Search

In-situ synthesized TiB2/6061 composites were prepared from Al-K2TiF6-KBF4 by high energy ball milling and stir casting. Phase analysis and microstructure observation of the samples were characterized by XRD, SEM and EDS, respectively. The effect of TiB2 particle content on the microstructure, tensile properties and wear resistance of the composites was studied. The results show that the average size of TiB2 particles is 1 μm, which is polygonal shape. The average grain size of the composites can be refined significantly as the TiB2 particle mass content increased from 1 to 3%; however, the grain coarsening occurs in the 5 wt.% TiB2/6061composites. The 3 wt.% TiB2/6061 composites have best tensile strength, yield strength and Young’s modulus among the composites in ranges of the TiB2 mass fraction from 1 to 5%. Strengthening mechanisms of the TiB2/6061 composites were fine grain strengthening, Orwan strengthening and CTE strengthening, in which the CTE strengthening plays an important role as increasing the TiB2 content. The pin-on-disk wear test results indicated that the average friction coefficient and wear rate of the TiB2/6061 composites increased firstly and then decreased with increasing the TiB2 content from 1 to 5 wt.%. The wear mechanism of the TiB2/6061 composites was discussed.

Ternary compound CuSbSe2-alloyed PbTe, CumPb100SbmTe100Se2m (CLAST), presents outstanding n-type thermoelectric transport behavior and features hierarchical Cu-based precipitates and interstitials that can balance phonon and carrier transport. Results show that a small amount of CuSbSe2 (∼3%) alloying in CLAST can realize a room-temperature carrier concentration of ∼1.7 × 1018 cm−3 and then optimize the power factor, and simultaneously precipitate out embedded Cu-based nanostructures in the matrix to lower the lattice thermal conductivity. Additionally, extra Cu atoms adding in CLAST can form interstitials and further improve both the carrier concentration to ∼3.0 × 1018 cm−3 and carrier mobility to ∼1227.8 cm2 V−1 s−1 at room temperature, which benefits a maximum power factor of ∼20.0 μW cm−1 K−2 in Cu3.3Pb100Sb3Te100Se6. Moreover, the Cu interstitials together with massive Cu-based nanoprecipitates can strongly scatter a wide set of phonons, and largely lower the lattice thermal conductivity to ∼0.44 W m−1 K−1 in Cu3.4Pb100Sb3Te100Se6 at 623 K. Finally, these Cu-based hierarchical structures in CLAST samples can synergistically optimize the phonon and carrier transport properties and contribute to a high ZT of ∼0.5 at 300 K and a peak ZT of ∼1.4 at 723 K. A remarkably high ZTave of ∼0.94 at 300–723 K is achieved in Cu3.3Pb100Sb3Te100Se6 due to high ZT values in the low temperature range, outperforming other high-performance n-type PbTe-based thermoelectric materials.

Gold clusters are considered as widely used catalyst for chemical industry, but the efficiency of catalyst has been limited by the aggregation of the gold atoms, since the active sites are only loc...

Tim3 is a negative immune checkpoint molecule and plays a crucial part in tumor-induced immune suppression. Tim3 is a cell surface molecule expressed on T cells marking dysfunctional CD8+ cells in various kinds of cancers. Tim3 expression was mainly reported in tumor-infiltrating lymphocytes (TILs). There are few studies focusing on the expression of Tim3 in tumor cells. Immunohistochemistry was performed to determine Tim3 expression level. The relationships between Tim3 expression in colorectal cancer cells and in tumor-infiltrating lymphocytes and cilicopathological parameters were statistically analyzed. Tim3 was differentially detected in TILs and in colorectal cancer cells. Positive expression of Tim3 in colorectal cancer cells was associated with tumor location (P=0.001), depth of tumor invasion (P0.001), lymph node metastasis (P=0.001), TNM stage (P=0.001), MSI (P=0.008), and Braf V600E mutation (P=0.001). On the other hand, positive expression of Tim3 in TILs was only related to depth of tumor invasion (P0.001). Positive expression of Tim3 in both colorectal cancer cells and TILs was associated with depth of tumor invasion (P0.001), lymph node metastasis (P=0.002), TNM stage (P=0.002), MSI (P=0.039), and Braf V600E mutation (P=0.009). Kaplan-Meier survival analysis showed that Tim3 expression in colorectal cancer and in TILs was significantly associated with patient overall survival (OS) rate (P=0.039, and 0.001). Tim3 may be a potential prognostic marker and a therapy target for colorectal cancer.

