18 results on '"Yudovin, S."'
Search Results
2. Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008.
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Hemb M, Velasco TR, Parnes MS, Wu JY, Lerner JT, Matsumoto JH, Yudovin S, Shields WD, Sankar R, Salamon N, Vinters HV, Mathern GW, Hemb, M, Velasco, T R, Parnes, M S, Wu, J Y, Lerner, J T, Matsumoto, J H, Yudovin, S, and Shields, W D
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- 2010
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3. Targeting the Epidemic.
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Choe, M. C., Valino, H., Fischer, J., Zeiger, M., Breault, J., McArthur, D. L., Leung, M., Madikians, A., Yudovin, S., Lerner, J. T., and Giza, C. C.
- Subjects
BRAIN injuries ,POSTCONCUSSION syndrome ,CHILDREN'S health ,PRIMARY care ,HEADACHE clinics - Abstract
Traumatic brain injury is a major public health problem in the pediatric population. Previously, management was acute emergency department/primary care evaluation with follow-up by primary care. However, persistent symptoms after traumatic brain injury are common, and many do not have access to a specialized traumatic brain injury clinic to manage chronic issues. The goal of this study was to determine the factors related to outcomes, and identify the interventions provided in this subspecialty clinic. Data were extracted from medical records of 151 retrospective and 403 prospective patients. Relationships between sequelae, injury characteristics, and clinical interventions were analyzed. Most patients returning to clinic were not fully recovered from their injury. Headaches were more common after milder injuries, and seizures were more common after severe. The majority of patients received clinical intervention. The presence of persistent sequelae for traumatic brain injury patients can be evaluated and managed by a specialty concussion/traumatic brain injury clinic ensuring that medical needs are met. [ABSTRACT FROM AUTHOR]
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- 2016
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4. Sports and Recreation Brain Injuries in a Pediatric Specialty Traumatic Brain Injury Clinic (P01.185)
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Valino, H., primary, McArthur, D., additional, Yudovin, S., additional, and Giza, C., additional
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- 2012
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5. Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex
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Wu, J. Y., primary, Sutherling, W. W., additional, Koh, S., additional, Salamon, N., additional, Jonas, R., additional, Yudovin, S., additional, Sankar, R., additional, Shields, W. D., additional, and Mathern, G. W., additional
- Published
- 2006
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6. Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms
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Jonas, R., primary, Asarnow, R. F., additional, LoPresti, C., additional, Yudovin, S., additional, Koh, S., additional, Wu, J. Y., additional, Sankar, R., additional, Shields, W. D., additional, Vinters, H. V., additional, and Mathern, G. W., additional
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- 2005
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7. Cerebral hemispherectomy
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Jonas, R., primary, Nguyen, S., additional, Hu, B., additional, Asarnow, R. F., additional, LoPresti, C., additional, Curtiss, S., additional, de Bode, S., additional, Yudovin, S., additional, Shields, W. D., additional, Vinters, H. V., additional, and Mathern, G. W., additional
- Published
- 2004
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8. Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes.
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Jonas, R, Nguyen, S, Hu, B, Asarnow, R F, LoPresti, C, Curtiss, S, de Bode, S, Yudovin, S, Shields, W D, Vinters, H V, and Mathern, G W
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- 2004
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9. Targeting the Epidemic: Interventions and Follow-up Are Necessary in the Pediatric Traumatic Brain Injury Clinic.
