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Вступ. Розробка нової фармацевтичної композиції у формі м’якого лікарського засобу потребує вивчення у тому числі структурно-механічні показники запропонованої фармацевтичної композиції. Структурно-механічні характеристики відображають таке поняття, як «консистенція», яка суттєво впливає на технологічні процеси під час виробництва (гомогенізація, транспортування по трубопроводам, фасування тощо), а також на споживчі властивості при їх використанні: видавлювання із туб, нанесення на шкіру чи слизову оболонку (рівномірне розподілення, адгезивні властивості), що в кінцевому результаті впливає на якість та ефективність лікарського засобу. Тому вивчення структурно-механічних властивостей фармацевтичної композиції у формі крему є актуальною проблемою фармацевтичної технології ліків. Мета дослідження – проведення структурно-механічних досліджень з метою подальшого обґрунтування технології виготовлення МЛЗ. Матеріали і методи. Структурно-механічні дослідження проводили на ротаційному реометрі Rheolab QC (Anton Paar, Австрія) з циліндричною вимірювальною системою C-CC27/SS. Діапазон градієнта швидкості зсуву від 0,1 сек-1 до 350 с-1 відповідало діапазону швидкості зсуву від 0,075 об/хв до 270 об/хв. Статистичну обробку результатів проведено при використанні програми Origin, теоретичну криву плину зразків та межу плину розраховували за математичною моделлю Hershel. Визначення коефіцієнту динамічного розрідження зразків вивчали при швидкостях зсуву 3,4с-1 та 10,3с-1, що відповідали швидкостям зсуву долоні при розподілі МЛЗ на поверхні та в’язкості системи за швидкостями зсуву 27,4 с-1 та 150с-1. Результати. Досліджувані зразки характеризуються псевдо-пластичним типом плину, що є характерним для МЛЗ. Показано, що структурно-механічні показники зразків залежать від температури. Встановлено коефіцієнти механічного розрідження Кd1 (відповідає швидкості нанесення препарату на поверхню долоні) та Кd2 (відповідає швидкостям технологічного процесу). Показано, що Кd2 > Кd1, що вказує на розрідження системи при високих швидкостях деформації. Висновки. Структурно-механічними дослідженнями встановлено, що опрацьована фармацевтична композиція у формі крему є в’язко-пружним твердим тілом та характеризується псевдо-пластичним типом плину. Структурно-механічні показники крему зменшуються при збільшенні температури, проте вони відновлювані, що є гарантією якості крему.

Aim. The purpose of this study was to conduct an up-to-date semantic analysis of the results of our own research and literature data on the medical and pharmacological characteristics of metabolites, metabolitotropic agents and nutritional supplements, the peculiarities of their use in sports practice and sports medicine. Materials and methods. This study used bibliosemantic, analytical, logical, and generalization methods. The life sciences and biomedical information bibliographic databases MEDLINE, EMBASE, Medline (PubMed), Web of Science, and Cochrane Central were searched to find publications in English that matched the research keywords. The authors carried out an independent search and selection of articles, assessment of the quality of the data, compliance of the presentation and interpretation with the main idea of the study, with the formation of the final list of references. Results. Based on the analysis of modern literature data and the results of our own studies, a generalized medical and pharmacological characteristic of metabolite agents, metabolitotropic drugs and nutritional supplements that can influence the main and compensatory mechanisms of macroergic phosphates production under the influence of physical activity is presented. The mechanisms of action, indications for use and main side effects of drugs and food additives based on ATP, malate, succinate, citrate, pyruvate, carnitine, carnosine, etc. are presented. Conclusions. Semantic analysis data indicate that an urgent problem for sports medicine physicians and pharmacologists is the development and use of metabolites, metabolitotropic agents and nutritional supplements, as well as approaches to their rational combination to improve energy metabolism, replenish ATP reserves in the body that will help ensure the intensity muscular activity and simultaneously protect target organs.

