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With silicone-oil-immersion Mirau objective utilizing high brightness Ce3+:YAG crystal fiber light source through multi-mode fiber, this system respectively images in vivo tomographic cellular structure of tissue and flowing pathway of red blood cell in dynamics.

Based on single-objective construction utilizing high brightness Ce3+:YAG single-clad crystal fiber light source, this Mirau-based full-field time-domain optical coherence tomography with circular polarization incident light represents deeper penetration in scattering medium. Using objective-changeable ability of home-designed Mirau objective, this system provides different applications, like biological tissue and single cells, by different spatial resolution with corresponding dynamics. High quality image relying on less ghost image and near common-path interference was demonstrated under this compact and power-stable system.

We report using ultrahigh-resolution optical coherence tomography for distinguishing keratinocytes and fibroblasts at the single-cell level. Linear discriminant analysis based on characteristic parameters extracted from volume data was applied for the prediction of cell types.

Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death at the cellular level.

A vertically aligned liquid crystal display panel was inspected with an optical coherence tomography system. The in-depth signal dispersion was numerically compensated so that high axial resolution can be maintained throughout the 3D microstructure.

A Ce(3+):YAG double-clad crystal fiber (DCF) visible emission was used as the light source for optical coherence tomography (OCT). The visible emission was produced from a 10 microm core DCF pumped by a diode laser. The broadband emission and short central wavelength of this light source enabled the realization of 1.5 microm axial resolution in air. The relatively clean spectrum reduced the side lobe of its point-spread function, and therefore facilitated the generation of a high-quality image with less crosstalk between adjacent image pixels. As a demonstration, an Aplocheilus lineatus goldfish was experimented on to map out the stroma of its cornea. This visible-light-based OCT can be utilized for industrial inspection as well as ocular applications.

A novel light source, emitted from 10-µm-core Ce3+:YAG double-clad crystal fiber, was applied on optical coherence tomography with 1.5-µm axial resolution in air. The 3-dimensional stroma of fish cornea was mapped as an in-vivo demonstration.

We have investigated a novel photodetector structure of coupling superlattice and quantum wells. This device can be operated at low bias range and even the photovoltaic mode. The broadband response is achieved by this structure.