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We have collected 10025 foreground-background quasar pairs with projected distances $d_p0.15$ Å around foreground quasars, including both the LOS (line-of-sights of foreground quasars) and transverse (TRA, perpendicular to the LOS) absorptions. Both the equivalent width (the correlation coefficient $ρ=-0.915$ and the probability $P < 10^{-4}$ of no correlation) and incident rate ($ρ=-0.964$ and $P < 10^{-6}$) of TRA \Mgii\ absorption lines are obviously anti-correlated with projected distance. The incident rate of TRA \Mgii\ absorption lines is obviously ($>4σ$) greater than that of LOS \Mgii\ absorption lines at projected distances $d_p200$ kpc. The anisotropic radiation from quasars would be the most possible interpretation for the anisotropic absorption around quasars. This could also indicate that the quasar radiation is not obviously impacting the gas halos of quasars at scales $d_p>200$ kpc., 15 pages, Accepted in ApJS

IL-17 plays essential roles in neutrophilic inflammation in the lower respiratory tract, however, the characteristics of local IL-17+ T cells in nasal inflammatory mucosa are not fully understood. We investigated the roles of IL-17+ T cells in regulating neutrophil infiltration and the effect of the mucosal microenvironment in modulating IL-17+ T cell differentiation in CRSwNP tissues. 47 polyp tissues from chronic rhinosinusitis with nasal polyps (CRSwNP) patients without corticosteroid therapy and 26 tissues from healthy mucosa were obtained. Immunohistochemistry and flow cytometry were used to analyze the neutrophil infiltration, local IL-17+ T cell subsets, as well as cytokine producing profiles of IL-17+ T cell; tissue homogenates were used to study neutrophil migration and IL-17+ T cell differentiation. Increase of IL-17+ cells and IL-17+ T cell subsets was significant in polyp tissues versus controls, IL-17+ cell number was positively correlated with neutrophil infiltration; while homogenates from polyp tissues with high IL-17 promoted neutrophil migration in vitro. IL-17 response was found in polyp-derived T cells upon Staphylococcus aureus infection. IL-17+ T cells were also down-regulated in polyps from patients treated with glucocorticoid steroids, and exhibited poly-functionality patterns in polyp tissues. Finally, IL-17+ T cell differentiation could be induced by IL-23, and homogenates from polyps could enhance IL-17+ T cell development. This study determined a functional association of IL-17+ T cells with neutrophils in CRSwNP, and revealed that polyp microenvironment could promote IL-17+ T cell differentiation, suggesting a potential feedback role for IL-17+ T cell development and local neutrophilic inflammation.

Radial velocity (RV) is among the most fundamental physical quantities obtainable from stellar spectra and is rather important in the analysis of time-domain phenomena. The LAMOST Medium-Resolution Survey (MRS) DR7 contains 5 million single-exposure stellar spectra at spectral resolution $R\sim7\,500$. However, the temporal variation of the RV zero-points (RVZPs) of the MRS survey, which makes the RVs from multiple epochs inconsistent, has not been addressed. In this paper, we measure the RVs of the 3.8 million single-exposure spectra (for 0.6 million stars) with signal-to-noise ratio (SNR) higher than 5 based on cross-correlation function (CCF) method, and propose a robust method to self-consistently determine the RVZPs exposure-by-exposure for each spectrograph with the help of \textit{Gaia} DR2 RVs. Such RVZPs are estimated for 3.6 million RVs and can reach a mean precision of $\sim 0.38\,\mathrm{km\,s}^{-1}$. The result of the temporal variation of RVZPs indicates that our algorithm is efficient and necessary before we use the absolute RVs to perform time-domain analysis. Validating the results with APOGEE DR16 shows that our absolute RVs can reach an overall precision of 0.84/0.80 $\mathrm{km\,s}^{-1}$ in the blue/red arm at $50, Comment: 23 pages, 15 figures, accepted by ApJS