The aim of the work to determine the dynamic characteristics of overall physical condition indicators in 11–13-year-old female weightlifters after injuries of the musculoskeletal system at the training stage of physical therapy. Materials and methods. The experimental population comprised 45 female weightlifters (aged 11–13 years, qualification ‒ I, II, III junior categories) from SСYSSOR “Spartak” of the Zaporizhzhia regional council, CYSS “Kolos” of Kamiansko-Dniprovskyi district of Zaporizhzhia region, Berdiansk CYSS of Zaporizhzhia Region City Council, and students of Kharkiv Regional Higher School of Physical Culture and Sports majoring in weightlifting. Patients after musculoskeletal injuries were divided into two groups: main (MG, n = 22) and control (CG, n = 23). Patients of the control group underwent standard treatment (generally prescribed in medical establishments). For main group patients in the training period, the program of physical therapy has been developed and implemented, with the current control of overall physical condition indicators. Research methods. Analysis of literature and sources of information presented on the Internet; clinical observations; pedagogical testing; methods of mathematical statistics. Results. Analysis of overall physical condition indicators of athletes of 11–13-year-old weightlifters of the main and control groups during the recovery and training periods allows us to state that main group athletes have higher growth rates, and dynamic characteristics of their overall physical condition are linear with constant focus on improvement. According to the indicators of “running 30 m, s” test, the following growth indicators were recorded: main group athletes (-0.48), control group athletes (-0.29), the difference (-0.19). According to the indicators of “standing long jump, cm” test, the following growth indicators were recorded: main group athletes (+14), control group athletes (+5), difference (+9). According to the results of the test “flexion-extension of the arms in the supine position, n” the following indicators were obtained: main group athletes (+4.44), control group athletes (+2.86), difference (+1.58). Conclusions. Intensification of the training process and forcing the training of junior athletes in weightlifting are the leading factors that result in injuries of the musculoskeletal system, multisystem pathologies and the development of pathomorphic phenomena. Indicators of overall physical condition of weightlifters aged 11–13 allow us to state that main group athletes have a higher difference in growth, and the tendency of their overall physical condition has a linear focus on improvement. Indicators of overall physical condition of control group athletes are nonlinear, according to “running 30 m, s” and “standing long jump, cm” the test results.

The aim. To determine the impact of implementing the extra early mobilization protocol (EEM) on the length of intensive care unit (LICU) stay and postoperative unit (LPOU) stay and to assess the role of age, heart contractility, functional class and surgical outcomes. Materials and methods. Participants – adult patients of 2018–2019 with less than 24-hour artificial lung ventilation (ALV). The first group were treated according to the early mobilization protocol (EM, patients of 2018); the second group were treated according to the EEM protocol (patients of 2019). Design: a retrospective analysis. Settings: cardiosurgical unit. Interventions: the major difference is that the resources of patient mobilization team have expanded since 2019, namely it included a physical therapist, which made it possible to modify the EM protocol (standing on the 2 postoperative day (POD), activation with the help of medical staff, respiratory exercise) to the EEM protocol (standing on the 1 POD following consultation with an anesthesiologist, exercises with a physical therapist, respiratory exercise). The main outcomes: LICU, LPOU and total postoperative hospitalization (LTPO) (number of nights). Results. There were no differences between the EEM and EM groups in LICU (3 (2; 4) vs. 2 (2; 4); P = 0.182), LPOU (7 (6; 10) vs. 8 (6; 10); P = 0.118), LTPO (10 (8; 13) vs. 10 (9; 13); P = 0.308). Correlation analysis revealed absence, weak and very weak relations between the LICU, LPOU, LTPO indicators and other criteria, including age, ejection fraction, ALV. Conclusions. The effectiveness of the EEM protocol seems doubtful to reduce LICU, LPOU, and LTPO as compared to the EM protocol. The obtained results also raise the importance of physical therapist time management.

