduit necrosis and performed an emergency operation. When we explored the abdominal cavity, we found not only gastric conduit necrosis but also intermittent necrotic changes in the intestinal wall from the jejunum to the rectum. Therefore, NOMI was diagnosed. We performed an excision of the gastric conduit and 2 m of the small intestine, as well as total colectomy. After the second operation, prostaglandin E1 was administered intravenously as the treatment for NOMI, and sepsis was improved. On POD 122, he was self-discharged. He died of recurrence of lung metastasis from the esophageal cancer 9 months after the first operation. Conclusion When a patient has a critical status, including severe sepsis or severe acidosis, after esophagectomy, we should consider the possibility of NOMI in addition to gastric conduit necrosis and aim to diagnose and treat it immediately with an urgent operation.
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- 2020
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8. Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer.
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Katsunobu Sakurai, Naoshi Kubo, Yutaka Tamamori, Naoki Aomatsu, Takafumi Nishii, Akiko Tachimori, Yukio Nishiguchi, and Kiyoshi Maeda
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Medicine ,Science - Abstract
BackgroundAlthough low skeletal muscle mass has an adverse impact on the treatment outcomes of cancer patients, whether the relationship between preoperative skeletal muscle mass and gastrectomy outcomes in gastric cancer (GC) differs between men and women is unclear. The study aimed to clarify this relationship based on gender.MethodsBetween January 2007 and December 2015, 1054 patients who underwent gastrectomy for GC at Osaka City General Hospital were enrolled in this study. We evaluated sarcopenia by the skeletal muscle index (SMI), which was measured by computed tomography (CT) using areas of muscle in the third lumbar vertebral body (L3). Male and female patients were each divided into two groups (low skeletal muscle and high skeletal muscle).ResultsThe SMI emerged as an independent predictor of 5-year overall survival (OS) in male GC patients (Hazard ratio 2.51; 95% confidence interval (CI) 1.73-3.63, p < 0.001) based on multivariate analysis. However, this index was not an independent predictive determinant of 5-year cancer-specific survival (CSS). The SMI was not an independent predictor of either OS or CSS in female GC patients. The incidence of leakage and major complication (Clavien Dindo grade ≧ 3) did not differ significantly across groups.ConclusionsPreoperative skeletal muscle mass is a valuable prognostic predictor of OS in male GC patients.
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- 2021
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9. Jejunal Mesentery Preservation Reduces Leakage at Esophagojejunostomy After Minimally Invasive Total Gastrectomy for Gastric Cancer: a Propensity Score–Matched Cohort Study
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Naoshi Kubo, Katsunobu Sakurai, Yutaka Tamamori, Tsuyoshi Hasegawa, Shuhei Kushiyama, Kenji Kuroda, Akihiro Murata, Shintaro Kodai, Takafumi Nishii, Akiko Tachimori, Sadatoshi Shimizu, Akishige Kanazawa, Toru Inoue, Kiyoshi Maeda, and Yukio Nishiguchi
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Anastomosis, Surgical ,Gastroenterology ,Anastomotic Leak ,Cohort Studies ,Postoperative Complications ,Treatment Outcome ,Stomach Neoplasms ,Gastrectomy ,Humans ,Laparoscopy ,Mesentery ,Surgery ,Propensity Score ,Retrospective Studies - Abstract
The mesentery of the jejunum (MJ) of the Roux limb is conventionally divided when Roux-en-Y reconstruction is performed after total gastrectomy for gastric cancer (GC). However, the impact of dividing or preserving the MJ on anastomotic leakage (AL) at the esophagojejunostomy (EJS) site after minimally invasive total gastrectomy for GC is unclear.This retrospective cohort study enrolled 226 patients with GC who underwent EJS after laparoscopic or robotic total gastrectomy, including preservation of the MJ (n = 87) and division of the MJ (n = 137). The prevalence of anastomotic complications at the EJS and short-term outcomes were compared between groups using propensity score (PS) matching.After PS matching, 69 patients were selected for the preserving and dividing MJ groups. There were no significant intergroup differences in patient backgrounds, including oncological stage, body mass index, and gender ratio. After PS matching, overall and severe complications after surgery were compared between the preserving and dividing MJ groups (21.7% vs. 27.5%, p = 0.554 and 8.7% vs. 13.8%, p = 0.137, respectively). However, the rate of AL at the EJS was significantly lower in the preserving than that in the dividing MJ group (1.4% vs. 13.0%, p = 0.017). In addition, the median postoperative hospital stay was significantly shorter in the preserving than that in the dividing MJ group (13.0 days vs. 16.0 days, p = 0.005).Preserving the MJ significantly reduced AL at the EJS after minimally invasive total gastrectomy for GC.
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- 2022
10. Risk factors of 'loss of independence' in elderly patients who received gastrectomy for gastric cancer
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Katsunobu Sakurai, Naoshi Kubo, Tsuyoshi Hasegawa, Yutaka Tamamori, Kenji Kuroda, Yasuhito Iseki, Takafumi Nishii, Akiko Tachimori, Toru Inoue, Yukio Nishiguchi, and Kiyoshi Maeda
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Cancer Research ,Oncology ,Gastroenterology ,General Medicine - Published
- 2023
11. Survey Regarding Gastrointestinal Stoma Construction and Closure in Japan
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Yoshihiro Kakeji, Toshimoto Kimura, Yuko Kitagawa, Yukio Nishiguchi, Hiroshi Hasegawa, Hiroaki Miyata, Yoshiko Ando, Tetsuya Tajima, Hiroyuki Yamamoto, Arata Takahashi, and Makoto Fujii
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medicine.medical_specialty ,Stoma (medicine) ,business.industry ,medicine.medical_treatment ,Enterostomy ,Gastroenterology ,medicine ,Colostomy ,Closure (topology) ,Surgery ,business - Abstract
In Japan, the actual number of stoma constructions and stoma closures is not known. The aim of this study was to conduct a survey to determine the number of gastrointestinal stoma constructions and closures in Japan.Enrolled participants comprised patients undergoing selected gastrointestinal surgeries who were recorded in the National Clinical Database. This database uses the "Common Items for Gastrointestinal Surgeons." These procedures were formulated by the Japanese Society of Gastroenterological Surgery during 2013-2018.According to the National Clinical Database, a total of 154,323 gastrointestinal stomas were constructed between January 1, 2013 and December 31, 2018. By procedure, there were 78,723 cases of stoma construction, 39,653 of abdominoperineal resection, 2470 total pelvic exenteration procedures, and 33,572 Hartmann's procedures. The ratio of stoma closures to stoma constructions increased annually in patients under 70 y of age but not in older patients. Approximately 35% of total colectomies, 60% of proctocolectomies, and 20% of low anterior resections were accompanied by stoma construction. The number of patients with rectal cancer who underwent colostomy increased gradually during the study period and the number who underwent stoma construction increased among older patients.The number of cases of gastrointestinal stoma construction has increased gradually in Japan, and the proportion of older patients is increasing each year. The purposes and surgical techniques for stoma construction are diverse and are expected to increase in Japan, a super-aged society.
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- 2021
12. Impact of Frailty on Treatment Outcomes for Elderly Patients with Gastric Cancer Undergoing Gastrectomy: A Prospective Cohort Study
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Katsunobu Sakurai, Naoshi Kubo, Tsuyoshi Hasegawa, Yutaka Tamamori, Yasuhiro Fukui, Kenji Kuroda, Kiyoshi Maeda, and Yukio Nishiguchi
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Objective. The aim of this study was to elucidate treatment outcomes for frail patients with gastric cancer (GC) who undergo gastrectomy.Methods. Frailty was assessed preoperatively by frailty index (FI) in 209 patients aged 65 and over undergoing gastrectomy for GC. Patients were assigned into two groups (frail vs. non-frail). Short-term outcomes and loss of independence (LOI) after discharge were compared. Results. Frail patients undergoing gastrectomy had more intraoperative blood transfusions, longer hospital stays, and higher medical costs. The overall complication rate was significantly higher in frail patients. Pneumonia and urinary tract infections were more frequent in the frail patients. In multivariate analysis for LOI after discharge, frailty, older age (≧ 75 years), and open surgery were independent risk factors. A risk score assigning 1 point for each of these variables was useful in predicting postoperative LOI (LOI: score 0, 6.8%; score 1, 26.1%; score 2, 47.6%; score 3, 100%; area under the curve [AUC]=0.748.) Conclusions. Frailty is associated with LOI after gastrectomy in elderly GC patients. A simple risk score assigning points for frailty, age ≧75, and open surgery was an accurate predictor of postoperative LOI. We propose that frailty screening should be applied for all elderly GC patients before surgery.
