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319 results on '"Yuki, Takafumi"'

6. Bleeding Risk Related to Upper Gastrointestinal Endoscopic Biopsy in Patients Receiving Antithrombotic Therapy: A Multicenter Prospective Observational Study

Author

Yuki, Takafumi, Ishihara, Shunji, Yashima, Kazuo, Kawaguchi, Koichiro, Fujishiro, Hirofumi, Miyaoka, Youichi, Yuki, Mika, Kushiyama, Yoshinori, Yasugi, Akiko, Shabana, Michiko, Furuta, Koichirou, Tanaka, Kiwamu, Koda, Masaharu, Hamamoto, Tetsuro, Sasaki, Yuichiro, Tanaka, Hisao, Yoshimura, Teiji, Murawaki, Yoshikazu, Isomoto, Hajime, and Kinoshita, Yoshikazu

Published
2017
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9. A multicenter prospective study of the treatment and outcome of patients with gastroduodenal peptic ulcer bleeding in Japan

Author

Kawaguchi, Koichiro, primary, Yoshida, Akira, additional, Yuki, Takafumi, additional, Shibagaki, Kotaro, additional, Tanaka, Hisao, additional, Fujishiro, Hirofumi, additional, Miyaoka, Youichi, additional, Yanagitani, Atsushi, additional, Koda, Masaharu, additional, Ikuta, Yukihiro, additional, Hamamoto, Tetsuro, additional, Mukoyama, Tomoyuki, additional, Sasaki, Yuichiro, additional, Kushiyama, Yoshinori, additional, Yuki, Mika, additional, Noguchi, Naoya, additional, Miura, Masahiko, additional, Ikebuchi, Yuichiro, additional, Yashima, Kazuo, additional, Kinoshita, Yoshikazu, additional, Ishihara, Shunji, additional, and Isomoto, Hajime, additional

Published
2022
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18. Increased expression of midkine in the rat colon during healing of experimental colitis

Author

Yuki, Takafumi, Ishihara, Shunji, Rumi, M.A.K., Ortega-Cava, Cesar F., Kadowaki, Yasunori, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Moriyama, Nobuyuki, and Kinoshita, Yoshikazu

Subjects
Colitis -- Care and treatment, Colitis -- Physiological aspects, Colitis -- Health aspects, Cell proliferation -- Research, Protein tyrosine kinase -- Research, Biological sciences
Abstract

Midkine (MK) is a unique growth and differentiation factor that modulates the proliferation and migration of various cells; however, little is known regarding its relationship to intestinal diseases. The aim of this study was to investigate MK expression and its role in dextran sulfate sodium (DSS)-induced colitis in rats. The expressions of MK, receptor-like protein-tyrosine phosphatase (RPTP)-[beta], and proinflammatory cytokines were examined in rat colonic tissues after the development of DSS-induced colitis using Northern blotting, immunohistochemistry, and laser-capture microdissection (LCM) coupled with RT-PCR. The effects of MK on the migration of intestinal epithelial cells (IEC-6) were also evaluated in vitro using an intestinal wound repair model. MK expression was significantly increased in damaged colonic mucosa, mainly from day 3 to day 5 after the end of DSS administration, with abundant MK immunoreactive signals detected in submucosal fibroblasts. Expressions of proinflammatory cytokines were most strongly induced on day 1, which preceded the augmentation of MK expression. Results of LCM coupled with RT-PCR clearly indicated RPTP-[beta] expression in colonic epithelial cells. The migration assay showed that wound repair in the MK-treated groups was accelerated dose dependently. The present results showed for the first time that intestinal inflammation upregulates the MK-RPTP-[beta] system, which may stimulate mucosal regeneration during the process of healing of colitis. Additional investigations regarding the role of MK may contribute to the development of new options for the treatment of inflammatory bowel diseases. receptor-like protein-tyrosine phosphatase-[beta]; proinflammatory cytokines; inflammatory bowel diseases; dextran sulfate sodium-induced colitis

Published
2006

19. A multicenter retrospective study of the esophageal triamcinolone acetonide-filling method in patients with extensive esophageal endoscopic submucosal dissection

Author

Kotani, Satoshi, primary, Shibagaki, Kotaro, additional, Yuki, Takafumi, additional, Aimi, Masahito, additional, Mikami, Hironobu, additional, Izumi, Daisuke, additional, Yamashita, Noritsugu, additional, Takahashi, Yusuke, additional, Fukuba, Nobuhiko, additional, Ishimura, Norihisa, additional, and Ishihara, Shunji, additional

