18 results on '"Yukie Hashimoto"'
Search Results
2. Morphological Changes of the Filamentous FungusMucor Mucedoand Inhibition of Chitin Synthase Activity Induced by Anethole
- Author
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Masahiro Yutani, Toshio Tanaka, Isao Kubo, Ken-ichi Fujita, Yukie Hashimoto, and Akira Ogita
- Subjects
Pharmacology ,Hypha ,biology ,fungi ,Polygodial ,Chitin synthase ,biology.organism_classification ,Yeast ,Microbiology ,Cell wall ,Mucor mucedo ,chemistry.chemical_compound ,Biochemistry ,chemistry ,biology.protein ,Candida albicans ,Anethole - Abstract
trans-Anethole (anethole), a major component of anise oil, has a broad antimicrobial spectrum with antimicrobial activity relatively weaker than those of well-known antibiotics, and significantly enhances the antifungal activity of polygodial and dodecanol against the baker's yeast Saccharomyces cerevisiae and human pathogenic yeast Candida albicans. However, the antifungal mechanism of anethole is unresolved. Anethole demonstrated antifungal activity against the filamentous fungus, Mucor mucedo IFO 7684, accompanied by hyphal morphological changes such as swollen hyphae at the tips. Its minimum growth inhibitory concentration was 0.625 mm. A hyperosmotic condition (1.2 m sorbitol) restricted the induction of morphological changes, while hypoosmotic treatment (distilled water) induced bursting of hyphal tips and leakage of cytoplasmic constituents. Furthermore, anethole dose-dependently inhibited chitin synthase (CHS) activity in permeabilized hyphae in an uncompetitive manner. These results suggest that the morphological changes of M. mucedo could be explained by the fragility of cell walls caused by CHS inhibition. Copyright © 2011 John Wiley & Sons, Ltd.
- Published
- 2011
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3. Study to Find Out What We Need to Do for Dietary Education for Female Japanese Urban and Suburban Adolescents
- Author
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Masako, YOKOTSUKA, Mariko, WATANABE, Yukie, HASHIMOTO, Nobuko, HIRATSUKA, Yuko, ARAI, Terumi, SUZUKI, Shoko, TAMAI, Naoyuki, FUJITA, Asami, KANEDA, Kazuki, ASO, and Naomi, ABE
- Subjects
dietary education ,食育 ,地方都市と大都市 ,suburban and urban areas ,女子生徒 ,schoolgirls - Abstract
OBJECTIVE: In this study we investigated dietary consciousness, dietary behavior, dietary environments, life-style and subjects evaluation of their own health in Japanese urban and suburban adolescents to get ideas for improving dietary education for these groups.METHODS: The survey was conducted in October and November, 2006. Participant: The subjects were 262 urban junior high school girls (Age 13-14 yrs) and 220 suburban junior high school girls (Age 12-14 yrs). Measure: 1.The questionnaire consisted of 76 questions related to subjects dietary behavior, dietary environments, lifestyles, and their evaluation of their own health.2.Age, height and body weight were measured by their teacher. Subjects body weight was checked using the TANITA scale. And subjects BMI was calculated based on the degree of obesity as established by the Japan Society for the Study of Obesity. RESULTS 1.In urban areas a lot of students thought that they are overweight. They perceived themselves to be overweight even when they were not.2.More students in urban areas than in suburban areas did not understand how much one should eat and what would constitute overeating. 3.More than 50% of both suburban and urban subjects reported feeling irritated. Subjects also reported experiencing headaches, stiff shoulders, and backaches.4.All subjects reported being basically satisfied with their lives and families.5.Significantly fewer urban subjects than suburban subjects reported having breakfast and supper with their families. 6.50% of both groups reported having conversations with their families during meals and that they are happy at home.