MiR-769-5p regulates tumor correlative genes, which plays a critical role in the progression of various types of tumor. However, the precise regulatory mechanism of miR-769-5p on nonsmall cell lung cancer (NSCLC) is unknown. This study was to discover the role and underlying mechanisms of miR-769-5p in NSCLC. MiR-769-5p expression was shown to be reduced, according to our findings. MiR-769-5p overexpression inhibited NSCLC cell proliferation while promoting NSCLC cell apoptosis. Furthermore, NSCLC cell migration and invasion were reduced when miR-769-5p was overexpressed. Furthermore

Background Lymphocyte activation gene 3 (LAG‐3, also known as CD223) is an immune checkpoint molecule expressed on various types of lymphocytes, and it is mainly involved in maintaining immune homeostasis. However, there are currently no data on LAG‐3 expression in non–small‐cell lung cancer cells. Methods Human lung cancer cells were cultured using conventional methods. The expression of LAG‐3 was measured by Western blot and flow cytometry. Between April 2018 and May 2019, we collected 52 surgical specimens of stage I‐III non–small‐cell lung cancer (NSCLC). Fourteen samples of benign lung tissue lesions were collected as the control group, and the expression levels of LAG‐3 in the lung cancer cells and tissue samples were measured via immunohistochemistry. Results Western blots showed that LAG‐3 was expressed in lung cancer cell lines. There was significant difference in the LAG‐3 expression levels in the NSCLC cells and benign lung tissue (χ 2 = 13.055, P = .0003). The LAG‐3 expression level was significantly associated with the NSCLC clinical stage, and LAG‐3 expression was significantly higher in stage III patients (P

Background In unresectable hepatocellular carcinoma (HCC), methods to predict patients at increased risk of progression are required. Purpose To investigate the feasibility of radiomics model in predicting early progression of unresectable HCC after transcatheter arterial chemoembolization (TACE) therapy using preoperative multiparametric magnetic resonance imaging (MP-MRI). Study type Retrospective. Population A total of 84 patients with BCLC B stage HCC from one medical center. According to the modified response evaluation criteria in solid tumors, patients who progressed at 6 months after TACE therapy were assigned as the progressive disease (PD) group (n = 32). Patients whose MRI was performed on four devices were divided into a training cohort (n = 67). Patients whose MRI was performed on other than the previous four devices were used as the testing set (n = 17). Field strength/sequence 3.0T, 1.5T axial T2 -weighted imaging (T2 WI), diffusion-weighted imaging (DWI, b = 0, 500 s/mm2 ), and apparent diffusion coefficient (ADC) ASSESSMENT: PD was confirmed via imaging studies with MRI. Risk factors, including age, alpha fetoprotein (AFP), size, and radiomic-related features of PD were assessed. In addition, the discrimination ability of each radiomics signature was tested on an independent testing set. Statistical tests The area under the receiver-operator characteristic (ROC) curve (AUC) was used to evaluate the predictive accuracy of the radiomic signature in both the training and testing sets. The results indicated that the MP-MRI model achieved the greatest benefit. Results In the testing set, the model based on DWI features presented an AUC of (b = 0, 0.786; b = 500, 0.729), followed by T2 WI features (0.729) and ADC (0.714). The AUC of the MP-MRI signature was increased to 0.800 compared to any single MRI signature. The multivariate logistic analysis identified the radiomics signature as independent parameters of PD, while clinical information such as age, AFP, size, etc., had no significance in the PD group. Data conclusion Preoperative MP-MRI has the potential to predict the outcome of TACE therapy for unresectable HCC. In addition, these image features may be complementary to the current staging systems of HCC patients. Level of evidence 2. Technical efficacy stage 3. J. Magn. Reson. Imaging 2020;52:1083-1090.