Published
2021
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25. Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Author

Nakahara, Ryotaro, primary, Amano, Yuji, additional, Murakami, Daisuke, additional, Ogawa, Sayaka, additional, Ujihara, Tetsuro, additional, Iwaki, Tomoyuki, additional, Katsuyama, Yasushi, additional, Hayasaka, Kenji, additional, Harada, Hideaki, additional, Tada, Yasumasa, additional, Yuki, Takafumi, additional, Miyaoka, Youichi, additional, Kushiyama, Yoshinori, additional, Fujishiro, Hirofumi, additional, and Ishihara, Shunji, additional

Published
2020
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26. Sa1876 LOW FECAL CALPROTECTIN LEVEL PREDICTS HISTOLOGICAL HEALING AND PROLONGED CLINICAL REMISSION IN ULCERATIVE COLITIS PATIENTS WITH CLINICAL REMISSION AND MUCOSAL HEALING

Author

Kawashima, Kousaku, primary, Oshima, Naoki, additional, Yuki, Takafumi, additional, Kotani, Satoshi, additional, Sonoyama, Hiroki, additional, Oka, Akihiko, additional, Fukuba, Nobuhiko, additional, Mishima, Yoshiyuki, additional, Kazumori, Hideaki, additional, Ishikawa, Noriyoshi, additional, Maruyama, Riruke, additional, Kinoshita, Yoshikazu, additional, and Ishihara, Shunji, additional

Published
2020
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27. Magnification endoscopy in combination with acetic acid enhancement and narrow-band imaging for the accurate diagnosis of colonic neoplasms

Author

Shibagaki, Kotaro, additional, Ishimura, Norihisa, additional, Yuki, Takafumi, additional, Taniguchi, Hideaki, additional, Aimi, Masahito, additional, Kobayashi, Keita, additional, Kotani, Satoshi, additional, Yazaki, Tomotaka, additional, Yamashita, Noritsugu, additional, Tamagawa, Yuji, additional, Mishiro, Tsuyoshi, additional, Ishihara, Shunji, additional, Yasuda, Akira, additional, and Kinshita, Yoshikazu, additional

Published
2020
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28. Prospective multicenter study of the esophageal triamcinolone acetonide‐filling method in patients with subcircumferential esophageal endoscopic submucosal dissection

Author

Shibagaki, Kotaro, primary, Yuki, Takafumi, additional, Taniguchi, Hideaki, additional, Aimi, Masahito, additional, Miyaoka, Yoichi, additional, Yuki, Mika, additional, Ishimura, Norihisa, additional, Oshima, Naoki, additional, Mishiro, Tsuyoshi, additional, Tamagawa, Yuji, additional, Mikami, Hironobu, additional, Izumi, Daisuke, additional, Yamashita, Noritsugu, additional, Sato, Shuichi, additional, Ishihara, Shunji, additional, and Kinoshita, Yoshikazu, additional

Published
2020
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34. Magnification endoscopy in combination with acetic acid enhancement and narrow-band imaging for the accurate diagnosis of colonic neoplasms

Author

SHIBAGAKI, Kotaro, Ishimura, Norihisa, Yuki, Takafumi, Taniguchi, Hideaki, Aimi, Masahito, Kobayashi, Keita, KOTANI, Satoshi, YAZAKI, Tomotaka, Yamashita, Noritsugu, Tamagawa, Yuji, MISHIRO, Tsuyoshi, Ishihara, Shunji, Yasuda, Akira, Kinshita, Yoshikazu, SHIBAGAKI, Kotaro, Ishimura, Norihisa, Yuki, Takafumi, Taniguchi, Hideaki, Aimi, Masahito, Kobayashi, Keita, KOTANI, Satoshi, YAZAKI, Tomotaka, Yamashita, Noritsugu, Tamagawa, Yuji, MISHIRO, Tsuyoshi, Ishihara, Shunji, Yasuda, Akira, and Kinshita, Yoshikazu

Published
2020

38. Interobserver variation in the endoscopic diagnosis of gastroduodenal ulcer scars: implications for clinical management of NSAIDs users

Author

Ishimura Norihisa, Fukuba Nobuhiko, Tada Yasumasa, Okada Mayumi, Yuki Takafumi, Uno Goichi, Amano Yuji, Ishihara Shunji, and Kinoshita Yoshikazu