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- 2022
13. Stent-graft placement for delayed extrahepatic portal hemorrhage after surgical treatment for perihilar cholangiocarcinoma: A case report
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Yukio Nishiguchi, Tadashi Tsukamoto, Toru Inoue, Ryoji Kaizaki, Tomohiro Kunimoto, Chihoko Nobori, and Tsuyoshi Nishiyama
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medicine.medical_specialty ,medicine.medical_treatment ,030230 surgery ,Portal vein pseudoaneurysm ,Covered stent ,Ileocolic vein ,03 medical and health sciences ,Pseudoaneurysm ,0302 clinical medicine ,Bile leakage ,Case report ,medicine ,cardiovascular diseases ,business.industry ,Bile duct ,Bleeding ,Stent ,Hepatoduodenal ligament ,Jaundice ,medicine.disease ,Surgery ,medicine.anatomical_structure ,surgical procedures, operative ,030220 oncology & carcinogenesis ,cardiovascular system ,CT, Computed tomography ,Lymphadenectomy ,medicine.symptom ,business ,Complication - Abstract
Highlights • Stent-graft placement is a viable option for treatment of portal vein hemorrhage. • Postoperative hemorrhage was caused by extrahepatic portal vein pseudoaneurysm formation. • Portal vein pseudoaneurysm occurred at the reconstructed portion., Introduction Potential curative therapy for perihilar cholangiocarcinoma requires extensive surgical treatment, which can still be associated with significant morbidity and mortality. Postoperative hemorrhage from the portal vein is a rare but life-threatening complication. We herein report postoperative hemorrhage from an extrahepatic portal vein pseudoaneurysm successfully treated by stent graft placement late after surgical treatment for perihilar cholangiocarcinoma. Presentation of case An 83-year-old man was referred to our hospital with a chief complaint of jaundice. Based on radiological findings, we diagnosed the patient with hilar cholangiocarcinoma. After endoscopic retrograde biliary drainage, resection of the extrahepatic bile duct combined with extended left hemi-hepatectomy, including the caudate lobe, lymphadenectomy of the hepatoduodenal ligament, partial resection and reconstruction of the portal vein, and right hepaticojejunostomy was performed. Fourteen days postoperatively, bleeding through the abdominal drain around the portal vein was observed. Twenty days postoperatively, abdominal computed tomography revealed a portal vein pseudoaneurysm that had formed at the portion of reconstruction. Therefore, 24 days postoperatively, a stent graft placement of the pseudoaneurysm through the ileocolic vein was performed. Subsequently, the portal vein hemorrhage ceased. Discussion Our present postoperative extrahepatic portal vein hemorrhage case was caused by an extrahepatic portal vein pseudoaneurysm that had formed at the reconstructed portion by erosion due to the chemical effect of the leaking bile and mechanical irritation of the surgical drain adjacent to the portal vein. Conclusion Stent-graft placement is a minimally-invasive, safe, and effective treatment option for hemorrhage from postoperative portal vein pseudoaneurysm.
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- 2020
14. [Synchronous Double Primary Non-B, and Non-C Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma-A Case Report]
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Tadashi, Tsukamoto, Shintaro, Kodai, Chihoko, Nobori, Yuki, Okazaki, Mikio, Nanbara, Eijiro, Edagawa, Yoshihiro, Mori, Akishige, Kanazawa, Tsuyoshi, Nishiyama, Tomohiro, Kunimoto, Ryoji, Kaizaki, Toru, Inoue, Satoshi, Takatsuka, and Yukio, Nishiguchi
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Cholangiocarcinoma ,Male ,Bile Ducts, Intrahepatic ,Carcinoma, Hepatocellular ,Bile Duct Neoplasms ,Liver Neoplasms ,COVID-19 ,Hepatectomy ,Humans ,Chemoembolization, Therapeutic ,Aged - Abstract
A 78-year-old man without hepatitis virus B or C underwent right hemi-hepatectomy and lymph node dissection for a tumor 5 cm in diameter located in the hepatic hilum of the posterior segment of the liver with portal vein thrombi extending into the main portal trunk and a tumor 1.5 cm in diameter in the peripheral side of segment 5 of the liver. Histopathologically, the former was diagnosed as intrahepatic cholangiocarcinoma and the latter as hepatocellular carcinoma(HCC). Five months after the surgery, intrahepatic and lymph node metastases were diagnosed based on computed tomography(CT); therefore, chemotherapy with S-1 for 3 months and gemcitabine and cisplatin(GC)for 5 months was administered, after which the metastatic lesions were not detected. Nineteen months after the surgery, partial resection of segment 2 of the liver was performed for a tumor 3 cm in diameter, which was diagnosed as HCC histopathologically. Two years after the second surgery, 2 recurrent nodules in the liver in segments 3 and 4 were detected on CT. Platinum-based hepatic arterial infusion chemotherapy(HAIC)and transcatheter arterial chemoembolization(TACE)were performed, and chemotherapy with GC was then administered for 7 months. For a new tumor detected in segment 1 in the liver, TACE was performed 17 months after initial HAIC. Seventy-four months after the initial surgery, 5 new nodules less than 1 cm in diameter were detected, and chemotherapy with sorafenib was administered for 5 months, after which the patient died of coronavirus disease 2019.
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- 2022
15. A Case of Sigmoid Colon Endometriosis Resection Diagnosed by EUS-FNA
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Kiyoshi Maeda, Toru Inoue, Akiko Tachimori, Genya Hamano, Takafumi Nishii, and Yukio Nishiguchi
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,medicine ,Endometriosis ,General Earth and Planetary Sciences ,Sigmoid colon ,Radiology ,business ,medicine.disease ,General Environmental Science ,Resection - Published
- 2019
16. [A Case of Disturbance of Consciousness Due to Hyperammonemia during Chemotherapy for Metastasis of Sigmoid Colon Cancer]
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Ryoji, Kaizaki, Toru, Inoue, Shinpei, Eguchi, Tsuyoshi, Nishiyama, Chihoko, Nobori, Tomohiro, Kunimoto, Yuki, Okazaki, Satoshi, Takatsuka, Tadashi, Tsukamoto, and Yukio, Nishiguchi
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Sigmoid Neoplasms ,Consciousness ,Antineoplastic Combined Chemotherapy Protocols ,Leucovorin ,Humans ,Hyperammonemia ,Female ,Fluorouracil ,Neoplasm Recurrence, Local ,Aged - Abstract
A 76-year-old woman had underwent 5-fluorouracil(5-FU), oxaliplatin(L-OHP)combination therapy(mFOLFOX6)as first-line chemotherapy for peritoneal recurrence after resection of sigmoid colon cancer. She showed severe general fatigue and disturbance of consciousness on the second day of the 12th course of chemotherapy. Computed tomography of the head detected no abnormal findings in the central nervous system. The laboratory results revealed a marked hyperammonemia. She was diagnosed as a disturbance of consciousness due to hyperammonemia and treated her with branched- chain amino acid solution. Then the disturbance of consciousness resolved on the following day. After changing the regimen of chemotherapy, the disturbance of consciousness was not found. Recently, it has been reported that high-dose 5-FU regimen such as mFOLFOX6 causes hyperammonemia as a rare adverse event. We should take hyperammonemia into account when disturbance of consciousness occurs during high-dose 5-FU chemotherapy.
