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Dependence of distributed generation (DG) outputs and load plays an essential role in renewable energy accommodation. This paper presents a novel DG hosting capacity (DGHC) evaluation method for distribution networks considering high-dimensional dependence relations among solar radiation, wind speed, and various load types (i.e., commercial, residential, and industrial). First, an advanced dependence modeling method called regular vine (R-vine) is applied to capture the complex dependence structure of solar radiation, wind speed, commercial loads, industrial loads, and residential loads. Then, a chance-constrained DGHC evaluation model is employed to figure out maximum hosting capacity of each DG and its optimal allocation plan with different operational risks. Finally, a Benders decomposition algorithm is also employed to reduce computational burden. The proposed approaches are validated using a set of historical data from China. Results show dependence among different DGs and loads has significant impact on hosting capacity. Results also suggest using the R-vine model to capture dependence among distributed energy resources (DERs) and load. This finding provides useful advice for distribution networks in installing renewable energy generations.

This study examines the measurement of film thickness, curvature, and defects on the surface or inside of an optical element using a highly accurate and efficient method. This is essential to ensure their quality and performance. Existing methods are unable to simultaneously extract the three types of information: thickness, curvature, and defects. Spectral-domain optical coherence tomography (SD-OCT), a non-invasive imaging technique with imaging depths down to the millimeter scale, provides the possibility of detecting the optical element components’ parameters. In this paper, we propose an error correction model for compensating delay differences in A-scan, field curvature, and aberration to improve the accuracy of system fitting measurements using SD-OCT. During data processing, we use the histogram-equalized gray stretching (IAH-GS) method to deal with strong reflections in the thin film layers inside the optics using individual A-scan averages. In addition, we propose a window threshold cutoff algorithm to accurately identify defects and boundaries in OCT images. Finally, the system is capable of rapidly detecting the thickness and curvature of film layers in optical elements with a maximum measurement depth of 4.508 mm, a diameter of 15 × 15 mm, a resolution of 5.69 microns, and a sampling rate of 70 kHz. Measurements were performed on different standard optical elements to verify the accuracy and reliability of the proposed method. To the best of our knowledge, this is the first time that thickness, curvature, and defects of an optical film have been measured simultaneously, with a thickness measurement accuracy of 1.924 µm, and with a difference between the calibrated and nominal curvature measurements consistently within 1%. We believe that this research will greatly advance the use of OCT technology in the testing of optical thin films, thereby improving productivity and product quality.

ObjectivesPrevious studies have confirmed a link between specific inflammatory cytokines and inflammatory bowel disease (IBD), but the causal relationship between them is not completely clear. This Mendelian Randomization (MR) study aims to evaluate the causal relationship between 18 inflammatory cytokines and inflammatory bowel disease.MethodTwo-sample Mendelian randomization utilized genetic variances associated with IBD from two extensive publicly available genome-wide association studies (GWAS) (Crohn’s Disease (CD): 12,194 cases and 28,072 controls; Ulcerative Colitis (UC): 12,336 cases and 33,609 controls). The data of inflammatory cytokines was acquired from a GWAS including 8,293 healthy participants. We used inverse variance weighted method, MR-Egger, weighted median, simple model and weighted model to evaluate the causal relationship between inflammatory cytokines and IBD. Sensitivity analysis includes heterogeneity and pleiotropy analysis to evaluate the robustness of the results.ResultsThe findings indicated suggestive positive associations between Interleukin-13 (IL-13) and macrophage migration inhibitory factor (MIF) with CD (odds ratio, OR: 1.101, 95%CI: 1.021-1.188, p = 0.013; OR: 1.134, 95%CI: 1.024-1.255, p = 0.015). IL-13 also displayed a significant positive correlation with UC (OR: 1.099, 95%CI: 1.018-1.186, p = 0.016). Stem cell factor (SCF) was suggested to be associated with the development of both CD and UC (OR: 1.032, 95%CI: 0.973-1.058, p = 0.012; OR: 1.038, 95%CI: 1.005-1.072, p = 0.024).ConclusionThis study proposes that IL-13 may be a factor correlated with the etiology of IBD (CD and UC), while MIF just be specifically associated with CD. Additionally, SCF appears more likely to be involved in the downstream development of IBD (CD and UC).

