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15. Corrigendum to < Corneal bioprinting using a high concentration pure collagen I transparent bioink. > <[Bioprinting, 28 (2022)/ e00235]>

Author

Song, Yihui, primary, Hua, Sheng, additional, Sayyar, Sepidar, additional, Chen, Zhi, additional, Chung, Johnson, additional, Liu, Xiao, additional, Yue, Zhilian, additional, Angus, Cameron, additional, Filippi, Benjamin, additional, Beirne, Stephen, additional, Wallace, Gordon, additional, Sutton, Gerard, additional, and You, Jingjing, additional

Published
2023
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23. The promises and future directions of wireless stimulation in biomedical applications

Author

Australian Research Council, Australian National Fabrication Facility, University of Wollongong, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Qin, Chunyan, Yue, Zhilian, Casañ Pastor, Nieves, Chen, Jun, Wallace, Gordon, Australian Research Council, Australian National Fabrication Facility, University of Wollongong, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Qin, Chunyan, Yue, Zhilian, Casañ Pastor, Nieves, Chen, Jun, and Wallace, Gordon

Abstract

Wireless stimulation (WS) technologies have been developed as powerful strategies to modulate cellular behaviour and biological activity remotely and noninvasively through wireless manipulation of electrical signal. These WS systems are constructed from the electrically stimulus-responsive materials (magnetoelectric, piezoelectric, optoelectronic, and bipolar electroactive materials) that are triggered by the primary driving force, general like magnetic field, ultrasound, light, and electric field. With a deeper understanding of the integral role of electrical stimulation played in biological cells, tissues, and organs, WS has become the promising technique to work on neural cell stimulation, for either functional or repair effects, and other biological activities including drug release, electroporation and cancer treatment. This paper summarises existing WS systems in accordance with the utilised stimulus-responsive materials. Also, future directions of WS in potential biomedical applications are discussed. Along with the development of emerging techniques such as bipolar electrochemistry and 3D printing, more effective WS systems will be allowed to apply in biosystems with a change of paradigm.

Published
2023

36. Laser Sintering Approaches for Bone Tissue Engineering

Author

DiNoro, Jeremy N., primary, Paxton, Naomi C., additional, Skewes, Jacob, additional, Yue, Zhilian, additional, Lewis, Philip M., additional, Thompson, Robert G., additional, Beirne, Stephen, additional, Woodruff, Maria A., additional, and Wallace, Gordon G., additional

Published
2022
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39. Laser Sintering Approaches for Bone Tissue Engineering

Author

Dinoro, Jeremy N., Paxton, Naomi C., Skewes, Jacob, Yue, Zhilian, Lewis, Philip M., Thompson, Robert G., Beirne, Stephen, Woodruff, Maria A., Wallace, Gordon G., Dinoro, Jeremy N., Paxton, Naomi C., Skewes, Jacob, Yue, Zhilian, Lewis, Philip M., Thompson, Robert G., Beirne, Stephen, Woodruff, Maria A., and Wallace, Gordon G.

Abstract

The adoption of additive manufacturing (AM) techniques into the medical space has revo-lutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue such as bone, powder bed fusion (PBF) techniques have significant potential, as they are capable of fabricating materials that can match the mechanical requirements necessary to maintain bone functionality and support regeneration. This review focuses on the PBF techniques that utilize laser sintering for creating scaffolds for bone tissue engineering (BTE) applications. Optimal scaffold requirements are explained, ranging from material biocompatibility and bioactivity, to generating specific architectures to recapitulate the porosity, interconnectivity, and mechanical properties of native human bone. The main objective of the review is to outline the most common materials processed using PBF in the context of BTE; initially outlining the most common polymers, including polyamide, polycaprolactone, polyethylene, and polyetheretherketone. Subsequent sections investigate the use of metals and ceramics in similar systems for BTE applications. The last section explores how composite materials can be used. Within each material section, the benefits and shortcomings are outlined, including their mechanical and biological performance, as well as associated printing parameters. The framework provided can be applied to the development of new, novel materials or laser-based approaches to ultimately generate bone tissue analogues or for guiding bone regeneration.

Published
2022

40. Optimizing the composition of gelatin methacryloyl and hyaluronic acid methacryloyl hydrogels to maximize mechanical and transport properties using response surface methodology.

Author

Talaei, Alireza, O'Connell, Cathal D., Sayyar, Sepidar, Maher, Malachy, Yue, Zhilian, Choong, Peter F., and Wallace, Gordon G.

Subjects
RESPONSE surfaces (Statistics), HYALURONIC acid, HYDROGELS, CHONDROGENESIS, GELATIN
Abstract

Hydrogel materials are promising candidates in cartilage tissue engineering as they provide a 3D porous environment for cell proliferation and the development of new cartilage tissue. Both the mechanical and transport properties of hydrogel scaffolds influence the ability of encapsulated cells to produce neocartilage. In photocrosslinkable hydrogels, both of these material properties can be tuned by changing the crosslinking density. However, the interdependent nature of the structural, physical and biological properties of photocrosslinkable hydrogels means that optimizing composition is typically a complicated process, involving sequential and/or iterative steps of physiochemical and biological characterization. The combinational nature of the variables indicates that an exhaustive analysis of all reasonable concentration ranges would be impractical. Herein, response surface methodology (RSM) was used to efficiently optimize the composition of a hybrid of gelatin‐methacryloyl (GelMA) and hyaluronic acid methacryloyl (HAMA) with respect to both mechanical and transport properties. RSM was employed to investigate the effect of GelMA, HAMA, and photoinitiator concentration on the shear modulus and diffusion coefficient of the hydrogel membrane. Two mathematical models were fitted to the experimental data and used to predict the optimum hydrogel composition. Finally, the optimal composition was tested and compared with the predicted values. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Electrowriting of silk fibroin: Towards 3D fabrication for tissue engineering applications.

Author

Hai, Abdul Moqeet, Yue, Zhilian, Beirne, Stephen, and Wallace, Gordon

Subjects
SILK fibroin, TISSUE engineering, TISSUE scaffolds, THREE-dimensional printing, SURFACE tension, MORPHOLOGY, SURFACE properties
Abstract

Electrowriting (EW) successfully combines the principles of two widely studied biofabrication techniques; 3D printing and electrospinning, and is capable of producing complex architectures, with submicron resolutions. However, the EW process so far is limited mainly to thermoplastic polymers of synthetic origin such as poly ε‐caprolactone. Herein we demonstrate the EW of silk fibroin (SF) on an in‐house build setup to identify the compatibility of water‐based SF ink with EW. More specifically, we optimized the SF ink composition and investigated the effect of EW process parameters including ink concentration, collector translation speed, applied voltage, and distance between nozzle and collector on filament orientation and diameter. During SF ink preparation, control over the silk degumming process and ink concentration enabled modulation of rheology and surface tension properties of SF inks. We envision that the EW of hydrophilic SF will offer a new class of material structures with biological properties akin to natural systems. [ABSTRACT FROM AUTHOR]

Published
2023
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