- Author
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Choe MC, Valino H, Fischer J, Zeiger M, Breault J, McArthur DL, Leung M, Madikians A, Yudovin S, Lerner JT, and Giza CC
- Subjects
- Adolescent, Adult, Age Factors, Brain Injuries diagnosis, Brain Injuries epidemiology, Brain Injuries etiology, Child, Child, Preschool, Cohort Studies, Electronic Health Records statistics & numerical data, Female, Humans, Infant, Infant, Newborn, Male, Young Adult, Brain Injuries therapy, Treatment Outcome
- Abstract
Traumatic brain injury is a major public health problem in the pediatric population. Previously, management was acute emergency department/primary care evaluation with follow-up by primary care. However, persistent symptoms after traumatic brain injury are common, and many do not have access to a specialized traumatic brain injury clinic to manage chronic issues. The goal of this study was to determine the factors related to outcomes, and identify the interventions provided in this subspecialty clinic. Data were extracted from medical records of 151 retrospective and 403 prospective patients. Relationships between sequelae, injury characteristics, and clinical interventions were analyzed. Most patients returning to clinic were not fully recovered from their injury. Headaches were more common after milder injuries, and seizures were more common after severe. The majority of patients received clinical intervention. The presence of persistent sequelae for traumatic brain injury patients can be evaluated and managed by a specialty concussion/traumatic brain injury clinic ensuring that medical needs are met., (© The Author(s) 2015.)
- Published
- 2016
- Full Text
- View/download PDF
10. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort.
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Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, and Giza CC
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- Adolescent, Anticonvulsants therapeutic use, Brain Injuries physiopathology, Child, Child, Preschool, Epilepsies, Partial drug therapy, Epilepsies, Partial etiology, Epilepsies, Partial physiopathology, Female, Glasgow Coma Scale, Humans, Infant, Male, Monitoring, Physiologic methods, Prospective Studies, Risk Factors, Seizures diagnosis, Seizures etiology, Seizures physiopathology, Status Epilepticus diagnosis, Status Epilepticus etiology, Status Epilepticus physiopathology, Brain Injuries complications, Electroencephalography methods, Epilepsies, Partial diagnosis
- Abstract
Purpose: Traumatic brain injury (TBI) is an important cause of morbidity and mortality in children, and early posttraumatic seizures (EPTS) are a contributing factor to ongoing acute damage. Continuous video-EEG monitoring (cEEG) was utilized to assess the burden of clinical and electrographic EPTS., Methods: Eighty-seven consecutive, unselected (mild - severe), acute TBI patients requiring pediatric intensive care unit (PICU) admission at two academic centers were monitored prospectively with cEEG per established clinical TBI protocols. Clinical and subclinical seizures and status epilepticus (SE, clinical and subclinical) were assessed for their relation to clinical risk factors and short-term outcome measures., Key Findings: Of all patients, 42.5% (37/87) had seizures. Younger age (p = 0.002) and injury mechanism (abusive head trauma - AHT, p < 0.001) were significant risk factors. Subclinical seizures occurred in 16.1% (14/87), while 6.9% (6/87) had only subclinical seizures. Risk factors for subclinical seizures included younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p < 0.001). SE occurred in 18.4% (16/87) with risk factors including younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p = 0.002). Subclinical SE was detected in 13.8% (12/87) with significant risk factors including younger age (p < 0.001), AHT (p = 0.001), and intraaxial bleed (p = 0.004). Subclinical seizures were associated with lower discharge King's Outcome Scale for Childhood Head Injury (KOSCHI) score (p = 0.002). SE and subclinical SE were associated with increased hospital length of stay (p = 0.017 and p = 0.041, respectively) and lower hospital discharge KOSCHI (p = 0.007 and p = 0.040, respectively)., Significance: cEEG monitoring significantly improves detection of seizures/SE and is the only way to detect subclinical seizures/SE. cEEG may be indicated after pediatric TBI, particularly in younger children, AHT cases, and those with intraaxial blood on computerized tomography (CT)., (Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.)
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- 2013
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11. Prevalence of epileptic and nonepileptic events after pediatric traumatic brain injury.