Subjects
NSAIDs, proton pump inhibitor, gastric ulcer scar, duodenal ulcer scar, interobserver diagnostic agreement, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background A clinical history of peptic ulcer has been reported to be associated with a high rate of ulcer recurrence in nonsteroidal anti-inflammatory drug (NSAID) users. Therefore, it is a very important issue to precisely know the previous history prior to NSAIDs administration. To clarify the possible difficulty to identify the history, we determined the sensitivity and diagnostic concordance of endoscopy for the identification of ulcer scars indicative of previous clinical history of peptic ulcer diseases. Methods The first study enrolled 200 consecutive patients with a clinical history of gastric or duodenal ulcers previously confirmed by esophagogastroduodenoscopy. The sensitivity of endoscopy for identifying scars was determined for these patients. In the second study, the extent of interobserver agreement was determined for 47 endoscopists who identified ulcer scars in endoscopic photographs of 30 sites of previous active gastric ulcers and 30 sites of previous active duodenal ulcers. The kappa coefficient of reliability was calculated to measure the interobserver agreement on the diagnosis of ulcer scars. Results Out of 190 patients eligible for analysis, 104 (54.7%) were found to have gastric or duodenal ulcer scars on endoscopy; there were no gastric or duodenal ulcer scars seen in the remaining patients (45%). In the second study, the kappa values for endoscopic diagnosis of gastric and duodenal ulcer scars were 0.14 (95% CI 0.13-0.16) and 0.29 (95% CI 0.27-0.32), respectively. The addition of indigo-carmine chromoendoscopy did not provide a statistically significant improvement in diagnostic concordance in patients with gastric ulcer scar since the kappa value for chromoendoscopic diagnosis was 0.15; 95% CI 0.13-0.17 as low as for un-contrasted scars. Conclusions The sensitivity and concordance of endoscopic diagnosis of gastric and duodenal ulcer scars are not satisfactory for the use of endoscopy only to identify previous ulcer disease. To avoid the overlooking the previous clinical history of peptic ulcer diseases, the diagnosis of peptic ulcer scar has to be carefully done prior to NSAIDs administration.

Published
2011
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39. Relationship between colonic diverticulosis and colon neoplasms in Japanese patients.

Author

Nakahara, Ryotaro, Amano, Yuji, Murakami, Daisuke, Ogawa, Sayaka, Ujihara, Tetsuro, Iwaki, Tomoyuki, Katsuyama, Yasushi, Hayasaka, Kenji, Harada, Hideaki, Tada, Yasumasa, Yuki, Takafumi, Miyaoka, Youichi, Kushiyama, Yoshinori, Fujishiro, Hirofumi, and Ishihara, Shunji

Subjects
COLON tumors, DIVERTICULOSIS, JAPANESE people, COLON cancer, SYMPTOMS, ASIANS
Abstract

Background and Aim: Colonic diverticulosis (CD) has been reported to be associated with presence of colon neoplasms (CNs) in Western patients, since most of the associated risk factors are common between them. However, such correlation has not been fully investigated in Asian patients. In this study, the association of CNs with CD was evaluated in a multicenter investigation. Methods: We enrolled 5633 patients who underwent both colonoscopy and esophagogastroduodenoscopy due to annual follow‐up, screening for positive occult blood testing and abdominal symptoms between January 2016 and December 2017 at three institutions. The relationship between the presence of CNs and CD was investigated, and predictors for presence of CNs were determined by multivariate logistic analysis. Results: The enrolled patients consisted of 1799 (31.9%) with CD (average age 70.0 years, male 64.0%) and 3834 without CD (66.0 years, male 52.9%), with the prevalence of CNs in those groups 46.6% and 44.2%, respectively (P = 0.090). Predictors for early colon cancer were shown to be age (OR 1.02, 95% CI 1.01–1.04, P = 0.010), laxatives use (OR 1.76, 95% CI 1.17–2.64, P = 0.007), gastric neoplasms (OR 2.16, 95% CI 1.23–3.81, P = 0.008), and CD (OR 1.64, 95% CI 1.16–2.31, P = 0.005). Early colon cancer in the distal colon was most frequently detected in patients with right‐sided CD (RR 2.50, P = 0.001). Conclusion: In Japanese patients, early colon cancer was more frequently found in those with as compared to those without CD. The presence of CD may be an important indicator for an index colonoscopy examination to detect colon cancer. (Clinical‐trial‐registry: UMIN000038985). [ABSTRACT FROM AUTHOR]

Published
2021
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40. Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type