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- 2021
17. [Laparoscopic Resection of Solitary Lymph Node Metastasis of Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization and Percutaneous Locoregional Therapies]
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Tadashi, Tsukamoto, Shintaro, Kodai, Satoshi, Yamamoto, Sadaaki, Yamazoe, Akishige, Kanazawa, Tsuyoshi, Nishiyama, Chihoko, Nobori, Tomohiro, Kunimoto, Ryoji, Kaizaki, Toru, Inoue, and Yukio, Nishiguchi
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Carcinoma, Hepatocellular ,Lymphatic Metastasis ,Liver Neoplasms ,Humans ,Female ,Laparoscopy ,Chemoembolization, Therapeutic ,Neoplasm Recurrence, Local ,Aged - Abstract
A 75-year-old woman underwent transcatheter chemoembolization(TACE)for 2 small hepatocellular carcinoma(HCC) lesions associated with severe alcoholic liver cirrhosis that necessitated management for ascites. Over 5 years after the initial TACE, she received multidisciplinary therapies with TACE, transcatheter arterial infusion of anticancer agents, percutaneous ethanol injections, or percutaneous radiofrequency ablation performed on 5 occasions for small recurrent HCC lesions. Computed tomography performed after the last therapy for HCC revealed a solitary lymph node swelling(39 mm in diameter) around the common hepatic artery. Magnetic resonance imaging performed 3 months later revealed that the lymph node had enlarged to 45 mm, without recurrence of the primary HCC, and after 4 months, to 60 mm; she then underwent laparoscopic lymph node resection. Histopathological examination of the resected specimen showed HCC metastasis. A recurrent metastatic lymph node(30 mm in diameter)was detected around the common hepatic artery and was resected laparoscopically 17 months postoperatively. Pancreatic head cancer was diagnosed 22 months after the second surgery; however, the patient refused cancer therapy and died 16 months after this diagnosis. No recurrence of the primary HCC or lymph node metastasis was observed over the 38 months after the second surgery.
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- 2021
18. [Laparoscopic Liver Resection for Liver Metastasis from Unresectable Pancreatic Ductal Adenocarcinoma Well-Controlled by Chemotherapy-A Case Report]
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Chihoko, Nobori, Tadashi, Tsukamoto, Tsuyoshi, Nishiyama, Tomohiro, Kunimoto, Ryoji, Kaizaki, Toru, Inoue, and Yukio, Nishiguchi
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Male ,Pancreatic Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Liver Neoplasms ,Humans ,Laparoscopy ,Adenocarcinoma ,Middle Aged ,Neoplasm Recurrence, Local - Abstract
A 45-year-old man with unresectable locally advanced pancreas head cancer with multiple synchronous liver metastases was treated with gemcitabine plus nab-paclitaxel therapy as a first-line chemotherapy. During 24 months of 30 courses of this therapy, the primary lesion remained stable and liver metastases were completely disappeared on CT. Three months later, however, solitary relapse of liver metastasis occurred in segment 2. Therefore, we changed the chemotherapy regimen to the second-line treatment, FOLFIRINOX. After 3 courses of FOLFIRINOX, the primary lesion was kept well-controlled, but the solitary metastatic liver lesion was enlarged. An interdisciplinary team suggested surgical resection of the liver metastasis to control disease progress. We performed laparoscopic lateral segmentectomy of the liver. The postoperative course was uneventful, and the patient was discharged on postoperative day 8. The patient underwent another round of gemcitabine therapy owing to the good response of the primary pancreatic lesion to this drug. Three years after starting the first-line chemotherapy, the patient is still alive with well-controlled PDAC without distant metastasis. Surgical intervention for liver metastases may be a promising treatment option when unresectable primary PDAC is well controlled by chemotherapy.
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- 2021
19. Percutaneous transesophageal gastro-tubing for the management of anastomotic leakage after upper GI surgery: a report of two clinical cases
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Junya Nishimura, Naoshi Kubo, Kiyoshi Maeda, Yukio Nishiguchi, Yasuhiro Fukui, Ken Yonemitsu, Katsunobu Sakurai, and Yutaka Tamamori
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medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Fistula ,lcsh:Surgery ,Case Report ,Anastomosis ,03 medical and health sciences ,0302 clinical medicine ,Laparotomy ,Percutaneous transesophageal gastro-tubing ,medicine ,Anastomotic leakage ,Thoracotomy ,Transnasal drainage ,Double-lumen feeding tube ,Upper GI surgery ,business.industry ,lcsh:RD1-811 ,medicine.disease ,Dysphagia ,Surgery ,Catheter ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Gastrectomy ,medicine.symptom ,business - Abstract
Background Anastomotic leakage is a serious, sometimes critical complication of upper gastrointestinal (GI) surgery. The cavity and target drainage tubes are difficult to reach; therefore, a nasogastric tube (NGT) and fasting are required for an extended period. We successfully treated and managed two patients with anastomotic leakage using percutaneous transesophageal gastro-tubing (PTEG). Case presentation In case 1, a 79-year-old man with gastric cancer underwent total gastrectomy; 1 week later, he underwent emergent open laparotomy due to panperitonitis attributed to anastomotic leakage-related jejunojejunostomy. We resected the portion between esophagojejunostomy and jejunojejunostomy and reconstructed it using the Roux-en-Y technique. On postoperative day (POD) 9, anastomotic leakage was diagnosed at the esophagojejunostomy site and jejunotomy staple line. After using a circular stapler for jejunojejunostomy, a stapled jejunal closure was added. We inserted an NGT and performed aspiration for bowel decompression. As he did not improve within 2 weeks, we decided to perform PTEG to free him of the NGT. We kept performing intermittent aspiration; leakage stopped shortly after, due to effective inner drainage. The PTEG catheter was removed after oral intake was restarted. In case 2, an 81-year-old man with esophagogastric junction cancer underwent resection of the distal esophagus and proximal stomach. After shaping the remnant stomach, esophagogastrostomy was performed under the right thoracotomy. On POD 11, anastomotic leakage was identified, along with a mediastinal abscess. We inserted an NGT into the abscess cavity through the anastomotic leakage site. On POD 25, we performed PTEG and inserted a drainage tube, instead of an NGT. Although the abscess cavity disappeared, anastomotic leakage persisted as a fistula. We exchanged the PTEG with a double elementary diet (W-ED) tube with jejunal extension, with the side hole located near the anastomosis. The anastomotic fistula disappeared after treatment. Dysphagia persisted due to disuse atrophy of swallowing musculature; PTEG was useful for enteral feeding, even after the leakage occurred. Conclusion Patients are sometimes forced to endure pain for a long time for transnasal inner drainage. Using PTEG, patients will be free of sinus pain and discomfort; PTEG should be helpful for patients withstanding NGT.
- Published
- 2020
20. [Descending Colon Cancer with Synchronous Solitary Small Intestinal Metastasis-A Case Report]
- Author
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Shinpei, Eguchi, Tomohiro, Lee, Yuki, Okazaki, Ryoji, Kaizaki, Tadashi, Tsukamoto, Satoshi, Takatsuka, and Yukio, Nishiguchi
- Subjects
Colon, Descending ,Male ,Colonic Neoplasms ,Intestine, Small ,Humans ,Colectomy ,Aged - Abstract
A 77-year-old man presented with biliary colic and was diagnosed with descending colon cancer and cholelithiasis.During the surgery, a mass was detected in the upper jejunum, located 5 cm from the Treitz ligament on the anal side.Open left hemicolectomy with partial jejunal resection was performed.The mass in the small intestine was diagnosed as solitary small intestinal metastasis of colon cancer through immunohistopathological examination.Isolated intestinal metastases of colorectal cancers are rare.Furthermore, synchronous metastases are rare among these cases.A previous study reported poor prognosis in patients with small intestinal metastasis; therefore, more studies on the small intestinal metastasis of colorectal cancer are necessary.
