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6 results on '"Yuebo Liang"'

1. Co-Circulation of 4 Dengue Virus Serotypes among Travelers Entering China from Myanmar, 2017

Author

Binghui Wang, Yuebo Liang, Shuting Yang, Yirong Du, Li-Na Xiong, Ting Zhao, Fang Yang, Weihong Qin, and Xueshan Xia

Subjects
dengue virus, epidemic, cross-border travelers, genotype, serotype, viruses, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We report 301 dengue virus infections among cross-border travelers entering Yunnan Province, China, from Myanmar during 2017. Phylogenetic analysis of 99 strains found all 4 serotypes co-circulating; genetic characteristics have also changed. This finding highlights the urgent need for monitoring dengue virus cross-border transmission as early warning of severe dengue fever.

Published
2018
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2. YAP/TAZ Pathway Promoted the Trastuzumab Resistance in HER2-Positive Breast Cancer.

Author

Wei Wang, Meifeng Zhou, Yuebo Liang, Fan Zhang, Zhong Wu, Shaowei Mo, and Yi Qing Wang

Abstract

The developed resistance of trastuzumab remained a problem for clinical therapy of HER2-positive breast cancer. However, effects of YAP/TAZ pathway on resistance of trastuzumab have not been explored. Tumor tissues were collected from 40 breast cancer patients for clinical studies. For in vitro studies, human breast cancer cell lines SK-BR-3-TS was obtained, and trastuzumab resistant model SK-BR-3-TR was constructed. Cell viability was determined using MTT assay. Cell apoptosis was analyzed by flow cytometry. Protein and mRNA expression was measured using western blotting and RT-qPCR, respectively. The mRNA and protein level of YAP was significantly increased in the tumor tissues of HER2-positive breast cancer patients. Consistently, the expression of YAP and TAZ were both dramatically upregulated in SK-BR-3-TR cells. The cell viability was increased, while cell apoptosis was inhibited in SK-BR-3-TS cells compared with SK-BR-3-TS. The depletion of YAP by si-YAP reversed the YAP/TAZ expression, cell viability and cell apoptosis in SK-BR-3-TR cells. YAP/TAZ pathway might induce the trastuzumab resistance in HER2-positive breast cancer and targeting YAP would be an alternative way for the clinical therapeutic methods of HER2 positive breast cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Nonindigenous East/Central/South African genotype of chikungunya virus identified in febrile returning travellers in Yunnan, China

Author

Xueshan Xia, Weihong Qin, Wei Yuan, Dongbiao Lv, Yue Feng, Yan Zhou, Yuebo Liang, Hui Xiao, Mengyuan Zheng, Jie Li, Ziyang Zhang, Yunlan Lu, and Xiaofei Li

Subjects
Microbiology (medical), China, Fever, Genotype, medicine.disease_cause, Virology, Virus, Disease Outbreaks, Infectious Diseases, Geography, medicine, Humans, Chikungunya, Chikungunya virus, Phylogeny
Published
2019

4. Co-Circulation of 4 Dengue Virus Serotypes among Travelers Entering China from Myanmar, 2017

Author

Shuting Yang, Xueshan Xia, Yirong Du, Li-Na Xiong, Binghui Wang, Weihong Qin, Ting Zhao, Fang Yang, and Yuebo Liang

Subjects
0301 basic medicine, Microbiology (medical), Serotype, Adult, Male, China, Epidemiology, genotype, 030231 tropical medicine, lcsh:Medicine, Myanmar, Dengue virus, medicine.disease_cause, Severe dengue, epidemic, lcsh:Infectious and parasitic diseases, Dengue fever, Dengue, 03 medical and health sciences, 0302 clinical medicine, medicine, Research Letter, Humans, lcsh:RC109-216, viruses, serotype, Serotyping, Co-Circulation of 4 Dengue Virus Serotypes among Travelers Entering China from Myanmar, 2017, Phylogeny, cross-border travelers, Travel, dengue virus, Transmission (medicine), lcsh:R, Yunnan, medicine.disease, Virology, humanities, 030104 developmental biology, Infectious Diseases, Geography, Female
Abstract

We report 301 dengue virus infections among cross-border travelers entering Yunnan Province, China, from Myanmar during 2017. Phylogenetic analysis of 99 strains found all 4 serotypes co-circulating; genetic characteristics have also changed. This finding highlights the urgent need for monitoring dengue virus cross-border transmission as early warning of severe dengue fever.

Published
2018

5. The importation of the phylogenetic-transition state of Zika virus to China in 2014

Author

Yuzhu Song, Binghui Wang, Yuebo Liang, Cheng-Feng Qin, Li Zhang, Zhiqing Xia, Xueshan Xia, Zhongxin Luo, Yaping Li, Yunnan Lu, and Weihong Qin

Subjects
0301 basic medicine, Microbiology (medical), China, Transition (genetics), Phylogenetic tree, Zika Virus Infection, 030231 tropical medicine, Genome, Viral, Zika Virus, Biology, biology.organism_classification, Genome, Zika virus, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, Evolutionary biology, Phylogenetics, Humans, Phylogeny
Published
2017

6. HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012

Author

Weihong Qin, Yajuan Wang, Xueshan Xia, Binghui Wang, Qicai Xuan, Li Zhang, Jing Miao, Yuebo Liang, Yue Feng, and Yaping Li

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, China, Adolescent, Genotype, Population, HIV Infections, Biology, gag Gene Products, Human Immunodeficiency Virus, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Phylogenetics, Virology, Epidemiology, medicine, Prevalence, Cluster Analysis, Humans, 030212 general & internal medicine, education, Phylogeny, Aged, Retrospective Studies, education.field_of_study, Travel, Phylogenetic tree, Sequence Analysis, DNA, Middle Aged, Hiv prevalence, medicine.disease, Infection rate, 030104 developmental biology, Infectious Diseases, pol Gene Products, Human Immunodeficiency Virus, HIV-1, Female
Abstract

Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos, and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91 432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV-1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B' (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV-1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV-1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies.

Published
2016

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