Changhao Chen,1,* Zhiwei Zhang,2,* Jie Li,3 Yuejun Sun4 1Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210003, China; 2Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; 3Department of Respiratory Medicine, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, China; 4Department of Pathology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, China *These authors contributed equally to this work Background: Recently, various dynamically expressed lncRNAs are known to play critical roles in cancer progression. Small nucleolar RNA host genes (SNHG), a stable cytoplasmic lncRNA, which have been widely reported to act as an oncogene in non-small cell lung cancer (NSCLC). As an important member of SNHG, SNHG8 have been suggested to over-expressed in several cancer disease, while the biological function in NSCLC remains unclear. Purpose: Here we investigated the biological function and underlying mechanism of SNHG8 in human NSCLC. Patients and methods: The relationship between SNHG8 expression and clinicopathologic characteristic in NSCLC patients were observed from January 2014 to December 2014 in 120 NSCLC patients. The expression of SNHG8 were analyzed by qRT-PCR assay in cancer tissues and cells. Cell proliferation ability were detected in NSCLC cells by CCK-8 assay. Flow cytometric analysis were performed to detected the cell apoptosis and cell cycle. Luciferase assay and Western blot assay were performed on NSCLC cells to detected the underlying mechanism of SNHG8 in NSCLC. Moreover, Tumor xenografts in nude mice were performed to detected the in vivo function of SNHG8. Results: SNHG8 was over-expressed in NSCLC tissues and cells. Patients with high SNHG8 expression have poorer overall survival (OS) and progression-free survival (PFS) than the patients with low SNHG8 expression. SNHG8 knockdown inhibited NSCLC cell proliferation in vitro and in vivo, arrested cell cycle in the G0/G1 phase via targeting miR-542-3p/CCND1/CDK6, and induced cell apoptosis via activation of Caspase-3. Conclusion: SNHG8 negatively regulated miR-542-3p in NSCLC progression by regulating downstream effectors including CCND1 and CDK6. SNHG8 showed great potential for the application in the treatment of NSCLC. Keywords: SNHG8, non-small-cell lung cancer, cell proliferation, miR-542-3p, CCND1/CDK6, Caspase-3, cell proliferation, therapeutic targetErratumfor this paper has been published.

In this study, tobermorite was successfully synthesized from two kinds of industrial wastes by single step hydrothermal method. The structural and morphological changes during synthesis show that well-crystallized tobermorite can be obtained within 6 h at 180 °C in this system. The carbon impurities lead to a longer synthesis time and lower crystallinity of tobermorite. The tobermorite displays attractive adsorption capacity for Cr3+ (4.87 mmol/g), which is 2–3 times higher than common clay minerals. Meanwhile, Cr3+ adsorption causes the exsolution of structural Ca2+ in tobermorite channels, leading to the damage of crystallinity and decrease in sorption capacity of adsorbent. Therefore, better crystallization of tobermorite is helpful to achieve higher sorption capacity for Cr3+. These results indicate tobermorite can be used in industrial processes to adsorb heavy metals from wastewater.

Eph tyrosine kinase receptors and their ephrin ligands are involved in normal development and tumorigenesis. Eph receptors are frequently over expressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, angiogenesis, and metastasis. This study aimed to evaluate the clinical significance of EphB4 and its ligand of ephrinB2 protein expressions in human lung adenocarcinomas. EphB4 and ephrinB2 protein expressions were assessed immunohistochemically on paraffin embedded tissues obtained from 93 patients with lung adenocarcinoma. Fifty-one out of 93 (54.8%) specimens were negative for EphB4 expression, and 42 out of 93 (45.2%) were positive for EphB4 expression. EphrinB2 expression was consistently negative in all tissues. EphB4 expression was significantly associated with tumor differentiation (P = 0.001), lymph node metastasis (P = 0.021), and Ki67 (P = 0.012). No significant relationship was found between EphB4 expression and gender, age, or ALK mutation. Our data show that EphB4 is differentially expressed in lung adenocarcinoma tissues. A high level of EphB4 protein expression was associated with lymph node metastasis in lung adenocarcinoma.