- Published
- 2020
21. [A Case of Rupture of Esophageal Varices during a Course of CAPOX with Bevacizumab Therapy for Sigmoid Colon Cancer with Multiple Liver Metastases]
- Author
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Tomohiro, Lee, Satoshi, Takatsuka, Ryoji, Kaizaki, Shinpei, Eguchi, Yuki, Okazaki, Koji, Sano, Seiko, Yamaguchi, Tadashi, Tsukamoto, and Yukio, Nishiguchi
- Subjects
Bevacizumab ,Male ,Rupture ,Sigmoid Neoplasms ,Esophagus ,Antineoplastic Combined Chemotherapy Protocols ,Liver Neoplasms ,Humans ,Neoplasm Recurrence, Local ,Esophageal and Gastric Varices ,Gastrointestinal Hemorrhage ,Aged - Abstract
The patient was a 67-year-old man with multiple liver metastases from sigmoid colon cancer and had received capecitabine, oxaliplatin, and bevacizumab(CAPOX plus Bev)combination chemotherapy. After 11 courses of this therapy, he had a rupture of esophageal varices and was treated with endoscopic variceal ligation(EVL). Esophageal varices are rare during the course of oxaliplatin-based chemotherapy. More studies are necessary for early detection of esophageal varices during this therapy.
- Published
- 2020
22. [A Resected Case of Retroperitoneal Metastasis and Small Bowel Metastasis from HCC]
- Author
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Tadashi, Tsukamoto, Shingo, Togano, Shinpei, Eguchi, Chikako, Nishihara, Hisao, Tanaka, Takahisa, Adachi, Masahide, Kaji, Tomohiro, Lee, Ryoji, Kaizaki, Satoshi, Takatsuka, Yukio, Nishiguchi, Seiko, Yamaguchi, and Osamu, Kurai
- Subjects
Male ,Carcinoma, Hepatocellular ,Intestinal Neoplasms ,Intestine, Small ,Liver Neoplasms ,Hepatectomy ,Humans ,Retroperitoneal Neoplasms ,Aged - Abstract
A 71-year-old man underwent right hemi-hepatectomyfor a hepatocellular carcinoma(HCC)measuring 18 cm in diameter. The pathological diagnosis was poorlydifferentiated HCC. Ten months after the surgery, computed tomographyrevealed a nodule 12mm in diameter in the right lung as well as 2 nodules measuring 19 and 11mm in diameter in the retroperitoneum at the cranial aspect of the left kidney. Four months later, the nodule in the right lung had enlarged to 44 mm, while the 2 nodules in the retroperitoneum had enlarged to 68mm and 34 mm. These nodules were resected and histopathologicallydiagnosed as metastasis from HCC. Twenty-one months after liver resection, computed tomographyrevealed nodules 16 and 25mm in diameter in the retroperitoneum around the urinarybladder and jejunum, respectively. One month later, intussusception resulted from the jejunal tumor. Laparoscopic surgerywas performed for both tumors, which were diagnosed as metastases from HCC. Twenty-five months after liver resection, metastasis from the HCC appeared in the left adrenal grand, at the site of the jejunal anastomosis, and in the fattytissue around the right scapula. Twenty-nine months after liver resection, the patient died of respiratoryfailure from multiple metastases in the left lung.
- Published
- 2020
23. Laparoscopic lithotripsy and lithotomy of impacted stone at the terminal end of the common bile duct using a laparotomy biliary lithotomy spoon: A case report
- Author
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Tadashi Tsukamoto, Chihoko Nobori, Tomohiro Kunimoto, Ryoji Kaizaki, Toru Inoue, and Yukio Nishiguchi
- Subjects
LCBDE, laparoscopic common bile duct exploration ,Biliary lithotomy spoon ,Common bile duct ,EHL, electrohydraulic lithotripsy ,Case Report ,Surgery ,Impacted stone ,CBD, common bile duct ,PTGBD, percutaneous transhepatic gallbaldder drainage ,ERCP, endoscopic retrograde cholangiopancreatography ,Laparoscopic choledocholithotomy - Abstract
Introduction and importance Endoscopic intervention is considered first-line therapy for common bile duct (CBD) stones, in recent times. However, surgically altered anatomy and consequent inaccessibility of the duodenal papilla necessitate surgery in some patients. Case presentation A 61-year-old woman presented with fever and right subcostal pain. She underwent total gastrectomy and Roux-en-Y reconstruction for gastric ulcer, 4 years prior to presentation. Based on the clinical findings, she was diagnosed with acute obstructive cholangitis secondary to a CBD stone. Endoscopic retrograde biliary drainage was attempted; however, the duodenal papilla was endoscopically inaccessible owing to the previous Roux-en-Y reconstruction, and we performed percutaneous transhepatic gallbladder drainage (PTGBD). She underwent laparoscopic cholecystectomy and choledocholithotomy, 6 days after the PTGBD. Choledocholithotomy was attempted using basket forceps under choledochoscopic guidance; however, this procedure was unsuccessful, and we performed laparoscopic choledocholithotomy using a laparotomy biliary lithotomy spoon. Clinical discussion Usually, laparoscopic cholecystectomy concomitant with CBD exploration is performed in patients with an endoscopically inaccessible duodenal papilla. However, an inadequately opened basket may not capture large impacted stones at the duodenal end of the CBD. Intraductal shock wave lithotripsy (electrohydraulic or laser lithotripsy) is considered in such cases; however, the specialized instruments required for this procedure are unavailable at all centers. Laparoscopic choledocholithotomy using a laparotomy biliary lithotomy spoon may be useful to overcome this surgically challenging situation. Conclusion A laparotomy biliary lithotomy spoon is a simple, user-friendly, and economical device that may be useful for laparoscopic lithotripsy and lithotomy of impacted stones., Highlights • Endoscopy did not show the duodenal papilla owing to surgically altered anatomy. • Stone impaction was observed at the terminal portion of the common bile duct. • Choledochoscopic basket lithotomy could not be performed. • Laparoscopic lithotomy was performed using a laparotomy biliary lithotomy spoon.
- Published
- 2022
24. Long-term survival estimates in older patients with pathological stage I gastric cancer undergoing gastrectomy: Duocentric analysis of simplified scoring system
- Author
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Katsunobu Sakurai, Kosei Hirakawa, Kiyoshi Maeda, Yutaka Tamamori, Masaichi Ohira, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Naoshi Kubo, Tatsuro Tamura, Hiroaki Tanaka, and Yukio Nishiguchi
- Subjects
Male ,medicine.medical_specialty ,Multivariate analysis ,Scoring system ,medicine.medical_treatment ,Health Status ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,Gastrectomy ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Long term survival ,medicine ,Humans ,030212 general & internal medicine ,Pathological ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Stage I Gastric Cancer ,business.industry ,Carcinoma ,Univariate ,Prognosis ,Survival Rate ,Nutrition Assessment ,Oncology ,030220 oncology & carcinogenesis ,Area Under Curve ,Multivariate Analysis ,Female ,Geriatrics and Gerontology ,business ,Follow-Up Studies - Abstract
Our aim was to determine factors predictive of long-term post-gastrectomy outcomes in older adults with pathological stage I gastric cancer (GC).A total of 175 patients with resected pathological stage I GC at two institutions were reviewed, each ≥75 years old at the time of gastrectomy and full participants in a 5-year follow-up program. The procedures were undertaken between January 2006 and December 2011. Patients were divided into two groups: survivors and non-survivors at postoperative Year 5. Univariate and multivariate analyses were applied to identify independent predictors of 5-years survival, including preoperative, surgical, and histopathologic variables.Multivariate analysis of overall survival (OS) at 5 years indicated that prognostic nutritional index (PNI)45 and the American Society of Anesthesiologists physical status (ASA-PS) 3 were independently associated with unfavorable outcomes. A clinical score consisting of 1-point each for these two variables proved useful in predicting survival after gastrectomy (5-year OS: 0 point, 86.6%; 1-point, 51.6%; 2-point, 33.3%; p .001, area under the curve [AUC] = 0.757).Long-term survival of older adults with pathological stage I GC is unfavorable in patients displaying both ASA-PS 3 and PNI 45. A simple scoring method, based on combined ASA-PS/PNI determinations, provides an accurate prognostic prediction for these patients.