Annexin A2 (ANXA2) encodes an oncoprotein whose expression has been found to correlate with poorer overall survival (OS) of pancreatic adenocarcinoma (PAAD) patients. Although peptides are available for targeting ANXA2, none of these were initially selected to target this protein specifically. Here, we took ANXA2 as a molecular target for PAAD and employed the phage display technique to screen for a new ANXA2‐targeted peptide. The resultant heptapeptide, YW7, was firstly labeled with fluorescein isothiocyanate (FITC) to evaluate its selectivity in cellular uptake, and further with the near‐infrared fluorescent (NIRF) dye Cy7 to assess in vivo distribution in a mouse model bearing PANC‐1 human pancreatic cancer xenografic tumors. We found that both FITC‐YW7 and Cy7‐YW7 probes showed significantly higher uptake in PANC‐1 cells compared to the HPDE6‐C7 pancreatic epithelium cells. Mice intravenously injected with Cy7‐YW7 showed higher tumor‐to‐background ratios (TBRs) (~ 2.7‐fold) in tumor tissues compared to those injected with Cy7 alone. Our study suggested that YW7 is a novel peptide targeting ANXA2 and Cy7‐YW7 is an NIRF probe potentially useful for the early detection of PAAD.

Abstract Handling stability control can improve the safety of four in‐wheel motor independent‐drive electric vehicle (4MIDEV). An adaptive motion state control strategy based on improved sliding mode control for 4MIDEV is proposed to improve the steering stability control of the vehicle under different adhesion conditions. This adaptive control strategy uses a multi‐layer structure, which mainly includes a motion reference layer, an upper‐layer motion controller, and a lower‐layer torque distribution controller. Aiming at the non‐linear dynamic characteristics of 4MIDEV under different adhesion conditions, a dynamically parameter‐varying motion reference layer is constructed to improve the accuracy of the reference values of sideslip angle and yaw rate, and realize the joint control of them. Considering the adhesion coefficient, construct the comprehensive yaw rate state variable, and use the improved sliding mode control algorithm to calculate the expected yaw moment. The lower‐level controller uses the optimal distribution method to distribute the torque of each drive wheel in combination with the adhesion coefficient. By constructing a joint simulation platform of Carsim and Simulink, simulations under different road adhesion conditions are realized, verifying that the proposed improved strategy can effectively adapt to different adhesion conditions, while improve the handling stability of 4MIDEV.

Multichannel metasurfaces are becoming a significant trend in the field of optical encryption due to their excellent manipulation of optical wavefronts. However, existent multichannel metasurfaces for optical encryption mostly implement only two channels in the near-field, or three channels by combining the near- and far-field. In this paper, we propose and simulate a three-channel metasurface that works entirely in the near-field and uses the polarization state of the incident light, left circularly polarized (LCP) light, right circularly polarized (RCP) light, and linearly polarized (LP) light as the security key. The metasurface consists of two types of nanostructures that work as a polarizer and a quarter-wave plate, providing an additional degree of freedom for encoding that enables independent near-field display at 633 nm wavelength incident light. The proposed three-channel metasurface has the advantages of high information density and high security, which will pave the way for multi-channel applications such as ultracompact displays, optical encryption, and information storage.

A steering stability control method for four-motor distributed drive high-speed tracked vehicle is proposed to improve handling stability and safety. The dynamic analysis and calculation of center steering, small radius steering and large radius steering for the four-motor distributed drive tracked vehicle are carried out respectively. In order to meet the power requirements of the outer drive motor in high-speed steering, a steering coupling system is constructed, which uses a steering motor to couple with the traction motor at the rear left or rear right side of the tracks respectively. The steering stability control strategy with the steering coupling takes the yaw angular velocity and longitudinal speed of the vehicle as the control objectives, and a direct yaw torque control strategy is proposed to optimize and distribute the torque of four traction motors in real time according to different steering conditions, and considers the synchronization of two traction motors on one side of the track, so as to improve the steering stability, safety, comfort and steering trajectory performance of the four-motor drive tracked vehicle. The simulation results of 0B, 0.2B, 2B and 8B steering radius show that the proposed control strategy with coupling system can ensure the steering stability for the four-motor distributed drive high-speed tracked vehicle.

