1. Three new anthraquinones from the twigs of Cassia fistula and their bioactivities
- Author
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Min Zhou, Qiu-Fen Hu, Xue-Mei Li, Huan-Huan Xing, Kun Zhou, Hu Weiyao, Yan Yang, Gan-Peng Li, Wei Dong, Qiang Liu, and Yue-de Wang
- Subjects
Paclitaxel ,Stereochemistry ,Fistula ,Cassia ,Pharmaceutical Science ,Positive control ,Anthraquinones ,Cytidine ,Antiviral Agents ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Ic50 values ,Humans ,Cytotoxicity ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,Molecular Structure ,Plant Stems ,biology ,Traditional medicine ,Mosaic virus ,010405 organic chemistry ,Organic Chemistry ,General Medicine ,biology.organism_classification ,medicine.disease ,0104 chemical sciences ,Plant Leaves ,Tobacco Mosaic Virus ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Drugs, Chinese Herbal - Abstract
Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.
- Published
- 2017