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Background Coronary artery disease (CAD) is one of the severe diseases that threaten human health worldwide. In addition, the associated rate of comorbidity with depression and anxiety is extremely high. Heat shock proteins (HSPs) are a group of proteins that possesses cardiovascular and psychological protection properties. The objective of this study is to determine the association of the two most widely studied HSPs, namely, HSP70 and HSP90, with CAD comorbid depression and anxiety in a Chinese population. Methods A case-control study involving 271 CAD patients and 113 healthy individuals was conducted. The 271 CAD patients include individuals with (123) and without depression (148) and individuals with (57) and without anxiety (214). Ten single nucleotide polymorphisms (SNPs) for HSP70 and seven SNPs for HSP90 were selected and genotyped. Results Results revealed that the HSP70 rs10892958 C allele and HSP70 rs2236658 T allele were associated with a decreased risk of CAD (P < 0.05), whereas the G allele of the rs11218941 polymorphism was associated with an increased risk of CAD. The haplotype analysis results indicated that the haplotype TGGGC of the HSPA8 gene (coded the HSP70 family, rs4936770/rs4802/rs10892958/rs11218941/rs2236658) significantly increased the risk of CAD (P = 0.008). Among the patients with CAD, the carriers of the CC genotype for the HSP90 rs1042665 showed higher risks of anxiety than the carriers of another genotypes. However, no significant relationships were found among the CAD with depression and CAD without depression groups for the selected SNPs. These findings suggested that the genetic polymorphisms in the HSP gene, especially the HSPA8 of HSP70, contribute to CAD susceptibility and rs1042665 genetic polymorphisms might have an effect on the anxiety incidence among CAD patients.

The BSL k-ω turbulence model was used to numerically simulate the inspiratory airflow of the airway with foreign bodies using a real CT scan human airway model. The paper selects three foreign bodies with different diameters, three different foreign body positions, and three different breathing intensities, and the FLUENT software is used to perform numerical simulation. This study has found that the increase in the diameter of the foreign body and flow velocity will make the flow structure in the airway more complicated. The airway pressure will increase so that the resistance of breathing will increase, and the shear force will also increase, which hurt the airway. The impact of the foreign body on the left side on the flow structure in the airway is less than that of the foreign body on the right side. The foreign body on the left side causes the pressure drop in the airway to be higher than that on the right side. Moreover, sharp changes in pressure driving force and airway curvature will affect the airflow pattern of the central airway. We concluded that foreign matter has a great influence on the characteristics of the airflow structure, and more research is needed to increase the understanding of the airflow pattern under the condition of foreign matter in the airway, and the research helps doctors avoid the influence of airflow when removing foreign bodies in the airway.