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COPD is the fourth leading cause of mortality, and is predicted to be the third leading cause of death worldwide by 2020. But few studies on Tibetan COPD of China. This study identifies distinctive miRNA signatures in Tibetan COPD patients from Tibetan healthy subjects that could serve as diagnostic biomarkers or describe differential molecular mechanisms with potential therapeutic implications. In this study, a total of 210 differentially expressed miRNAs were screened. Analysis of the functions of target genes of differentially expressed miRNAs via GO enrichment analysis revealed that they mainly influenced guanyl-nucleotide exchange factor activity, cell morphogenesis and the positive regulation of GTPase activity. KEGG pathway enrichment analysis showed that these target genes were mainly enriched in signaling by NGF, Axon guidance, developmental biology, ubiquitin mediated proteolysis, and PDGF signaling pathways. MiR-106-5p and miR-486-5p expression was validated in the complete cohort. Age, plasma miR-106-5p, miR-486-5p, SP-D protein levels, and SP-D mRNA level were also determined to be correlated with FEV1%Pred, and may as the risk factors of Tibetan COPD. The combination of plasma miR-106-5p, miR-486-5p and SP-D mRNA expression may be the best model to assist the diagnosis of Tibetan COPD.

Based on characteristics and operating principle of reciprocating machinery, we presented fault diagnosis and data testing method of reciprocating machinery, which features the testing based on crank phase signal, cylinder pressure, temperature, vibration and ultrasonic signal, developed a embedded data acquisition system, and described system composition and module functions. We also realized a CAN bus-based data transmission and communication mode, introduced the slave computer software working flow of the testing system, and developed the data processing and fault analysis software with LABVIEW. The practical tests show that crank phase signal-based data testing can meet requirements on fault diagnosis and data acquisition of reciprocating machinery.

In order to improve accuracy of measuring motor speed in precision motor control systems, a method of precise measurement of speed with CPLD is proposed, which measures the truncated parts of the measured pulse on the basis of measuring raster count pulse within the equal period, and takes them as compensation, thus improving accuracy of measuring the raster pulse. In this paper, a speed measuring formula is given. Measuring system is provided with parallel and serial communication interfaces for output of measurement results.

This paper discusses disadvantages of existing diagnosis fault system for reciprocating machinery, and based on structural characteristics and operating principle of the reciprocating machinery, it also presents that a portable fault diagnosis system of reciprocating machinery shall be composed of three parts: sensor, data acquisition device and hand-held terminal, in which the data recorder is mainly prSovided for signal conditioning, A/D for data conversion and transmission, and hand-held terminal for data receiving and processing, fault diagnosis, display and storage. The experiment and tests show that this portable fault diagnosis system is feasible for field online monitoring of status and fault diagnosis for reciprocating machinery.

Portability has become an inevitable trend of spectrometer. Faced with the trend, one micro fiber-optic spectrometer hardware circuit system, which regarded XC3S250E as master chip to control CCD scan, A/D conversion and USB data transmission, etc, was designed, and the corresponding circuits were designed. After consecutive spectral scan test, we can find that the designed spectrometer is able to complete the acquisition, conversion and transmission of spectrum. The system stability is very good and the scanning accuracy can reach 1nm.