Author

Sonoyama, Hiroki, primary, Kawashima, Kousaku, additional, Ishihara, Shunji, additional, Kotani, Satoshi, additional, Fukuba, Nobuhiko, additional, Oka, Akihiko, additional, Kusunoki, Ryusaku, additional, Tada, Yasumasa, additional, Mishima, Yoshiyuki, additional, Oshima, Naoki, additional, Moriyama, Ichiro, additional, Yuki, Takafumi, additional, Onishi, Koji, additional, and Kinoshita, Yoshikazu, additional

Published
2019
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43. Bleeding Risk Related to Upper Gastrointestinal Endoscopic Biopsy in Patients Receiving Antithrombotic Therapy: A Multicenter Prospective Observational Study

Author

Yuki Takafumi, Ishihara Shunji, Yashima Kazuo, Kawaguchi Koichiro, Fujishiro Hirofumi, Miyaoka Youichi, Yuki Mika, Kushiyama Yoshinori, Yasugi Akiko, Shabana Michiko, Furuta Koichirou, Tanaka Kiwamu, Koda Masaharu, Hamamoto Tetsuro, Sasaki Yuichiro, Tanaka Hisao, Yoshimura Teiji, Murawaki Yoshikazu, Isomoto Hajime, Kinoshita Yoshikazu, Yuki Takafumi, Ishihara Shunji, Yashima Kazuo, Kawaguchi Koichiro, Fujishiro Hirofumi, Miyaoka Youichi, Yuki Mika, Kushiyama Yoshinori, Yasugi Akiko, Shabana Michiko, Furuta Koichirou, Tanaka Kiwamu, Koda Masaharu, Hamamoto Tetsuro, Sasaki Yuichiro, Tanaka Hisao, Yoshimura Teiji, Murawaki Yoshikazu, Isomoto Hajime, and Kinoshita Yoshikazu

Published
2017

44. Simplified Classification of Capillary Pattern in Barrett Esophagus Using Magnifying Endoscopy With Narrow Band Imaging

Author

Uno, Goichi, Ishimura, Norihisa, Tada, Yasumasa, Tamagawa, Yuji, Yuki, Takafumi, Matsushita, Takashi, Ishihara, Shunji, Amano, Yuji, Maruyama, Riruke, and Kinoshita, Yoshikazu

Subjects
Homeodomain Proteins, Male, Observer Variation, Esophageal Neoplasms, Biopsy, Observational Study, Antigens, CD34, Endoscopy, Middle Aged, Article, Capillaries, Barrett Esophagus, Narrow Band Imaging, Cross-Sectional Studies, Esophagus, Cyclooxygenase 2, Risk Factors, Proliferating Cell Nuclear Antigen, Humans, CDX2 Transcription Factor, Female, Biomarkers, Aged
Abstract

The classification of Barrett esophagus (BE) using magnifying endoscopy with narrow band imaging (ME-NBI) is not widely used in clinical settings because of its complexity. To establish a new simplified available classification using ME-NBI. We conducted a cross-sectional study in a single-referral center. One hundred eight consecutive patients with BE using ME-NBI and crystal violet (CV) chromoendoscopy, and histological findings were enrolled. BE areas observed by ME-NBI were classified as type I or II on the basis of capillary pattern (CP), and as closed or open type on the basis of a mucosal pit pattern using CV chromoendoscopy; then, biopsy samples were obtained. We evaluated the relation between CP and pit pattern, expression of the factors with malignant potential, percentage of microvascular density, and interobserver agreement. One hundred thirty lesions from 91 patients were analyzed. Type II CP had more open type pit pattern areas and significantly greater microvascular density than type I. The presence of dysplasia, specialized intestinal metaplasia, expressions of COX-2, CDX2, and CD34, and PCNA index were significantly higher in type II, whereas the multivariate analysis showed that type II was the best predictor for the presence of dysplasia (OR 11.14), CD34 expression (OR 3.60), and PCNA (OR 3.29). Interobserver agreement for this classification was substantial (κ = 0.66). A simplified CP classification based on observation with ME-NBI is presented. Our results indicate that the classification may be useful for surveillance of BE with high malignant potential.

