321 results on '"Yu SW"'
Search Results
2. Probing covalency with oxidant K edge x-ray absorption spectroscopy of UF4 and UO2
- Author
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Tobin, JG, Yu, SW, Qiao, R, Yang, WL, and Shuh, DK
- Subjects
Engineering ,Physical Sciences ,Applied Physics - Abstract
There are some interesting discrepancies between what has been observed experimentally and the predictions of cluster theory. In particular, the F 1s x-ray absorption spectroscopy (XAS) of uranium tetrafluoride and the U 4d XAS branching ratio for oxidized uranium are two cases in point. These discrepancies may be driven by the overestimation of covalency in cluster calculations.
- Published
- 2018
3. Oxidant K edge x-ray emission spectroscopy of UF4 and UO2
- Author
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Tobin, JG, Yu, SW, Qiao, R, Yang, WL, and Shuh, DK
- Subjects
Applied Physics ,Engineering ,Physical Sciences - Abstract
The K-Edge (1s) x-ray emission spectroscopy of uranium tetrafluoride and uranium dioxide were compared to each other and to the results of a pair of earlier cluster calculations. Using a very simplified approach, it is possible to qualitatively reconstruct the main features of the x-ray emission spectra from the cluster calculation state energies and 2p percentages.
- Published
- 2018
4. Surface degradation of uranium tetrafluoride
- Author
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Tobin, JG, Duffin, AM, Yu, SW, Qiao, R, Yang, WL, Booth, CH, and Shuh, DK
- Subjects
Applied Physics ,Engineering ,Physical Sciences - Abstract
A detailed analysis of a single crystal of uranium tetrafluoride has been carried out. The techniques include x-ray absorption spectroscopy, as well as x-ray photoelectron spectroscopy and x-ray emission spectroscopy. Evidence will be presented for the presence of a uranyl species, possibly UO2F2, as a product of, or participant in the surface degradation.
- Published
- 2017
5. Covalency in oxidized uranium
- Author
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Tobin, JG, Yu, SW, Qiao, R, Yang, WL, Booth, CH, Shuh, DK, Duffin, AM, Sokaras, D, Nordlund, D, and Weng, TC
- Subjects
Fluids & Plasmas ,Physical Sciences ,Chemical Sciences ,Engineering - Abstract
Using x-ray emission spectroscopy and absorption spectroscopy, it has been possible to directly access the states in the unoccupied conduction bands that are involved with 5f and 6d covalency in oxidized uranium. By varying the oxidizing agent, the degree of 5f covalency can be manipulated and monitored, clearly and irrevocably establishing the importance of 5f covalency in the electronic structure of the key nuclear fuel, uranium dioxide.
- Published
- 2015
6. Oxidation and crystal field effects in uranium
- Author
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Tobin, JG, Yu, SW, Booth, CH, Tyliszczak, T, Shuh, DK, Van Der Laan, G, Sokaras, D, Nordlund, D, Weng, TC, and Bagus, PS
- Subjects
Fluids & Plasmas ,Physical Sciences ,Chemical Sciences ,Engineering - Abstract
An extensive investigation of oxidation in uranium has been pursued. This includes the utilization of soft x-ray absorption spectroscopy, hard x-ray absorption near-edge structure, resonant (hard) x-ray emission spectroscopy, cluster calculations, and a branching ratio analysis founded on atomic theory. The samples utilized were uranium dioxide (UO2), uranium trioxide (UO3), and uranium tetrafluoride (UF4). A discussion of the role of nonspherical perturbations, i.e., crystal or ligand field effects, will be presented.
- Published
- 2015
7. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Klionsky, Dj, Abdel-Aziz, Ak, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, Mh, Abudu, Yp, Acevedo-Arozena, A, Adamopoulos, Ie, Adeli, K, Adolph, Te, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, Bb, Agnello, M, Agostinis, P, Agrewala, Jn, Agrotis, A, Aguilar, Pv, Ahmad, St, Ahmed, Zm, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, Ha, Al-Abd, Am, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, Ma, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, Ma, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, Gd, Altan-Bonnet, N, Altieri, Dc, Álvarez, Émc, Alves, S, Alves da Costa, C, Alzaharna, Mm, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, Ao, Ammanathan, V, An, Z, Andersen, Su, Andrabi, Sa, Andrade-Silva, M, Andres, Am, Angelini, S, Ann, D, Anozie, Uc, Ansari, My, Antas, P, Antebi, A, Antón, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araújo, Wl, Araya, J, Arden, C, Arévalo, Ma, Arguelles, S, Arias, E, Arikkath, J, Arimoto, H, Ariosa, Ar, Armstrong-James, D, Arnauné-Pelloquin, L, Aroca, A, Arroyo, D, Arsov, I, Artero, R, Asaro, Dml, Aschner, M, Ashrafizadeh, M, Ashur-Fabian, O, Atanasov, Ag, Au, Ak, Auberger, P, Auner, Hw, Aurelian, L, Autelli, R, Avagliano, L, Ávalos, Y, Aveic, S, Aveleira, Ca, Avin-Wittenberg, T, Aydin, Y, Ayton, S, Ayyadevara, S, Azzopardi, M, Baba, M, Backer, Jm, Backues, Sk, Bae, Dh, Bae, On, Bae, Sh, Baehrecke, Eh, Baek, A, Baek, Sh, Bagetta, G, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, X, Bai, Y, Bairagi, N, Baksi, S, Balbi, T, Baldari, Ct, Balduini, W, Ballabio, A, Ballester, M, Balazadeh, S, Balzan, R, Bandopadhyay, R, Banerjee, S, Bánréti, Á, Bao, Y, Baptista, M, Baracca, A, Barbati, C, Bargiela, A, Barilà, D, Barlow, Pg, Barmada, Sj, Barreiro, E, Barreto, Ge, Bartek, J, Bartel, B, Bartolome, A, Barve, Gr, Basagoudanavar, Sh, Bassham, Dc, Bast RC, Jr, Basu, A, Batoko, H, Batten, I, Baulieu, Ee, Baumgarner, Bl, Bayry, J, Beale, R, Beau, I, Beaumatin, F, Bechara, Lrg, Beck