Two Li-rich candidates, TYC 1338-1410-1 and TYC 2825-596-1, were observed with the new high-resolution echelle spectrograph, LAMOST/HRS. Based on the high-resolution and high-signal-to-noise ratio (SNR) spectra, we derived stellar parameters and abundances of 14 important elements for the two candidates. The stellar parameters and lithium abundances indicate that they are Li-rich K-type giants, and they have A(Li)$_\mathrm{NLTE}$ of 1.77 and 2.91 dex, respectively. Our analysis suggests that TYC 1338-1410-1 is likely a red giant branch (RGB) star at the bump stage, while TYC 2825-596-1 is most likely a core helium-burning red clump (RC) star. The line profiles of both spectra indicate that the two Li-rich giants are slow rotators and do not show infrared (IR) excess. We conclude that engulfment is not the lithium enrichment mechanism for either star. The enriched lithium of TYC 1338-1410-1 could be created via Cameron-Fowler mechanism, while the lithium excess in TYC 2825-596-1 could be associated with either non-canonical mixing processes or He-flash., 12 pages, 5 figures, to be published in Research in Astronomy and Astrophysics

Lithium has confused scientists for decades at almost each scale of the universe. Lithium-rich giants are peculiar stars with lithium abundances over model prediction. A large fraction of lithium-rich low-mass evolved stars are traditionally supposed to be red giant branch (RGB) stars. Recent studies, however, report that red clump (RC) stars are more frequent than RGB. Here, we present a uniquely large systematic study combining the direct asteroseismic analysis with the spectroscopy on the lithium-rich stars. The majority of lithium-rich stars are confirmed to be RCs, whereas RGBs are minor. We reveal that the distribution of lithium-rich RGBs steeply decline with the increasing lithium abundance, showing an upper limit around 2.6 dex, whereas the Li abundances of RCs extend to much higher values. We also find that the distributions of mass and nitrogen abundance are notably different between RC and RGB stars. These findings indicate that there is still unknown process that significantly affects surface chemical composition in low-mass stellar evolution., 27 pages, 10 figures, 3 tables

Background Recent studies have shown that human nasal epithelial progenitor cells (hNEPCs) are characterized by poor proliferation capacities during chronic nasal inflammation. Objective We sought to investigate the key molecular functions and candidates that contribute to the reduced growth potential of hNEPCs in chronically inflamed nasal mucosa. Methods Nasal biopsy specimens were obtained from 28 patients with nasal polyps (NPs) and 13 healthy controls. hNEPCs from nasal samples were cultured for 3 consecutive passages, and their molecular and functional profiles were analyzed by RNA sequencing. The minichromosome maintenance protein (MCM) family gene MCM2 was validated in hNEPCs and tissue samples from patients with NPs and control subjects by cell cycle, quantitative PCR, and Western blot analyses; small interfering RNA–mediated knockdown assay; and immunofluorescent staining. Results Compared with control hNEPCs, NP-derived hNEPCs showed (1) reduced growth kinetics, as evidenced by the colony-forming efficiency and doubling time; (2) inhibited cell cycle progression, as evidenced by gene ontology and/or pathway and cell cycle analyses; and (3) downregulated expression of MCM2, the key protein of the MCM complex, which is critical for DNA replication at the G1/S checkpoint. Moreover, hNEPCs with MCM2 knockdown showed a decreased proliferation rate, and the MCM2 protein level in basal cells was significantly lower in abnormally remodeled nasal epithelium than in normal epithelium. Conclusion These results demonstrate inhibited cell cycle progression and MCM2 downregulation in basal or progenitor nasal epithelial cells from NP tissue, which may contribute to the decreased growth potential of hNEPCs in chronically inflamed upper airways.

