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The significant prevalence and severe medical and social consequences of comorbidity dictate the need to determine the etiopathogenetic risk factors that contribute to its formation. Purpose of the study: to study the associations of metabolic factors (arterial hypertension, obesity, hyperglycemia, dyslipidemia, hyperuricemia, increased serum concentration of C-reactive protein (CRP) with a high degree of comorbidity in patients with somatic pathology. Material and methods. An analytical retrospective study was carried out including data from the medical records of 5296 patients at a therapeutic clinic, men and women, aged from 18 to 92 years (56.4 ± 0.2 years). Comorbidity was taken into account in the presence of two or more nosologies in one patient, its degree was assessed by the number of nosologies in one patient. The following risk factors were assessed: arterial hypertension, obesity, hyperglycemia, dyslipidemia, hyperuricemia, increased concentration of CRP. The presence of non-alcoholic fatty liver disease (NAFLD) was also taken into account. The association of the considered factors with a high degree of comorbidity was assessed using logistic regression analysis. Results and discussion. The relations have been established between NAFLD, age over 52 years, female gender, as well as the considered metabolic factors with a high degree of comorbidity. NAFLD, age, obesity and hyperglycemia had the strongest associations with comorbidity. NAFLD increased the risk of developing a high degree of comorbidity by 5.6 times (odds ratio (OR) 5.59, 95 % confidence interval (CI) 4.40–7.11), age over 52 years – by 2.6 times (OR 2.60, 95 % CI 2.30–2.95); obesity – by 2.4 times (OR 2.37, 95 % CI 2.08–2.70), hyperglycemia – by 2.1 times (OR 2.05, 95 % CI 1.69–2. 49). Conclusions. The data obtained indicate the importance of NAFLD, as well as metabolic risk factors for CND, in increasing the likelihood of developing a high degree of comorbidity, which must be taken into account when developing programs for the prevention and treatment.

Chronic heart failure (CHF) is a common complication of many cardiovascular diseases. It is important to study the clinical and functional features of CHF to clarify the further prognosis of this disease due to the unfavorable course and high mortality rate. Diagnosis and treatment of CHF is an issue for doctors of various specialties, in particular when it comes to geriatric patients with multiple concomitant diseases. Various physiological and morphological transformations in the aging population contribute to heart failure. The most common type of HF in older people is HF with preserved ejection fraction. Atypical clinical symptoms of CHF are much more common in elderly people than in young people. The prevalence of HF with age is associated with a longer period of influence of damaging factors on the heart, such as arterial hypertension, metabolic stress or ischemia-related damage. Due to the unfavorable course and high mortality rate, it is important to study the clinical and functional characteristics of CHF to clarify its prognosis. However, the data available on this issue vary significantly; the mechanisms, issues of diagnosis and treatment of patients with heart failure in different age groups have not been sufficiently studied, which determined the purpose of this study ‒ to investigate the features of the clinical and functional characteristics of CHF depending on age. Material and methods. The study included 90 male and female patients with diagnosed CHF stages I-IIB, NYHA functional class I-IV, aged 40–86 years, who underwent echocardiography, general and biochemical blood tests. The patients were divided into two groups: group 1 – patients of working age (women 16–54 years old and men 16–59 years old, n = 20), group 2 – patients older than working age (women 55 years and older, men 60 years and older, n = 70). Results and its discussion. According to the data obtained, the average age of all surveyed was 68.1 ± 9.8 years. The second stage of CHF prevailed in both the first and second groups of the studied categories of participants. Atypical symptoms prevailed, which creates difficulties in its diagnosis and treatment. The frequency of CHF decompensation in patients over working age, as well as the concentration of natriuretic peptide, is higher compared to the group of CHF patients of working age, which is probably due to the presence of comorbid pathology and cognitive deficit. The data obtained can be used to develop an approach to stratify the risk of CHF.