Metasurfaces, employed to simultaneously generate nanoprinting and holographic images, have been extensively explored recently. Among them, multi-wavelength multiplexing in a single metasurface is often accompanied by dispersion and crosstalk, which hinder the display of multicolor patterns. Here, we propose an efficient phase method to decouple the wavelength and realize a three-channel display operating at different wavelengths. Holographic images appear in the far field with the illumination of two different circularly polarized lights while a nanoprinting image is reconstructed by inserting an orthogonal optical path with the illumination of linear polarization light. The proposed metasurface is only composed of four types of unit cells, which significantly decreases the complexity of fabrication and improves the information capacity. Benefiting from its different decoding strategies and capability of multi-wavelength control, this approach may develop broad applications in information encryption, security, and color display.

Background The relationship between interleukin-8 (IL-8) expression and the prognosis of gastric cancer (GC) patients has been reported, but the results are contradictory. Aim To investigate the effect of IL-8 expression on the prognosis of patients with GC. Method A comprehensive search strategy was used to search the PubMed, Web of Science and Cochrane Library databases. The total survival time was analysed using the RevMan 5.4 software. Through extensive search and meta-analysis of relevant studies, studies examining the relationship between IL-8 expression and prognosis in patients with GC were conducted to obtain more accurate estimates. Findings Eight studies (1843 patients) were included. The combined results of all the studies showed that high expression of IL-8 was a risk factor for poor prognosis in patients with GC (hazard ratio (HR): 2.08; 95% CI: 1.81–2.39). Sensitivity analysis suggested that the pooled HR was stable, and omitting a single study did not change the significance of the pooled HR. Funnel plots revealed no significant publication bias in the meta-analysis. Conclusion High IL-8 expression could be a negative prognostic biomarker for patients with GC.

In order to improve the steering stability of a four in-wheel motor independent-drive electric vehicles (4MIDEVs) on a road with varying adhesion coefficient, such as on a joint road and a μ-split road, this paper presents a hierarchical electronic steering control (ESC) strategy. The upper level controller of the proposed ESC strategy achieves the adaptive control of the yaw rate and sideslip angle in the direct yaw-moment control based on the influence of road adhesion. The lower level controller is designed as a two-hierarchy structure, which can adaptively change the torque allocation algorithm and achieve different weight controls of each wheel torque according to road adhesion coefficient. The results of real-time simulation conducted in the RT-LAB testing platform and a real-car test indicate an improvement in the steering stability of the 4MIDEV on a road with varying adhesion coefficient. Particularly the “double lane change”testing carried out on a joint road and a μ-split road shows a yaw rate error reduction of up to 55.1%, compared with the ordinary control strategy, with output torque and its fluctuation of each in-wheel motor significantly reduced.

The optical vortex (OV) beams characterized by orbital angular momentum (OAM) possess ubiquitous applications in optical communication and nanoparticle manipulation. Particularly, the vortex vector beams are important in classical physics and quantum sciences. Here, based on an all-dielectric transmission metasurface platform, we demonstrate a spin-multiplexed metadevice combining propagation phase and Pancharatnam–Berry (PB) phase. By utilizing a phase-only modulation method, the metadevice can generate spin-dependent and multidimensional focused optical vortex (FOV) under the orthogonally circularly polarized incident light, and it can successfully realize the multiplexed of the above-mentioned FOVs for linearly polarized light. Meanwhile, the superposition of multiple OAM states can also produce vector vortex beams with different modes. Additionally, the evolution process of the electric field intensity profile is presented after the resultant vector vortex beams through a horizontal linear polarization. This work paves an innovative way for generating structured beams, and it provides promising opportunities for advanced applications in optical data storage, optical micromanipulation, and data communication.