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Matsumoto JH, Caplan R, McArthur DL, Forgey MJ, Yudovin S, and Giza CC
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- Adolescent, Age Factors, Chi-Square Distribution, Child, Child, Preschool, Cohort Studies, Databases, Factual statistics & numerical data, Electroencephalography, Epilepsy, Post-Traumatic diagnosis, Humans, Prevalence, Retrospective Studies, Seizures diagnosis, Brain Injuries complications, Epilepsy, Post-Traumatic epidemiology, Pediatrics, Seizures epidemiology, Seizures etiology
- Abstract
Though posttraumatic epilepsy (PTE) is a prominent sequela of traumatic brain injury (TBI), other nonepileptic phenomena also warrant consideration. Within two UCLA pediatric TBI cohorts, we categorized five spell types: 1) PTE; 2) Epilepsy with other potential etiologies (cortical dysplasia, primary generalized); 3) Psychopathology; 4) Behavior misinterpreted as seizures; and 5) Other neurologic events. The two cohort subsets differed slightly in injury severity, but they were otherwise similar. Overall, PTE occurred in 40%, other epilepsy etiologies in 14%, and nonepileptic spells collectively in 46%. Among children with spells, PTE was associated with severe TBI (p=0.001), whereas psychopathology (p=0.014) and epilepsy with other etiologies (p=0.006) were associated with milder TBI severity. Posttraumatic epilepsy (p=0.002) and misinterpreted behavior (p=0.049) occurred with younger injury age. Psychopathology (p=0.020) and other neurologic events (p=0.002) occurred with older injury age. In evaluating possible PTE, clinicians should maintain a broad differential diagnosis to prevent misdiagnosis and inappropriate treatment., (Copyright © 2013 Elsevier Inc. All rights reserved.)
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- 2013
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12. Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients.
- Author
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Koh S, Mathern GW, Glasser G, Wu JY, Shields WD, Jonas R, Yudovin S, Cepeda C, Salamon N, Vinters HV, and Sankar R
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- Adolescent, Anticonvulsants therapeutic use, Brain abnormalities, Child, Child, Preschool, Cohort Studies, Comorbidity, Electroencephalography, Encephalitis complications, Encephalitis epidemiology, Epilepsy diagnosis, Epilepsy epidemiology, Female, Functional Laterality, Humans, Incidence, Infant, Magnetic Resonance Imaging, Male, Retrospective Studies, Risk Factors, Spasms, Infantile diagnosis, Spasms, Infantile drug therapy, Spasms, Infantile epidemiology, Status Epilepticus drug therapy, Epilepsy surgery, Status Epilepticus diagnosis, Status Epilepticus epidemiology
- Abstract
Purpose: The literature suggests that pediatric epilepsy surgery cases that present in status epilepticus (SE) are an unusual occurrence. However, this concept is based on case reports, and the incidence and clinical characteristics of these patients have not been systematically assessed., Methods: The cohort consisted of resective epilepsy surgery cases from 2000 to 2005 (n = 115), and they were classified as presenting with continuous SE requiring medical suppression therapy (n = 6) or intermittent SE (greater than 3 seizures/hour; n = 17). The SE categories were compared with extratemporal surgery patients without SE (non-SE; n = 64) for differences in clinical variables abstracted from the medical record., Results: Continuous SE was noted in 5% and intermittent SE in 15% of resective surgery cases, and all had extratemporal cortical involvement. Compared with continuous SE and non-SE cases, intermittent SE patients were younger at surgery with shorter duration of seizures, and had an increased incidence of active infantile spasms during video scalp EEG monitoring. Compared with non-SE cases, the continuous and intermittent SE groups required a larger number of antiepileptic medications presurgery and 6-months postsurgery, underwent hemispherectomy more frequently, and had an increased incidence of hemimegalencephaly and Rasmussen encephalitis and a lower occurrence of infarct/ischemia and infectious etiologies. Seizure control was over 71% up to 2 years postsurgery, and there were no differences between patient groups. Finally, seizure frequency per hour was greater in continuous SE cases compared with the intermittent SE group., Conclusions: Children presenting with continuous or intermittent SE are not rare in pediatric epilepsy surgery centers, and such cases are more commonly associated with infantile spasms, Rasmussen's syndrome, and hemimegalencephaly pathologies. Seizure outcome after surgery was not altered in pediatric patients because they had presented with continuous or intermittent SE.
