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4. New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.

Author

Yan LH, Wei WY, Xie YB, and Xiao Q

Subjects
Apoptosis, CDX2 Transcription Factor, Cell Line, Tumor, Cell Nucleus metabolism, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Humans, Intestines pathology, Mutation, Oncogenes, Signal Transduction, Treatment Outcome, Gene Expression Regulation, Neoplastic, Homeodomain Proteins genetics, Stomach Neoplasms genetics
Abstract

Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. In addition, gastric epithelial cell mutations in CDX2 result in tumor promotion, which is characterized by cellular drug resistance and a high proclivity for developing cancer. A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance. CDX2 appears to forward control regenerating IV and the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.

Published
2014
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