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- 2008
4. Comparison of Male and Female Adolescents to Understand What We Need to Do in Dietary Education in Japanese Suburban Areas
- Author
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Yukie, HASHIMOTO, Mariko, WATANABE, Masako, YOKOTSUKA, Nobuko, HIRATSUKA, Yuko, ARAI, Terumi, TSUZUKI, Shoko, TAMAI, Naoyuki, FUJITA, Asami, KANEDA, and Kazuki, ASO
- Subjects
dietary education ,食育 ,男子・女子中学生 ,male and female junior high school students ,食行動 ,dietary behavior - Abstract
OBJECTIVE: We investigated dietary consciousness, dietary behavior, dietary environment and students feeling about their own health in Japanese male and female junior high school students, and examined the differences and similarities between the two gender groups to understand what we need to do in dietary education. METHODS: The survey was conducted during the month of October, 2006. Participants: The subjects were 477 junior high school boys (257) and girls (220) (age 12-14 years). Measure:1.We gave subjects a questionnaire of 68 questions asking about their perceptions of their own weight, dietary consciousnesses, dietary behavior, dietary environment, how healthy they believed themselves to be, and their lifestyles.2.Age, height and body weight were measured or supplied by the subjects teachers. Subjects whose weight was greater than or equal to 120% of the baseline degree of obesity as determined by the Ministry of Education were considered to have a tendency toward obesity, and subjects whose weight was less than or equal to 80% of the Ministry of Educations baseline degree of obesity were considered underweight. The TANITA scale was used and BMI was calculated based on the degree of obesity as established by the Japan Society for the Study of Obesity. RESULTS:1.Significant differences were observed between the two gender groups in the disparities between their classification of their own body types and their actual BMI scores (p
- Published
- 2008
5. Learning curve of video-assisted thoracoscopic esophagectomy and extensive lymphadenectomy for squamous cell cancer of the thoracic esophagus and results
- Author
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H. Osugi, Masayuki Higashino, Yoshinori Tanaka, Yushi Fujiwara, Yukie Hashimoto, Sigeru Lee, Nobuyasu Takada, Haruhito Kinoshita, Masashi Takemura, Kennichirou Fukuhara, and Masakatsu Ueno
- Subjects
Adult ,Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Blood Loss, Surgical ,medicine ,Thoracoscopy ,Humans ,Learning ,Esophagus ,Aged ,Aged, 80 and over ,Analysis of Variance ,medicine.diagnostic_test ,Thoracic Surgery, Video-Assisted ,Esophageal disease ,business.industry ,Cancer ,Middle Aged ,Esophageal cancer ,medicine.disease ,Surgery ,Esophagectomy ,medicine.anatomical_structure ,Epidermoid carcinoma ,Carcinoma, Squamous Cell ,Lymph Node Excision ,Female ,Lymphadenectomy ,business - Abstract
Background: The efficacy of thoracoscopic radical esophagectomy for cancer of the thoracic esophagus and the learning curve required have yet to be clearly established. Methods: Eighty treatment-naive patients with esophageal cancer without contiguous spread underwent esophageal mobilization and extensive mediastinal lymphadenectomy through a 5-cm minithoracotomy and four trocar ports. The outcomes in the first 34 patients (group 1) and the last 46 patients (group 2) were compared. Results: There were no differences in background or clinicopathologic factors between the two groups. The duration of the thoracoscopic procedure and blood loss were less (p
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- 2003
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6. Video-assisted thoracoscopic esophagectomy and radical lymph node dissection for esophageal cancer
- Author
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Masayuki Higashino, Nobuyasu Takada, Masakatsu Ueno, Hiroaki Kinoshita, H. Osugi, Yukie Hashimoto, Masashi Takemura, Sigeru Lee, Yushi Fujiwara, Yoshinori Tanaka, and Kennichirou Fukuhara
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medicine.medical_specialty ,medicine.diagnostic_test ,Esophageal disease ,business.industry ,medicine.medical_treatment ,Radical Lymph Node Dissection ,Esophageal cancer ,medicine.disease ,Surgery ,Esophagectomy ,Cardiothoracic surgery ,medicine ,Thoracoscopy ,Lymphadenectomy ,business ,Abdominal surgery - Abstract
Background: The efficacy of thoracoscopic radical esophagectomy for cancer has yet to be established, mainly because previous reports have not included a sufficient number of cases. Methods: Seventy-five treatment-naive patients with esophageal cancer without contiguous spread underwent esophageal mobilization and extensive mediastinal lymphadenectomy through a 5-cm mini-thoracotomy and four trocar ports. Results: Video-assisted thoracoscopic surgery was performed without major intraoperative complications or emergency conversion to open surgery. We retrieved 34.1±13.0 mediastinal nodes, including 11.5±3.8 tracheobronchial nodes and 6.2±3.0 recurrent laryngeal nodes. Mean time of operation and blood loss were less in the last 39 patients than the first 36 (186.7±25.3 min and 165.4±101.8 g vs 270. 2±96.0 min and 421.5±31.2 g, respectively: p
