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Abstract In recent years, wide voltage range DC/DC converters have been widely used in telecom power, solar generation and electric vehicle charger applications. Based on this, a new multi‐resonant converter with wide input voltage is proposed here. Compared with the traditional LLC converter, the proposed converter can maintain the output voltage within a narrow frequency regulation range in both under‐resonance and over‐resonance areas. Thus, a wide voltage range can be realized without additional switch components or complex control strategies. The topology and the corresponding working principle of the proposed converter are introduced. In addition, the equivalent model by considering the fundamental wave is established and the influence of the resonance parameters on the voltage gain characteristic is analysed in detail. With these considerations, the resonance parameters are designed. Finally, a 500 W experiment platform is established to verify the effectiveness and feasibility of the proposed converter.

Abstract Peptide surfactants have been extensively investigated with various applications in detergents, foods, and pharmaceutics due to their biodegradability, biocompatibility, and customizable structures. Traditional peptide surfactants are often designed in a head-to-tail fashion mimicking chemical surfactants. Alternatively, a side-by-side design pattern based on heptad repeats offers an approach to designing peptide surfactants. However, minimalist peptide design using a single heptad for stabilizing interfaces remains largely unexplored. Here, we design four heptad surfactants (AM1.2, 6H, 6H7K, and HK) responsive to metal ions and compare their emulsification performance with a three-heptad peptide, AM1. Among them, the HK peptide generates emulsions exhibiting good stability over months. We further optimize factors such as buffering salts, ionic strength, and emulsion dilutions to uncover their impacts on emulsion properties. Our findings deepen the understanding of emulsion properties and provide practical insights for characterizing peptide-based emulsions, paving the way for their broader utilization in diverse applications.

Enzymes, as highly efficient biocatalysts, excel in catalyzing diverse reactions with exceptional activity and selective properties under mild conditions. Nonetheless, their broad applications are hindered by their inherent fragility, including low thermal stability, limited pH tolerance, and sensitivity to organic solvents and denaturants. Encapsulating enzymes within metal–organic frameworks (MOFs) can protect them from denaturation in these harsh environments. However, this often leads to a compromised enzyme activity. In recent years, extensive research efforts have been dedicated to enhancing enzymatic activity within MOFs, leading to the development of new enzyme–MOF composites that not only preserve their catalytic potential but also outperform their free counterparts. This Review provides a comprehensive review on recent developments in enzyme–MOF composites with a specific emphasis on their enhanced enzymatic activity compared to free enzymes.

The connection of single-phase AC loads to a DC microgrid not only large secondary currents flowing into energy storage units with droop control cause, but also lead to secondary voltage ripples appeared on the DC bus, which seriously affects the normal operation of DC microgrids. In this paper, the secondary currents and voltages can be suppressed simultaneously by means of reconstructing the output impedances of energy storage converter and active capacitor converter. The main characteristics, impedance model, control strategies, and system stability in terms of secondary ripples are comprehensively investigated. Particularly, it is shown that the output impedance of the energy storage converter with droop control is relatively small and the input impedance DC loads buck converter are relatively large, so the secondary currents mainly flow into energy storage units and DC bus capacitor. Based on this, the output impedance of the energy storage converter and active capacitor converter are reconstructed relatively larger and smaller respectively, so the secondary currents mainly flowing into the active capacitor. Therefore, the secondary ripple currents flowing into energy storage units and the secondary ripple voltages appeared on the DC bus can be suppressed. Finally, the proposed methods are varied through simulations results.

Highlights A facile and generalized design strategy of polymer precursor inks was developed for direct ink writing of metal oxide into submicron 3D architectures. The Maillard reaction between polyethyleneimine and glucose endows the 3D-printed precursors with the excellent shape fidelity during high-temperature pyrolysis. As-printed 3D periodic dielectric structure with woodpile geometry shows a significant light-matter effect in mid-infrared region.

Objectives: Ethnic minorities (EM) are still underrepresented in research recruitment. Despite wide literature outlining the barriers, enablers and recommendations for driving inclusion and diversity in research, there is still little evidence for successful diversity in research participation, which has a direct impact on the quality of care provided to ethnically diverse individuals. A new, comprehensive approach to recruitment strategies is therefore necessary. Study design: service improvement initiative. Methods: In the light of the Covid-19 pandemic and the key public health need to address the disparity in care provided to non-white populations, we used a novel, comprehensive approach (The King's Model) comprising of local and community actions to promote inclusive research recruitment. We then compared rates of diverse recruitment in studies where the novel approach, was applied to studies which had been closed to recruitment at the time of analysis and where ethnicity data was available. Results: Our results demonstrate that following the introduction of the King's Model for diverse recruitment, commercial interventional study diverse recruitment increased from 6.4% to 16.1%, and for non-commercial studies, from 30.2% to 41.0% and 59.2% in the selected studies. Conclusions: King's Model is potentially a useful tool in enhancing non-Caucasian recruitment to clinical research. Enriched by additional recommendations based on our experiences during the Covid-19 research recruitment drive, we propose the King's Model is used to support ethnically diverse research recruitment. Further evidence is needed to replicate our findings, although this preliminary evidence provides granular details necessary to address the key unmet need of validating clinical research outcomes in non-white populations.