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- 2005
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13. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy.
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Koh S, Nguyen S, Asarnow RF, LoPresti C, Yudovin S, Shields WD, Vinters HV, and Mathern GW
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- Acute Disease, Age of Onset, Anticonvulsants therapeutic use, Child, Child, Preschool, Cohort Studies, Epilepsy diagnosis, Epilepsy drug therapy, Female, Hospitalization, Humans, Intensive Care Units, Pediatric, Length of Stay, Male, Postoperative Complications diagnosis, Preoperative Care, Prognosis, Reoperation, Retrospective Studies, Seizures diagnosis, Treatment Outcome, Epilepsy surgery, Hemispherectomy, Postoperative Complications epidemiology, Seizures epidemiology
- Abstract
Purpose: Acute postoperative seizures (APOSs) are those that occur in the first 7 to 10 days after surgery, and previous studies in temporal lobe epilepsy patients support the notion that APOSs may foretell failure of long-term seizure control. It is unknown whether APOSs also predict seizure outcome or hospital course after hemispherectomy., Methods: Hemispherectomy patients (n = 114) were studied retrospectively and subdivided into the following groups: No APOSs, 1 to 5 APOSs, or >5 APOSs. Intensive care unit (ICU) nursing staff or family members reported and described the APOS events. APOS categories were compared with pre- and postsurgery clinical variables abstracted from the medical record., Results: APOSs occurred in 22.6% of hemispherectomy patients. Compared with the 0 and 1 to 5 APOS groups, patients with >5 APOS showed (a) longer seizure durations before surgery, (b) longer hospitalizations, (c) later oral food intake, (d) more frequent lumbar punctures, (e) worse seizure control at 0.5 and 1 year after surgery, (f) more antiepileptic drug (AED) use at 2 and 5 years after surgery, and (g) higher reoperation rate. No similar differences were found between the 0 and 1 to 5 APOS groups. The day of the APOS, whether the APOS was typical of preoperative seizures, and postsurgery scalp EEG did not predict long-term seizure control. APOS patients in the 1 to 5 and >5 groups had lower pre- and postsurgery Vineland developmental quotients compared with those without an APOS., Conclusions: Hemispherectomy patients with >5 APOSs had a more prolonged and complicated hospital course and worse postsurgery seizure control, more AED use, and higher reoperation rate than did patients with 0 or 1 to 5 APOSs. Thus the number of APOSs was a predictor of postsurgery seizure control and can be used to counsel patients and families about prognosis after hemispherectomy.
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- 2004
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14. Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients.
- Author
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Cook SW, Nguyen ST, Hu B, Yudovin S, Shields WD, Vinters HV, Van de Wiele BM, Harrison RE, and Mathern GW
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- Cerebral Cortex abnormalities, Cerebral Cortex pathology, Cerebral Cortex surgery, Cerebral Infarction pathology, Cerebral Infarction surgery, Child, Child, Preschool, Cohort Studies, Encephalitis pathology, Encephalitis surgery, Epilepsy pathology, Epilepsy physiopathology, Female, Follow-Up Studies, Humans, Infant, Magnetic Resonance Imaging, Male, Outcome and Process Assessment, Health Care, Postoperative Complications diagnosis, Retrospective Studies, Risk Factors, Epilepsy surgery, Hemispherectomy methods
- Abstract
Object: Cerebral hemispherectomy for intractable seizures has evolved over the past 50 years, and current operations focus less on brain resection and more on disconnection. In addition, cases involving cortical dysplasia and Rasmussen encephalitis are being identified and surgically treated in younger individuals. Few studies have been conducted to compare whether there are perioperative differences based on hemispherectomy technique and/or pathological substrate in pediatric patients with epilepsy., Methods: In this study the authors compared, stratified by disease, anatomical (37 cases) and Rasmussen functional hemispherectomy (32 cases) with a new modified lateral hemispherotomy (46 cases). Pathological processes included