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- 2002
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7. Seasonal cycle of water storage in major river basins of the world
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Yukie Hashimoto, Kooiti Masuda, Taikan Oki, and Hiroshi Matsuyama
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Hydrology ,Wet season ,geography ,geography.geographical_feature_category ,Water storage ,Northern Hemisphere ,Drainage basin ,Tropics ,Water balance ,Geophysics ,Temperate climate ,General Earth and Planetary Sciences ,Environmental science ,Surface runoff - Abstract
The seasonal cycle of water storage of each of the 70 major river basins of the world is evaluated by means of basin-atmosphere water budgets. The atmospheric data of National Centers for Environmental Prediction (NCEP) Reanalysis is used together with river runoff data. In the tropics and in the temperate zone of East Asia, storage becomes largest at the end of the rainy season and smallest at the beginning of the rainy season. In the cold region and in the temperate zone of North America, storage becomes largest in spring and smallest in summer or autumn. The global sum of storage becomes largest in spring of the northern hemisphere, when the contribution of the northern cold region and the southern tropics coincide.
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- 2001
- Full Text
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8. Recurrent Anterior Dislocation of Shoulder in the Aged: A Report of Two Cases
- Author
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Kenichiro Miyazaki, Yukie Hashimoto, Toyoaki Yamanouchi, Kenji Yoshida, and Kimiaki Sato
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medicine.medical_specialty ,business.industry ,Dislocation (syntax) ,Medicine ,business ,Surgery - Published
- 2000
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9. Autologous Blood Predeposit before Surgery of Hip and Knee
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Fujio Higuchi, Yukie Hashimoto, Yoshiyuki Saito, Naoto Sato, and Akio Inoue
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medicine.medical_specialty ,Erythropoietin ,business.industry ,Anesthesia ,medicine.medical_treatment ,Autologous blood ,medicine ,business ,Arthroplasty ,medicine.drug ,Surgery ,Autotransfusion - Abstract
We retrospectively studied autologous blood transfusion in 65 cases of hip and knee arthroplasty. The cases consisted of 10 males and 45 females whose age ranged from 34 to 81, with an average age of 61.3 years.Autologous blood was preserved by liquid, and in 35 cases, Erythropoietin (EPO) was intravenously administrated 3 times a week.We have been performing autologous blood transfusion on patients treated with hip and knee arthroplasty since 1990, and the method allows us to avoid homologous transfusion in 88.9% of our patients.
- Published
- 1998
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10. Patellar Revision Following Total Knee Arthroplasty
- Author
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Kenichro Miyazaki, Iwao Yanagida, Yukie Hashimoto, Hiroteru Takamori, Kensuke Yamanaka, and Masashi Sagara
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musculoskeletal diseases ,Subluxation ,Orthodontics ,Patellar subluxation ,business.industry ,medicine.medical_treatment ,Total knee arthroplasty ,Patellofemoral disorders ,Extensor mechanism ,musculoskeletal system ,medicine.disease ,Prosthesis ,Condyle ,medicine ,Patella fracture ,business ,human activities - Abstract
Eight knees with patellofemoral disorders following total knee arthroplasty had patellar revision surgery including proximal realignment of the extensor mechanism using the Insall procedure. The primary prosthesis was the Miller-Galante 1 (MG1) in seven knees and the Press Fit Condylar in one. Patellar dislocation occurred in three knees, patellar subluxation in two, patellar lateralization in two and patellar fractures in one. The MG1 prosthesis in four knees (2 subluxation and 2 lateralization), the metal-backed patellar implants failed because polyethylene wear or fracture exposed the metal backing.Revision of a failed patellar prosthesis is difficult. Complications occurred in three of the eight patients. There was a patellar fracture in two patients and patellar subluxation in one.With the current use of total condylar prosthesis that have improved design and instrumentation, patellofemoral complications following total knee arthroplasty can be best avoided by meticulous operative technique.