Background Our study sought to investigate the therapeutic effects and mechanisms of miR-326-5p-overexpressing endothelial progenitor cells (EPCs) on acute myocardial infarction (AMI). Methods Mouse EPCs were isolated, purified, and identified by flow cytometry and uptake of DiI-ac-LDL. The target gene of miR-326-5p was predicted using target prediction algorithms and verified by dual-luciferase reporter assay, RT-qPCR, and Western blot. After EPCs were transfected with the agomir or antagomir of miR-326-5p, tube formation assay and Matrigel plug angiogenesis assay were conducted in four groups (NC, miR-326-5p agomir, miR-326-5p antagomir, and miR-326-5p agomir+Wnt1 agonist). In addition, a mouse model of MI was established and treated with the injection of miR-326-5p-EPCs, miR-326-5p-EPCs+ Wnt1 agonist, EPCs-NC, or PBS/control into the peri-infarcted myocardium. Subsequently, cardiac function was monitored by echocardiography at 7 and 28 days postoperatively. Finally, the infarcted hearts were collected at 28 days, and the size of myocardial infarction was measured by Masson’s trichrome staining and the neovascularization in the peri-infarcted area was examined through immunofluorescence staining. Results Luciferase reporter assay indicated that Wnt1 was a direct target of miR-326-5p. Using RT-qPCR and Western blot analysis, we further demonstrated that the expression level of Wnt1 was negatively correlated with miR-326-5p expression in EPCs. Both in vitro study of tube formation assay and in vivo investigation of subcutaneous Matrigel plug assay revealed that the miR-326-5p agomir could significantly enhance the angiogenic capacity of EPCs, and this effect was partially inhibited by Wnt1 agonist. Meanwhile, miR-326-5p antagomir could obviously reduce the the angiogenic capacity of EPCs in vivo compared with that in the NC group. Moreover, the transplantation of miR-326-5p-overexpressing EPCs in the ischemic hearts of mice significantly enhanced the angiogenesis in the peri-infarcted zone and improved the cardiac function. However, the enhanced capacity of angiogenesis of miR-326-5p-overexpressing EPCs was remarkably neutralized by Wnt1 agonist, accompanied by the decreased improvement in cardiac function. Conclusion miR-326-5p significantly enhanced the angiogenic capacity of EPCs. Transplantation of miR-326-5p-overexpressing EPCs improved cardiac function for AMI therapy, which can be a novel strategy for enhancing therapeutic angiogenesis in ischemic heart diseases.

Additional file 1: Figure S1. The effect of Wnt-1 agonist alone on angiogenesis in vitro. (A) Tube formation assay on Matrigel was assessed 6 h after seeding HUVECs treated with Wnt-1 agonist (0 nM, 50 nM, 100 nM). (B) Tube length was measured and compared to NC (n = 5/group). Figure S2. The expression level of miR-326-5p and Wnt-1 mRNA in the peri-infarcted region. After the injection of miR-326-5p-EPCs, relative expression level of miR-326-5p and Wnt-1 mRNA in the peri-infarcted region was measured compared with negative control using QT-qPCR at 1, 3, 7, 14, 28 days. (A) Relative expression level of miR-326-5p. *P

The lysosome inhibitors bafilomycin A1 and chloroquine have both lysosomotropic properties and autophagy inhibition ability, and are promising clinical agents to be used in combination with anticancer drugs. In order to investigate this combination effect, HepG2 cells were treated with bafilomycin A1, chloroquine, or/and doxorubicin, and their proliferative ability, induction of apoptosis, and the changes of lysosomal membrane permeabilization and mitochondrial membrane potential were studied. The results demonstrate that treatment with bafilomycin A1 or chloroquine alone at a relatively low concentration promotes the inhibitory effect of doxorubicin on cell growth and apoptosis. Further studies reveal that bafilomycin A1 and chloroquine promote lysosomal membrane permeabilization and the reduction of mitochondrial membrane potential induced by doxorubicin. Our findings suggest that bafilomycin A1 and chloroquine potentiate the anticancer effect of doxorubicin in hepatic cancer cells and that supplementation of conventional chemotherapy with lysosome inhibitors may provide a more efficient anticancer therapy.