We developed a convolutional neural network model to distinguish the double-lined spectroscopic binaries (SB2s) from others based on single-exposure medium-resolution spectra (R ∼ 7500). The training set consists of a large set of mock spectra of single stars and binaries synthesized based on the MIST stellar evolutionary model and ATLAS9 atmospheric model. Our model reaches a novel theoretic false-positive rate by adding a proper penalty on the negative sample (e.g., 0.12% and 0.16% for the blue/red arm when the penalty parameter Λ = 16). Tests show that the performance is as expected and favors FGK-type main-sequence (MS) binaries with high mass ratio (q ≥ 0.7) and large radial velocity separation (Δv ≥ 50 km s−1). Although the real false-positive rate cannot be estimated reliably, validating on eclipsing binaries identified from Kepler light curves indicates that our model predicts low binary probabilities at eclipsing phases (0, 0.5, and 1.0) as expected. The color–magnitude diagram also helps illustrate its feasibility and capability of identifying FGK MS binaries from spectra. We conclude that this model is reasonably reliable and can provide an automatic approach to identify SB2s with period ≲10 days. This work yields a catalog of binary probabilities for over 5 million spectra of 1 million sources from the LAMOST medium-resolution survey (MRS) and a catalog of 2198 SB2 candidates whose physical properties will be analyzed in a follow-up paper. Data products are made publicly available online, as well as our Github website.

Correlations between the variations of quasar absorption lines and the ionizing continuum have been confirmed recently in systematic studies. However, no convincing individual case is reported. We present a statistical analysis of the variable C iv broad absorption line (BAL) in the quasar SDSS J141007.74+541203.3, which has been observed with 44 epochs by the Sloan Digital Sky Survey Data Release 14. Grier et al. have concluded that the most likely cause of the variability of the BAL in SDSS J141007.74+541203.3 is a rapid response to changes in the incident ionizing continuum. In this paper, we confirm the anticorrelation between the equivalent width of BALs and the flux of the continuum based on the spectra of this quasar, which show significant variations. This serves as further independent evidence for the conclusions of Grier et al.

Objective Neutrophil infiltration in patients with sinonasal inverted papilloma (SNIP) is significantly high. Whether IL-17, which is a potent factor mediating neutrophilic inflammation, is involved in the neutrophilic phenotype of SNIP is investigated in the current study. Study design Laboratorial study. Participants Nasal papilloma and inferior turbinate were collected from patients with SNIP (n = 50) and control subjects with septal deviation (n = 15). Methods IL-17 + cells were evaluated in tissues obtained from patients with SNIP and control subjects with septal deviation, by immunohistochemistry and flow cytometry. Main outcome measures The IL-17 + cells were mainly localised in mononuclear cells and neutrophils, and were up-regulated in the SNIP samples compared with those in the controls. The IL-17 + T-cell subsets mainly included CD4+ (Th17, 60.0%) and CD8+ (Tc17, 30.0%), and both subsets were enhanced in the SNIP samples than controls. The total level of IL-17 + cells was significantly correlated with neutrophil infiltration in the SNIP tissues. Furthermore, the SNIP homogenates could significantly promote IL-17 production in peripheral blood mononuclear cells. Conclusions An increase in IL-17 + cells is evident in SNIP and may be involved in neutrophil infiltration in local tissues. IL-17 could be a potential therapeutic target to relieve the neutrophilic pathological change in SNIP.

About one percent of giants\upcite{Brown1989} are detected to have anomalously high lithium (Li) abundances in their atmospheres, conflicting directly with the prediction of the standard stellar evolution models\upcite{Iben1967}, and making the production and evolution of Li more intriguing, not only in the sense of the Big Bang nucleosynthesis\upcite{Cyburt2016,Spite1982} or the Galactic medium\upcite{Tajitsu2015}, but also the evolution of stars. Decades of efforts have been put into explaining why such outliers exist\upcite{Sackmann1999, Denissenkov2004, Charbonnel2010}, yet the origins of Li-rich giants are still being debated. Here we report the discovery of the most Li-rich giant known to date, with a super-high Li abundance of 4.51. This rare phenomenon was snapshotted together with another short-term event that the star is experiencing its luminosity bump on the red giant branch. Such high Li abundance indicates that the star might be at the very beginning of its Li-rich phase, which provides a great opportunity to investigate the origin and evolution of Li in the Galaxy. A detailed nuclear simulation is presented with up-to-date reaction rates to recreate the Li enriching process in this star. Our results provide tight constraints on both observational and theoretical points of view, suggesting that low-mass giants can produce Li inside themselves to a super high level via $^{7}$Be transportation during the red giant phase., 17 pages, 6 figures