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- 1997
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11. Morphological changes of the filamentous fungus Mucor mucedo and inhibition of chitin synthase activity induced by anethole
- Author
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Masahiro, Yutani, Yukie, Hashimoto, Akira, Ogita, Isao, Kubo, Toshio, Tanaka, and Ken-ichi, Fujita
- Subjects
Chitin Synthase ,Fungal Proteins ,Antifungal Agents ,Cell Membrane Permeability ,Cell Wall ,Mucor ,Hyphae ,Allylbenzene Derivatives ,Microbial Sensitivity Tests ,Anisoles - Abstract
trans-Anethole (anethole), a major component of anise oil, has a broad antimicrobial spectrum with antimicrobial activity relatively weaker than those of well-known antibiotics, and significantly enhances the antifungal activity of polygodial and dodecanol against the baker's yeast Saccharomyces cerevisiae and human pathogenic yeast Candida albicans. However, the antifungal mechanism of anethole is unresolved. Anethole demonstrated antifungal activity against the filamentous fungus, Mucor mucedo IFO 7684, accompanied by hyphal morphological changes such as swollen hyphae at the tips. Its minimum growth inhibitory concentration was 0.625 mM. A hyperosmotic condition (1.2 M sorbitol) restricted the induction of morphological changes, while hypoosmotic treatment (distilled water) induced bursting of hyphal tips and leakage of cytoplasmic constituents. Furthermore, anethole dose-dependently inhibited chitin synthase (CHS) activity in permeabilized hyphae in an uncompetitive manner. These results suggest that the morphological changes of M. mucedo could be explained by the fragility of cell walls caused by CHS inhibition.
- Published
- 2010
12. ChemInform Abstract: The First Anionic Sulfonamide-Binding Zinc(II) Complexes with a Macrocyclic Triamine: Chemical Verification of the Sulfonamide Inhibition of Carbonic Anhydrase
- Author
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Ikushi Nakamura, Eiichi Kimura, Motoo Shiro, Tohru Koike, and Yukie Hashimoto
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chemistry.chemical_classification ,chemistry ,biology ,Stereochemistry ,Carbonic anhydrase ,biology.protein ,chemistry.chemical_element ,General Medicine ,Crystal structure ,Zinc ,Medicinal chemistry ,Sulfonamide - Abstract
A zinc(II) complex with 1-(3-(p-toluensulfonamido)propyl)-1,5,9-triazacycloundecane («tosylamidopropyl[12]aneN 3 », L 2 ), has been synthesized as a model for sulfonamide inhibition of carbonic anhydrase (CA). X-ray crystal structure analysis showed a distorted tetrahedral structure.
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- 2010
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13. The first anionic sulfonamide-binding zinc(II) complexes with a macrocyclic triamine: chemical verification of the sulfonamide inhibition of carbonic anhydrase
- Author
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Yukie Hashimoto, Motoo Shiro, Ikushi Nakamura, Eiichi Kimura, and Tohru Koike
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chemistry.chemical_classification ,biology ,chemistry.chemical_element ,General Chemistry ,Zinc ,Crystal structure ,Biochemistry ,Catalysis ,Sulfonamide ,Crystallography ,Colloid and Surface Chemistry ,Enzyme ,chemistry ,Carbonic anhydrase ,Enzyme model ,X-ray crystallography ,biology.protein ,Molecule - Abstract
A zinc(II) complex with 1-(3-(p-toluensulfonamido)propyl)-1,5,9-triazacycloundecane («tosylamidopropyl[12]aneN 3 », L 2 ), has been synthesized as a model for sulfonamide inhibition of carbonic anhydrase (CA). X-ray crystal structure analysis showed a distorted tetrahedral structure.