Published
2015

45. An evaluation of the usefullness of magnifying colonoscopy for the diagnosis of tumor invasion depth in early colorectal cancer

Author

Amano, Yuji, Komazawa, Yoshinori, Oose, Takayuki, Miyaoka, Youichi, Yuki, Takafumi, Yoshino, Nagisa, Ishimura, Norihisa, Fujishiro, Hirofumi, Kadowaki, Yasunori, Ishihara, Shunji, Adachi, Kiyoichi, and Kinoshita, Yoshikazu

Abstract

Magnifying colonoscopy can be used to observe colonic mucosal pits. Using this technique, a pit pattern classification system consisting of seven categories has been established. We evaluated the role of magnifying colonoscopy for the diagnosis of colorectal tumors, particularly for the assessment of the invasion depth of early colorectal carcinoma, which is an important indicator for successful and complete endoscopic resection. Thirty-two of early colorectal cancers in twenty-seven cases were examined by magnifying colonoscopy using 0.05％ crystal violet solution. The main and accessory pit patterns of all of the lesions were classified by magnifying colonoscopy. The depth of vertical invasion of the tumor was also assessed by endoscopic ultrasonography as well as by histological examination following endoscopic mucosal resection or surgical operation. An accurate determination of tumor depth by magnifying colonoscopy was possible in 84.3％ of the cases, compared to 78.1％ that were properly diagnosed by endoscopic ultrasonography.

Published
2002

46. Usefulness of computed tomography with air insufflation of the stomach prior to percutaneous endoscopic gastrostomy procedure

Author

KAWASHIMA, Kosaku, Adachi Kyoichi, Onishi Koji, Fukuda Kosuke, Kazumori Hideaki, Ohno Yasuhiko, Katoh Takao, Sonoyama Hiroki, Tada Yasumasa, Kusunoki Ryusaku, Akihiko, Oka, Fukuba Nobuhiko, Ohshima, Naoki, Yuki Takafumi, Ishihara Shunji, Kinoshita, Yoshikazu, KAWASHIMA, Kosaku, Adachi Kyoichi, Onishi Koji, Fukuda Kosuke, Kazumori Hideaki, Ohno Yasuhiko, Katoh Takao, Sonoyama Hiroki, Tada Yasumasa, Kusunoki Ryusaku, Akihiko, Oka, Fukuba Nobuhiko, Ohshima, Naoki, Yuki Takafumi, Ishihara Shunji, and Kinoshita, Yoshikazu

Published
2016

47. Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis

Author

KAWASHIMA, Kosaku, Ishihara Shunji, Yuki Takafumi, Fukuba Nobuhiko, Ohshima, Naoki, Kazumori Hideaki, SONOYAMA, Hiroki, Yamashita Noritsugu, Tada Yasumasa, Kusunoki Ryusaku, Akihiko, Oka, MISHIMA, Yoshiyuki, MORIYAMA, Ichiro, Kinoshita, Yoshikazu, KAWASHIMA, Kosaku, Ishihara Shunji, Yuki Takafumi, Fukuba Nobuhiko, Ohshima, Naoki, Kazumori Hideaki, SONOYAMA, Hiroki, Yamashita Noritsugu, Tada Yasumasa, Kusunoki Ryusaku, Akihiko, Oka, MISHIMA, Yoshiyuki, MORIYAMA, Ichiro, and Kinoshita, Yoshikazu

Published
2016

48. Decreased Frequency of Intestinal Regulatory CD5(+) B Cells in Colonic Inflammation

Author

MISHIMA, Yoshiyuki, Ishihara Shunji, Akihiko, Oka, Fukuba Nobuhiko, Ohshima, Naoki, SONOYAMA, Hiroki, Yamashita Noritsugu, Tada Yasumasa, Kusunoki Ryusaku, MORIYAMA, Ichiro, Yuki Takafumi, KAWASHIMA, Kosaku, Kinoshita, Yoshikazu, MISHIMA, Yoshiyuki, Ishihara Shunji, Akihiko, Oka, Fukuba Nobuhiko, Ohshima, Naoki, SONOYAMA, Hiroki, Yamashita Noritsugu, Tada Yasumasa, Kusunoki Ryusaku, MORIYAMA, Ichiro, Yuki Takafumi, KAWASHIMA, Kosaku, and Kinoshita, Yoshikazu

Published
2016

50. Downregulation of serotonin reuptake transporter gene expression in healing colonic mucosa in presence of remaining low-grade inflammation in ulcerative colitis

Author

Tada, Yasumasa, primary, Ishihara, Shunji, additional, Kawashima, Kousaku, additional, Fukuba, Nobuhiko, additional, Sonoyama, Hiroki, additional, Kusunoki, Ryusaku, additional, Oka, Akihiko, additional, Mishima, Yoshiyuki, additional, Oshima, Naoki, additional, Moriyama, Ichiro, additional, Yuki, Takafumi, additional, Ishikawa, Noriyoshi, additional, Araki, Asuka, additional, Harada, Yuji, additional, Maruyama, Riruke, additional, and Kinoshita, Yoshikazu, additional

Published
2016
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