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243 results on '"Yuge K"'

1. A Gas Diffusion Analysis Method for Simulating Surface Nitrous Oxide Emissions in Soil Gas Concentrations Measurement

Author

Bandara, KMTS, Sakai, K, Nakandakari, T, Yuge, K, Bandara, KMTS, Sakai, K, Nakandakari, T, and Yuge, K

Abstract

The detection of low gas concentrations from the soil surface demands expensive high-precision devices to estimate nitrous oxide (N2O) flux. As the prevalence of N2O concentration in the soil atmosphere is higher than its surface, the present study aimed to simulate N2O surface flux (CF) from soil gas measured in a soil-interred silicone diffusion cell using a low-cost device. The methodological steps included the determination of the diffusion coefficient of silicone membrane (Dslcn), the measurement of the temporal variations in the N2O gas in the soil (Csi) and on the surface (MF), and the development of a simulation process for predicting CF. Two experiments varying the procedure and periods of soil moisture saturation in each fertilized soil sample were conducted to detect Csi and MF. Using Dslcn and Csi, the variations in the soil gas (Csoil) were predicted by solving the diffusion equation using the implicit finite difference analysis method. Similarly, using six soil gas diffusivity models, the CF values were simulated from Csoil. For both experiments, statistical tests confirmed the good agreement of CF with MF for soil gas diffusivity models 4 and 5. We suggest that the tested simulation method is appropriate for predicting N2O surface emissions.

Published
2022

2. A Low-Cost NDIR-Based N2O Gas Detection Device for Agricultural Soils: Assembly, Calibration Model Validation, and Laboratory Testing.

Author

Bandara, KMTS, Sakai, K, Nakandakari, T, Yuge, K, Bandara, KMTS, Sakai, K, Nakandakari, T, and Yuge, K

Abstract

This research presents a low-cost, easy-to-assemble nondispersive infrared (NDIR) device for monitoring N2O gas concentration in agricultural soils during field and laboratory experiments. The study aimed to develop a cost-effective instrument with a simple optic structure suitable for detecting a wide range of soil N2O gas concentrations with a submerged silicone diffusion cell. A commercially available, 59 cm path-length gas cell, microelectromechanical systems (MEMS)-based infrared emitter, pyroelectric detector, two anti-reflective (AR) coated optical windows, and one convex lens were assembled into a simple instrument with secure preciseness and responsivity. Control of the IR emitter and data recording processes was achieved through a microcontroller unit (MCU). Tests on humidity tolerance and the saturation rate of the diffusion cell were carried out to test the instrument function with the soil atmosphere. The developed calibration model was validated by repeatability tests and accuracy tests. The soil N2O gas concentration was monitored at the laboratory level by a specific experimental setup. The coefficient of determination (R2) of the repeatability tests was more than 0.9995 with a 1-2000 ppm measurability range and no impact of air humidity on the device output. The new device achieved continuous measuring of soil N2O gas through a submerged diffusion cell.

Published
2021

6. Bevacizumab plus trifluridine/tipiracil in elderly patients with previously untreated metastatic colorectal cancer (KSCC 1602): A single-arm, phase II study

Author

Makiyama, A., primary, Oki, E., additional, Miyamoto, Y., additional, Kotaka, M., additional, Kawanaka, H., additional, Miwa, K., additional, Kabashima, A., additional, Noguchi, T., additional, Yuge, K., additional, Kashiwada, T., additional, Shimokawa, M., additional, Saeki, H., additional, Akagi, Y., additional, Baba, H., additional, and Mori, M., additional

Published
2019
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14. Neonatal cholestasis in two siblings: A variant of Dubin-Johnson syndrome?

Author

Yuge K, Inoue T, Takuji Fujisawa, Masayoshi Kage, Yasuhiro Yamashita, Hirohisa Kato, Akihiko Kimura, Eisuke Nakashima, and Ken-ichiro Kosai

Subjects
Male, medicine.medical_specialty, Cholestasis, Apolipoprotein B, biology, Jaundice, Chronic Idiopathic, business.industry, Urinary system, Infant, Newborn, Familial hypertriglyceridaemia, medicine.disease, Pedigree, Endocrinology, Dubin–Johnson syndrome, Internal medicine, Pediatrics, Perinatology and Child Health, Pigment accumulation, medicine, biology.protein, Humans, Neonatal cholestasis, business, Lipoprotein
Abstract

Objective : Two Japanese brothers with neonatal cholestasis associated with pigment granules in the hepatocytes and hepatosteatosis were evaluated for the possible role of hepatosteatosis in the Dubin-Johnson syndrome. Methodology and results The morphology of pigment accumulation and the laboratory data in these cases were examined. The elevation of urinary coproporphrin isomer I to more than 90% and the presence cholestasis resembled that in the Dubin-Johnson syndrome, but the hypertriglyceridaemia (

Published
1995
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20. A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons

Author

Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka A, Fujita T, Ohta T, Yusuke Furukawa, Iwase S, Yamada H, and Yoshimura A

Subjects
Drug Resistance, Intracellular Signaling Peptides and Proteins, Gene Expression, Suppressor of Cytokine Signaling Proteins, 3T3 Cells, Interferon-beta, Janus Kinase 1, Janus Kinase 2, Protein-Tyrosine Kinases, DNA-Binding Proteins, Enzyme Activation, Repressor Proteins, Interferon-gamma, Mice, STAT1 Transcription Factor, Suppressor of Cytokine Signaling 1 Protein, Leukemia, Myeloid, Proto-Oncogene Proteins, Trans-Activators, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Phosphorylation, Carrier Proteins
Abstract

It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular mechanism of regulation of IFN signaling has not been fully understood. We have reported novel cytokine-inducible SH2 protein (CIS) and JAK binding protein (JAB) family genes that can potentially modulate cytokine signaling. Here we report that JAB is strongly induced by IFN-gamma but not by IFN-beta in mouse myeloid leukemia M1 cells and NIH-3T3 fibroblasts. NIH-3T3 cells ectopically expressing JAB but not CIS3 lost responsiveness to the antiviral effect of IFN-beta and IFN-gamma. M1 leukemic cells stably expressing JAB were also resistant to IFN-gamma and IFN-beta-induced growth arrest. In both NIH-3T3 and M1 transformants expressing JAB, IFN-gamma did not induce tyrosine phosphorylation and DNA binding activity of STAT1. Moreover, IFN-gamma-induced activation of JAK1 and JAK2 and IFN-beta-induced JAK1 and Tyk2 activation were inhibited in NIH-3T3 JAB transformants. These results suggest that JAB inhibits IFN signaling by blocking JAK activity. We also found that IFN-resistant clones derived from LoVo cells and Daudi cells expressed high levels of JAB without stimulation. In IFN-resistant Daudi cells, IFN-induced STAT1 and JAK phosphorylation was partially reduced. Therefore, overexpression of JAB could be, at least in part, a mechanism of IFN resistance.

Published
1998

31. Photoreceptor apoptosis induced by a single systemic administration of N-methyl-N-nitrosourea in the rat retina

Author

Nakajima, M., Yuge, K., Senzaki, H., Shikata, N., Miki, H., Uyama, M., and Tsubura, A.

Subjects
Cell Nucleus, Retinal Degeneration, Apoptosis, Cell Count, Methylnitrosourea, Retina, Rats, Rats, Sprague-Dawley, Microscopy, Electron, Proliferating Cell Nuclear Antigen, Rats, Inbred BN, Animals, Vimentin, Female, Photoreceptor Cells, sense organs, Pigment Epithelium of Eye, Injections, Intraperitoneal, Research Article
Abstract

Retinal degeneration was induced by a single intraperitoneal injection of N-methyl-N-nitrosourea in female Sprague-Dawley albino rats at 50 days of age by two dose regimens, which were observed sequentially at 24, 48, and 72 hours and 7, 21, and 35 days after the treatment. After a dose of 75 mg/kg, methylnitrosourea evoked progressive retinal degeneration in all treated rats whereas a dose of 50 mg/kg was less effective. The 75-mg/kg-treated rats showed selective destruction of the photoreceptor cells by an apoptotic mechanism, as confirmed morphologically and by the terminal dUTP nick end labeling method. Apoptosis had already started at 24 hours after the treatment and was completed by day 7. During the photoreceptor degeneration, proliferation of glial fibrillary acidic protein and vimentin-positive Müller cells as detected by proliferating cell nuclear antigen labeling appeared at 48 hours and was prominent 72 hours after the treatment, and macrophage infiltration within the retina as recognized by ED1 positivity was maximal 7 and 21 days after the treatment. Retinal degeneration was also induced in female Brown-Norway colored rats in a similar dose-dependent manner. Pigment epithelium was discontinuous above Bruch's membrane, and migration of the swollen pigment epithelium toward the inner nuclear layer was seen 7 days after the treatment. Therefore, as also confirmed electron microscopically, the most striking change was the destruction of photoreceptor cells by the apoptotic process, followed by Müller cell proliferation, pigment epithelium migration, and macrophage infiltration for cell debris phagocytosis, resulting in a thin remnant of retina with attenuated inner nuclear cells in direct contact with Bruch's membrane or with the pigment epithelium and/or with the Müller cells 35 days after the treatment.