The expression of EphA4 has been well documented in the development of nerve and in certain types of human cancer. Few studies of EphA4, however, have focused on breast carcinoma. In this study, a set of breast carcinomas was subjected to immunohistochemical staining. In normal luminal cells, EphA4 was weakly detected in 11 (14.3 %), moderately detected in 15 (19.5 %) and highly detected in 51 out of 77 (66.2 %) samples, while in breast carcinoma cells, EphA4 was weakly detected in 42 (54.5 %), moderately detected in 19 (24.7 %) and highly detected in 16 out of 77 (20.8 %) samples (P < 0.001). The expression of EphA4 protein was significantly reduced in 68.8 % of breast carcinoma samples comparing with normal cells. The expression of EphA4 was significantly associated with tumor grade (P = 0.003), TNM stage (P = 0.034), lymph node metastasis (P = 0.034) and Ki-67 (P < 0.001). No significant relationship was found between the expression of EphA4 and age, molecular subtypes, and HER2 status. Survival analysis showed that significant association of low expression of EphA4 in tumor cells with short overall survival (P = 0.048) and disease-free survival (P = 0.051). Our data show that EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM stage, lymph node metastasis, and poor outcome of patients.

The n-type PbTe still maintains relatively low thermoelectric performance compared with its p-type counterpart. Thus, to promote its performance in n-type PbTe, we conduct successive strategies that firstly suppressing the lattice thermal conductivity (κlat) through alloying with ternary compound AgSbSe2, and then optimizing carrier density with Sb, Bi or I doping. In AgSbSe2-alloyed PbTe samples, the κlat can be evidently reduced, and the minimum κlat decreases from ∼1.1 Wm−1K−1 in undoped PbTe to ∼0.8 Wm−1K−1 in PbTe–5%AgSbSe2. Based on PbTe–5%AgSbSe2 matrix, several dopants (Sb, Bi or I) are used to optimize its carrier density, and found that I element is verified to be the most effective dopant to enhance its electrical transport properties. In I-doped PbTe–5%AgSbSe2 samples, the carrier density raises from ∼2.49 × 1016 cm−3 in PbTe–5%AgSbSe2 to ∼1.15 × 1019 cm−3 in PbTe0.992I0.008-5%AgSbSe2, which contributes to the maximum power factor ∼14.8 μWcm−1K−2. Combining the reduced lattice thermal conductivity and improved power factor, the maximum ZTmax and average ZTave values in PbTe0.992I0.008-5%AgSbSe2 are boosted to ∼1.0 at 723 K and ∼0.77 at 300–823 K, respectively. This work points out a valid avenue to improve thermoelectric transport property in n-type PbTe with separately successive strategies to adjust its thermal and electrical performance.

PbTe-based thermoelectric materials are considered to be a medium-temperature thermoelectric candidates and the high-performance n-type PbTe is urgently to be developed to match its p-type counterpart on account of practical application. Herein, we firstly optimized the carrier density of n-type PbTe through Sb doping, and obtained a maximum ZT value of ∼1.0. Then, based on the optimized carrier density, we introduced ternary compounds AgSb(Se, Te)2 to suppress the lattice thermal conductivity. Minimum lattice thermal conductivity of n-type PbTe was reduced as low as ∼0.53 W m−1K−1 and ∼0.62 Wm−1K−1 through introducing AgSbSe2 and AgSbTe2, respectively. Combining the maintained electrical properties with suppressed thermal conductivity, maximum ZT values ∼1.2 and ∼1.3 were obtained in PbTe+2%AgSbSe2 and PbTe+2%AgSbTe2, respectively. This work provides an effective strategy of synergistically balancing charge and phonon transports in n-type PbTe with ternary AgSb(Se, Te)2 compounds.

Cryptocurrency is a digital or virtual currency using cryptography for security purposes. A cryptocurrency is difficult to counterfeit because of its unique security feature. The key advantages of cryptocurrencies include easier fund transfers between parties and the facilitation of these transactions through the use of public and private keys for security purposes. These fund transfers are performed with lower processing costs by avoiding costly bank transactions. The most popular cryptocurrency is Bitcoin, which uses the blockchain technology. The blockchain technology provides a data structure that stores all data in an online ledger that can be copied across all computers running Bitcoin software. Every new block must be verified by ledgers of each user, which makes it almost impossible to forge transaction history. This paper uses the nonlinear autoregressive network with a Bayesian regularization training algorithm to analyze Bitcoin fluctuations from historical data and predict future prices. The paper constructs a machine learning model that can better predict price trends and forecast Bitcoin prices than random selection.

Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis. Effective biomarkers are necessary to predict the clinical course and outcome of patients with HCC. Wntless (Wls) is a key modulator of Wnt protein secretion and is overexpressed in various human cancers. However, the mechanism and alteration of Wls expression in HCC have not been clarified. The aim of this study was to evaluate expression level of Wls in HCC and its clinical significance. The levels of Wls expression were investigated in 84 HCC tissues using immunohistochemistry. Wls was negatively expressed in normal liver tissue and was negatively or weakly (score 0) expressed in liver cirrhosis. Twenty-eight out of 84 samples (33.3%) were negative or weakly (score 0) expressed Wls, 38 out of 84 (45.2%) moderately (1+) expressed Wls, and 18 out of 84 (21.4%) strongly (2+) expressed Wls. Wls expression was positively associated with tumor size (P = 0.005, r = 0.302), tumor TNM stage (P = 0.017, r = 0.261), AFP (P = 0.051), and HBV infection (P = 0.009, r = 0.283), and was negatively associated with differentiation (P

Two-dimensional (2D) ultrathin silicon nanosheets (Si NSs) were synthesized by DC arc discharge method and investigated as anode material for Li-ion batteries. The 2D ultrathin characteristics of Si NSs is confirmed by means of transmission electron microscopy (TEM) and atomic force microscopy (AFM). The average size of Si NSs is about 20 nm, with thickness less than 2.5 nm. The characteristic Raman peak of Si NSs is found to have an appreciable (20 nm) shift to low frequency, presumably due to the size effect. The synergistic effects of Ar(+) and H(+) lead to 2D growth of Si NSs under high temperature and energy. Electrochemical analyses reveal that Si NSs anode possesses stable cycling performance and fast diffusion of Li-ions with insertion/extraction processes. Such Si NSs might be a promising candidate for anode of Li-ion batteries.

Chen C, Zhang Z, Li J, Sun Y. Onco Targets Ther. 2018;11: 6081–6090.On page 6089, the acknowledgment section was not included:AcknowledgmentThis study was funded by National Natural Science Foundation of China (No 81600217), Natural Science Foundation of Jiangsu Province (BK20160346), Jiangyin Municipal Transformation of Scientific and Technological Achievements Project of China (No JYKJ3308).Read the original article.

The expression of EphA4 has been well documented in the development of nerve and in certain types of human cancer. Few studies of EphA4, however, have focused on breast carcinoma. In this study, a set of breast carcinomas was subjected to immunohistochemical staining. In normal luminal cells, EphA4 was weakly detected in 11 (14.3 %), moderately detected in 15 (19.5 %) and highly detected in 51 out of 77 (66.2 %) samples, while in breast carcinoma cells, EphA4 was weakly detected in 42 (54.5 %), moderately detected in 19 (24.7 %) and highly detected in 16 out of 77 (20.8 %) samples (P0.001). The expression of EphA4 protein was significantly reduced in 68.8 % of breast carcinoma samples comparing with normal cells. The expression of EphA4 was significantly associated with tumor grade (P = 0.003), TNM stage (P = 0.034), lymph node metastasis (P = 0.034) and Ki-67 (P0.001). No significant relationship was found between the expression of EphA4 and age, molecular subtypes, and HER2 status. Survival analysis showed that significant association of low expression of EphA4 in tumor cells with short overall survival (P = 0.048) and disease-free survival (P = 0.051). Our data show that EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM stage, lymph node metastasis, and poor outcome of patients.

Peanut albumin which possesses protease inhibitor activity could be used as an anticancer regent. This paper would discuss the effect and mechanism of apoptosis induced by peanut albumin on human adenocarcinoma lung cancer A549. MTT assay was used to evaluate the inhibition of peanut albumin on 11 kinds of cancer cells. Compared with other cells, there was the great significant change in A549 cells. Morphological structures were detected by fluorescence microscope, and cell cycle was measured by flow cytometry (FCM). Annexin V/PI was used to detect cell cycle of A549 treated with peanut albumin. The differential expressions between the group treated with peanut albumin and the control were detected by Western-blot and quantitative-PCR. It was found that peanut albumin could inhibit proliferation of A549 cells, and induce apoptosis of A549. The possibility apoptosis of A549 cells induced by peanut albumin maybe correlated with mitochondrial apoptosis pathway.