An increase in the frequency of patients with arterial hypertension (AH) seeking medical care and its more severe course after a novel coronavirus infection (NCI), COVID-19, determines the need to study possible pathogenetic mechanisms of disease progression. Aim of the study was to investigate some features of lipid metabolism and changes in hemostasis in patients with AH after NCI COVID-19. Material and methods. An analysis of the most informative indicators of lipid metabolism and hemostasis was carried out in 104 patients with AH underwent (more than 2 months ago) NCI, in comparison with 117 patients with AH, with no history of COVID-19. The study included men and women aged from 30 to 75 years. Determination of the concentration of lipids in blood serum was carried out using the photometric method on a biochemical analyzer AU 480 (Beckman Coulter, США). Hemostatic parameters were determined by the chromogenic method using an automatic hemostasis analyzer Technology Solution 190 (USA). Results and discussion. It was found that patients with AH underwent NCI had significantly higher serum levels of total cholesterol, LDL cho- lesterol, triglycerides, D-dimers, platelets and lower activated partial thromboplastin and thrombin time compared with patients without COVID-19. Conclusions. The data obtained indicate a tendency to atherogenic changes in the blood lipid profile and increased coagulation processes in patients with AH in the long-term period (more than 2 months) after suffering a NCI COVID-19.

Aim of the study was to identify the features of susceptibility to a new coronavirus infection СOVID-19 depending on gender, age, social factors and polymorbidity. Material and methods. An analysis of the structural features of gender, age, and social factors in 620 patients who underwent examination and treatment at the Federal Research Center of Fundamental and Translational Medicine clinic (Novosibirsk) was carried out. The patients were divided into 2 groups: the main group (group 2, age 56.4 ± 0.7 years) included 272 patients who underwent a new coronavirus infection COVID-19, confirmed by a positive PCR test or antibody testing, a comparison group (group 1, age 60.7 ± 0.7 years) – 348 people who did not have COVID-19 and were undergoing examination and treatment for chronic non-communicable diseases. Results. An analysis of the incidence of COVID-19 depending on gender showed that disease was more common, by 22 %, in women than in men. Patients who had COVID-19 were statistically significantly more likely (30%) to be in the second adult age period than those in the comparison group. When studying the social features of patients who underwent COVID-19, it was found that employees and employees of the administrative and managerial apparatus were significantly more likely to suffer from this infectious disease. An analysis of the structure of polymorbid pathology revealed that patients with COVID-19 had a significantly higher value of transsystemic polymorbidity.

The continuing interest in the problem of vibration disease (VD), especially when combined with arterial hypertension (AH), is due to the steady development of industrial sectors associated with vibration acceleration and the tendency towards the early development of AH. Aim of the study was to investigate the features of clinical, nutritional and anthropometric indicators and frequency of occurrence of Ala16Val (rs4880) polymorphic locus of the manganese superoxide dismutase (MnSOD) gene in VD combined with AH. Material and methods. 431 people were examined, among them 104 patients with VD stage I, 101 – with VD stage I in combination with AH I–II stage, 107 – with AH I–II stage, without contact with vibration, and 119 people working at the same enterprise without contact with vibration, without signs of hypertension. A complex of clinical, anthropometric, laboratory, functional and genetic studies has been carried out. Results. In case of VD comorbid with AH, the frequency of complaints, both general and specific, significantly increases compared to other groups. Body mass index, waist circumference / hip circumference (WC/HC) ratio, fat mass increase, extracellular fluid content with a decrease in active cell mass, musculoskeletal mass and phase angle compared with the control group. An imbalance of nutrition in terms of macro- and micronutrients, an increased content of the fat component in the diet with a deficiency in the diet of omega-3 polyunsaturated fatty acids has been established. In persons with VD and AH, the C/C genotype, which is more common in healthy people, is registered in only 16% of cases, while the polymorphic variant T/T is in 29 %, which exceeds the corresponding value in the control and isolated AH groups by 1.9 and 1.5 times, respectively. Discussion. The common pathogenetic features of VD and AH lead to the development of adipose tissue dysfunction and trophological insufficiency. There is no doubt that hypertension is associated with increased body weight, obesity, and adipocytokine serum concentration. An indicator of a high risk of developing cardiovascular pathology, including heart attack, stroke, is an increase in the WC/HC index. The role of the Ala16Val polymorphism of the MnSOD gene in the formation of AH and some variants of occupational diseases has been shown in a number of studies. Conclusions. The variant of VD, comorbid with AH, is characterized by a significant increase in the frequency of detection of the T/T genotype in the polymorphic locus Ala16Val (rs4880) of the MnSOD gene in combination with an altered nutritional and anthropometric status of such patients. The presence of this polymorphism may be associated with an increased risk of developing concomitant vascular pathologies in VD, however, in combination with malnutrition and associated changes in anthropometric parameters, this risk increases many times over. Thus, early diagnosis of the risk of developing comorbid vascular pathology in VD can be aimed at identifying the genotype, and prevention can be aimed at modifying nutrition.

