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Your search keyword '"Yuan, Weizhuo"' showing total 14 results
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14 results on '"Yuan, Weizhuo"'

6. AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance.

Author

Qiu, Tianming, Wu, Chenbing, Yao, Xiaofeng, Han, Qiuyue, Wang, Ningning, Yuan, Weizhuo, Zhang, Jingyuan, Shi, Yan, Jiang, Liping, Liu, Xiaofang, Yang, Guang, and Sun, Xiance

Subjects
NLRP3 protein, INSULIN resistance, NON-alcoholic fatty liver disease, INFLAMMASOMES, RNA methylation
Abstract

N6-methyladenosine (m6A) messenger RNA methylation is the most widespread gene regulatory mechanism affecting liver functions and disorders. However, the relationship between m6A methylation and arsenic-induced hepatic insulin resistance (IR), which is a critical initiating event in arsenic-induced metabolic syndromes such as type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), remains unclear. Here, we showed that arsenic treatment facilitated methyltransferase-like 14 (METTL14)-mediated m6A methylation, and that METTL14 interference reversed arsenic-impaired hepatic insulin sensitivity. We previously showed that arsenic-induced NOD-like receptor protein 3 (NLRP3) inflammasome activation contributed to hepatic IR. However, the regulatory mechanisms underlying the role of arsenic toward the post-transcriptional modification of NLRP3 remain unclear. Here, we showed that NLRP3 mRNA stability was enhanced by METTL14-mediated m6A methylation during arsenic-induced hepatic IR. Furthermore, we demonstrated that arsenite methyltransferase (AS3MT), an essential enzyme in arsenic metabolic processes, interacted with NLRP3 to activate the inflammasome, thereby contributing to arsenic-induced hepatic IR. Also, AS3MT strengthened the m6A methylase association with NLRP3 to stabilize m6A-modified NLRP3. In summary, we showed that AS3MT-induced m6A modification critically regulated NLRP3 inflammasome activation during arsenic-induced hepatic IR, and we identified a novel post-transcriptional function of AS3MT in promoting arsenicosis. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver

Author

Zhu, Yuhan, primary, Zhang, Jingyuan, additional, Yao, Xiaofeng, additional, Qiu, Tianming, additional, Jiang, Liping, additional, Wang, Ningning, additional, Shi, Yan, additional, Wu, Chenbing, additional, Yuan, Weizhuo, additional, Yang, Guang, additional, Liu, Xiaofang, additional, Bai, Jie, additional, Men, Lili, additional, and Sun, Xiance, additional

Published
2022
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