The purpose of the work is to evaluate the effectiveness of a comprehensive program of physical therapy in patients after surgical reconstruction of the Achilles tendon. Materials and methods. Subjects population comprises 58 patients (aged 34–57 years), including 39 (67.24 %) males and 19 (32.76 %) females, who were up to the surgical restoration of the Achilles tendon. All patients were divided into two groups: the main group (MG, n = 29) and the control one (CG, n = 29). Research methods embraced a review of scientific literature presented on the Internet; experimental research of ascertaining and formative orientation; pedagogical observation; goniometry, plantodynamometry, modified Romberg test; methods of mathematical statistics. Results. After surgery, the angle of plantar flexion was better (P < 0.01) in MG patients compared with CG patients (4 weeks): 29.1 ± 1.19° and 28.1 ± 1.13°. However, statistically significant differences between MG and CG patients in subsequent measurements were not found (P > 0.05). The percentage values of the load distribution on the operated extremity had improved by the final measurement date (16 weeks), which reduced the difference in the load distribution on the extremities to 9.20 ± 3.09 % in MG patients and up to 14.60 ± 2.98 % in CG patients (Me (25 %; 75 %) ) ‒ 8 (6; 12) % and 16 (12; 18) %). The indicators of the final performance of Romberg test were significantly better in MG patients, making 11.4 ± 2.13 s, which is 2.5 seconds better than in CG patients (P < 0.01). Conclusions. Dynamic characteristics of plantar flexion were restored by the following means: adaptive physical exercises and corrective gymnastics, different walking exercises, exercises with fitball, exercises on an exercise bike and step platforms, hydrotherapeutic exercises, orthopedic shoes, physiotherapeutic methods, and massage. The proposed comprehensive program is effective and can be used for post-surgical physical therapy in patients diagnosed with Achilles tendon rupture.

The aim of the work was to evaluate the effectiveness of a physical therapy program for athletes specializing in team sports games with diaphysis fractures of the shin after intramedullary osteosynthesis. Materials and methods. Experimental studies were conducted with athletes in game sports (n = 58) with diaphyseal fractures of the tibia, who were treated in the Department of Traumatology and Orthopedics of the Clinical Hospital № 7, Kyiv, SI “Institute of Traumatology and Orthopedics NAMS of Ukraine”, sports clinic injuries of NUFVSU during 2014–2019. Methods of analysis and generalization of literature sources were used; method of anthropometric measurements to determine the comprehensiveness of a healthy and injured limb; goniometry method for measuring the available range of motion in the knee joint of a healthy and injured limb; myotonometry method to determine the tone of the quadriceps femoris; testing to calculate the symmetry index of the lower extremities (LSI ‒ Lower Extremity Symmetry Index); methods of mathematical statistics. Results. The developed complex program of physical therapy is a cycle of restorative measures that meet the achievement of previous functionality, meets the requirements for the level of motor skills, general and special physical performance of athletes, and meets their personal ideas about the quality of life. Evaluation of the effectiveness of the physical therapy program allows us to state that in BG the normative values were reached by 25 out of 29 athletes (86.21 %), in CG ‒ 19 athletes out of 29 (65.52 %), which indicates the high efficiency of the proposed physical therapy program. Conclusions. In the process of forming physical therapy programs for patients ‒ athletes with diaphysis fractures of the tibia after intramedullary osteosynthesis, therapeutic exercises should be grouped depending on the specific objectives of rehabilitation measures and their predominant focus: to restore motor function; to restore general physical fitness; to restore special physical fitness; to restore basic motor skills and abilities; to restore special motor skills and abilities in accordance with the specifics of training and competitive activities in sports games.