Early-morning off periods, causing early-morning akinesia, can lead to significant motor and nonmotor morbidity in levodopa-treated fluctuating Parkinson’s disease (PD) cases. Despite validated bedside scales in clinical practice, such early-morning off periods may remain undetected unless specific wearable technologies, such as the Parkinson’s KinetiGraph™ (PKG) watch, are used. We report five PD cases for whom the PKG detected early-morning off periods that were initially clinically undetected and as such, untreated. These five cases serve as exemplars of this clinical gap in care. Post-PKG assessment, clinicians were alerted and targeted therapies helped abolish the early-morning off periods.

Abstract Increasing drug loading remains a critical challenge in the development and translation of nanomedicine. High drug‐loading nanoparticles have demonstrated unique advantages such as less carrier material used, better‐controlled drug release, and improved efficacy and safety. Herein, we report a simple and efficient salt concentration screening method for making polymer nanoparticles with exceptionally high drug loading (up to 66.5 wt%) based on phase separation‐induced nanoprecipitation. Upon addition of salt, phase separation occurs in a miscible solvent‐water solution delaying the precipitation time of drugs and polymers to different extents, facilitating their co‐precipitation thus the formation of high drug‐loading nanoparticles with high encapsulation efficiency (>90%) and excellent stability (>1 month). This technology is versatile and easy to be adapted to various hydrophobic drugs, different polymers, and solvents. This salt‐induced nanoprecipitation strategy offers a novel approach to fabricating polymer nanoparticles with tunable drug loading, and opens great potentials for future nanomedicines.

Ionogels have garnered great attention as promising soft conducting materials for the fabrication of flexible energy storage devices, soft actuators, and ionotronics. However, the leakage of the ionic liquids, weak mechanical strength, and poor manufacturability have greatly limited their reliability and applications. Here, we propose a new ionogel synthesis strategy by utilizing granular zwitterionic microparticles to stabilize ionic liquids. The ionic liquids swell the microparticles and physically crosslink microparticles via either electronic interaction or hydrogen bonding. Further introducing a photocurable acrylic monomer enables the fabrication of double-network (DN) ionogels with high stretchability (>600%) and ultrahigh toughness (fracture energy > 10 kJ/m2). The synthesized ionogels exhibit a wide working temperature of −60 to 90 °C. By tuning the crosslinking density of microparticles and physical crosslinking strength of ionogels, we synthesize DN ionogel inks and print them into three-dimensional (3D) motifs. Several ionogel-based ionotronics are 3D printed as demonstrations, including strain gauges, humidity sensors, and ionic skins made of capacitive touch sensor arrays. Via covalently linking ionogels with silicone elastomers, we integrate the ionogel sensors onto pneumatic soft actuators and demonstrate their capacities in sensing large deformation. As our last demonstration, multimaterial direct ink writing is harnessed to fabricate highly stretchable and durable alternating-current electroluminescent devices with arbitrary structures. Our printable granular ionogel ink represents a versatile platform for the future manufacturing of ionotronics.

The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a serious global health crisis. Increasing evidence suggests that elderly individuals with underlying chronic diseases, including Parkinson’s disease (PD), are particularly vulnerable to this infection. Changes in the routine care of PD patients should be implemented carefully without affecting the quality provided. The utilization of telemedicine for clinical consultation, assessment and rehabilitation has also been widely recommended. Therefore, the aim of this review is to provide recommendations in the management of PD during the pandemic as well as in the early phase of vaccination programs to highlight the potential sequelae and future perspectives of vaccination and further research in PD. Even though a year has passed since COVID- 19 emerged, most of us are still facing great challenges in providing a continuum of care to patients with chronic neurological disorders. However, we should regard this health crisis as an opportunity to change our routine approach in managing PD patients and learn more about the impact of SARS-CoV-2. Hopefully, PD patients can be vaccinated promptly, and more detailed research related to PD in COVID-19 can still be carried out.

Objective: We detailed the electrophysiological patterns of peripheral nerve temporal dispersion across spectrum of POEMS syndrome and Castleman disease (CD). Methods: Compound muscle action potentials (CMAP) duration of 3 patients with POEMS syndrome and 2 with hyaline vascular type CD without clonal plasma cell dyscrasia were retrospectively analysed. Results: Median and ulnar nerves distal CMAP duration were prolonged in all patients irrespective of plasma cell dyscrasia or M protein. All lower limbs distal CMAP responses were absent. Greatest distal CMAP duration prolongation was observed in median nerves for POEMS syndrome (17.0 ms, 158% upper limit normal) and in ulnar nerves for CD (9.8 ms, 47% upper limit normal). Distal/proximal CMAP duration ratio of 0.7, all had distal CMAP duration prolongation (Range 7%–158% of upper limit normal). Conclusions: Abnormal distal CMAP dispersion is not uncommon in POEMS syndrome and CD without clonal plasma cell dyscrasia or M protein. POEMS syndrome has greater distal CMAP duration in median and ulnar nerves, particularly in median nerve that can reach up to 150% of upper limit normal, compared to