Bi-site time-series photometric and high-resolution spectroscopic observations were made for the double-mode high-amplitude $\delta$ Scuti star VX\ Hya. The fundamental frequency $f_{0}=4.4763\ \rm{c\ days^{-1}}$, the first overtone $f_{1}=5.7897\ \rm{c\ days^{-1}}$ and 23 harmonics and linear combinations of $f_{0}$ and $f_{1}$ are detected by pulsation analysis. From the spectroscopic data, we get $\rm{[Fe/H] = -0.2\pm0.1\ dex}$. The period change rate of the fundamental mode is obtained by using the Fourier-phase diagram method, which gives the value of $(1/P_{0})(dP_{0}/dt)=(1.81\pm0.09) \times 10^{-7}\ \rm{yr}^{-1}$. With these results from the observations, we perform theoretical explorations with the stellar evolution code MESA, and constrain the models by fitting $f_{0}$, $f_{1}$, and $(1/P_{0})(dP_{0}/dt)$ within $3\sigma$ deviations. The results show that the period change of VX\ Hya could be ascribed to the evolutionary effect. The stellar parameters of VX\ Hya could be derived as: the mass $2.385\pm0.025\ M_{\odot}$, the luminosity $\log(L/L_{\odot})=1.93\pm0.02$ and the age $(4.43\pm0.13)\times 10^8$ years. VX\ Hya is found to locate at the post-main-sequence stage with a helium core and a hydrogen-burning shell on the H${-}$R diagram., Comment: 23 pages, 9 figures, 12 tables. ApJ version

Background Curcumin (Cur), derived from Curcuma species, exhibits anti‐inflammatory, antioxidant, and anticancer effects. Although Cur has some beneficial effects on asthma, its clinical application is limited by its low bioavailability. Tetrahydrocurcumin (THC), the major active metabolite of Cur, has multiple biological functions, similarly to Cur, and importantly, it showed enhanced bioavailability in tissues and plasma. However, the effect of THC on asthma has not been reported. Objective The current study sought to investigate the efficacy of dietary THC on allergic asthma compared to that of Cur in an animal model. Methods The anti‐inflammatory effects of Cur and THC were evaluated in an ovalbumin‐induced asthmatic mouse model. The nasal symptoms, pathological alterations of the lung tissues, oxidants and antioxidants, cytokine production, T cell subsets, and Th2‐related signalling pathway activity were assessed. Results Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper‐production), oxidative stress (malondialdehyde), cytokine production (IL‐13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 axis) activity. THC was more effective than Cur in suppressing tissue eosinophilia, mucus production, and IL‐4Rα/Jak1/STAT6 pathway activity. Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL‐4 and IL‐5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione). Conclusion and Clinical Relevance The above results demonstrated for the first time that THC was superior to Cur in modulating allergic asthmatic phenotypes, especially attenuating the Th2 response. THC might be a potentially effective agent for asthma treatment.