The aim of the study was to identify the features of the unfavorable clinical course of a new coronavirus infection.Material and methods. The analysis of clinical data, laboratory results and comorbidity of 168 patients with a confirmed diagnosis of a new coronavirus infection aged 65,0 [57,0; 74,0] years was carried out. Two groups of patients were distinguished – 126 persons with a moderate course and with clinical recovery in the outcome of the disease and 42 persons with a severe course and a fatal outcome of the disease. Transnosological polymorbidity was assessed by the average number of nosologies corresponding to the three-digit ICD-10 rubricification, transsystemic – by the number of affected systems. Hemogram parameters, blood content of C-reactive protein, creatinine, urea, glucose, prothrombin index, international normalized ratio, activated partial thromboplastin time, platelet count, D-dimer concentration were estimated.Results. In the group of patients with fatal outcomes, compared to patients with recovery, there were statistically significantly higher indices of transnosological and transsystemic polymorbidity (1.5 and 2 times, respectively), they were more likely to have ischaemic heart disease, myocardial infarction, transient ischemic attack in anamnesis, atrial fibrillation, chronic heart failure; blood concentration of C-reactive protein, fasting glucose, urea, D-dimer in the blood serum was higher, the number of thrombocytes was less.Conclusions. A high degree of transnosological and transsystemic polymorbidity, a history of myocardial infarction and transient ischemic attack, comorbid chronic heart failure, atrial fibrillation, an increase in D-dimer, CRP content, and a decrease in platelet number are predictors of severe course and the lethal outcome of COVID-19.

Microbiological examination of contamination of imported and domestic meat products with pathogenic bacteria Listeria monocytogenes depending on a meat type, technology and season was carried out during 2017–2019. In total, 2777 product samples were analyzed; the presence of this pathogen was revealed in 8.8% of products (244 positive samples). It was found that the prevalence of L. monocytogenes in meat products increased over three years of observation (2017–2019). The highest occurrence of this pathogen was found in poultry meat (on average 18.7%) followed by products from beef (13.2%). Meat products from mixed raw materials (beef and pork) accounted for 5.3% of tested samples, while in pork semi-finished products L. monocytogenes was found only in 3.2% of cases. It was noted that the technology of semi-finished products significantly affected the level of contamination of meat products with L. monocytogenes. Various technological approaches are used in the production process increasing the risk of contamination of the finished product since there is no timely data on Listeria contamination of raw materials used for production of a particular product. It has been established that a significant role in microbiological studies is played by various approaches to sample preparation of analyzed samples of meat cuts, semi-finished products in large and small pieces, as well as minced semi-finished products. Not knowing the real level of surface contamination with L. monocytogenes of carcasses, half-carcasses, semi-finished products in large pieces, manufacturers use such raw materials for the subsequent production of other types of semi-finished meat products, increasing the risk of manufacturing unsafe products with following contamination of equipment, work surfaces and other objects of the production environment. The highest occurrence of L. monocytogenes in meat products during three years of observation was found in the summer period (14.2%). The proportions of positive samples in the winter, spring and autumn months varied on average within 6.7–7.1%.

A review of modern studies on the problem of multimorbidity, its definition, frequency of occurrence, prevalence, medical and social consequences, factors predisposing to its formation, and approaches to diagnosis, therapy, and rehabilitation is presented. According to modern understanding, multimorbidity is the presence of two and / or more chronic diseases that are pathogenetically interconnected and / or coincide in time in one patient.Currently, multimorbidity is becoming an epidemic, affecting people of different ages and gender and with various diseases. The literature describes multiple adverse medical and social consequences of multimorbidity, such as increased rates of hospitalization, disability, and mortality, decreased functional capabilities and quality of life in patients, as well as increased volume, timing, and cost of medical care. Today, issues of the unified terminology, identification of multimorbidity, and the structure and clinical manifestations of associated pathology are being studied. There are single works on the study of possible factors contributing to the formation of multimorbidity. Approaches to management of patients in conditions of multimorbidity are being developed. A more detailed study of the mechanisms of multimorbidity formation and common pathogenetic links of associated diseases will make it possible to develop more effective strategies for the diagnosis, treatment and rehabilitation of multimorbid patients.

