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Background: We sought to study the blood pressure variability statuses among different subtypes of acute ischemic stroke. Methods: From July 2009 to July 2011, 226 acute ischemic stroke patients aged 66.2±11.9 years, including 128 men and 98 women, were enrolled from the Departments of Neurology and Emergency at Urumqi Friendship Hospital. Based on the criteria and classification of “trial of Org 10 172 in acute stroke treatment,” the patients were divided into 3 groups: arterial atherothrombolism (AT) group (n = 98), cardioaortic embolism (CE) group (n = 39), and small artery disease (SAD) group (n = 89). Two-hundred twenty-six healthy subjects aged 65.6±10.8 years, including 140 men and 86 women were selected as control subjects. Their blood pressure level and variability were examined by 24-hour ambulatory blood pressure monitoring. Results: Compared with the control group, patients in the AT, CE and SAD groups had significantly higher 24-hour mean systolic blood pressure (136.7±11.7, 131.2±12.5, and 138.1±15.3mm Hg, respectively, vs. 116.7±13.2mm Hg), 24-hour mean diastolic blood pressure (77.9±12.5, 70.2±11.4, and 77.2±12.7mm Hg, respectively vs. 64.4±11.5mm Hg), pulse pressure index (0.46±0.08, 0.42±0.07, and 0.45±0.05, respectively, vs. 0.37±0.07), and variability of 24-hour diastolic blood pressure (0.17±0.05, 0.14±0.02, and 0.17±0.01, respectively, vs. 0.11±0.04) (all P < 0.05). There were significant differences in the distribution of blood pressure circadian rhythms among patients in the 3 groups (P < 0.05). Conclusions: The blood pressure variability in acute ischemic stroke patients was significantly larger than that in the control group. Furthermore, there were also significant differences in blood pressure variability among different ischemic stroke subtypes. [ABSTRACT FROM PUBLISHER]

Background: The aim of the present study is to determine the association of serum lipid level in the above 55-year-old age elderly with ischemic stroke (IS) in Xinjiang regions, China., Methods: 408 patients with IS and 347 healthy individuals as control in the ≥55-year-old elderly were selected for the present study in Xinjiang province of China from July 2010 to July 2012. Patients were divided into different groups according to the IS subtypes (large-artery atherosclerosis, LAA; cardio-aortic embolism CE; small-artery occlusion, SAO), plague stability, hypertension and diabetes. The serum lipid level including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), Lipoprotein(a) (Lp(a)) and their ratios(TC/HDL, LDL/HDL, ApoA1/ApoB) were measured., Results: Patients in LAA group had higher ratio of TC/HDL, ApoA1/ApoB and lower level of ApoA1 than SAO group(p<0.05); higher level of TC, HDL, LDL, TC/HDL, LDL/HDL, ApoA1/ApoB and lower level of ApoB compared with CE group. Patients in SAO group had higher level of LDL, ApoA1, ApoB, TC/HDL, LDL/HDL and ApoA1/ApoB than CE group. Patients with stable plaque had higher level of HDL and low level of LDL, ApoB, Lp(a), TC/HDL, LDL/HDL and ApoA1/ApoB than unstable plaque group. Patients with hypertension had higher level of TG, ApoB, Lp(a), LDL/HDL and ApoA1/ApoB than non-hypertensive group. Patients with diabetes had higher level of TC, TG, ApoB, TC/HDL, LDL/HDL, ApoA1/ApoB and low level of ApoA1 than non-diabetic group. Multiple logistic regression analysis revealed that high LDL, ApoB, LDL/HDL and ApoA1/ApoB might be the risk factors for ischemic stroke., Conclusion: An abnormal serum lipid level of the patients with IS in older Xinjiang population is significantly associated with the stroke subtypes, plaque stability, hypertension and diabetes.

Objective: To investigate the relationship between the low density lipoprotein receptor-related protein gene (LRP) 766C/T polymorphisms and Alzheimer's disease (AD) in Xinjiang Uygurs and Hans populations., Methods: Those included in the study were > or = 50 years of age and of either Xinjiang Uygur or Han descents. Two hundred and nine individuals had AD and 220 were healthy controls. They were recruited according to ADRDA-NINCDS criteriaîThe polymorphisms of the LRP gene were determined by the PCR-restriction fragment length polymorphism technique. The case-control analysis was adopted to analyze the frequencies of genotypes and alleles., Results: (1) The distribution of genotypes or alleles of LRP gene had significant differences between the AD group and the control group in both the Xinjiang Uygurs and Hans populations (P < 0.05). (2) The frequencies of genotypes and alleles were significantly different between the Han AD and Han control group (P < 0.05). (3) The frequencies of genotypes and alleles in those > or = 65 years were significantly different from that in others (P < 0.05). There was a significant increase of AD in the C allele carriers (OR=1.98, P < 0.05). (4) The frequencies of the CC genotype and C allele in female AD patients were higher than that in female controls (P < 0.05), and the C allele carriers had significant increase of AD (OR=2.927, P < 0.05)., Conclusion: The LRP 766C/T polymorphisms were significantly different between the Chinese Xinjiang Uygur and Han populations. The LRP 766C/T polymorphisms might be associated with AD in the Han population, in females and those of > or = 65 years old.