Aim. To define the quality of life in outpatients with the orthopedic profile disorders and to study its dynamics during the physical therapy course depending on the disorder localization and psychotype. Material and methods. The study involved 113 patients enrolled in a course of physical therapy at FESCO Medical Center in 2013–2015. Patients were grouped by the disorder localization and psychotype of the disease. The quality of life assessment was performed using the EQ-5D-5L questionnaire. The course of physical therapy consisted of 12–15 sessions (40–60 minutes; therapeutic physical exercises and mechanotherapy according to a complex ordered by a doctor), physiotherapy (magnetic therapy, electromyostimulation as instructed) and massage (7–8 procedures). The course duration was 5–6 weeks. Results. Statistically worse initial results were found in patients with lumbar disorders, disorders in the pelvic girdle and the lower extremity on the “mobility”, “pain/discomfort”, and EQ-VAS scales compared with patients who had upper-body disorders. Differences in “anxiety/depression” and EQ-VAS scales were obtained when dividing patients according to a psychotype. In patients with rational disease perception, the analysis of dynamics revealed better changes and final results on the “anxiety/depression” scale compared with the group of irrational psychotypes. The dynamics on other scales also showed benefits in patients with rational disease perception, although no significant. Conclusions. The data obtained indicate that not only localization but also features of disease perception affect the quality of life and the effectiveness of physical therapy. The prospects for further research are identifying directions to improve the dynamics through the introduction of new physical therapy tools and methods of their use as well as techniques of managing the physical therapy process.

The purpose of the work is to investigate the effectiveness of the use of physical condition control of students of special medical groups for the development of physical therapy programs. Materials and methods. 40 students of 1st and 2nd year students of National University “Lviv Polytechnic” and Zaporizhzhya State Medical University participated in the experimental studies, which on the basis of the medical examinations were assigned to a special medical group for the presence of diseases of the musculoskeletal system (scoliosis I, II and III degrees). The following methods were used in the research process: analysis and generalization of scientific literature and Internet data; analysis of medical records of students; instrumental methods of morphometric and psychophysiological studies; pedagogical observations; pedagogical experiment of ascertaining orientation; methods of mathematical statistics. The results of the study show that the application of theoretical and methodological provisions and recommendations of corrective measures in the system of test control of physical conditions in students of a special medical group in the practical work, on the basis of integration of specially selected means of physical therapy, enables to activate compensatory mechanisms, mobilize reserve mechanisms ability of the body to increase the competence to perform motor actions, helps to accelerate the formation of knowledge, skills, and elimination of defects motive sphere, eliminating the difference in indicators of psychophysical development between students of the main, preparatory and special medical group. Conclusions. The control of morphofunctional and psychophysiological indicators is an effective mechanism of correction of the physical condition of students of a special medical group with functional disorders of the musculoskeletal system and a necessary prerequisite for the development of complex programs of rehabilitation based on the use of therapeutic exercises.

The purpose of the work is to evaluate the degree of dynamic recovery of the movements of the operated limb during the second period of rehabilitation by means of physical therapy in patients who underwent hip replacement and strengthening of the capsule-ligament apparatus with a polypropylene mesh. Materials and methods. A retrospective study of case histories, radiographs, and laboratory data of 47 patients requiring restoration or strengthening of the hip capsule was performed, of which primary endoprosthesis was performed in 26 (55.3 %) patients, and revision in 21 (44.7 %). Among the studied patients, 27 patients (57.4 %) were male, 20 patients (42.6 %) – female. The average age of the patients was 57 years (from 20 to 86 years). Results. Based on the analysis of the results of the study, we note that the quality of life of patients in both groups, the overall subjective condition of the joint, the volume of movements of the operated limb, as well as the evaluation of clinical and functional outcomes of treatment on the Harris Hip Score (HHS) directly correlate with performance preoperative exercises of a therapeutic nature and adherence to the postoperative rehabilitation program of physical therapy. Such correlation is more significant at 12 months after surgery, at 24 months of observation the indexes of the operated hip joint in the two groups of patients were not significantly different: 65.3 % of the observation group and 52.2 % of the comparison group at 12 months after surgery and 91.3 % and 81.0 % after 24 months, respectively. Conclusions. The use of polypropylene mesh to strengthen the posterior capsule ligaments of the hip joint enhances the functionality of the operated limb and restores patients overall, accelerates the physical rehabilitation process after discharge from the hospital. The expediency of careful preoperative preparation of patients and active management of the postoperative period (complexes of therapeutic exercises, informing of patients) is proved.