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- 1992
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14. Osteomyelitis after Surgical Treatment for a Trochanteric Fracture. A Report of Two Cases
- Author
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Kimiaki Sato, Kenji Tanaka, Hiroyuki Araki, Yukie Hashimoto, and Takuya Watanabe
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medicine.medical_specialty ,Medullary cavity ,business.industry ,medicine.medical_treatment ,Osteomyelitis ,Granulation tissue ,Femoral fracture ,medicine.disease ,Curettage ,Surgery ,law.invention ,Intramedullary rod ,medicine.anatomical_structure ,law ,medicine ,Femur ,Implant ,business - Abstract
Between January 1996 and December 1998, we treated 76 cases of trochanteric femoral fracture. The patients included 16 males and 60 females, with a mean age of 82 years. 22 cases with stable fracture were treated using a compression hip screw (CHS), and the other 54 cases with unstable fracture were treated using an intramedullary hip screw (IMHS). As post operative complications, osteomyelitis occurred in 2 cases after IMHS. They were delayed infections, occurring approximately at 5 months and at 15 months after IMHS. For treatment, we performed removal of the implant, curettage of the focus, closed continuous irrigation, followed by general infusion of antibiotics. In one case, the organism was Methicillin-resistant Staphylococcus aureus (MRSA), and in another case, the organism was Acinetobacter calcoaceticus in laboratory cultures. The case with MRSA additionally underwent local irrigation and hyperbaric oxygenation (HBO) therapy because the wound was dehiscent and a marrow cavity in the femur was exposed. A split-thickness skin graft was performed after filling up the dead space with granulation tissue. 2 cases were successfully treated.
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- 2000
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15. Surgical repair of esophagobronchial fistula caused by radiation injury
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Kenichiro, Fukuhara, Harushi, Osugi, Taigo, Tokuhara, Nobuyasu, Takada, Masashi, Takemura, Shigeru, Lee, Masakatsu, Ueno, Yoshinori, Tanaka, Yushi, Fujiwara, Satoshi, Nishizawa, Yukie, Hashimoto, and Hiroaki, Kinoshita
- Subjects
Male ,Esophageal Fistula ,Esophageal Neoplasms ,Radiotherapy ,Carcinoma, Squamous Cell ,Humans ,Bronchial Fistula ,Middle Aged ,Radiation Injuries - Abstract
We present an unusual case of a benign esophagobronchial fistula caused by radiotherapy to treat esophageal carcinoma which was closed successfully. A 62-year-old man with superficial squamous cell carcinoma of the esophagus underwent radiotherapy, including 60 Gy externally and 10 Gy intraluminally from January to March 1995. Esophagography revealed a fistula between the esophagus and left main stem bronchus on January 14, 1996. No residual cancer existed. Neither stenting with a silicone tube nor with a covered flexible metallic stent occluded the fistula. Thoracic esophagectomy, closure of the esophagobronchial fistula using a 2-cm nubbin of esophageal wall, surrounding the orifice of the fistula and antesternal gastric pull-through reconstruction with mediastinal lymphadenectomy were performed. The postoperative course was uneventful and there is no evidence of recurrence of the fistula or the cancer 5 years postoperatively. Radiotherapy may cause esophagobronchial fistula even in cases of superficial esophageal cancer. Bypass surgery should be considered because stenting is not effective for benign fistula without stricture.