GR, Jr, Beers, Mf, Begun, J, Behrends, C, Behrens, Gmn, Bei, R, Bejarano, E, Bel, S, Behl, C, Belaid, A, Belgareh-Touzé, N, Bellarosa, C, Belleudi, F, Belló Pérez, M, Bello-Morales, R, Beltran, Jso, Beltran, S, Benbrook, Dm, Bendorius, M, Benitez, Ba, Benito-Cuesta, I, Bensalem, J, Berchtold, Mw, Berezowska, S, Bergamaschi, D, Bergami, M, Bergmann, A, Berliocchi, L, Berlioz-Torrent, C, Bernard, A, Berthoux, L, Besirli, Cg, Besteiro, S, Betin, Vm, Beyaert, R, Bezbradica, J, Bhaskar, K, Bhatia-Kissova, I, Bhattacharya, R, Bhattacharya, S, Bhattacharyya, S, Bhuiyan, M, Bhutia, Sk, Bi, L, Bi, X, Biden, Tj, Bijian, K, Billes, Va, Binart, N, Bincoletto, C, Birgisdottir, Ab, Bjorkoy, G, Blanco, G, Blas-Garcia, A, Blasiak, J, Blomgran, R, Blomgren, K, Blum, J, Boada-Romero, E, Boban, M, Boesze-Battaglia, K, Boeuf, P, Boland, B, Bomont, P, Bonaldo, P, Bonam, Sr, Bonfili, L, Bonifacino, J, Boone, Ba, Bootman, Md, Bordi, M, Borner, C, Bornhauser, Bc, Borthakur, G, Bosch, J, Bose, S, Botana, Lm, Botas, J, Boulanger, Cm, Boulton, Me, Bourdenx, M, Bourgeois, B, Bourke, Nm, Bousquet, G, Boya, P, Bozhkov, Pv, Bozi, Lhm, Bozkurt, To, Brackney, De, Brandts, Ch, Braun, Rj, Braus, Gh, Bravo-Sagua, R, Bravo-San Pedro, Jm, Brest, P, Bringer, Ma, Briones-Herrera, A, Broaddus, Vc, Brodersen, P, Brodsky, Jl, Brody, Sl, Bronson, Pg, Bronstein, Jm, Brown, Cn, Brown, Re, Brum, Pc, Brumell, Jh, Brunetti-Pierri, N, Bruno, D, Bryson-Richardson, Rj, Bucci, C, Buchrieser, C, Bueno, M, Buitrago-Molina, Le, Buraschi, S, Buch, S, Buchan, Jr, Buckingham, Em, Budak, H, Budini, M, Bultynck, G, Burada, F, Burgoyne, Jr, Burón, Mi, Bustos, V, Büttner, S, Butturini, E, Byrd, A, Cabas, I, Cabrera-Benitez, S, Cadwell, K, Cai, J, Cai, L, Cai, Q, Cairó, M, Calbet, Ja, Caldwell, Ga, Caldwell, Ka, Call, Ja, Calvani, Riccardo, Calvo, Ac, Calvo-Rubio Barrera, M, Camara, No, Camonis, Jh, Camougrand, N, Campanella, M, Campbell, Em, Campbell-Valois, Fx, Campello, S, Campesi, I, Campos, Jc, Camuzard, O, Cancino, J, Candido de Almeida, D, Canesi, L, Caniggia, I, Canonico, B, Cantí, C, Cao, B, Caraglia, M, Caramés, B, Carchman, Eh, Cardenal-Muñoz, E, Cardenas, C, Cardenas, L, Cardoso, Sm, Carew, J, Carle, Gf, Carleton, G, Carloni, S, Carmona-Gutierrez, D, Carneiro, La, Carnevali, O, Carosi, Jm, Carra, S, Carrier, A, Carrier, L, Carroll, B, Carter, Ab, Carvalho, An, Casanova, M, Casas, C, Casas, J, Cassioli, C, Castillo, Ef, Castillo, K, Castillo-Lluva, S, Castoldi, F, Castori, M, Castro, Af, Castro-Caldas, M, Castro-Hernandez, J, Castro-Obregon, S, Catz, Sd, Cavadas, C, Cavaliere, F, Cavallini, G, Cavinato, M, Cayuela, Ml, Cebollada Rica, P, Cecarini, V, Cecconi, F, Cechowska-Pasko, M, Cenci, S, Ceperuelo-Mallafré, V, Cerqueira, Jj, Cerutti, Jm, Cervia, D, Cetintas, Vb, Cetrullo, S, Chae, Hj, Chagin, A, Chai, Cy, Chakrabarti, G, Chakrabarti, O, Chakraborty, T, Chami, M, Chamilos, G, Chan, Dw, Chan, Eyw, Chan, Ed, Chan, Hye, Chan, Hh, Chan, H, Chan, Mtv, Chan, Y, Chandra, Pk, Chang, Cp, Chang, C, Chang, Hc, Chang, K, Chao, J, Chapman, T, Charlet-Berguerand, N, Chatterjee, S, Chaube, Sk, Chaudhary, A, Chauhan, S, Chaum, E, Checler, F, Cheetham, Me, Chen, C, Chen, Gc, Chen, Jf, Chen, Ll, Chen, L, Chen, M, Chen, Mk, Chen, N, Chen, Q, Chen, Rh, Chen, S, Chen, W, Chen, Xm, Chen, Xw, Chen, X, Chen, Y, Chen, Yg, Chen, Yj, Chen, Yq, Chen, Z, Chen, Zh, Chen, Zj, Cheng, H, Cheng, J, Cheng, Sy, Cheng, W, Cheng, X, Cheng, Xt, Cheng, Y, Cheng, Z, Cheong, H, Cheong, Jk, Chernyak, Bv, Cherry, S, Cheung, Cfr, Cheung, Cha, Cheung, Kh, Chevet, E, Chi, Rj, Chiang, Ak, Chiaradonna, F, Chiarelli, R, Chiariello, M, Chica, N, Chiocca, S, Chiong, M, Chiou, Sh, Chiramel, Ai, Chiurchiù, V, Cho, Dh, Choe, Sk, Choi, Amk, Choi, Me, Choudhury, Kr, Chow, N, Chu, Ct, Chua, Jp, Chua, Jje, Chung, H, Chung, Kp, Chung, S, Chung, Sh, Chung, Yl, Cianfanelli, V, Ciechomska, Ia, Cifuentes, M, Cinque, L, Cirak, S, Cirone, M, Clague, Mj, Clarke, R, Clementi, E, Coccia, Em, Codogno, P, Cohen, E, Cohen, Mm, Colasanti, T, Colasuonno, F, Colbert, Ra, Colell, A, Čolić, M, Coll, N, Collins, Mo, Colombo, Mi, Colón-Ramos, Da, Combaret, L, Comincini, S, Cominetti, Mr, Consiglio, A, Conte, A, Conti, F, Contu, Vr, Cookson, Mr, Coombs, Km, Coppens, I, Corasaniti, Mt, Corkery, Dp, Cordes, N, Cortese, K, Costa, Mdc, Costantino, S, Costelli, P, Coto-Montes, A, Crack, Pj, Crespo, Jl, Criollo, A, Crippa, V, Cristofani, R, Csizmadia, T, Cuadrado, A, Cui, B, Cui, J, Cui, Y, Culetto, E, Cumino, Ac, Cybulsky, Av, Czaja, Mj, Czuczwar, Sj, D'Adamo, S, D'Amelio, M, D'Arcangelo, D, D'Lugos, Ac, D'Orazi, G, da Silva, Ja, Dafsari, H, Dagda, Rk, Dagdas, Y, Daglia, M, Dai, X, Dai, Y, Dal Col, J, Dalhaimer, P, Dalla Valle, L, Dallenga, T, Dalmasso, G, Damme, M, Dando, I, Dantuma, Np, Darling, Al, Das, H, Dasarathy, S, Dasari, Sk, Dash, S, Daumke, O, Dauphinee, An, Davies, J, Dávila, Va, Davis, Rj, Davis, T, Dayalan Naidu, S, De Amicis, F, De Bosscher, K, De Felice, F, De Franceschi, L, De Leonibus, C, de Mattos Barbosa, Mg, De Meyer, Gry, De Milito, A, De Nunzio, C, De Palma, C, De Santi, M, De Virgilio, C, De Zio, D, Debnath, J, Debosch, Bj, Decuypere, Jp, Deehan, Ma, Deflorian, G, Degregori, J, Dehay, B, Del Rio, G, Delaney, Jr, Delbridge, Lmd, Delorme-Axford, E, Delpino, Mv, Demarchi, F, Dembitz, V, Demers, Nd, Deng, H, Deng, Z, Dengjel, J, Dent, P, Denton, D, Depamphilis, Ml, Der, Cj, Deretic, V, Descoteaux, A, Devis, L, Devkota, S, Devuyst, O, Dewson, G, Dharmasivam, M, Dhiman, R, di Bernardo, D, Di Cristina, M, Di Domenico, F, Di Fazio, P, Di Fonzo, A, Di Guardo, G, Di Guglielmo, Gm, Di