Purpose. The study of clinical features of the course of bronchial asthma and the study of the effectiveness of the use of therapeutic measures with the involvement of physical therapy in children living in Zaporizhzhia and from the Zaporizhzhia region, taking into account their physical development and indices of the initial vegetative tonus and vegetative provision. Materials and Methods. According to the set task, the first group of observation included 87 children with bronchial asthma (BA) living in Zaporizhzhia, 57 of which were boys and 30 girls, and the second group consisted of 40 children with BA from the Zaporizhzhia region, 24 of which were boys and 16 girls. As a comparison, 56 practically healthy children (31 boys and 25 girls) who formed the control groups (CGs) were examined. Thus, 29 of them (16 boys and 13 girls) from Zaporizhzhia made the CGI and 27 children (15 boys and 12 girls) from Zaporizhzhia region were included in CGII. The average age of the examined children was 11.40 ± 3.68 years. To evaluate the effectiveness of physical therapy in children with bronchial asthma, their catamnestic observation has been conducted for at least 2 years. Statistical data processing was performed by commonly used methods of variation statistics of the licensed software package Statistica for Windows 13 (StatSoft Inc., № JPZ804I382130ARCN10-J). Results. Bronchial asthma in children, irrespective of place of residence, clinical course and severity, was characterized by a mild and moderate persistent course in 50.57% and 40.23 % of urban and 47.50 % and 45.00 % of regional patients with obstructive type of violation of bronchial conduction. Physical development of children with bronchial asthma, grown up in the conditions of district centers, had more often harmonious physical development (85.00 %) than patients from the city (56.32 %) (P < 0.05), and, on the contrary, disharmonious prevailed in urban patients (43.68 %) and was less common in regional (15.00 %) patients, mainly in boys (59.65 % vs. 16.67 %, P < 0.05). In all patients with bronchial asthma, unlike healthy children from control group, eutonia (34.48 % and 42.50 %) was rarely recorded but more often sympathicotonia (33.33 % and 32.50 %) and vagotonia (32.18 % and 25.00 %) with a significant difference with the control group of the regional children with asthma for the hypersympathicotonic version of vegetative provision and in urban areas for sympathoasthenic, asthenosympathetic and hyperdiastolic variants. Conclusions. The use of physical therapy in the treatment of children with bronchial asthma has significantly reduced complaints, disease symptoms, accelerated remission and increased its duration to 24 months and reduced the risk of transformation of the disease into more severe forms.

The aim of the study – to evaluate the psychological approach to the social and psychological rehabilitation of paralympic athletes negatively experienced subjective loneliness. Materials and methods are based on theoretical and empirical data, which include the history of the loneliness phenomenon and its modern understanding study. Negative experiences requiring rehabilitation were determined using psychological methods: “Questionnaire for determining the type of loneliness” (S. Korchaginа), “Methods for the subjective feeling of loneliness” (D. Russell, M. Ferguson), “Methods for diagnosing character accentuations” (Leonhard-Shmishyok in the modification A. Lychko), test “Neuropsychic Adaptation” (S. Korchagina at V. Bekhterev Research Institute) with subsequent computer processing of the results using the software package Statistica 6.0 (StatSoft Inc., USA). The study enrolled 50 paralympic athletes aged 18 to 24, who were engaged in powerlifting. Results. Significant intercorrelations between subjective feelings of loneliness and its varieties were found (r = 0.3–0.5) based on the Pearson correlation coefficient, which allowed to consider subjective loneliness as an independent internal phenomenon. The experience of diffuse loneliness did not reveal a significant correlation (r = -0.153) with the subjective state of paralympic athletes. Two directions, which provide a mechanism of development and rehabilitation taking into account the type of loneliness, were identified. The first was the desire to be with others, identification with them through the correction of their own personality. The second one, as a result of the first, was the coping with feeling of loneliness and lack of meaning in life. Conclusions. It was established that the feeling of subjective loneliness negative experiences was associated with the deterioration of neuropsychiatric adaptation and required the socio-psychological rehabilitation of paralympic athletes who specialized in powerlifting. The significant positive relationship between diffuse loneliness and the emotional type of character accentuation in an athlete was proved. It was determined that in the process of the negative experiences of subjective loneliness rehabilitation for paralympic athletes specializing in powerlifting, it is important to consider the types of loneliness which are associated with the psychological state deterioration, which will allow to broaden the understanding of this phenomenon and increase in efficiency of rehabilitation measures.