Published
1996

42. Abstracts

Author

Zhou, Xinhua, primary, Kudo, Akihiko, additional, Kawakami, Hayato, additional, Hirano, Hiroshi, additional, FAYED, M.H., additional, MAKITA, T., additional, SUZAKI, Etsuko, additional, KATAOKA, Katsuko, additional, Katsumata, Osamu, additional, Fujimoto, Kazushi, additional, Yamashina, Shohei, additional, USUDA, Nobuteru, additional, JOHKURA, Kohhei, additional, SUGANUMA, Tatsuo, additional, SAWAGUCHI, Akira, additional, NAGAIKE, Ryoko, additional, KAWANO, Jun-ichi, additional, OINUMA, Tsutomu, additional, Izumi, Shin-ichi, additional, Iwamoto, Michiko, additional, Shin, Masashi, additional, Nakano, Paul K., additional, Ueda, Tadashi, additional, Ishikawa, Yoshimaro, additional, Kubo, Eri, additional, Miyoshi, Norio, additional, Fukuda, Masaru, additional, Akagi, Yoshio, additional, Miki, H., additional, Nakajima, M., additional, Yuge, K., additional, Taomoto, M., additional, Tsubura, A., additional, Shikata, N., additional, Senzaki, H., additional, MASUDA, Atsushi, additional, NAGAOKA, Takanori, additional, OYAMADA, Masahito, additional, TAKAMATSU, Tetsuro, additional, Furuta, Hirokazu, additional, Hata, Yoshinobu, additional, Yokoyama, Keiichi, additional, Takamatsu, Tetsuro, additional, Itoh, J., additional, Takumi, I., additional, Kawai, K., additional, Serizawa, A., additional, Sanno, N., additional, Teramoto, A., additional, Osamura, R.Y., additional, MATSUTA, Morimasa, additional, MATSUTA, Mayumi, additional, I, Nishiya, additional, TAKAHASHI, Satoru, additional, KAWABE, Kazuki, additional, LIEBER, Michael M., additional, JENKINS, Robert B, additional, SASANO, HIRONOBU, additional, IINO, KAZUMI, additional, SUZUKI, TAKASHI, additional, NAGURA, HIROSHI, additional, Ge, Y-B, additional, Ohmori, J., additional, Tsuyama, S., additional, Yang, D-H, additional, Murata, F., additional, JOHKURA, Kohei, additional, LIANG, Yan, additional, MATSUI, Toshifumi, additional, NAKAZAWA, Ayami, additional, HIGUCHI, Susumu, additional, MATSUSHITA, Yukio, additional, Naritaka, Heiji, additional, Kameya, Toru, additional, Sato, Yuichi, additional, Inoue, Hiroshi, additional, Otani, Mitsuhiro, additional, Kawase, Takeshi, additional, KUROOKA, Yuji, additional, NASU, Kimio, additional, KAMEYAMA, Shuji, additional, MORIYAMA, Nobuo, additional, YANO, Junichi, additional, TSUJIMOTO, Gozo, additional, Matsushita, Tsutomu, additional, Oyamada, Masahito, additional, YAMAMOTO, Hitoshi, additional, MATSUURA, Junko, additional, NOMURA, Takako, additional, SASAKI, Junzo, additional, NAWA, Tokio, additional, KITAZAWA, Riko, additional, KITAZAWA, Sohei, additional, KASIMOTO, Hideyoshi, additional, MAEDA, Sakan, additional, WATANABE, Jun, additional, Mino, Kazuto, additional, KONDO, Kazumasa, additional, KANAMURA, Shinsuke, additional, Ueki, Tetsuo, additional, Takeuchi, Takumi, additional, Nishimatsu, Hiroaki, additional, Kajiwara, Takahiro, additional, Moriyama, Nobuo, additional, Kawabe, Kazuki, additional, Tominaga, Takashi, additional, Kobayashi, Ken-ichiro, additional, Minei, Sadatugu, additional, Okada, Yasuhiro, additional, Yamanaka, Yataro, additional, Ichinose, Taketo, additional, Hachiya, Takahiko, additional, Hirano, Daisaku, additional, Ishida, Hajime, additional, Okada, Kiyoki, additional, HASEGAWA, Hideaki, additional, WATANABE, Keiichi, additional, ITOH, J., additional, HASEGAWA, H., additional, UMEMURA, S., additional, YASUDA, M., additional, TAKEKOSHI, S., additional, OSAMURA, R.Y., additional, WATANABE, K., additional, TAKEDA, Kazuo, additional, HOSHI, Tatsuya, additional, KATO, Katsuaki, additional, OHARA, Shuichi, additional, KONNO, Ryo, additional, ASAKI, Shigeru, additional, TOYOTA, Takayoshi, additional, TATENO, Hiroo, additional, NISHIKAWA, Sumio, additional, SASAKI, Fumie, additional, Ito, Yuko, additional, Matsumoto, Kenji, additional, Daikoku, Eriko, additional, Otsuki, Yoshinori, additional, SANO, Makoto, additional, UMEZAWA, Akihiro, additional, ABE, Hitoshi, additional, FUKUMA, Mariko, additional, SUZUKI, Atsushi, additional, ANDO, Takashi, additional, and HATA, Jun-ichi, additional

Published
1998
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