Aim of the study was to investigate the role of C-reactive protein as an indicator of multimorbidity in patients with arterial hypertension.Material and methods. A retrospective archival study of the data of 1958 patients with arterial hypertension who were examined and treated at the clinic of the Federal Research Center for Fundamental and Translational Medicine (Novosibirsk) was carried out. 2 groups of patients were allocated depending on the concentration of C-reactive protein in the blood serum: normal and elevated (> 5 mg/l). A comparative analysis of the severity of polymorbidity, as well as clinical, laboratory and biochemical parameters in the selected groups were carried out.Results. It has been established that patients with arterial hypertension with elevated values of C-reactive protein had higher rates of transnosological and transsystemic polymorbidity, accompanied by changes in lipid, carbohydrate and purine metabolism (a decrease in high-density lipoprotein cholesterol, an increase in the concentration of glucose and uric acid in blood serum, an increase in the index atherogenicity), as well as an increase in the content of fibrinogen in the blood serum.Conclusions. The concentration of C-reactive protein in the blood serum can serve as a biochemical marker of polymorbidity in patients with arterial hypertension.

An increase in the proportion of comorbid cardiac patients with primary nosologies such as arterial hypertension and atherosclerosis actualizes the search for optimal approaches to their diagnosis and treatment. The emerging pathogenetic mechanisms of concomitant diseases must be taken into account on an individual basis. Aim of the study was to investigate the patterns of atherosclerotic changes in carotid arteries in patients with coronary heart disease who underwent percutaneous transluminal coronary angioplasty and their correlation with biochemical and hemodynamic markers of atherosclerosis. Material and methods. 53 patients with coronary heart disease (CHD) were examined and treated in the clinic of the Federal Research Center of Fundamental and Translational Medicine. The average age of the patients was 64.73 ± 1.66 years. A comprehensive clinical laboratory examination was conducted, including the blood lipids test to measure content of total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, as well as serum markers of systemic inflammation (concentration of C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR)) and carotid artery duplex scan. Results. A direct correlation between the severity of atherosclerotic changes in the carotid arteries and indicators of systemic inflammation, i.e. CRP, ESR and fibrinogen was found. The study also revealed greater severity of atherosclerotic stenosis of the carotid arteries in patients with coronary artery disease who underwent percutaneous transluminal coronary angioplasty with coronary artery stenting compared to patients without any intervention. Conclusion. The obtained data indicate the effectiveness of ultrasound scan of the carotid arteries for the early diagnosis of multifocal atherosclerosis for timely treatment and prevention of cardiovascular polymorbidity in patients with a cardiovascular profile.

Aim of the study was to investigate the peculiarities of the relationship of polymorbid pathology in arterial hypertension with disorders of lipid, purine and carbohydrate metabolism. Material and methods. Patients with arterial hypertension with the presence of polymorbid pathology, who underwent examination and treatment at the clinic of the Federal Research Center for Fundamental and Translational Medicine (Novosibirsk), were examined. A total of 9775 people were examined. The patients were divided into 2 groups: with arterial hypertension in the dyslipidemia absence (n = 561(252 men (44.9 %), 309 women (55.1 %), average age 57.1 ± 0.60 years) and in the dyslipidemia presence (n = 9214 (3879 (42.1 %) men, 5335 (57.9 %) women, average age 57.82 ± 0.12 years). Results and discussion. Hyperglycemia and hyperuricemia were more common in patients with arterial hypertension with dyslipidemia; the indicators were statistically higher: total serum cholesterol, low-density lipoprotein cholesterol, triglycerides, atherogenic index, serum glucose, uric acid compared with patients with arterial hypertension without dyslipidemia. In patients with dyslipidemia, compared with patients without dyslipidemia, arterial hypertension was more often combined with diseases of the endocrine system, nutritional disorders and metabolic disorders, and other diseases of the circulatory system. Conclusion. The data obtained can serve as a theoretical basis for the concept of care for polymorbid patients, based on the impact on the main key pathogenetic mechanisms of diseases, and new approaches to complex treatment, rehabilitation and personalized prevention, taking into account the impact on modifiable risk factors.