Leo, L, Di Malta, C, Di Nardo, A, Di Rienzo, M, Di Sano, F, Diallinas, G, Diao, J, Diaz-Araya, G, Díaz-Laviada, I, Dickinson, Jm, Diederich, M, Dieudé, M, Dikic, I, Ding, S, Ding, Wx, Dini, L, Dinić, J, Dinic, M, Dinkova-Kostova, At, Dionne, M, Distler, Jhw, Diwan, A, Dixon, Imc, Djavaheri-Mergny, M, Dobrinski, I, Dobrovinskaya, O, Dobrowolski, R, Dobson, Rcj, Đokić, J, Dokmeci Emre, S, Donadelli, M, Dong, B, Dong, X, Dong, Z, Dorn Ii, Gw, Dotsch, V, Dou, H, Dou, J, Dowaidar, M, Dridi, S, Drucker, L, Du, A, Du, C, Du, G, Du, Hn, Du, Ll, du Toit, A, Duan, Sb, Duan, X, Duarte, Sp, Dubrovska, A, Dunlop, Ea, Dupont, N, Durán, Rv, Dwarakanath, B, Dyshlovoy, Sa, Ebrahimi-Fakhari, D, Eckhart, L, Edelstein, Cl, Efferth, T, Eftekharpour, E, Eichinger, L, Eid, N, Eisenberg, T, Eissa, Nt, Eissa, S, Ejarque, M, El Andaloussi, A, El-Hage, N, El-Naggar, S, Eleuteri, Am, El-Shafey, E, Elgendy, M, Eliopoulos, Ag, Elizalde, Mm, Elks, Pm, Elsasser, Hp, Elsherbiny, E, Emerling, Bm, Emre, Nct, Eng, Ch, Engedal, N, Engelbrecht, Am, Engelsen, Ast, Enserink, Jm, Escalante, R, Esclatine, A, Escobar-Henriques, M, Eskelinen, El, Espert, L, Eusebio, Mo, Fabrias, G, Fabrizi, C, Facchiano, A, Facchiano, F, Fadeel, B, Fader, C, Faesen, Ac, Fairlie, Wd, Falcó, A, Falkenburger, Bh, Fan, D, Fan, J, Fan, Y, Fang, Ef, Fang, Y, Fanto, M, Farfel-Becker, T, Faure, M, Fazeli, G, Fedele, Ao, Feldman, Am, Feng, D, Feng, J, Feng, L, Feng, Y, Feng, W, Fenz Araujo, T, Ferguson, Ta, Fernández, Áf, Fernandez-Checa, Jc, Fernández-Veledo, S, Fernie, Ar, Ferrante AW, Jr, Ferraresi, A, Ferrari, Mf, Ferreira, Jcb, Ferro-Novick, S, Figueras, A, Filadi, R, Filigheddu, N, Filippi-Chiela, E, Filomeni, G, Fimia, Gm, Fineschi, V, Finetti, F, Finkbeiner, S, Fisher, Ea, Fisher, Pb, Flamigni, F, Fliesler, Sj, Flo, Th, Florance, I, Florey, O, Florio, T, Fodor, E, Follo, C, Fon, Ea, Forlino, A, Fornai, F, Fortini, P, Fracassi, A, Fraldi, A, Franco, B, Franco, R, Franconi, F, Frankel, Lb, Friedman, Sl, Fröhlich, Lf, Frühbeck, G, Fuentes, Jm, Fujiki, Y, Fujita, N, Fujiwara, Y, Fukuda, M, Fulda, S, Furic, L, Furuya, N, Fusco, C, Gack, Mu, Gaffke, L, Galadari, S, Galasso, A, Galindo, Mf, Gallolu Kankanamalage, S, Galluzzi, L, Galy, V, Gammoh, N, Gan, B, Ganley, Ig, Gao, F, Gao, H, Gao, M, Gao, P, Gao, Sj, Gao, W, Gao, X, Garcera, A, Garcia, Mn, Garcia, Ve, García-Del Portillo, F, Garcia-Escudero, V, Garcia-Garcia, A, Garcia-Macia, M, García-Moreno, D, Garcia-Ruiz, C, García-Sanz, P, Garg, Ad, Gargini, R, Garofalo, T, Garry, Rf, Gassen, Nc, Gatica, D, Ge, L, Ge, W, Geiss-Friedlander, R, Gelfi, C, Genschik, P, Gentle, Ie, Gerbino, V, Gerhardt, C, Germain, K, Germain, M, Gewirtz, Da, Ghasemipour Afshar, E, Ghavami, S, Ghigo, A, Ghosh, M, Giamas, G, Giampietri, C, Giatromanolaki, A, Gibson, Ge, Gibson, Sb, Ginet, V, Giniger, E, Giorgi, C, Girao, H, Girardin, Se, Giridharan, M, Giuliano, S, Giulivi, C, Giuriato, S, Giustiniani, J, Gluschko, A, Goder, V, Goginashvili, A, Golab, J, Goldstone, Dc, Golebiewska, A, Gomes, Lr, Gomez, R, Gómez-Sánchez, R, Gomez-Puerto, Mc, Gomez-Sintes, R, Gong, Q, Goni, Fm, González-Gallego, J, Gonzalez-Hernandez, T, Gonzalez-Polo, Ra, Gonzalez-Reyes, Ja, González-Rodríguez, P, Goping, I, Gorbatyuk, M, Gorbunov, Nv, Görgülü, K, Gorojod, Rm, Gorski, Sm, Goruppi, S, Gotor, C, Gottlieb, Ra, Gozes, I, Gozuacik, D, Graef, M, Gräler, Mh, Granatiero, V, Grasso, D, Gray, Jp, Green, Dr, Greenhough, A, Gregory, Sl, Griffin, Ef, Grinstaff, Mw, Gros, F, Grose, C, Gross, A, Gruber, F, Grumati, P, Grune, T, Gu, X, Guan, Jl, Guardia, Cm, Guda, K, Guerra, F, Guerri, C, Guha, P, Guillén, C, Gujar, S, Gukovskaya, A, Gukovsky, I, Gunst, J, Günther, A, Guntur, Ar, Guo, C, Guo, H, Guo, Lw, Guo, M, Gupta, P, Gupta, Sk, Gupta, S, Gupta, Vb, Gupta, V, Gustafsson, Ab, Gutterman, Dd, H B, R, Haapasalo, A, Haber, Je, Hać, A, Hadano, S, Hafrén, Aj, Haidar, M, Hall, B, Halldén, G, Hamacher-Brady, A, Hamann, A, Hamasaki, M, Han, W, Hansen, M, Hanson, Pi, Hao, Z, Harada, M, Harhaji-Trajkovic, L, Hariharan, N, Haroon, N, Harris, J, Hasegawa, T, Hasima Nagoor, N, Haspel, Ja, Haucke, V, Hawkins, Wd, Hay, Ba, Haynes, Cm, Hayrabedyan, Sb, Hays, T, He, C, He, Q, He, Rr, He, Yw, He, Yy, Heakal, Y, Heberle, Am, Hejtmancik, Jf, Helgason, Gv, Henkel, V, Herb, M, Hergovich, A, Herman-Antosiewicz, A, Hernández, A, Hernandez, C, Hernandez-Diaz, S, Hernandez-Gea, V, Herpin, A, Herreros, J, Hervás, Jh, Hesselson, D, Hetz, C, Heussler, Vt, Higuchi, Y, Hilfiker, S, Hill, Ja, Hlavacek, W, Ho, Ea, Ho, Iht, Ho, Pw, Ho, Sl, Ho, Wy, Hobbs, Ga, Hochstrasser, M, Hoet, Phm, Hofius, D, Hofman, P, Höhn, A, Holmberg, Ci, Hombrebueno, Jr, Yi-Ren Hong, Ch, Hooper, Lv, Hoppe, T, Horos, R, Hoshida, Y, Hsin, Il, Hsu, Hy, Hu, B, Hu, D, Hu, Lf, Hu, Mc, Hu, R, Hu, W, Hu, Yc, Hu, Zw, Hua, F, Hua, J, Hua, Y, Huan, C, Huang, C, Huang, H, Huang, K, Huang, Mlh, Huang, R, Huang, S, Huang, T, Huang, X, Huang, Yj, Huber, Tb, Hubert, V, Hubner, Ca, Hughes, Sm, Hughes, We, Humbert, M, Hummer, G, Hurley, Jh, Hussain, S, Hussey, Pj, Hutabarat, M, Hwang, Hy, Hwang, S, Ieni, A, Ikeda, F, Imagawa, Y, Imai, Y, Imbriano, C, Imoto, M, Inman, Dm, Inoki, K, Iovanna, J, Iozzo, Rv, Ippolito, G, Irazoqui, Je, Iribarren, P, Ishaq, M, Ishikawa, M, Ishimwe, N, Isidoro, C, Ismail, N, Issazadeh-Navikas, S, Itakura, E, Ito, D, Ivankovic, D, 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- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
8. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Sarparanta J, Sathyanarayan A, Sathyanarayanan R, Scaglione KM, Scatozza F, Schaefer L, Schafer ZT, Schaible UE, Schapira AHV, Scharl M, Schatzl HM, Schein CH, Scheper W, Scheuring D, Schiaffino MV, Schiappacassi M, Schindl R, Schlattner U, Schmidt O, Schmitt R, Schmidt SD, Schmitz I, Schmukler E, Schneider A, Schneider BE, Schober R, Schoijet AC, Schott MB, Schramm M, Schröder B, Schuh K, Schüller C, Schulze RJ, Schürmanns L, Schwamborn JC, Schwarten M, Scialo F, Sciarretta S, Scott MJ, Scotto KW, Scovassi AI, Scrima A, Scrivo A, Sebastian D, Sebti S, Sedej S, Segatori L, Segev N, Seglen PO, Seiliez I, Seki E, Selleck SB, Sellke FW, Selsby JT, Sendtner M, Senturk S, Seranova E, Sergi C, Serra-Moreno R, Sesaki H, Settembre C, Setty SRG, Sgarbi G, Sha O, Shacka JJ, Shah JA, Shang D, Shao C, Shao F, Sharbati S, Sharkey LM, Sharma D, Sharma G, Sharma K, Sharma P, Sharma S, Shen HM, Shen H, Shen J, Shen M, Shen W, Shen Z, Sheng R, Sheng Z, Sheng ZH, Shi J, Shi X, Shi YH, Shiba-Fukushima K, Shieh JJ, Shimada Y, Shimizu S, Shimozawa M, Shintani T, Shoemaker CJ, Shojaei S, Shoji I, Shravage BV, Shridhar V, Shu CW, Shu HB, Shui K, Shukla AK, Shutt TE, Sica V, Siddiqui A, Sierra A, Sierra-Torre V, Signorelli S, Sil P, Silva BJA, Silva JD, Silva-Pavez E, Silvente-Poirot S, Simmonds RE, Simon AK, Simon HU, Simons M, Singh A, Singh LP, Singh R, Singh SV, Singh SK, Singh SB, Singh S, Singh SP, Sinha D, Sinha RA, Sinha S, Sirko A, Sirohi K, Sivridis EL, Skendros P, Skirycz A, Slaninová I, Smaili SS, Smertenko A, Smith MD, Soenen SJ, Sohn EJ, Sok SPM, Solaini G, Soldati T, Soleimanpour SA, Soler RM, Solovchenko A, Somarelli JA, Sonawane A, Song F, Song HK, Song JX, Song K, Song Z, Soria LR, Sorice M, Soukas AA, Soukup SF, Sousa D, Sousa N, Spagnuolo PA, Spector SA, Srinivas Bharath MM, St Clair D, Stagni V, Staiano L, Stalnecker CA, Stankov MV, Stathopulos PB, Stefan K, Stefan SM, Stefanis L, Steffan JS, Steinkasserer A, Stenmark H, Sterneckert J, Stevens C, Stoka V, Storch S, Stork B, Strappazzon F, Strohecker AM, Stupack DG, Su H, Su LY, Su L, Suarez-Fontes AM, Subauste CS, Subbian S, Subirada PV, Sudhandiran G, Sue CM, Sui X, Summers C, Sun G, Sun J, Sun K, Sun MX, Sun Q, Sun Y, Sun Z, Sunahara KKS, Sundberg E, Susztak K, Sutovsky P, Suzuki H, Sweeney G, Symons JD, Sze SCW, Szewczyk NJ, Tabecka-Lonczynska A, Tabolacci C, Tacke F, Taegtmeyer H, Tafani M, Tagaya M, Tai H, Tait SWG, Takahashi Y, Takats S, Talwar P, Tam C, Tam SY, Tampellini D, Tamura A, Tan CT, Tan EK, Tan YQ, Tanaka M, Tang D, Tang J, Tang TS, Tanida I, Tao Z, Taouis M, Tatenhorst L, Tavernarakis N, Taylor A, Taylor GA, Taylor JM, Tchetina E, Tee AR, Tegeder I, Teis D, Teixeira N, Teixeira-Clerc F, Tekirdag KA, Tencomnao T, Tenreiro S, Tepikin AV, Testillano PS, Tettamanti G, Tharaux PL, Thedieck K, Thekkinghat AA, Thellung S, Thinwa JW, Thirumalaikumar VP, Thomas SM, Thomes PG, Thorburn A, Thukral L, Thum T, Thumm M, Tian L, Tichy A, Till A, Timmerman V, Titorenko VI, Todi SV, Todorova K, Toivonen JM, Tomaipitinca L, Tomar D, Tomas-Zapico C, Tomic S, Tong BC, Tong C, Tong X, Tooze SA, Torgersen ML, Torii S, Torres-López L, Torriglia A, Towers CG, Towns R, Toyokuni S, Trajkovic V, Tramontano D, Tran QG, Travassos LH, Trelford CB, Tremel S, Trougakos IP, Tsao BP, Tschan MP, Tse HF, Tse TF, Tsugawa H, Tsvetkov AS, Tumbarello DA, Tumtas Y, Tuñón MJ, Turcotte S, Turk B, Turk V, Turner BJ, Tuxworth RI, Tyler JK, Tyutereva EV, Uchiyama Y, Ugun-Klusek A, Uhlig HH, Ulamek-Koziol M, Ulasov IV, Umekawa M, Ungermann C, Unno R, Urbe S, Uribe-Carretero E, Üstün S, Uversky VN, Vaccari T, Vaccaro MI, Vahsen BF, Vakifahmetoglu-Norberg H, Valdor R, Valente MJ, Valko A, Vallee RB, Valverde AM, Van den Berghe G, van der Veen S, Van Kaer L, van Loosdregt J, van Wijk SJL, Vandenberghe W, Vanhorebeek I, Vannier-Santos MA, Vannini N, Vanrell MC, Vantaggiato C, Varano G, Varela-Nieto I, Varga M, Vasconcelos MH, Vats S, Vavvas DG, Vega-Naredo I, Vega-Rubin-de-Celis S, Velasco G, Velázquez AP, Vellai T, Vellenga E, Velotti F, Verdier M, Verginis P, Vergne I, Verkade P, Verma M, Verstreken P, Vervliet T, Vervoorts J, Vessoni AT, Victor VM, Vidal M, Vidoni C, Vieira OV, Vierstra RD, Viganó S, Vihinen H, Vijayan V, Vila M, Vilar M, Villalba JM, Villalobo A, Villarejo-Zori B, Villarroya F, Villarroya J, Vincent O, Vindis C, Viret C, Viscomi MT, Visnjic D, Vitale I, Vocadlo DJ, Voitsekhovskaja OV, Volonté C, Volta M, Vomero M, Von Haefen C, Vooijs MA, Voos W, Vucicevic L, Wade-Martins R, Waguri S, Waite KA, Wakatsuki S, Walker DW, Walker MJ, Walker SA, Walter J, Wandosell FG, Wang B, Wang CY, Wang C, Wang D, Wang F, Wang G, Wang H, Wang HG, Wang J, Wang K, Wang L, Wang MH, Wang M, Wang N, Wang P, Wang QJ, Wang Q, Wang QK, Wang QA, Wang WT, Wang W, Wang X, Wang Y, Wang YY, Wang Z, Warnes G, Warnsmann V, Watada H, Watanabe E, Watchon M, Wawrzynska A, Weaver TE, Wegrzyn G, Wehman AM, Wei H, Wei L, Wei T, Wei Y, Weiergräber OH, Weihl CC, Weindl G, Weiskirchen R, Wells A, Wen RH, Wen X, Werner A, Weykopf B, Wheatley SP, Whitton JL, Whitworth AJ, Wiktorska K, Wildenberg ME, Wileman T, Wilkinson S, Willbold D, Williams B, Williams RSB, Williams RL, Williamson PR, Wilson RA, Winner B, Winsor NJ, Witkin SS, Wodrich H, Woehlbier U, Wollert T, Wong E, Wong JH, Wong RW, Wong VKW, Wong WW, Wu AG, Wu C, Wu J, Wu KK, Wu M, Wu SY, Wu S, Wu WKK, Wu X, Wu YW, Wu Y, Xavier RJ, Xia H, Xia L, Xia Z, Xiang G, Xiang J, Xiang M, Xiang W, Xiao B, Xiao G, Xiao H, Xiao HT, Xiao J, Xiao L, Xiao S, Xiao Y, Xie B, Xie CM, Xie M, Xie Y, Xie Z, Xilouri M, Xu C, Xu E, Xu H, Xu J, Xu L, Xu WW, Xu X, Xue Y, Yakhine-Diop SMS, Yamaguchi M, Yamaguchi O, Yamamoto A, Yamashina S, Yan S, Yan SJ, Yan Z, Yanagi Y, Yang C, Yang DS, Yang H, Yang