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Objective To assess prognostic factors of patients with operable oral cavity squamous cell carcinoma (OSCC), focusing on the associations with smoking/alcohol exposure and age. Materials and methods A total of 247 patients with OSCC who received curative surgery ± adjuvant radiotherapy were analyzed. The patient subgroups were divided according to pretreatment smoking/alcohol exposure. Individuals aged 45 years or less were classified as younger patients. Results The median follow-up was 52.2 months. The 5-year locoregional progression-free survival (LRFFS), distant metastasis-free survival (DMFS), overall survival (OS), and cancer-specific survival (CSS) rates were 85.2%, 88.3%, 78.1%, and 83.5%, respectively. An advanced stage, differentiation, and lympho-vascular space invasion were significantly associated with lower OS and CSS. In a subgroup analysis of younger patients (n = 49), more smoking/alcohol exposure was significantly associated with better OS (hazard ratio [HR]: 0.21, 95% confidence interval [CI]: 0.05-0.95, p = .043). With increasing age, the HR for smoking/alcohol exposure with respect to OS increased up to 11.59 (95% CI: 1.49-89.84, p = .019) in older patients. Conclusion Younger OSCC patients with non- or less smoking/alcohol exposure showed unfavorable outcomes. The prognostic significance of pretreatment smoking/alcohol exposure changed from favorable to detrimental with increasing age in operable OSCC.

Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to develop clinical practice guidelines for the surgical treatment of laryngeal cancer. This Task Force conducted a systematic search of the EMBASE, MEDLINE, Cochrane Library, and KoreaMed databases to identify relevant articles, using search terms selected according to the key questions. Evidence-based recommendations were then created on the basis of these articles. An external expert review and Delphi questionnaire were applied to reach consensus regarding the recommendations. The resulting guidelines focus on the surgical treatment of laryngeal cancer with the assumption that surgery is the selected treatment modality after a multidisciplinary discussion in any context. These guidelines do not, therefore, address non-surgical treatment such as radiation therapy or chemotherapy. The committee developed 62 evidence-based recommendations in 32 categories intended to assist clinicians during management of patients with laryngeal cancer and patients with laryngeal cancer, and counselors and health policy-makers.

이 가 희·김 수 영·김 도 훈·김 선 욱·나 동 규·이 유 진·정 기 욱·최 귀 선·고 윤 우·김 원 배·남 기 현·백 승 국· 백 정 환·이 순 영·정 유 석·조 정 진·주 영 수·당 지 연·김 열·이 원 철 | 서울특별시 보라매병원 내분비내과, 한림 대학교 의과대학 강동성심병원 가정의학과, 고려대학교 안산병원 가정의학과, 성균관대학교 의과대학 삼성서울병원 내분비대사내과 및 갑상선센터, 휴먼영상의학센터 영상의학과, 국립암센터 갑상선암센터 내분비내과, 울산대학교 의과대학 서울아산병원 유방내분비외과, 국립암센터 국제암대학원대학교, 연세대학교 의과대학 신촌세브란스병원 이비인후과, 울산대학교 의과대학 서울아산병원 내과, 연세 대학교 의과대학 외과학교실, 고려대학교 의과대학 이비인후과교실, 울산대학교 의과대학 서울아산병원 영상의학과, 아주대학교 의과 대학 예방의학교실, 국립암센터 갑상선암센터 특수암연구과, 한림대학교 의과대학 동탄성심병원 가정의학과, 한림대학교성심병원 직 업환경의학과, 국립암센터 국가암관리사업본부 암검진사업과, 가톨릭대학교 의과대학 예방의학교실