cortical dysplasia (55 cases), Rasmussen encephalitis (21 cases), infarction/ischemia (27 cases), and other/miscellaneous (12 cases). The authors found differences in perioperative clinical factors based on operative technique and/or pathological substrate. In terms of technique, the lateral hemispherotomy was associated with the least intraoperative blood loss, shortest intensive care unit stay, and lowest complication rate. The anatomical hemispherectomy was associated with the longest hospital stay, delayed oral food intake, highest postsurgery fevers, and the highest incidence of shunt requirement. The functional hemispherectomy was associated with the highest reoperation rate for recurrent seizures (25%). In terms of pathology, patients with cortical dysplasia were the youngest at surgery, suffered the greatest amount of blood loss, and required the longest operative/anesthesia times compared with the other pathologically defined groups. Postoperative seizure control (range 0.5-2 years) was not statistically different according to technique or disease process and was similar to that in cases of pediatric temporal lobe epilepsy., Conclusions: The authors found differences in perioperative risks and hospital course but not postsurgery seizure control, which vary by hemispherectomy technique and/or disease process. The modified lateral hemispherotomy approach offers various advantages related to operative blood loss and reoperation compared with anatomical and functional hemispherectomies that are especially relevant in younger patients with cortical dysplasia and Rasmussen encephalitis with small and/or malformed ventricles.
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- 2004
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15. Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997.
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Mathern GW, Giza CC, Yudovin S, Vinters HV, Peacock WJ, Shewmon DA, and Shields WD
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- Age Factors, California, Cerebral Cortex abnormalities, Child, Epilepsy etiology, Epilepsy prevention & control, Epilepsy, Temporal Lobe surgery, Follow-Up Studies, Humans, Regression Analysis, Treatment Outcome, Anticonvulsants therapeutic use, Epilepsy surgery, Postoperative Complications prevention & control, Seizures prevention & control
- Abstract
Purpose: Young children with refractory symptomatic epilepsy are at risk for developing neurologic and cognitive disabilities. Stopping the seizures may prevent these disabilities, but it is unclear whether resective surgery is associated with adequate long-term seizure control., Methods: This study determined pre- and postsurgery seizure frequency and antiepileptic drug (AED) use (6 months to 10 years) in children with symptomatic seizures from unilateral cortical dysplasia (CD; n = 64) and non-CD etiologies (i.e., ischemia, infection; n = 71), and compared them with older temporal lobe epilepsy (TLE; n = 31) patients with complex partial seizures., Results: Compared with presurgery, postsurgery seizure frequencies were decreased for CD, non-CD, and TLE patients (p < 0.002), and there were no differences between the three groups from 6 to 24 months after surgery (p > 0.12). At 5 years after surgery, seizure frequencies were greater in CD compared with TLE cases (p = 0.009). Compared with presurgery, the number of AEDs declined after surgery in all three groups (p < 0.002), and positively correlated with seizure frequencies (p = 0.0001)., Conclusions: This study indicates that seizure relief and AED use after resective surgery for symptomatic CD and non-CD etiologies was comparable with complex partial TLE cases up to 2 years after surgery. Furthermore, at 5 years after surgery, CD patients had outcomes better than those before surgery, but worse than TLE cases. In young children, these findings support the concept that early removal of symptomatic pathologic substrates is associated with seizure control and reduced AED use, similar to that noted in older TLE cases up to 2 years after surgery. Seizure control may reduce the risk of developing the seizure-related encephalopathy associated with severe symptomatic early-onset childhood epilepsy.
- Published
- 1999
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16. Surgery for the treatment of medically intractable infantile spasms: a cautionary case.