Study of primary stars lying in Sirius-like systems with various masses of WD companions and orbital separations is one of the key aspects to understand the origin and nature of Barium (Ba) stars. In this paper, based on high resolution and high S/N spectra, we present systematic analysis of photospheric abundances for 18 FGK primary stars of Sirius-like systems including six giants and 12 dwarfs. Atmospheric parameters, stellar masses, and abundances of 24 elements (C, Na, Mg, Al, Si, S, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Sr, Y, Zr, Ba, La, Ce and Nd) are determined homogeneously. The abundance patterns in these sample stars show that most of the elements in our sample follow the behavior of field stars with similar metallicity. As expected, s-process elements in four known Ba giants show overabundance. A weak correlation was found between anomalies of s-process elemental abundance and orbital separation, suggesting the orbital separation of the binaries could not be the main constraint to differentiate strong Ba stars from mild Ba stars. Our study shows that the large mass (>0.51 M ) of a WD companion in a binary system is not a sufficient condition to form a Ba star, even if the separation between the two components is small. Although not sufficient it seems to be a necessary condition since Ba stars with lower mass WDs in the observed sample were not found. Our results support that [s/Fe] and [hs/ls] ratios of Ba stars are anti-correlated with the metallicity. However, the different levels of s-process overabundance among Ba stars may not to be dominated mainly by the metallicity., 19 pages, 10 figures, 8 tables

Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted papilloma. Our results demonstrate that P and Ca are the most abundant elements in mucosa and their distinct difference between epithelial and subepithelial regions; more importantly, our results reveal decreased amounts of Cu and Zn in the remodeled epithelium as compared to the normal epithelium. These findings suggest that Cu and Zn may be beneficial targets to regulate aberrant epithelial remodeling in airway inflammation.

We investigate the connections between radio, optical and soft X-ray luminosities with a sample of 538 FSRQs. We find that the radio luminosity is strongly correlated with the optical luminosity, as well as with the soft X-ray luminosity. We also find that the optical luminosity is strongly correlated with the soft X-ray luminosity.

Standard stellar evolution model predicts a severe depletion of lithium (Li) abundance during the first dredge up process (FDU). Yet a small fraction of giant stars are still found to preserve a considerable amount of Li in their atmospheres after the FDU. Those giants are usually identified as Li-rich by a widely used criterion, A(Li) > 1.5 dex. A large number of works dedicated to searching for investigating this minority of the giant family, and the amount of Li-rich giants, has been largely expanded on, especially in the era of big data. In this paper, we present a catalog of Li-rich giants found from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey with Li abundances derived from a template-matching method developed for LAMOST low-resolution spectra.

Background The airway epithelium maintains mucosal homeostasis and effectively responds to pathogens. The roles of the epithelial NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in human rhinovirus (hRV) infection and its effects mediating epithelial functional changes remain poorly understood. Objective We investigated the mechanisms and cellular functions mediated by the epithelial NLRP3 inflammasome on hRV infection. Methods Using models of primary human nasal epithelial progenitor cells and differentiated human nasal epithelial cells (hNECs) infected by hRV, we functionally examined key factors for NLRP3 inflammasome activation, cell death, and mucus production. Furthermore, NLRP3 and IL-1β in human epithelium from nasal mucosal inflammation induced by hRV were evaluated. Results The inflammasome-mediated IL-1β secretion and pyroptosis in human nasal epithelial progenitor cells and hNECs on hRV infection were dependent on the DDX33/DDX58–NLRP3–caspase-1–GSDMD axis. In differentiated hNECs hRV could also promote major airway epithelial mucin (MUC5AC) production through this axis. Our results further confirmed that the NLRP3 inflammasome signaling pathway was responsible for suppressing hRV replication in airway epithelium. Finally, hRV infection in chronically inflamed nasal mucosa was associated with epithelial mucus hyperproduction, whereas NLRP3 and IL-1β expression levels were significantly increased in hRV-infected epithelium with goblet cell hyperplasia compared with normal epithelium without viral infection. Conclusion The current study showed that the NLRP3 inflammasome signaling axis could functionally mediate hRV-induced inflammation, pyroptosis, and mucus production in airway epithelium, which might be an essential mechanism associated with hRV-induced airway remodeling.