Multimorbidity is an urgent problem of modern medicine, associated with a greater severity and more serious prognosis of diseases, a large number of complications, difficulty and the high cost of diagnosis and treatment. The study of the quality of life of patients with multimorbidity is necessary for the competent distribution of health resources. Aim of the study was to investigate the effect of transnozologic multimorbidity (TMM) on the components of quality of life (QoL) in patients of a therapeutic clinic. Material and methods. A total of 116 patients, men and women aged 20 to 75 years were examined at the clinic of the Federal Research Center for Fundamental and Translational Medicine in Novosibirsk. TMM was evaluated by the average number of nosologies corresponding to the three-digit classification of ICD-10. Assessment of QoL indicators was carried out using the validated questionnaire SF-36. To assess the number and severity of chronic diseases in the structure of TMM, the CIRS (Cumulative Illness Rating Scale) system was used. Results. Depending on the severity of TMM, 3 groups of patients were formed – with low (n = 42), medium (n = 52) and high TMM (n = 22). A comparative analysis of indicators of QoL, as well as TMM structure in 3 groups was carried out. A comparative analysis showed a significant decrease in the level of physical functioning (by 27 %), physical and mental health components (by 26.3 % and 15.8 %, respectively), and the integral indicator of quality of life (by 19.2 %) in patients with a high level TMM, compared with patients with low TMM. Correlation analysis confirmed the presence of a statistically significant relationship between an increase in TP and a decrease in the main indicators of QoL. Conclusion. An increase in the degree of TMM in patients is significantly associated with a decrease in the main indicators of QoL.

Purpose of the study was to investigate the features of the occurrence of risk factors in patients with non-alcoholic fatty liver disease associated with arterial hypertension, overweight and obesity.Material and methods. The object of the study was the data of 14 393 case histories of patients with arterial hypertension (AH), non-alcoholic fatty liver disease (NFLD), overweight body (OB) and obesity, examined and treated at the clinic of the Federal Research Center forFundamental and Translational Medicine (Novosibirsk).Results and discussion. Features of biochemical parameters in patients with NFLD with AH, OB and obesity were studied in comparison with patients with isolated diseases. It was shown that in patients, in case of the presence of this comorbidity, the value of transsystem polymorbidity is statistically significantly increased compared with groups of patients with isolated diseases. It was established that patients with concomitant diseases have higher, statistically significant values of systolic and diastolic blood pressure, body mass index. They have higher concentrations of total cholesterol, triglycerides, high density lipoprotein cholesterol, glucose, uric acid in the blood serum, higher atherogenic index. A study of the frequency of occurrence of risk factors in the groups showed the highest frequency values in patients with associated diseases: high blood pressure, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, hypoalphacholesterolemia, hyperlipidemia, increased atherogenic index, hyperglycemia, hyperuricemia, the higher levels of C-reactive protein, which indicates that with associated pathology, changes in carbohydrate, lipid and purine metabolism are more pronounced. These changes are factors that aggravate the course of the pathology and are risk factors for the development of diabetes mellitus, atherosclerosis and associated conditions, which requires a personalized approach to the treatment and prevention of this category of patients. The results of this study can form the basis for the development of new medical technology for assessing the severity of condition in patients with non-alcoholic fatty liver disease combined with arterial hypertension, overweight and obesity.

Aim. The aim of the study was to study the effectiveness of complex treatment of arterial hypertension comorbid with dorsopathy depending on the severity of atherosclerotic lesions of the carotid arteries.Material and Methods. The object of the study were 80 patients with arterial hypertension comorbid with dorsopathy, admitted for examination and treatment at the clinic of Federal Research Centre of Fundamental and Translational Medicine (FRC FTM.) in Novosibirsk. Patients were men and women aged 18 to 75 years. They underwent clinical, laboratory and functional examination in the inpatient facility of the FRC FTM. Assessment of the degree of atherosclerotic lesions of the carotid arteries was carried out using ultrasound duplex scanning of arteries.Results. It was found that in patients with hypertension combined with dorsopathy and atherosclerotic lesions of the carotid arteries without hemodynamically significant stenosis and signs of instability of atherosclerotic plaques, complex treatment with the use of SMT therapy or magnetotherapy more effectively reduces systolic blood pressure than treatment without hardware physiotherapy and more quickly stabilises blood pressure on targets.Conclusion. In patients with hypertension accounting for the presence of comorbidities in the form of dorsopathy of the cervical spine and atherosclerosis of the carotid arteries that allows the personalization of the therapy of such patients using methods of physiotherapy, reducing the time to achieve the therapeutic effect improved the quality of life of patients.