- Author
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Shields WD, Shewmon DA, Peacock WJ, LoPresti CM, Nakagawa JA, and Yudovin S
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- Age Factors, Brain abnormalities, Brain surgery, Cerebral Cortex diagnostic imaging, Cerebral Cortex surgery, Child, Preschool, Female, Fluorodeoxyglucose F18, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Patient Selection, Spasms, Infantile diagnosis, Time Factors, Tomography, Emission-Computed, Child Development, Spasms, Infantile surgery
- Abstract
Unlabelled: The most appropriate time to consider cortical resection to treat medically intractable infantile spasms has not been clearly defined. The risks that need to be reconciled to make this decision are: What is the risk of loss of developmental potential if surgery is delayed too long versus what is the risk of unnecessary surgery if it is done too soon. We propose that, in addition to evaluation of seizures, developmental assessment is a key factor in the surgical decision. The case report illustrates this concept., Case Report: HC had onset of seizures at 9 days of age and developed infantile spasms due to mild right hemimegancephaly. At 19 months, she was having up to 50 seizures/day and was evaluated and approved for right hemispherectomy but surgery was delayed. Despite the seizures, her development had been much better than most patients with hemimegencephaly and infantile spasms. At 25 months her seizure control was much improved but she had several seizures/week. EcoG at the time of surgery did not demonstrate the usual abnormalities so no resection was performed. She has had only 5 seizures in the 2(1/2) year since., Conclusions: (a) Hemimegalencephaly is not always associated with severe mental retardation; (b) normal or near-normal development may, in some cases, indicate the possibility of medical control of seizures as the child grows; (c) a localized developmental brain abnormality in a child with intractable seizures should not necessarily lead to cortical resection; and (d) when a child meets developmental milestones, it may be appropriate to delay surgical intervention.
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- 1999
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17. Communication deficits in children undergoing temporal lobectomy.
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Caplan R, Guthrie D, Shields WD, Peacock WJ, Vinters HV, and Yudovin S
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- Adolescent, Brain physiopathology, Brain Diseases diagnosis, Brain Diseases physiopathology, Brain Diseases psychology, Child, Communication Disorders diagnosis, Epilepsy, Temporal Lobe physiopathology, Female, Humans, Language Disorders diagnosis, Language Disorders etiology, Language Tests, Male, Neuropsychological Tests, Verbal Behavior, Communication Disorders etiology, Epilepsy, Temporal Lobe surgery, Temporal Lobe surgery
- Abstract
Objective: To examine formal thought disorder and discourse (cohesive) devices that make speech coherent prospectively in seven children, aged 5.7 to 16.7 years, before and after temporal lobectomy for intractable cut points determined from sensitivity and specificity analyses of formal thought disorder and discourse measures in 22 children with complex partial seizure disorder and 45 normal children., Results: Before surgery, the mean illogical thinking and discourse scores of the surgical candidates were in the pathological range. After a mean postoperative follow-up period of 15.1 months, their illogical thinking (but not their discourse scores) decreased significantly to the normal range., Conclusions: These preliminary findings are discussed in terms of the possible role of postsurgical changes in seizure control, behavior, antiepileptic drugs, cognition, and prefrontal function.
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- 1993
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18. Middle childhood onset of interictal psychosis.
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Caplan R, Shields WD, Mori L, and Yudovin S
- Subjects
- Child, Electroencephalography, Epilepsy, Temporal Lobe physiopathology, Female, Hallucinations physiopathology, Hallucinations psychology, Humans, Magnetic Resonance Imaging, Male, Neurocognitive Disorders physiopathology, Psychiatric Status Rating Scales, Schizophrenia, Childhood physiopathology, Temporal Lobe physiopathology, Epilepsy, Temporal Lobe psychology, Neurocognitive Disorders psychology, Schizophrenia, Childhood psychology
- Abstract
The authors describe three children (mean age = 7.8 years) with complex partial epilepsy, left temporal lobe involvement, and interictal schizophrenia-like psychosis. As described in adults with complex partial epilepsy, these children met DSM-III criteria for schizophrenia, their affect was intact, and they demonstrated no negative signs of schizophrenia. Unlike adult epileptic patients, these children demonstrated psychotic symptomatology despite inadequate seizure control and after a short latency period. The possible role of early onset seizures, temporal lobe lesions, and kindling on the developing brain are discussed.
- Published
- 1991
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