HT, Yang JM, Yang J, Yang L, Yang M, Yang PM, Yang Q, Yang S, Yang SF, Yang W, Yang WY, Yang X, Yang Y, Yao H, Yao S, Yao X, Yao YG, Yao YM, Yasui T, Yazdankhah M, Yen PM, Yi C, Yin XM, Yin Y, Yin Z, Ying M, Ying Z, Yip CK, Yiu SPT, Yoo YH, Yoshida K, Yoshii SR, Yoshimori T, Yousefi B, Yu B, Yu H, Yu J, Yu L, Yu ML, Yu SW, Yu VC, Yu WH, Yu Z, Yuan J, Yuan LQ, Yuan S, Yuan SF, Yuan Y, Yuan Z, Yue J, Yue Z, Yun J, Yung RL, Zacks DN, Zaffagnini G, Zambelli VO, Zanella I, Zang QS, Zanivan S, Zappavigna S, Zaragoza P, Zarbalis KS, Zarebkohan A, Zarrouk A, Zeitlin SO, Zeng J, Zeng JD, Žerovnik E, Zhan L, Zhang B, Zhang DD, Zhang H, Zhang HL, Zhang J, Zhang JP, Zhang KYB, Zhang LW, Zhang L, Zhang M, Zhang P, Zhang S, Zhang W, Zhang X, Zhang XW, Zhang XD, Zhang Y, Zhang YD, Zhang YY, Zhang Z, Zhao H, Zhao L, Zhao S, Zhao T, Zhao XF, Zhao Y, Zheng G, Zheng K, Zheng L, Zheng S, Zheng XL, Zheng Y, Zheng ZG, Zhivotovsky B, Zhong Q, Zhou A, Zhou B, Zhou C, Zhou G, Zhou H, Zhou J, Zhou K, Zhou R, Zhou XJ, Zhou Y, Zhou ZY, Zhou Z, Zhu B, Zhu C, Zhu GQ, Zhu H, Zhu WG, Zhu Y, Zhuang H, Zhuang X, Zientara-Rytter K, Zimmermann CM, Ziviani E, Zoladek T, Zong WX, Zorov DB, Zorzano A, Zou W, Zou Z, Zuryn S, Zwerschke W, Brand-Saberi B, Dong XC, Kenchappa CS, Lin Y, Oshima S, Rong Y, Sluimer JC, Stallings CL, and Tong CK
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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
9. Oxidant K edge x-ray emission spectroscopy of UF4and UO2
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Tobin, JG, Yu, SW, Qiao, R, Yang, WL, and Shuh, DK
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Astrophysics::High Energy Astrophysical Phenomena - Abstract
© 2018 Author(s). The K-Edge (1s) x-ray emission spectroscopy of uranium tetrafluoride and uranium dioxide were compared to each other and to the results of a pair of earlier cluster calculations. Using a very simplified approach, it is possible to qualitatively reconstruct the main features of the x-ray emission spectra from the cluster calculation state energies and 2p percentages.
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- 2018
10. Investigation of vibration induced by moving cranes in high-tech factories
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Ju, SH, primary, Kuo, HH, additional, Yu, SW, additional, and Ni, SH, additional
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- 2019
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11. Investigation of vibration induced by moving cranes in high-tech factories.
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Ju, SH, Kuo, HH, Yu, SW, and Ni, SH
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CRANES (Machinery) ,INVESTIGATIONS ,FACTORIES - Abstract
A finite element model was developed to simulate the crane induced vibration on the floor of high-tech factories, in which the mesh include beam, plate, spring-damper, and moving wheel elements. The finite element results were first compared with the experimental measurements in good agreement. The parametric studies were then performed to study the vibration behavior of high-tech factories due to the effects of rail irregularities, slab depth, and crane speed. The rail irregularities induce the vibration of the crane and slab at their natural frequencies, and both rail irregularities and the crane acceleration induce the crane rotation in its natural frequency, so that smoothing the wheel and rail should be the first priority to decrease slab vibration. The crane speed is another important issue to influence slab vibration, which decreases with the reduction of the crane speed clearly from the parametric study. Thus, decreasing the crane speed to reduce slab vibration is an alternative, and experiments are caused to find the optimal crane speed and acceleration. The crane induced vibration is the relatively largest and smallest at the column location and beam center, respectively. Therefore, increasing the slab and beam depth to decrease the slab vibration induced by the moving crane is an additional option. [ABSTRACT FROM AUTHOR]
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- 2020
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12. Atomic origin of 3d(9)4 f(1) configuration in La(3+) solids
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F. Ponce, Stephan Friedrich, Jun-Sik Lee, Yu Sw, and Carpenter Mh
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X-ray absorption spectroscopy ,X-ray photoelectron spectroscopy ,Absorption spectroscopy ,Chemistry ,Excited state ,Binding energy ,Analytical chemistry ,General Materials Science ,Nanotechnology ,Electronic structure ,Emission spectrum ,Condensed Matter Physics ,Spectroscopy - Abstract
We have studied the excited electronic structure of LaBr3(Ce) scintillator by soft x-ray spectroscopy such as x-ray absorption spectroscopy (XAS) and x-ray emission spectroscopy (XES). The La 3d XAS and XES spectra of LaBr3(Ce) are compared with those of other La(3+) solids (LaF3, La2O3, and La metal). From this comparison, it turns out that the La 3d XAS and XES spectra from all the La(3+) solids considered here appear at almost the same energy, even though the corresponding binding energies of the 3d core holes determined by XPS (x-ray photoelectron spectroscopy) are very different. As a result, we argue that the atomic nature of the 3d⁹4f¹ configuration created by 3d¹⁰4f⁰ → 3d⁹4f¹ x-ray absorption process in La(3+) solids is maintained via the localized 4 f (1) state, which screens the 3d core holes differently from one La(3+) solid to another.
