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170 results on '"Yuan, Jianmei"'

17. l‐borneol promotes neurovascular unit protection in the subacute phase of transient middle cerebral artery occlusion rats: p38‐MAPK pathway activation, anti‐inflammatory, and anti‐apoptotic effect.

Author

Xie, Qian, Lu, Danni, Yuan, Jianmei, Ren, Mihong, Li, Yong, Wang, Jiajun, Ma, Rong, and Wang, Jian

Abstract

Our previous study showed l‐borneol reduced cerebral infarction in the acute stage after cerebral ischemia, but there is little about the study of subacute phase. We herein investigated the cerebral protective effects of l‐borneol on neurovascular units (NVU) in the subacute phase after transient middle cerebral artery occlusion (t‐MCAO). The t‐MCAO model was prepared by the line embolus method. Zea Longa, mNss, HE, and TTC staining were used to evaluate the effect of l‐borneol. We evaluated the mechanisms of l‐borneol on inflammation, p38 MAPK pathway, and apoptosis, etc. through various technologies. l‐borneol 0.2, 0.1, 0.05 g·kg−1 could significantly reduce cerebral infarction rate, alleviate the pathological injury, and inhibit inflammation reaction. l‐borneol could also significantly increase brain blood supply, Nissl bodies, and the expression of GFAP. Additionally, l‐borneol activated the p38 MAPK signaling pathway, inhibited cell apoptosis, and maintained BBB integrity. l‐borneol had a neuroprotective effect, which was related to activating the p38 MAPK signaling pathway, inhibiting inflammatory response and apoptosis, and improving cerebral blood supply to protect BBB and stabilize and remodel NVU. The study will provide a reference for the use of l‐borneol in the treatment of ischemic stroke in the subacute phase. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury.

Author

Xie, Qian, Li, Jinxiu, Dong, Taiwei, Yuan, Jianmei, Lu, Danni, Ma, Rong, Li, Hongyan, Li, Yong, Ren, Mihong, Chen, Hai, and Wang, Jian

Subjects
CEREBRAL infarction, ISCHEMIC stroke, TRANSMISSION electron microscopy, WOUNDS & injuries, CLINICAL medicine, NEUROPROTECTIVE agents
Abstract

Objectives: Natural borneol and synthetic borneol were commonly used to treat ischaemic stroke in clinical practice. This study evaluated their different neuroprotective effects on the remodelling and repair of the neurovascular unit (NVU) after cerebral ischaemia. Methods: We evaluated the different effects of borneol through neurological test and staining methods in cerebral ischaemia injury. Western blot, immunohistochemistry and transmission electron microscopy were used to evaluate the reparative effects of borneol on NVU. Key findings: The prevention and treatment of borneol could prolong recovery time, reduce body temperature and cerebral infarction rate and improve pathological conditions. Further investigations revealed that borneol could inhibit the expression of DII4, Hes1, Hes5 and p65 and increase the Nissl body number and microvessel density. They also inhibited the activation of the microglia. It was also observed through an ultramicroelectron microscope that the structural stability of the NVU has also been repaired. Moreover, natural borneol shows better results in most indicators when compared with synthetic borneol. Conclusions: Natural borneol showed a stronger effectiveness and had better regulation and neuroprotection on the NVU when compared with synthetic borneol, indicating that it may be better to use natural borneol in the prescription of Chinese patent medicine in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Estrone removal by horseradish peroxidase immobilized on a nanofibrous support with Fe3O4 nanoparticles

Author

Bingru Zhang, Fengting Li, Ran Xu, Yuan Jianmei, and Yifang Si

Subjects
Vinyl alcohol, Chromatography, biology, General Chemical Engineering, technology, industry, and agriculture, 02 engineering and technology, General Chemistry, 010501 environmental sciences, 021001 nanoscience & nanotechnology, 01 natural sciences, Horseradish peroxidase, Electrospinning, Catalysis, chemistry.chemical_compound, Membrane, Adsorption, chemistry, biology.protein, Degradation (geology), 0210 nano-technology, 0105 earth and related environmental sciences, Acrylic acid, Nuclear chemistry
Abstract

The occurrence, fate, and removal of estrone (E1) from environmental systems have attracted considerable research interests in recent years because of the potential risks of human and wildlife exposure to E1. This study aims to develop an efficient enzymatic method to remove E1 from water. Electrospinning composite fibers (200–300 nm in diameter), comprising poly(vinyl alcohol) (PVA), poly(acrylic acid) (PAA), SiO2, and Fe3O4 nanoparticles (NPs), were used as supports for horseradish peroxidase (HRP) immobilization. The immobilized HRP was used for E1 removal. The effects of Fe3O4 NPs on the degradation and adsorption of E1 by the prepared materials were investigated. The results showed that the immobilized HRP was less sensitive to the changes in pH and temperature compared with free HRP. The immobilized HRP also exhibited relatively high stability and reusability. HRP-PAA/PVA/SiO2 nanofibrous membranes with Fe3O4 NPs (HRP-Fe3O4 NPs/NFM) showed a significantly higher relative activity for E1 removal (84.5%) than the nanofibrous membranes without Fe3O4 NPs (79.4% P < 0.05). This improvement can be attributed to the addition of Fe3O4 NPs which increased the adsorption ability of the membranes and improved the catalytic activity of the immobilized HRP. The HRP-Fe3O4 NPs/NFM is suitable for use in wastewater treatment owing to its high reusability.

Published
2016

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