The purpose of the work is to investigate and to test the effectiveness of therapeutic exercises in the process of physical rehabilitation of players in futsal after traumatic injuries of the musculoskeletal system. Materials and research methods. 36 athletes (18–27 years old), who during 2016–2019 were members of the ZSMU futsal team, took part in the experimental studies. Quantitative indicators of traumatic injuries of the musculoskeletal system are determined in the training and competition processes in annual training cycles based on the processing of official competition protocols and athletes' medical cards. Analysis and generalized data from scientific literature and the Internet; pedagogical observations; analysis of official competition protocols; analysis of medical records of athletes; pedagogical experiment stating orientation; methods of mathematical statistics were used in this experiment. Results. Analysis and synthesis of the obtained data allows us to state that the main feature using to therapeutic exercises in the generalized physical rehabilitation program is that they have restorative, training orientation and comprehensively affect the restoration of stability and mobility in injured joints, muscle tone and coordination of movements, proprioceptive function, special motor skills, skills, physical qualities, general and special physical performance. Conclusions. It was determined that the main therapeutic exercises which are used in the physical rehabilitation of athletes in futsal after injuries of the musculoskeletal system are massage exercises, stretching exercises, low-intensity cyclic locomotion, tension and relaxation exercises for healthy limbs, therapeutic exercises, conditioning exercises for large muscle groups, breathing exercises, local exercises on simulators and technical rehabilitation equipment.

FTIR spectra of a dehydrofluorinated poly(vinylidene fluoride) film were registered at different stages of its aging. A number of spectral features were noticed to grow with the sample aging. Three of them were assigned to the stretching vibrations of triple carbon-carbon bonds. Other bands were assigned to the libration, stretching, and combination vibrations of embedded water clusters consisting of 4, 5, or 6 molecules. The mechanism explaining synchronous formation of triple carbon-carbon bonds and small water clusters in the sample during its aging is proposed. SEM data on the surface morphology of the sample confirm the proposed mechanism.

Urpose: to evaluate the influence of creating the program of training process in the competition period of the annual macro cycles on the level of special physical training of women volleyball players. Material and methods: women volleyball players of high qualification participated in the experiment (n=14, age 20-22 years). An assessment of the level of special physical fitness of volleyball players was conducted. It is used author’s program. Results: features of the functional dependence of the level of general physical preparedness with the separate components of the special physical preparedness of volleyball players are established. The peculiarities of dynamics of indicators of athletes’ special physical training in the competition period are determined. The strongest correlation relationship was the level of general physical fitness with: the level of general and hopping endurance; the level of development of jumping; special dexterity; special endurance; speed and strength of hands. As part of corrective modules, the training load of aerobic-anaerobic direction was increased. The main means of compound character training are: complex-coordinated and technical actions in combination with the accuracy of transmission; response to moving object; locking; attacking strikes. Conclusions: application of the experimental program of training process construction helps to maintain high level of basic indicators of athletes’ special physical fitness during the competitive season. The experimental program involved the redistribution of training loads of aerobic and anaerobic-aerobic orientation within the framework of correcting modules.

A model and computational method is offered for the high performance forecasting regional meteorological processes. Relying on "unilateral influence" relationship of macro- and mesoscale models it suggests avoiding the Cauchy problem in the atmospheric model and replacing it by a boundary-value problem with specific interpolation technique that has a number of advantages of computational efficiency and good suitability for parallelization. The method and its parallel implementation on multiprocessor cluster architecture are considered.