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- 2015
13. Laryngeal mask airway with inhalational induction and maintenance of sevoflurane anaesthesia and prophylactic dexamethasone for outpatient surgery
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Fong Wp, Yang Lc, Tan Ph, Hsiao Ht, Wu Ji, and Yu Sw
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Methyl Ethers ,medicine.medical_specialty ,business.industry ,Outpatient surgery ,Sevoflurane ,Dexamethasone ,Laryngeal Masks ,Surgery ,Anesthesiology and Pain Medicine ,Laryngeal mask airway ,Ambulatory Surgical Procedures ,Anesthesia ,medicine ,Humans ,Inhalational induction ,business ,Anesthesia, Inhalation ,medicine.drug - Published
- 2009
14. Energy levels of the Ce activator relative to the YAP(Ce) scintillator host (2015 J. Phys.: Condens. Matter 27 185501)
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Yu Sw, Stephan Friedrich, Wanli Yang, Carpenter Mh, Daniel Åberg, Jun-Sik Lee, F. Ponce, and Paul Olalde-Velasco
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Physics ,Nuclear physics ,Activator (phosphor) ,General Materials Science ,Scintillator ,Condensed Matter Physics - Published
- 2015
15. Energy levels of the Ce activator relative to the YAP(Ce) scintillator host
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Carpenter Mh, Daniel Åberg, Jun-Sik Lee, Paul Olalde-Velasco, Yu Sw, Stephan Friedrich, Wanli Yang, and F. Ponce
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Materials science ,Valence (chemistry) ,Absorption spectroscopy ,Band gap ,Analytical chemistry ,chemistry.chemical_element ,Yttrium ,Scintillator ,Condensed Matter Physics ,Cerium ,chemistry ,Activator (phosphor) ,General Materials Science ,Spectroscopy - Abstract
The electronic structure of the cerium-activated yttrium aluminum perovskite [YAP(Ce)] scintillator has been studied by core level x-ray spectroscopy and first-principles calculations. X-ray absorption and emission spectra at the oxygen K-edge of YAP(Ce) and CeO2 have been measured and compared with the calculated partial density of states. With the known band gap of CeO2, the measured oxygen K-edge absorption and emission spectra are used to construct a fixed relation between the valence and conduction bands of YAP and CeO2. This allows us to determine the fundamental band gap of YAP to be 8.1 ± 0.3 eV. A comparison between the cerium M4,5-edges x-ray absorption spectra of the YAP(Ce) and Ce model compounds (CeO2, CeF3, and Ce foils) then shows that the Ce activator is in the desired Ce(3+), with a small fraction of Ce(4+) due to oxidization at the surface. Finally, we determine that the ground state 4f(1) energy level of the Ce(3+) activator lies 1.8 ± 0.5 eV above the top of the valence band of the host YAP.
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- 2015
16. Guidelines for the use and interpretation of assays for monitoring autophagy.
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Klionsky, Dj, Abdalla, Fc, Abeliovich, H, Abraham, Rt, Acevedo-Arozena, A, Adeli, K, Agholme, L, Agnello, M, Agostinis, P, Aguirre-Ghiso, Ja, Ahn, Hj, Ait-Mohamed, O, Ait-Si-Ali, S, Akematsu, T, Akira, S, Al-Younes, Hm, Al-Zeer, Ma, Albert, Ml, Albin, Rl, Alegre-Abarrategui, J, Aleo, Mf, Alirezaei, M, Almasan, A, Almonte-Becerril, M, Amano, A, Amaravadi, R, Amarnath, S, Amer, Ao, Andrieu-Abadie, N, Anantharam, V, Ann, Dk, Anoopkumar-Dukie, S, Aoki, H, Apostolova, N, Arancia, G, Aris, Jp, Asanuma, K, Asare, Ny, Ashida, H, Askanas, V, Askew, D, Auberger, P, Baba, M, Backues, Sk, Baehrecke, Eh, Bahr, Ba, Bai, Xy, Bailly, Y, Baiocchi, R, Baldini, G, Balduini, W, Ballabio, A, Bamber, Ba, Bampton, Et, Bánhegyi, G, Bartholomew, Cr, Bassham, Dc, Bast RC, Jr, Batoko, H, Bay, Bh, Beau, I, Béchet, Dm, Begley, Tj, Behl, C, Behrends, C, Bekri, S, Bellaire, B, Bendall, Lj, Benetti, L, Berliocchi, L, Bernardi, H, Bernassola, F, Besteiro, S, Bhatia-Kissova, I, Bi, X, Biard-Piechaczyk, M, Blum, J, Boise, Lh, Bonaldo, P, Boone, Dl, Bornhauser, Bc, Bortoluci, Kr, Bossis, I, Bost, F, Bourquin, Jp, Boya, P, Boyer-Guittaut, M, Bozhkov, Pv, Brady, Nr, Brancolini, C, Brech, A, Brenman, Je, Brennand, A, Bresnick, Eh, Brest, P, Bridges, D, Bristol, Ml, Brookes, P, Brown, Ej, Brumell, Jh, Brunetti-Pierri, N, Brunk, Ut, Bulman, De, Bultman, Sj, Bultynck, G, Burbulla, Lf, Bursch, W, Butchar, Jp, Buzgariu, W, Bydlowski, Sp, Cadwell, K, Cahová, M, Cai, D, Cai, J, Cai, Q, Calabretta, B, Calvo-Garrido, J, Camougrand, N, Campanella, M, Campos-Salinas, J, Candi, E, Cao, L, Caplan, Ab, Carding, Sr, Cardoso, Sm, Carew, J, Carlin, Cr, Carmignac, V, Carneiro, La, Carra, S, Caruso, Ra, Casari, G, Casas, C, Castino, R, Cebollero, E, Cecconi, F, Celli, J, Chaachouay, H, Chae, Hj, Chai, Cy, Chan, Dc, Chan, Ey, Chang, Rc, Che, Cm, Chen, Cc, Chen, Gc, Chen, Gq, Chen, M, Chen, Q, Chen, S, Chen, W, Chen, X, Chen, Yg, Chen, Y, Chen, Yj, Chen, Z, Cheng, A, Cheng, Ch, Cheng, Y, Cheong, H, Cheong, Jh, Cherry, S, Chess-Williams, R, Cheung, Zh, Chevet, E, Chiang, Hl, Chiarelli, R, Chiba, T, Chin, L, Chiou, Sh, Chisari, Fv, Cho, Ch, Cho, Dh, Choi, Am, Choi, D, Choi, K, Choi, Me, Chouaib, S, Choubey, D, Choubey, V, Chu, Ct, Chuang, Th, Chueh, Sh, Chun, T, Chwae, Yj, Chye, Ml, Ciarcia, R, Ciriolo, Mr, Clague, Mj, Clark, R, Clarke, Pg, Clarke, R, Codogno, P, Coller, Ha, Colombo, Mi, Comincini, S, Condello, M, Condorelli, F, Cookson, Mr, Coombs, Gh, Coppens, I, Corbalan, R, Cossart, P, Costelli, P, Costes, S, Coto-Montes, A, Couve, E, Coxon, Fp, Cregg, Jm, Crespo, Jl, Cronjé, Mj, Cuervo, Am, Cullen, Jj, Czaja, Mj, D'Amelio, M, Darfeuille-Michaud, A, Davids, Lm, Davies, Fe, De