1. Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study
- Author
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Yue, John K, Kobeissy, Firas H, Jain, Sonia, Sun, Xiaoying, Phelps, Ryan RL, Korley, Frederick K, Gardner, Raquel C, Ferguson, Adam R, Huie, J Russell, Schneider, Andrea LC, Yang, Zhihui, Xu, Haiyan, Lynch, Cillian E, Deng, Hansen, Rabinowitz, Miri, Vassar, Mary J, Taylor, Sabrina R, Mukherjee, Pratik, Yuh, Esther L, Markowitz, Amy J, Puccio, Ava M, Okonkwo, David O, Diaz-Arrastia, Ramon, Manley, Geoffrey T, Wang, Kevin KW, Badjatia, Neeraj, Foreman, Brandon, Gopinath, Shankar, Grandhi, Ramesh, Jha, Ruchira M, Lingsma, Hester F, Madden, Christopher, Madhok, Debbie Y, McCrea, Michael A, Merchant, Randall, Nelson, Lindsay D, Ngwenya, Laura B, Robertson, Claudia S, Rodgers, Richard B, Satris, Gabriela G, Schnyer, David M, Valadka, Alex B, van Essen, Thomas A, and Zafonte, Ross
- Subjects
Clinical Research ,Brain Disorders ,Traumatic Brain Injury (TBI) ,Traumatic Head and Spine Injury ,Physical Injury - Accidents and Adverse Effects ,Neurosciences ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,acute phase reactant ,alarmin ,cytokine ,neuroinflammation ,prognosis ,traumatic brain injury - Abstract
The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospective TRACK-TBI Pilot (Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot) study enrolled TBI patients triaged to head computed tomography (CT) and received blood draw within 24 h of injury. Healthy controls (HCs) and orthopedic controls (OCs) were included. Thirty-one inflammatory markers were analyzed from plasma. Area under the receiver operating characteristic curve (AUC) was used to evaluate discriminatory ability. AUC >0.7 was considered acceptable. Criteria included: TBI diagnosis (vs. OC/HC); moderate/severe vs. mild TBI (Glasgow Coma Scale; GCS); radiographic TBI (CT positive vs. CT negative); 3- and 6-month Glasgow Outcome Scale-Extended (GOSE) dichotomized to death/greater relative disability versus less relative disability (GOSE 1-4/5-8); and incomplete versus full recovery (GOSE
- Published
- 2023