- Published
- 2018
25. [A Resected Case of Adenosquamous Carcinoma of Pancreas That Relapsed in Remnant Pancreas]
- Author
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Kotaro, Miura, Akishige, Kanazawa, Sadatoshi, Shimizu, Akihiro, Murata, Shintaro, Kodai, Takafumi, Nishii, Katsunobu, Sakurai, Akiko, Tachimori, Yutaka, Tamamori, Naoshi, Kubo, Toru, Inoue, and Yukio, Nishiguchi
- Subjects
Male ,Pancreatic Neoplasms ,Carcinoma, Adenosquamous ,Humans ,Neoplasm Recurrence, Local ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Aged ,Pancreaticoduodenectomy - Abstract
A 70's man underwent subtotal stomach preserving pancreatoduodenectomy(SSPPD)for pancreatic head cancer. The pathological diagnosis was adenosquamous carcinoma(ASC)of the pancreas. Two months after surgery, a recurrent tumor in the remnant pancreas was confirmed with a CT scan and suspected to be ASC by endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). As the recurrent lesion was limited in the pancreas, total remnant pancreatectomy(TP)was performed 4 months after SSPPD. The final pathological diagnosis was ASC. Two months after TP, liver and para-aortic lymph node metastases were revealed. The patient has been alive for 14 months after SSPPD with chemotherapy. Because of its rarity, it is difficult to implement treatment plans for recurrent ASC in the remnant pancreas.
- Published
- 2018
26. [A Case of Liver Metastasis from Esophageal Cancer Successfully Treated by Surgical Resection after Chemotherapy with Weekly-Paclitaxel]
- Author
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Akinori, Nozawa, Naoshi, Kubo, Sadatoshi, Shimizu, Akihiro, Murata, Akishige, Kanazawa, Shintaro, Kodai, Yorihisa, Urata, Kotaro, Miura, Jun, Tauchi, Katsunori, Sakurai, Akiko, Tachimori, Yutaka, Tamamori, Toru, Inoue, Yoshito, Yamashita, and Yukio, Nishiguchi
- Subjects
Esophagectomy ,Male ,Esophageal Neoplasms ,Paclitaxel ,Liver Neoplasms ,Humans ,Middle Aged ,Prognosis ,Antineoplastic Agents, Phytogenic ,Combined Modality Therapy - Abstract
A 58-year-old man complaining of dysphagia was admitted to our hospital and diagnosed with esophageal cancer.He underwent thoracoscopic subtotal esophagectomy with 3-field lymph node dissection and reconstruction with a gastric tube created by hand-assisted laparoscopy.The pathological diagnosis was classified as AeLtG, pT3N2M0, pStage III .He was subsequently treated with systemic chemotherapy with 5-fluorouracil and cisplatin.After 2 courses, a single liver metastatic tumor appeared at segment 5.As chemotherapy against the recurrence, weekly-paclitaxel was administered.After 2 courses, the metastatic liver tumor reduced in size.Subsequently, laparoscopic partial liver resection was performed 11 months after first surgery.The pathological finding was negative for malignancy(pathological complete response).
- Published
- 2018
27. A Resected Case of Amputation Neuroma of the Bile Duct Diagnosed by Intraoperative Frozen Section Examination
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Wataru Goto, Tadashi Tsukamoto, Akishige Kanazawa, Sadatoshi Shimizu, Yoshito Yamashita, and Yukio Nishiguchi
- Subjects
medicine.medical_specialty ,Frozen section procedure ,medicine.anatomical_structure ,business.industry ,Bile duct ,General Engineering ,medicine ,General Earth and Planetary Sciences ,Amputation Neuroma ,business ,General Environmental Science ,Surgery - Published
- 2015
28. A Case of a Giant Fibrovascular Polyp of the Esophagus Successfully Resected through a Cervical Approach
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Mami Yoshii, Tomohiro Lee, Yutaka Tamamori, Yukio Nishiguchi, Yoshito Yamashita, and Kokoro Yamane
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medicine.medical_specialty ,business.industry ,General surgery ,Medicine ,business - Published
- 2015
29. Impact of the Japanese Gastric Cancer Screening System on Treatment Outcomes in Gastric Gastrointestinal Stromal Tumor (GIST): An Analysis Based on the GIST Registry
- Author
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Kazuya Muguruma, Yasuo Nakashima, Tsuyoshi Takahashi, Toshimasa Tsujinaka, Toshiro Nishida, Seiichi Hirota, Shinsuke Sato, Yukio Nishiguchi, and Kazuyoshi Yamamoto
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Gastrointestinal Stromal Tumors ,Gastroenterology ,Asymptomatic ,Young Adult ,Japan ,Surgical oncology ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Registries ,Gastric Gastrointestinal Stromal Tumor ,Young adult ,Survival rate ,Early Detection of Cancer ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,GiST ,business.industry ,Stomach ,Retrospective cohort study ,Middle Aged ,Prognosis ,Combined Modality Therapy ,digestive system diseases ,Survival Rate ,medicine.anatomical_structure ,Oncology ,Female ,Laparoscopy ,Surgery ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Gastrointestinal stromal tumors (GISTs) of the stomach are found incidentally during gastric cancer screening in Japan. This study investigated whether the Japanese gastric cancer screening system helps to improve treatment outcomes in gastric GIST based on an analysis of the GIST registry conducted by the Kinki GIST Study Group. The registry was designed to collect data on background characteristics, treatment methods, pathologic characteristics, and prognosis of GIST from January 2003 through December 2007 at 40 participating institutions. The study enrolled 672 GIST patients, 482 of whom had gastric GIST. According to the modified National Institutes of Health consensus criteria, 22.6 % of the patients were classified as high risk for recurrence, 18.5 % as intermediate risk, 35.9 % as low risk, and 13.9 % as very low risk. After exclusion of the patients inevaluable for treatment outcome, the study included 137 symptomatic patients (symptomatic group) and 147 asymptomatic patients (asymptomatic group). The diagnosis of the asymptomatic patients was determined through gastric cancer screening. The median tumor size in the asymptomatic group was significantly smaller than in the symptomatic group (3.5 vs. 5.3 cm; P
- Published
- 2014
30. Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer
- Author
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Kosei Hirakawa, Yukio Nishiguchi, Kiyoshi Maeda, Hiroshi Ohtani, Masatsune Shibutani, Eiji Noda, and Hisashi Nagahara
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Multivariate analysis ,Colorectal cancer ,Metastasis ,Surgical oncology ,Internal medicine ,Biomarkers, Tumor ,Humans ,Medicine ,Clinical significance ,Aged ,Neoplasm Staging ,Aged, 80 and over ,biology ,business.industry ,C-reactive protein ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,C-Reactive Protein ,Lymphatic system ,Preoperative Period ,biology.protein ,Biomarker (medicine) ,Female ,Surgery ,Colorectal Neoplasms ,business - Abstract
Previous studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer.We enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of ≥ 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed.The cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (≥ 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (≥ 1.0 mg/dl) were independent risk factors for a poor survival.A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.
