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2. Low Serum Calcitonin Gene-Related Peptide Level is Associated with Severity of Coronary Stenosis

Author

Xian-Feng Dong, Jia-Xin Zhong, Yuan-Ming Yan, Ming-Fang Ye, Qiong Jiang, Liang-Long Chen, Yu-Kun Luo, and Qin Chen

Subjects
Calcitonin Gene-Related Peptide, Coronary Stenosis, Odds Ratio, Humans, Coronary Artery Disease, General Medicine, Atherosclerosis, Coronary Angiography, Severity of Illness Index
Abstract

Purpose: To evaluate the relationship between the serum calcitonin gene-related peptide (CGRP) level and severity of coronary stenosis. Methods: A total of 233 eligible patients who underwent coronary angiography were divided into two groups: a control and a coronary heart disease (CHD) group. The angiographic severity of coronary stenosis was evaluated by SYNTAX and Gensini scores. The incidence of major adverse cardiovascular events within two years was collected. Results: A negative correlation between serum CGRP levels and Gensini scores was observed in all patients (r=-0.352, p22) was 0.772 [95% confidence interval (CI): 0.673-0.870, p22 [odds ratio (OR) =5.819, 95% CI: 2.240-15.116; p64) (OR=4.943, 95% CI: 2.020-12.095; p

Published
2021

4. Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives.

Author

Chi, Xiao-Qian, Hou, Bo, Yang, Liu, Zi, Cheng-Ting, Lv, Yong-Feng, Li, Jin-Yu, Ren, Fu-Cai, Yuan, Ming-Yan, Hu, Jiang-Miao, and Zhou, Jun

Subjects
ACETYLCHOLINESTERASE, MANGOSTEEN, CHALCONE, CHOLINESTERASE inhibitors
Abstract

α-mangostin, a polyphenol xanthone derivative, was mainly isolated from pericarps of the mangosteen fruit (Garcinia mangostana L.). In present investigation, a series of derivatives were designed, synthesised and evaluated in vitro for their inhibitory activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among the synthesised xanthones, compounds 1, 9, 13 and 16 showed AChE selective inhibitory activity, 15 was a BuChE selective inhibitor while 2, 3, 5, 6, 7, 12 and 14 were dual inhibitors. The most potent inhibitor of AChE was 16 while 5 was the most potent inhibitor of BuChE with IC50 values of 5.26 μM and 7.55 μM respectively. [ABSTRACT FROM AUTHOR]

Published
2020
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