- Published
- 2004
16. Causes of death and pattern of recurrence after esophagectomy and extended lymphadenectomy for squamous cell carcinoma of the thoracic esophagus
- Author
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Yoshinori Tanaka, Masashi Takemura, Hiroaki Kinoshita, Masayuki Higashino, Harushi Osugi, Nobuyasu Takada, Masakatsu Ueno, Yushi Fujiwara, Kennichirou Fukuhara, Yukie Hashimoto, and Sigeru Lee
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Male ,Cancer Research ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Cause of Death ,Adjuvant therapy ,Medicine ,Humans ,Neoplasm Invasiveness ,Esophagus ,Aged ,Demography ,Neoplasm Staging ,Performance status ,business.industry ,Esophageal disease ,General Medicine ,Esophageal cancer ,Middle Aged ,Thorax ,medicine.disease ,Prognosis ,Surgery ,Esophagectomy ,medicine.anatomical_structure ,Oncology ,Epidermoid carcinoma ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Lymph Node Excision ,Lymphadenectomy ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Improved understanding of how esophageal cancer behaves following curative resection, including knowledge of other causes of death, is essential for informed decision making. The medical records of 246 consecutive patients with squamous cell carcinoma of the thoracic esophagus who had undergone esophagectomy and lymphadenectomy of the neck, chest, and abdomen that was deemed macroscopically curative, were reviewed. Patients who had had other malignancies or anticancer treatment were excluded. Median follow-up period was 1289 days (minimum, 730 days). The initial patterns of recurrence were classified as intramediastinal, hematogenous, or lymphatic. Forty-two patients died of a cause other than recurrence. The in-hospital death rate was 3.6%, and 19 patients died of pulmonary disease. Sixteen patients developed a second primary, most of which were in the upper aerodigestive tract; five of those patients died. Ninety-eight patients developed recurrence. Depth of invasion and number of nodal metastases predicted recurrence. The pattern of recurrence was intra-mediastinal, lymphatic, and hematogenous in 11, 21, and 67 patients, respectively. The patients with lymphatic recurrence survived longer than the patients with either of the other types of recurrences. Eighty-three percent of recurrences presented within 24 months. The time-to-recurrence correlated with survival after recurrence. The disease recurred earlier in patients with advanced stage than unadvanced disease at the time of esophagectomy. The time-to-recurrence, and anticancer therapy after the recurrence related to the survival. Meticulous care must be taken to detect hematogenous recurrence as early as possible so that adjuvant therapy may be started. Maintaining a good performance status permits the use of aggressive therapy should there be a recurrence. Pulmonary physiotherapy and treatment of metachronous primary tumors may improve overall survival.
- Published
- 2002
17. [A case of gastric cancer in the stomach wall used for mediastinal reconstruction after esophagectomy in which surgery was abandoned due to advanced age and complications but TS-1 was useful]
- Author
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Masashi, Takemura, Harushi, Osugi, Nobuyasu, Takada, Sigeru, Lee, Masakatsu, Ueno, Yoshinori, Tanaka, Kenichirou, Fukuhara, Yuuji, Fujiwara, Satoshi, Nishizawa, Yukie, Hashimoto, and Hiroaki, Kinoshita
- Subjects
Male ,Antimetabolites, Antineoplastic ,Esophageal Neoplasms ,Pyridines ,Mediastinum ,Drug Administration Schedule ,Esophagectomy ,Drug Combinations ,Oxonic Acid ,Stomach Neoplasms ,Esophagoplasty ,Carcinoma, Squamous Cell ,Humans ,Aged ,Tegafur - Abstract
The patient was a 78-year-old man. Gastric cancer, type 3, was diagnosed by endoscopy in the subtotal stomach used for posterior mediastinal reconstruction after resection of thoracic esophageal cancer. Surgery was not considered to be feasible in this case because of cerebral infarction and decreased pulmonary functions; instead, the patient received TS-1 chemotherapy. Drug administration was started at the dose of 100 mg/day, one level lower than the standard dose of TS-1. Reduction in tumor size was noted endoscopically during the first course of treatment. At the end of the 4th course of treatment, the ulcerous lesion was found to have disappeared almost completely, and only mild mural irregularity was noted. The incidence of gastric cancer in the stomach tissue used for mediastinal reconstruction after esophagectomy has been reported to be 0.8%. In many of these cases, the cancer is already advanced at the time of diagnosis, precluding surgical resection. In this situation, chemotherapy with TS-1 is expected to be an effective method of treatment that can be administered at home in elderly patients with a variety of complications.
- Published
- 2002
18. Involvement of inhibition of chitin synthase activity in anethole-induced morphological changes of filamentous fungus Mucor mucedo
- Author
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Yukie, Hashimoto, primary, Ogita, Akira, additional, Tanaka, Toshio, additional, and Fujita, Ken-ichi, additional
- Published
- 2008
- Full Text
- View/download PDF
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