The gear meshing noise generated by the helicopter main reducer is one of the important sources of noise in the helicopter cabin. By improving the isolation performance of the struts supporting reducer to the gear meshing vibration, the purpose of reducing the gear meshing noise in the helicopter cabin can be achieved. Piezoelectric stack periodic strut (PSPS) composed of piezoelectric stacks and passive materials periodically arranged is an original type of strut with active and passive hybrid isolation characteristics. Piezoelectric stacks and passive materials form a periodic structure, which makes PSPS have a unique stopband characteristic. The propagation of elastic waves in the stopband frequency range is attenuated, which can improve the broadband passive vibration isolation capability of the PSPS; The piezoelectric stacks can adjust the elastic wave propagation in the PSPS and improve the single-frequency or multifrequency active isolation performance of the PSPS. Since the driving voltage and current range of the piezoelectric stacks significantly affect the isolation performance of the PSPS, this article focuses on the relationship between the isolation performance of the PSPS and the voltage and current required by the piezoelectric stacks. Firstly, based on the passive material periodic structure transfer matrix model, the driving voltage and current of the piezoelectric stacks are introduced into the model, and a PSPS electromechanical coupling model based on the transfer matrix form is established. Secondly, the correctness of the model is verified by the finite element software. Based on the model, the design process of PSPS parameters is proposed. The optimal isolation performance of PSPS is predicted under the limitation of maximum driving voltage and current. The effects of damping loss factor, exciting force, period number and passive material on the requirements of electrical parameters for active control are studied. A three-period PSPS strut composed of piezoelectric stack actuator and PV strut is used for experimental research, and the matching of electrical parameters of this PSPS in the test is analyzed.

To understand the influence of underground mining disturbances on the shallow soil moisture in the Daliuta coal mine, remote sensing monitoring of the temporal and spatial evolution of surface soil moisture and the influence of mining on multi-source, multi-temporal and high spatial resolution remote sensing data were carried out. The scale effect of monitoring the soil moisture at different scales was analyzed using the Scaled Soil Moisture Monitor Index (S-SMMI). In this paper, SPOT 5/6 and Worldview-2 were used as the data source and mainly made up two aspects of the research: 1) based on the three SPOT data sets with the use of S-SMMI from different angles from the Daliuta mine from nearly three years of soil moisture temporal and spatial changes, the results show that the perturbation has a negative effect on the shallow soil moisture in the Daliuta coal mine, and average soil moisture of the mining area is smaller than the non-mining area, but the surface ecological construction has effectively improved the impact of the underground mining disturbance on the surface soil moisture. 2) the scale conversion of Worldview-2 data was carried out based on the resampling method. S-SMMI was used to analyze the scale effect of soil moisture monitoring at different scales. The results show that the difference between the soil moisture is only 0.0016 during the conversion process of 2 m-30 m.

A method for preparing iron-based friction material directly from the vanadium-bearing titanomagnetite concentrates by means of in-situ carbothermic reaction and sintering was presented. Effect of Ni content (1%-4%, mass fraction, the same below)on microstructure, mechanical properties and wear performance of iron-based friction material was investigated. The results show that the sintered sample consists of iron matrix, graphite lubricating phases and hard particles (mainly TiC). The matrix is predominantly composed of laminated pearlite with higher strength and hardness than those of ferrite. Compared with the sintered sample without Ni, the microstructure and properties of iron-based friction material are improved in varying degrees with different Ni contents. Low Ni content (1%-2%) promotes sintering process, which exhibits the decreasing amount of pores and uniform distribution of lubricating graphite phases and hard particles. Besides, the hardness and wear performance are improved significantly with the increase of Ni content. However, when Ni content exceeds 2%, not only the amount of pores increases, but also graphite phases and hard particles segregate in the microstructure, which result in decreasing hardness and poor wear performance of the material. To sum up, the microstructure and properties are the best when the Ni content is 2%.

Various pesticide nanocarriers have been developed. However, their pest-control applications remain limited in laboratories. Herein, we developed silica nanocapsules encapsulating fipronil (SNC) and their engineered form, poly(ethyleneimine)-coated SNC (SNC-PEI), based on recombinant catalytic modular protein D4S2 and used them against termite colonies Coptotermes lacteus in fields. To achieve this, an integrated biomolecular bioprocess was developed to produce D4S2 for manufacturing SNC containing fipronil with high encapsulation efficiency of approximately 97% at benign reaction conditions and at scales sufficient for the field applications. PEI coating was achieved via electrostatic interactions to yield SNC-PEI with a slower release of fipronil than SNC without coating. As a proof-of-concept, bait toxicants containing varied fipronil concentrations were formulated and exposed to nine termite mounds, aiming to prolong fipronil release hence allowing sufficient time for termites to relocate the baits into and distribute throughout the colony, and to eliminate that colony. Some baits were relocated into the mounds, but colonies were not eliminated due to several reasons. We caution others interested in producing bait toxicants to be aware of the multilevel resistance mechanisms of the Coptotermes spp. “superorganism”.