- Published
- 2014
31. Surgical Management for Focally Progressive Disease in Metastatic/Recurrent Gastrointestinal Stromal Tumors Treated with Imatinib
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Yukio Nishiguchi, Takahiro Toyokawa, Atsushi Yamamoto, Sadatoshi Shimizu, Hitoshi Teraoka, and Yoshito Yamashita
- Subjects
Oncology ,Metastatic/Recurrent ,medicine.medical_specialty ,Pathology ,Stromal cell ,business.industry ,Internal medicine ,medicine ,Imatinib ,business ,medicine.disease ,Progressive disease ,medicine.drug - Published
- 2014
32. Side overlap esophagogastrostomy to prevent reflux after proximal gastrectomy
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Yutaka Tamamori, Yoshito Yamashita, Yukio Nishiguchi, Mami Yoshii, and Atsushi Yamamoto
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Diaphragmatic breathing ,Esophagogastrectomy ,Anastomosis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Esophagus ,Reflux esophagitis ,Aged ,Aged, 80 and over ,Gastrostomy ,business.industry ,Stomach ,digestive, oral, and skin physiology ,Reflux ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,digestive system diseases ,Surgery ,Stenosis ,medicine.anatomical_structure ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Gastroesophageal Reflux ,030211 gastroenterology & hepatology ,Female ,Esophagoscopy ,business - Abstract
No optimal method of reconstruction for proximal gastrectomy has been established because of problems associated with postoperative reflux and anastomotic stenosis. It is also important that the reconstruction is easily performed laparoscopically because laparoscopic gastrectomy has become widely accepted in recent years. We have developed a new method of esophagogastrostomy, side overlap with fundoplication by Yamashita (SOFY). The remnant stomach is fixated to the diaphragmatic crus on the dorsal side of the esophagus. The esophagus and the remnant stomach are overlapped by a length of 5 cm. A linear stapler is inserted in two holes on the left side of the esophageal stump and the anterior gastric wall. The stapler is rotated counterclockwise on its axis and fired. The entry hole is closed, and the right side of the esophagus is fixated to the stomach so that the esophagus sticks flat to the gastric wall. The surgical outcomes of the SOFY method were compared with those of esophagogastrectomy different from SOFY. Thirteen of the 14 patients in the SOFY group were asymptomatic without a proton pump inhibitor, but reflux esophagitis was observed in 5 of the 16 patients in the non-SOFY group and anastomotic stenosis was observed in 3 patients. Contrast enhancement findings in the SOFY group showed inflow of Gastrografin to the remnant stomach was extremely good, and no reflux into the esophagus was observed even with patients in the head-down tilt position. SOFY can be easily performed laparoscopically and may overcome the problems of postoperative reflux and stenosis.
- Published
- 2016
33. [A Case of Multiple HCC with Vp2 and Vv3 Invasion Controlled by Multidisciplinary Treatment Including Surgery]
- Author
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Sota, Deguchi, Tadashi, Tsukamoto, Akishige, Kanazawa, Sadatoshi, Shimizu, Satoshi, Yamamoto, Akihiro, Murata, Takayoshi, Nakajima, Masayuki, Sakae, Akiko, Tachimori, Yutaka, Tamamori, Atsushi, Yamamoto, Toru, Inoue, Yoshito, Yamashita, and Yukio, Nishiguchi
- Subjects
Male ,Niacinamide ,Carcinoma, Hepatocellular ,Portal Vein ,Phenylurea Compounds ,Liver Neoplasms ,Antineoplastic Agents ,Sorafenib ,Prognosis ,Combined Modality Therapy ,Catheter Ablation ,Hepatectomy ,Humans ,Infusions, Intra-Arterial ,Neoplasm Invasiveness ,Cisplatin ,Aged - Abstract
The prognosis of HCC with vascular invasion is dismal, but surgery is elected when the hepatic reserve is adequate. The case involved a 68-year-old male HCV carrier. A 10 cm diameter tumor occupying the central 2 segments of the liver and liver metastasis in the left lobe were detected. The patient was diagnosed with multiple HCC with severe vascular invasion of Vp2 and Vv3. The tumor shrunk dramatically after starting HAIC therapy with cisplatin and oral administration of sorafenib. A laparoscopic partial hepatectomy was performed for the viable lesion. The tumor showed almost complete coagulative necrosis. Multiple hepatic metastases were found 4 months after surgery, but the tumor was under control at 25 months after the first HAIC due to HAIC, oral administration of sorafenib, and RFA. An improved prognosis for multiple HCC with severe vascular invasion can be expected by performing multidisciplinary treatments including surgery.
- Published
- 2016
34. Meta-analysis of the Results of Randomized Controlled Trials that Compared Laparoscopic and Open Surgery for Acute Appendicitis
- Author
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Kosei Hirakawa, Hiroshi Ohtani, Yuichi Arimoto, Yukio Nishiguchi, Kiyoshi Maeda, and Yutaka Tamamori
- Subjects
Laparoscopic surgery ,medicine.medical_specialty ,medicine.medical_treatment ,Operative Time ,MEDLINE ,law.invention ,Cicatrix ,Postoperative Complications ,Randomized controlled trial ,law ,medicine ,Appendectomy ,Humans ,Randomized Controlled Trials as Topic ,business.industry ,Open surgery ,General surgery ,Standard treatment ,Gastroenterology ,Cosmesis ,Recovery of Function ,Length of Stay ,Appendicitis ,Hospital Charges ,Surgery ,Treatment Outcome ,Meta-analysis ,Acute Disease ,Acute appendicitis ,Laparoscopy ,business - Abstract
We conducted a meta-analysis to evaluate and compare the outcomes of laparoscopic and open surgery for the treatment of patients with acute appendicitis. We searched MEDLINE, EMBASE, Science Citation Index, and the Cochrane Controlled Trial Register for relevant papers published between January 1990 and February 2012. We analyzed 22 outcomes of laparoscopic and open surgery for acute appendicitis. We identified 39 papers reporting results from randomized controlled trials that compared laparoscopic surgery with open surgery for acute appendicitis. Our meta-analysis included 5,896 patients with acute appendicitis; 2,847 had undergone laparoscopic surgery, and 3,049 had undergone open surgery. Compared with open surgery, laparoscopic surgery was associated with longer operative time (by 13.12 min). However, compared with open surgery, laparoscopic surgery for acute appendicitis was associated with earlier resumption of liquid and solid intake; shorter duration of postoperative hospital stay; a reduction in dose numbers of parenteral and oral analgesics; earlier return to normal activity, work, and normal life; decreased occurrence of wound infection; a better cosmesis; and similar hospital charges. Laparoscopic surgery may now be the standard treatment for acute appendicitis.
- Published
- 2012
35. Evaluation of the clinicopathologic features of bilateral primary breast cancer patients
- Author
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Takeshi Inoue, Yuko Hukushima, Tetsuro Ikeya, Yoshinari Ogawa, Yukio Nishiguchi, and Katsumi Ikeda
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Primary breast cancer ,business - Published
- 2012
36. A Meta-Analysis of the Short- And Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Open Colectomy for Colon Cancer
- Author
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Hiroshi Ohtani, Yutaka Tamamori, Yuichi Arimoto, Yukio Nishiguchi, Kiyoshi Maeda, Kosei Hirakawa
- Subjects
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Abstract
Purpose: We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer.Methods: We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between January 1990 and October 2011 by using the search terms “laparoscopy,” “laparoscopy-assisted,” “surgery,” “colectomy,” “colon cancer,” and “randomized clinical trials (RCTs)”. We analyzed the outcomes of each type of surgery over short- and long-term periods.Results: We selected 12 papers reporting RCTs that compared LAC with OC for colon cancer. Our meta-analysis included 4614 patients with colon cancer; of these, 2444 had undergone LAC and 2170 had undergone OC. In the short-term period, we found that the rates of overall postoperative complications and ileus in LAC were lower than in OC groups. LAC was associated with a reduction in intraoperative blood loss, a shorter duration of time to resumption and hospital stay, and lower rates of overall complication and ileus over the short-term, but with similar long-term oncologic outcomes such as overall and cancer-related mortality, overall recurrence, local recurrence, distant metastasis, and wound-site recurrence, compared to OC.Conclusions: It is suggested that LAC may be preferred to OC for colon cancer.