Felici, M, de Groot, Jf, de Haan, Ca, De Martino, L, De Milito, A, De Tata, V, Debnath, J, Degterev, A, Dehay, B, Delbridge, Lm, Demarchi, F, Deng, Yz, Dengjel, J, Dent, P, Denton, D, Deretic, V, Desai, Sd, Devenish, Rj, Di Gioacchino, M, Di Paolo, G, Di Pietro, C, Díaz-Araya, G, Díaz-Laviada, I, Diaz-Meco, Mt, Diaz-Nido, J, 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Cheong, H, Cheong, Jh, Cherry, S, Chess-Williams, R, Cheung, Zh, Chevet, E, Chiang, Hl, Chiarelli, R, Chiba, T, Chin, L, Chiou, Sh, Chisari, Fv, Cho, Ch, Cho, Dh, Choi, Am, Choi, D, Choi, K, Choi, Me, Chouaib, S, Choubey, D, Choubey, V, Chu, Ct, Chuang, Th, Chueh, Sh, Chun, T, Chwae, Yj, Chye, Ml, Ciarcia, R, Ciriolo, Mr, Clague, Mj, Clark, R, Clarke, Pg, Clarke, R, Codogno, P, Coller, Ha, Colombo, Mi, Comincini, S, Condello, M, Condorelli, F, Cookson, Mr, Coombs, Gh, Coppens, I, Corbalan, R, Cossart, P, Costelli, P, Costes, S, Coto-Montes, A, Couve, E, Coxon, Fp, Cregg, Jm, Crespo, Jl, Cronjé, Mj, Cuervo, Am, Cullen, Jj, Czaja, Mj, D'Amelio, M, Darfeuille-Michaud, A, Davids, Lm, Davies, Fe, De Felici, M, de Groot, Jf, de Haan, Ca, De Martino, L, De Milito, A, De Tata, V, Debnath, J, Degterev, A, Dehay, B, Delbridge, Lm, Demarchi, F, Deng, Yz, Dengjel, J, Dent, P, Denton, D, Deretic, V, Desai, Sd, Devenish, Rj, Di Gioacchino, M, Di Paolo, G, Di Pietro, C, Díaz-Araya, G, Díaz-Laviada, 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Fujii, J, Fujisaki, K, Fujita, E, Fukuda, M, Furukawa, Rh, Gaestel, M, Gailly, P, Gajewska, M, Galliot, B, Galy, V, Ganesh, S, Ganetzky, B, Ganley, Ig, Gao, Fb, Gao, Gf, Gao, J, Garcia, L, Garcia-Manero, G, Garcia-Marcos, M, Garmyn, M, Gartel, Al, Gatti, E, Gautel, M, Gawriluk, Tr, Gegg, Me, Geng, J, Germain, M, Gestwicki, Je, Gewirtz, Da, Ghavami, S, Ghosh, P, Giammarioli, Am, Giatromanolaki, An, Gibson, Sb, Gilkerson, Rw, Ginger, Ml, Ginsberg, Hn, Golab, J, Goligorsky, M, Golstein, P, Gomez-Manzano, C, Goncu, E, Gongora, C, Gonzalez, Cd, Gonzalez, R, González-Estévez, C, González-Polo, Ra, Gonzalez-Rey, E, Gorbunov, Nv, Gorski, S, Goruppi, S, Gottlieb, Ra, Gozuacik, D, Granato, Ge, Grant, Gd, Green, Kn, Gregorc, A, Gros, F, Grose, C, Grunt, Tw, Gual, P, Guan, Jl, Guan, Kl, Guichard, Sm, Gukovskaya, A, Gukovsky, I, Gunst, J, Gustafsson, Ab, Halayko, Aj, Hale, An, Halonen, Sk, Hamasaki, M, Han, F, Han, T, Hancock, Mk, Hansen, M, Harada, H, Harada, M, Hardt, Se, Harper, Jw, Harris, Al, Harris, J, Harris, Sd, Hashimoto, M, Haspel, Ja, Hayashi, S, Hazelhurst, La, He, C, He, Yw, Hébert, Mj, Heidenreich, Ka, Helfrich, Mh, Helgason, Gv, Henske, Ep, Herman, B, Herman, Pk, Hetz, C, Hilfiker, S, Hill, Ja, Hocking, Lj, Hofman, P, Hofmann, Tg, Höhfeld, J, Holyoake, Tl, Hong, Mh, Hood, Da, Hotamisligil, G, Houwerzijl, Ej, Høyer-Hansen, M, Hu, B, Hu, Ca, Hu, Hm, Hua, Y, Huang, C, Huang, J, Huang, S, Huang, Wp, Huber, Tb, Huh, Wk, Hung, Th, Hupp, Tr, Hur, Gm, Hurley, Jb, Hussain, Sn, Hussey, Pj, Hwang, Jj, Hwang, S, Ichihara, A, Ilkhanizadeh, S, Inoki, K, Into, T, Iovane, V, Iovanna, Jl, Ip, Ny, Isaka, Y, Ishida, H, Isidoro, C, Isobe, K, Iwasaki, A, Izquierdo, M, Izumi, Y, Jaakkola, Pm, Jäättelä, M, Jackson, Gr, Jackson, Wt, Janji, B, Jendrach, M, Jeon, Jh, Jeung, Eb, Jiang, H, Jiang, Jx, Jiang, M, Jiang, Q, Jiang, X, Jiménez, A, Jin, M, Jin, S, Joe, Co, Johansen, T, Johnson, De, Johnson, Gv, Jones, Nl, Joseph, B, Joseph, Sk, Joubert, Am, Juhász, G, Juillerat-Jeanneret, L, Jung, Ch, Jung, Yk, Kaarniranta, K, Kaasik, A, Kabuta, T, Kadowaki, M, Kagedal, K, Kamada, Y, Kaminskyy, Vo, Kampinga, Hh, Kanamori, H, Kang, C, Kang, Kb, Kang, Ki, Kang, R, Kang, Ya, Kanki, T, Kanneganti, Td, Kanno, H, Kanthasamy, Ag, Kanthasamy, A, Karantza, V, Kaushal, Gp, Kaushik, S, Kawazoe, Y, Ke, Py, Kehrl, Jh, Kelekar, A, Kerkhoff, C, Kessel, Dh, Khalil, H, Kiel, Ja, Kiger, Aa, Kihara, A, Kim, Dr, Kim, Dh, Kim, Ek, Kim, Hr, Kim, J, Kim, Jh, Kim, Jc, Kim, Jk, Kim, Pk, Kim, Sw, Kim, Y, Kimchi, A, Kimmelman, Ac, King, J, Kinsella, Tj, Kirkin, V, Kirshenbaum, La, Kitamoto, K, Kitazato, K, Klein, L, Klimecki, Wt, Klucken, J, Knecht, E, Ko, Bc, Koch, Jc, Koga, H, Koh, Jy, Koh, Yh, Koike, M, Komatsu, M, Kominami, E, Kong, Hj, Kong, Wj, Korolchuk, Vi, Kotake, Y, Koukourakis, Mi, Kouri Flores, Jb, Kovács, Al, Kraft, C, Krainc, D, Krämer, H, Kretz-Remy, C, Krichevsky, Am, Kroemer, G, Krüger, R, Krut, O, Ktistakis, Nt, Kuan, Cy, Kucharczyk, R, Kumar, A, Kumar, R, Kumar, S, Kundu, M, Kung, Hj, Kurz, T, Kwon, Hj, La Spada, Ar, Lafont, F, Lamark, T, Landry, J, Lane, Jd, Lapaquette, P, Laporte, Jf, László, L, Lavandero, S, Lavoie, Jn, Layfield, R, Lazo, Pa, Le, W, Le