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Objective: To systematically evaluate the efficacy and safety of Shufeng Jiedu Capsules in the treatment of acute attacks of chronic bronchitis. Methods: CNKI, VIP, CBM, WanFang, PubMed, EMbase, Cochrane Library and ChiCTR were searched by computer, and randomized controlled trials of Shufeng Jiedu capsules in the treatment of AECB were integrated. The retrieval time was from the date of establishing the database to December 31, 2020. Meta-analysis of outcome indicators [including effective rate, C-reactive protein (CRP), lung function [FEV1% and/or FEV1/FVC], interleukin-8 (IL-8), tumor necrosis factor-a (TNF-a)] were carried out by RevMan 5.3 software, and the effective rate was tested by sequential analysis (TSA), and the quality of evidence was evaluated according to GRADE standards. Results: A total of 680 cases in 8 articles were included. Shufeng Jiedu Capsules improved the effective rate of clinicaltreatment [RR=1.20, 95%CI (1.13, 1.28)], improved lung function [FEV1:MD=0.33, 95% CI (0.22, 0.45), FEV1/FVC:MD=10.17,95%CI(8.15,12.19) ], reduced CRP[MD=-7.32, 95%CI(-8.42,-6.22)], IL-8[MD=-63.39, 95%CI(-73.49,- 53.29)], TNF-a[MD=-7.44, 95%CI (-8.35, -6.53)] levels. The above differences were statistically significant (P<0.05), and no serious adverse reactions were reported in all studies. The results of TSA analysis showed that the experimental group had definite evidence for improving the efficiency. According to the GRADE evaluation system, the efficiency, TNF-awere mediumquality evidences, FEV1 was low-quality evidence, and FEV1/FVC, CRP, and IL-8 were extremely low-quality evidence. Conclusions: The curative effect of Shufeng Jiedu capsule combined with western medicine in the treatment of AECB was better than that of single western medicine. Nevertheless, considering the limited sample size and the quality of included articles, higher quality RCTs are still needed to further confirm its effectiveness and safety. [ABSTRACT FROM AUTHOR]