- Published
- 2012
37. A Meta-Analysis of the Short- And Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Open Colectomy for Colon Cancer
- Author
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Kiyoshi Maeda, Hiroshi Ohtani, Kosei Hirakawa, Yukio Nishiguchi, Yuichi Arimoto, and Yutaka Tamamori
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Ileus ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,MEDLINE ,medicine.disease ,laparoscopy-assisted colectomy ,Surgery ,law.invention ,meta-analysis ,colon cancer ,Oncology ,Randomized controlled trial ,law ,Meta-analysis ,medicine ,business ,Laparoscopy ,Complication ,Research Paper ,Colectomy - Abstract
Purpose: We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. Methods: We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between January 1990 and October 2011 by using the search terms “laparoscopy,” “laparoscopy-assisted,” “surgery,” “colectomy,” “colon cancer,” and “randomized clinical trials (RCTs)”. We analyzed the outcomes of each type of surgery over short- and long-term periods. Results: We selected 12 papers reporting RCTs that compared LAC with OC for colon cancer. Our meta-analysis included 4614 patients with colon cancer; of these, 2444 had undergone LAC and 2170 had undergone OC. In the short-term period, we found that the rates of overall postoperative complications and ileus in LAC were lower than in OC groups. LAC was associated with a reduction in intraoperative blood loss, a shorter duration of time to resumption and hospital stay, and lower rates of overall complication and ileus over the short-term, but with similar long-term oncologic outcomes such as overall and cancer-related mortality, overall recurrence, local recurrence, distant metastasis, and wound-site recurrence, compared to OC. Conclusions: It is suggested that LAC may be preferred to OC for colon cancer.
- Published
- 2012
38. A long-surviving case of jejunal gastrointestinal stromal tumor with multiple liver metastases treated by combined modality therapy
- Author
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Sadatoshi Shimizu, Takahiro Toyokawa, Yukio Nishiguchi, Akishige Kanazawa, Yoshito Yamashita, and Atsushi Yamamoto
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Combined Modality Therapy ,Stromal tumor ,business - Published
- 2012
39. A role for elastography in the diagnosis of breast lesions by measuring the maximum fat lesion ratio (max-FLR) by tissue Doppler imaging
- Author
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Shinya Tokunaga, Katsumi Ikeda, Tetsuro Ikeya, Yoshinari Ogawa, Kenji Sugano, Mamiko Takii, Teruyuki Ikehara, and Yukio Nishiguchi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,fungi ,food and beverages ,General Medicine ,Breast pathology ,medicine.disease ,Doppler imaging ,Lesion ,Breast cancer ,Oncology ,Surgical oncology ,Needle biopsy ,medicine ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,Elastography ,Radiology ,Ultrasonography ,medicine.symptom ,skin and connective tissue diseases ,business - Abstract
Background The role of elastography for breast tumors is still ambiguous. The purpose of this study was to inquire how effectively elastography can be used in the diagnosis of breast tumors.
- Published
- 2011
40. A CASE OF GASTROCOLIC FISTULA ORIGINATING FROM DESCENDING COLON CANCER DIAGNOSED BY ENDOSCOPIC EXAMINATION
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Yukio Nishiguchi, Atsushi Yamamoto, Teruyuki Ikehara, Takahiro Toyokawa, Ken Inoue, Yoshito Yamashita, and Tohru Inoue
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Gastrocolic fistula ,Radiology ,Descending colon cancer ,business ,Surgery - Abstract
症例は68歳,男性.不消化性の下痢,曖気の精査加療目的で入院となった.腹部CTで下行結腸~脾彎曲にかけて13cm大の腫瘤性病変を認めた.下部消化管内視鏡検査では下行結腸に隆起を主体とする5型病変を認め,ファイバーは潰瘍底より容易に胃内へと挿入された.腫瘍からの生検で高分化型腺癌と診断された.胃結腸瘻を形成した進行下行結腸癌と診断し,左半結腸切除術,D3リンパ節郭清,胃全摘,膵尾部・脾臓合併切除術を施行した.最終診断はmuc,si,n0,ly0,v0,ow(-),aw(-),stageIIで,手術根治度Aであった.われわれは内視鏡が通過することで診断できた胃結腸瘻を形成した下行結腸癌の1例を経験したので,自験例を加えた本邦報告25例の集計および文献的考察を行った.
- Published
- 2011
41. A CASE OF A TRANSVERSE COLON CANCER DURING PREGNANCY
- Author
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Yuichi Arimoto, Toru Inoue, Tatsunari Fukuoka, Yukio Nishiguchi, Yoshito Yamashita, and Teruyuki Ikehara
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,business ,Transverse colon cancer - Abstract
症例は41歳,女性.妊娠28週目に腹痛を認めたため,前医を受診した.精査にて横行結腸癌を疑われたため,当科紹介となった.大腸内視鏡検査にて横行結腸腫瘍を認め,生検にてtub2と診断された.明らかな遠隔転移は認めなかったため,産科医および小児科医との相談の上,妊娠29週であることから,帝王切開術および横行結腸切除術を施行した.帝王切開にては1,280gの女児(Apgar score 8/9)を出産した.病理組織検査にて横行結腸癌(tub2,ss,n2,ly0,v1,H0,P0,M0,Stage IIIb)と診断した.妊娠中に消化器癌を合併する頻度は非常に少なく,なかでも大腸癌は妊娠10万例に1~2例といわれ,非常に稀である.治療方針は妊娠時期や患者および家族の意思を考慮する必要がある.今回妊娠中に切除した横行結腸癌の1例を経験したので,若干の文献的考察を加えて報告する.
- Published
- 2011
42. A Case of Intraductal Tubular Carcinoma (ITC)
- Author
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Zhang Xiang, Tadashi Tsukamoto, Yoshito Yamashita, Teruyuki Ikehara, Yukio Nishiguchi, Takeshi Inoue, Akishige Kanazawa, Sadatoshi Shimizu, Katsunobu Sakurai, and Satoshi Yamamoto
- Subjects
medicine.medical_specialty ,business.industry ,Gastroenterology ,Urology ,medicine ,Surgery ,Tubular carcinoma ,business - Abstract
症例は63歳男性で,急性膵炎を発症し,精査の結果膵体部の主膵管に腫瘍性病変が認められた.膵管内腫瘍または小膵癌の診断のもと膵体尾部切除およびリンパ節郭清を行った.切除標本において,主膵管内に充満するやや白色調の10mm大の腫瘍を認めた.腫瘍内部は異型細胞がスリット状の管腔を有しながら増殖しており,周囲の膵管に乳頭状隆起を伴っていた.膵管内乳頭粘液性腺癌との鑑別に苦慮したが,膵管内管状腺癌と診断した.膵管内管状腫瘍は,2010年に出されたWHO分類ではIntraductal papillary mucinous neoplasm(IPMN)とは別にIntraductal tubulopapillary neoplasm(ITPN)として新しく定義されるようになったが,膵癌取扱い規約第6版では膵管内乳頭粘液性腫瘍に含まれており,その位置づけは明確にされていない.本邦では膵管内管状腺癌は自験例を含め13例の報告をみるにすぎず,臨床病理学的に不明な点が多い.今後さらに症例を蓄積し,病態の検討を重ねていく必要があると考えられた.
- Published
- 2011
43. A CASE OF INTERNAL HERNIA THROUGH THE BROAD LIGAMENT OF THE UTERUS AFTER COLONOFIBERSCOPY
- Author
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Yukio Nishiguchi, Teruyuki Ikehara, Yoshito Yamashita, Toru Inoue, Atsushi Yamamoto, and Tetsuro Ikeya
- Subjects
Internal hernia ,medicine.anatomical_structure ,business.industry ,Uterus ,Medicine ,Anatomy ,business ,Broad ligament - Abstract
症例は58歳,女性.他院にて上行結腸のポリープに対し,大腸内視鏡下ポリープ切除術を施行された.当日夕より腹痛と嘔吐を認めた.間欠的な腹痛の増悪を認めるため,翌日朝に当院救急外来を受診した.来院時の腹部CT検査では明らかなイレウス像を認めなかったが,嘔気と腹痛が持続していたため,経過観察目的にて入院となった.同日夕に腹痛の増悪を認めたため,入院時CT検査より10時間後に腹部CT検査を再度施行した.骨盤内に小腸のループ形成を認め,腹水の貯留も認めたため,内ヘルニアによる絞扼性イレウスの診断にて同日緊急手術を施行した.左子宮広間膜の異常裂孔に小腸が迷入し,終末回腸近傍の小腸が嵌頓しており,虚血性変化をきたしていた.子宮広間膜裂孔を開放し,回盲部切除を行った.大腸内視鏡を契機として発症したと考えられるまれな子宮広間膜ヘルニアの1例を経験したので,若干の文献的考察を交えて報告する.