Objective of the study was to assess the diagnostic significance of hemodynamic disorders in the area of carotid and vertebral arteries in patients with hypertension combined with benign paroxysmal positional vertigo (DPPG) using ultrasound duplex scanning of neck vessels.Material and methods. Thirty eight patients of the clinic of Federal Research Center for Fundamental and Translational Medicine with hypertension and concomitant dizziness were examined. The state of carotid and vertebral arteries, blood flow in the arteries were assessed by duplex ultrasound scanning using the Vivid E9 apparatus.Results and discussion. The influence of the blood flow at the level of carotid and vertebral arteries on the severity of clinical symptoms of dizziness in patients with hypertension with concomitant DPPG was shown. The clinical significance of atherosclerotic changes in carotid arteries, tortuosity of carotid and vertebral arteries of the effectiveness of treatment and prevention of dizziness in patients with hypertension and DPPG was revealed. It is shown that in patients with hypertension and comorbid DPP, the severity of the relationship of hemodynamically significant changes in the carotid and vertebral arteries with clinical manifestations of dizziness is greater than in patients with hypertension without DPP. The use of ultrasound duplex scanning of brachiocephalic arteries in hypertension with comorbid vertigo allows for differential diagnosis of benign paroxysmal positional vertigo and cerebrovascular dyscirculatory disorders, the degree of their participation in clinical manifestations of dizziness. A new medical technology for the diagnosis of pathogenic mechanisms of dizziness in patients with hypertension, using ultrasound duplex scanning of carotid and vertebral arteries, allows to personalize treatment and prevention in such patients.

Aim. To study the associations of the frequency and values of parameters of the main risk factors (RF) of cardiovascular diseases (CVD) and the degree of transnosological polymorbidity (PM) in patients with nonalcoholic fatty liver disease (NAFLD).Material and methods. The analysis of 3667 medical records (men, women) treated in the clinic of Research Institute of Experimental and Clinical Medicine (Novosibirsk) was carried out. Index of polymorbidity was evaluated by the number of nosological forms in accordance with the International Classification of Diseases, 10th revision (ICD-10). The following risk factors were assessed according to clinical and laboratory tests: arterial hypertension, dyslipidemia, hyperglycemia, obesity.Results. Both among men and women with increasing index of PM there was identified growth of the parameters that determine the main RF: systolic BP, diastolic BP, obesity (both in men and women), atherogenicity index (in women), glucose concentration in the blood serum (in women). Frequency of AH occurrence in persons with a high degree of PM among men was 49%, and among women — 69% higher, compared with persons with a low degree of PM. Among men, there was an increase in the incidence of AH (by 9%) and obesity (by 9%) in individuals with a high degree of PM, compared with individuals with an average degree of PM. Among women, there was an increase in the incidence of AH (by 15%), obesity (by 9%), hyperglycemia (by 11%) in persons with a high degree of PM, compared with individuals with an average degree of PM.Conclusion. There was established the role of risk factors for cardiovascular diseases, arterial hypertension mainly, in the development of polymorbidity in patients with NAFLD. The findings indicate the need for personified prevention and treatment of such patients with mandatory identification and correction of modifiable CVD RF.

A survey and follow- up of 120 patients with Stage 1–2 stage, grade 1–2. Rated isolated and combined effects of pulsed electro transtserebralnoy and sodium chloride baths on lipid metabolism. Have shown that patients with arterial hypertension and dyslipidemia to non-drug correction justified Course assignment transtserebralnoy pulse electrotherapy and sodium chloride baths. In the presence of dyslipidemia in patients with arterial hypertension, hypercholesterolemia, with the presence of low-density lipoprotein, as a non-pharmacological treatment is advisable to use sessions transtserebralnoy pulse electrotherapy. For correction of dyslipidemia in patients with hypertension accompanied by hypertriglyceridemia, justified the combined exchange application transtserebralnoy, pulse electrotherapy and sodium chloride baths, allowing for a personalized approach to drug-free correction of lipid metabolism in patients with hypertension.

The results were received from the screening surveys of workers of the industrial enterprises of Myrnyi town among non native nationalities according to the report of the program of European regional Bureau WHO / CINDI. The purpose was to reveal risk factors of development of chronic noncommunicable diseases in 1991, 2000 and 2007 and for the characteristics of trends in prevalence of lipid disorders in a population. Among men during the period from 1991 to 2007 the concentration of blood total cholesterol, cholesterol of low density and high density lipoproteins (LDL-C and HDL-C) have decreased, the concentration of triglycerides increased and the index of atherogenesis increased too. Among women similar changes were found. Prevalence of lipid disorders among men and women were more than 70 %. During the specified years (1991–2007) the prevalence of hypertriglyceridemia and hyper-HDL-C increased. The greatest increasing of the parameters has been marked during the period from 1991 to 2000.