- Published
- 2011
44. A Meta-Analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Colorectal Cancer
- Author
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Hiroshi Ohtani, Yutaka Tamamori, Yuichi Arimoto, Yukio Nishiguchi, Kiyoshi Maeda, Kosei Hirakawa
- Subjects
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Abstract
Purpose: We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC).Methods: We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each type of surgery over the short- and long-term periods.Results: In the short-term period, we found no significant differences in overall perioperative complications and anastomotic leakage between LCRS and OCRS groups. We found no significant differences in overall, distant, local and wound-site recurrence, overall mortality, 3 and 5 year disease-free survival rate, and cancer-related mortality between the 2 groups.Conclusions: LCRS has the benefits of reducing intraoperative blood loss, earlier resumption of oral intake, and shorter duration of hospital stay in the short-term. The long-term outcomes of LCRS seem to be similar to those of OCRS.
- Published
- 2011
45. Standard Method and Problem of the Creation of End-stoma
- Author
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Toru Inoue, Tatsunari Fukuoka, Atsushi Yamamoto, Teruyuki Ikehara, and Yukio Nishiguchi
- Subjects
medicine.medical_specialty ,Stoma (medicine) ,business.industry ,General surgery ,Gastroenterology ,medicine ,Surgery ,business - Abstract
単孔式のストーマの造設術は,消化器外科手術,とくに大腸外科領域においては基本となる手術手技である.手術手技については施設,術者によって種々報告されているが,明確なエビデンスにもとづいた「標準」といったものはない.現時点での標準と考えられる,単孔式ストーマ造設手術手技について解説する.合併症の少ない,管理しやすい良好な消化管ストーマを造設することは,患者および家族にとってとても重要であり,すべての外科医が会得すべき手技である.
- Published
- 2011
46. A CASE OF AFFERENT LOOP OBSTRUCTION ASSOCIATED WITH REMNANT GASTRIC CANCER
- Author
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Atsushi Yamamoto, Teruyuki Ikehara, Takahiro Toyokawa, Yoshito Yamashita, Tohru Inoue, and Yukio Nishiguchi
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,medicine ,Afferent loop ,Cancer ,business ,medicine.disease - Abstract
症例は62歳,男性.37年前に十二指腸潰瘍に対して胃切除術の既往がある.1カ月前から嘔気・嘔吐を認めるようになり近医受診した.腹部CTで吻合部に腫瘤影と輸入脚の著明な拡張を認めた.同日の上部消化管内視鏡検査では吻合部に全周性の3型腫瘍を認め,残胃癌による輸入脚閉塞症と診断し緊急手術を施行した.前回手術はBillroth-II法の結腸後経路で再建されており,Treitz靱帯から吻合部の空腸は暗赤色を呈し著明に拡張していた.残胃全摘術,膵尾部・脾臓合併切除術を施行した.治癒切除であったが,術後3カ月で胃癌死された.残胃癌による輸入脚閉塞症の本邦論文報告7例について,集計および文献的考察を行った.
- Published
- 2011
47. A case of neuroendocrine carcinoma originating from the pancreas with multiple liver metastasis resected after chemotherapy with etoposide and cisplatin
- Author
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Shintaro Kodai, Yoshito Yamashita, Sadatoshi Shimizu, Yuichi Arimoto, Akishige Kanazawa, Satoshi Yamamoto, Katsunobu Sakurai, Tadashi Tsukamoto, and Yukio Nishiguchi
- Subjects
Cisplatin ,Oncology ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Urology ,medicine.disease ,Metastasis ,medicine.anatomical_structure ,Pancreatic tumor ,Internal medicine ,medicine ,Neuroendocrine carcinoma ,Pancreas ,business ,Etoposide ,medicine.drug - Abstract
症例は34歳,男性.腹痛を自覚し近医を受診した.腹部超音波検査,腹部CT検査にて膵鈎部尾側に4cm大の腫瘤と多発肝腫瘍を認めた.同病院にて試験開腹術を施行し,術中診断は膵腫瘍及び多発肝転移であった.術中に施行した肝生検の組織診断は高分化型膵内分泌細胞癌であった.術後軽快退院後,当院を紹介受診した.血液検査所見では血中インスリン値,ガストリン値,グルカゴン値は正常範囲内であった.以上より,非機能性膵内分泌細胞癌の多発肝転移と診断し,etoposide(ETP)とcisplatin(CDDP)による化学療法を行った.化学療法後の腹部CT検査では膵腫瘍と肝転移巣の増大はなく,新たな肝転移巣も認めず,肉眼的に切除可能と判断し,幽門輪温存膵頭十二指腸切除術,横行結腸部分切除術及び肝部分切除術を施行した.切除標本の病理組織診断は高分化型膵内分泌癌であり,免疫組織学的にはsynaptophysin(+), chromograninA(-),glucagon(+),serotonin(-),insulin(-),SSTR2a(+)であった.術後14カ月後の現在,残肝再発を認めるも健存中である.
- Published
- 2011
48. Two Cases of Breast Cancer with Cartilaginous and Osseous Metaplasia
- Author
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Tatsunari Fukuoka, Yuki Kubo, Yukio Nishiguchi, Katsumi Ikeda, Mamiko Takii, Teruyuki Ikehara, Takeshi Inoue, and Yoshinari Ogawa
- Subjects
Oncology ,Pathology ,medicine.medical_specialty ,Breast cancer ,business.industry ,Internal medicine ,medicine ,Osseous metaplasia ,medicine.disease ,business - Published
- 2010
49. A case of colon metastasis after resection of bladder cancer
- Author
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Kosei Hirakawa, Kiyoshi Maeda, Tatsunari Fukuoka, Yukio Nishiguchi, Eiji Noda, and Toru Inoue
- Subjects
Oncology ,medicine.medical_specialty ,Bladder cancer ,business.industry ,Internal medicine ,medicine ,medicine.disease ,business ,Metastasis ,Resection - Published
- 2010
50. A CASE OF NEUROENDOCRINE CARCINOMA ORIGINATING FROM THE PAPILLA VATER OF THE DUODENUM
- Author
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Tadashi Tsukamoto, Yoshito Yamashita, Katsunobu Sakurai, Sadatoshi Shimizu, Akishige Kanazawa, and Yukio Nishiguchi
- Subjects
Major duodenal papilla ,medicine.medical_specialty ,Pathology ,medicine.anatomical_structure ,business.industry ,General surgery ,medicine ,Duodenum ,Neuroendocrine carcinoma ,business - Abstract
稀な十二指腸乳頭部神経内分泌細胞癌の1例を経験したので報告する.症例は78歳,女性.肝機能異常を指摘され当院を紹介受診した.腹部CT検査で膵頭部に1.5cm大の腫瘤と肝内胆管の拡張を認め,精査加療目的に入院となった.上部消化管内視鏡検査で十二指腸乳頭部の粘膜の不整を認めた.同部の生検組織の免疫染色でCD56,synaptophysin,chromogranin Aが陽性で,神経内分泌細胞由来と考えられた.リンパ節郭清を伴う幽門輪温存膵頭十二指腸切除術を行った.病理組織検査結果は十二指腸乳頭部の神経内分泌腫瘍で,Ki-67/MIB1指数は低く,リンパ節転移を認めたため高分化型神経内分泌癌と診断された.患者は術後1年4カ月の現在,無再発健存中である.
- Published
- 2010
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