Cam, L, Ledbetter, Dj, Lee, Aj, Lee, Bw, Lee, Gm, Lee, J, Lee, Jh, Lee, M, Lee, Sh, Leeuwenburgh, C, Legembre, P, Legouis, R, Lehmann, M, Lei, Hy, Lei, Qy, Leib, Da, Leiro, J, Lemasters, Jj, Lemoine, A, Lesniak, M, Lev, D, Levenson, Vv, Levine, B, Levy, E, Li, F, Li, Jl, Li, L, Li, S, Li, W, Li, Xj, Li, Yb, Li, Yp, Liang, C, Liang, Q, Liao, Yf, Liberski, Pp, Lieberman, A, Lim, Hj, Lim, Kl, Lim, K, Lin, Cf, Lin, Fc, Lin, J, Lin, Jd, Lin, K, Lin, Ww, Lin, Wc, Lin, Yl, Linden, R, Lingor, P, Lippincott-Schwartz, J, Lisanti, Mp, Liton, Pb, Liu, B, Liu, Cf, Liu, K, Liu, L, Liu, Qa, Liu, W, Liu, Yc, Liu, Y, Lockshin, Ra, Lok, Cn, Lonial, S, Loos, B, Lopez-Berestein, G, López-Otín, C, Lossi, L, Lotze, Mt, Lőw, P, Lu, B, Lu, Z, Luciano, F, Lukacs, Nw, Lund, Ah, Lynch-Day, Ma, Ma, Y, Macian, F, Mackeigan, Jp, Macleod, Kf, Madeo, F, Maiuri, L, Maiuri, Mc, Malagoli, D, Malicdan, Mc, Malorni, W, Man, N, Mandelkow, Em, Manon, S, Manov, I, Mao, K, Mao, X, Mao, Z, Marambaud, P, Marazziti, D, Marcel, Yl, Marchbank, K, Marchetti, P, Marciniak, Sj, Marcondes, M, Mardi, M, Marfe, G, Mariño, G, Markaki, M, Marten, Mr, Martin, Sj, Martinand-Mari, C, Martinet, W, Martinez-Vicente, M, Masini, M, Matarrese, P, Matsuo, S, Matteoni, R, Mayer, A, Mazure, Nm, Mcconkey, Dj, Mcconnell, Mj, Mcdermott, C, Mcdonald, C, Mcinerney, Gm, Mckenna, Sl, Mclaughlin, B, Mclean, Pj, Mcmaster, Cr, Mcquibban, Ga, Meijer, Aj, Meisler, Mh, Meléndez, A, Melia, Tj, Melino, G, Mena, Ma, Menendez, Ja, Menna-Barreto, Rf, Menon, Mb, Menzies, Fm, Mercer, Ca, Merighi, A, Merry, De, Meschini, S, Meyer, Cg, Meyer, Tf, Miao, Cy, Miao, Jy, Michels, Pa, Michiels, C, Mijaljica, D, Milojkovic, A, Minucci, S, Miracco, C, Miranti, Ck, Mitroulis, I, Miyazawa, K, Mizushima, N, Mograbi, B, Mohseni, S, Molero, X, Mollereau, B, Mollinedo, F, Momoi, T, Monastyrska, I, Monick, Mm, Monteiro, Mj, Moore, Mn, Mora, R, Moreau, K, Moreira, Pi, Moriyasu, Y, Moscat, J, Mostowy, S, Mottram, Jc, Motyl, T, Moussa, Ce, Müller, S, Muller, S, Münger, K, Münz, C, Murphy, Lo, Murphy, Me, Musarò, A, Mysorekar, I, Nagata, E, Nagata, K, Nahimana, A, Nair, U, Nakagawa, T, Nakahira, K, Nakano, H, Nakatogawa, H, Nanjundan, M, Naqvi, Ni, Narendra, Dp, Narita, M, Navarro, M, Nawrocki, St, Nazarko, Ty, Nemchenko, A, Netea, Mg, Neufeld, Tp, Ney, Pa, Nezis, Ip, Nguyen, Hp, Nie, D, Nishino, I, Nislow, C, Nixon, Ra, Noda, T, Noegel, Aa, Nogalska, A, Noguchi, S, Notterpek, L, Novak, I, Nozaki, T, Nukina, N, Nürnberger, T, Nyfeler, B, Obara, K, Oberley, Td, Oddo, S, Ogawa, M, Ohashi, T, Okamoto, K, Oleinick, Nl, Oliver, Fj, Olsen, Lj, Olsson, S, Opota, O, Osborne, Tf, Ostrander, Gk, Otsu, K, Ou, Jh, Ouimet, M, Overholtzer, M, Ozpolat, B, Paganetti, P, Pagnini, U, Pallet, N, Palmer, Ge, Palumbo, C, Pan, T, Panaretakis, T, Pandey, Ub, Papackova, Z, Papassideri, I, Paris, I, Park, J, Park, Ok, Parys, Jb, Parzych, Kr, Patschan, S, Patterson, C, Pattingre, S, Pawelek, Jm, Peng, J, Perlmutter, Dh, Perrotta, I, Perry, G, Pervaiz, S, Peter, M, Peters, Gj, Petersen, M, Petrovski, G, Phang, Jm, Piacentini, M, Pierre, P, Pierrefite-Carle, V, Pierron, G, Pinkas-Kramarski, R, Piras, A, Piri, N, Platanias, Lc, Pöggeler, S, Poirot, M, Poletti, A, Poüs, C, Pozuelo-Rubio, M, Prætorius-Ibba, M, Prasad, A, Prescott, M, Priault, M, Produit-Zengaffinen, N, Progulske-Fox, A, Proikas-Cezanne, T, Przedborski, S, Przyklenk, K, Puertollano, R, Puyal, J, Qian, Sb, Qin, L, Qin, Zh, Quaggin, Se, Raben, N, Rabinowich, H, Rabkin, Sw, Rahman, I, Rami, A, Ramm, G, Randall, G, Randow, F, Rao, Va, Rathmell, Jc, Ravikumar, B, Ray, Sk, Reed, Bh, Reed, Jc, Reggiori, F, Régnier-Vigouroux, A, Reichert, A, Reiners JJ, Jr, Reiter, Rj, Ren, J, Revuelta, Jl, Rhodes, Cj, Ritis, K, Rizzo, E, Robbins, J, Roberge, M, Roca, H, Roccheri, Mc, Rocchi, S, Rodemann, Hp, Rodríguez de Córdoba, S, Rohrer, B, Roninson, Ib, Rosen, K, Rost-Roszkowska, Mm, Rouis, M, Rouschop, Km, Rovetta, F, Rubin, Bp, Rubinsztein, Dc, Ruckdeschel, K, Rucker EB, 3rd, Rudich, A, Rudolf, E, Ruiz-Opazo, N, Russo, R, Rusten, Te, Ryan, Km, Ryter, Sw, Sabatini, Dm, Sadoshima, J, Saha, T, Saitoh, T, Sakagami, H, Sakai, Y, Salekdeh, Gh, Salomoni, P, Salvaterra, Pm, Salvesen, G, Salvioli, R, Sanchez, Am, Sánchez-Alcázar, Ja, Sánchez-Prieto, R, Sandri, M, Sankar, U, Sansanwal, P, Santambrogio, L, Saran, S, Sarkar, S, Sarwal, M, Sasakawa, C, Sasnauskiene, A, Sass, M, Sato, K, Sato, M, Schapira, Ah, Scharl, M, Schätzl, Hm, Scheper, W, Schiaffino, S, Schneider, C, Schneider, Me, Schneider-Stock, R, Schoenlein, Pv, Schorderet, Df, Schüller, C, Schwartz, Gk, Scorrano, L, Sealy, L, Seglen, Po, Segura-Aguilar, J, Seiliez, I, Seleverstov, O, Sell, C, Seo, Jb, Separovic, D, Setaluri, V, Setoguchi, T, Settembre, C, Shacka, Jj, Shanmugam, M, Shapiro, Im, Shaulian, E, Shaw, Rj, Shelhamer, Jh, Shen, Hm, Shen, Wc, Sheng, Zh, Shi, Y, Shibuya, K, Shidoji, Y, Shieh, Jj, Shih, Cm, Shimada, Y, Shimizu, S, Shintani, T, Shirihai, O, Shore, Gc, Sibirny, Aa, Sidhu, Sb, Sikorska, B, Silva-Zacarin, Ec, Simmons, A, Simon, Ak, Simon, Hu, Simone, C, Simonsen, A, Sinclair, Da, Singh, R, Sinha, D, Sinicrope, Fa, Sirko, A, Siu, Pm, Sivridis, E, Skop, V, Skulachev, Vp, Slack, R, Smaili, S, Smith, Dr, Soengas, M, Soldati, T, Song, X, Sood, Ak, Soong, Tw, Sotgia, F, Spector, Sa, Spies, Cd, Springer, W, Srinivasula, Sm, Stefanis, L, Steffan, J, Stendel, R, Stenmark, H, Stephanou, A, Stern, St, Sternberg, C, Stork, B, Strålfors, P, Subauste, C, Sui, X, Sulzer, D, Sun, J, Sun, Sy, Sun, Zj, Sung, Jj, Suzuki, K, Suzuki, T, Swanson, M, Swanton, C, Sweeney, St, Sy, Lk, Szabadkai, G, Tabas, I, Taegtmeyer, H, Tafani, M, Takács-Vellai, K, Takano, Y, Takegawa, K, Takemura, G, Takeshita, F, Talbot, Nj, Tan, K, Tanaka, K, Tang, D, Tanida, I, Tannous, Ba, Tavernarakis, N, Taylor, G, Taylor, Ga, Taylor, Jp, Terada, L, Terman, A, 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Weiss, Wa, Welford, Sm, Wen, Lp, Whitehouse, Ca, Whitton, Jl, Whitworth, Aj, Wileman, T, Wiley, Jw, Wilkinson, S, Willbold, D, Williams, Rl, Williamson, Pr, Wouters, Bg, Wu, C, Wu, Dc, Wu, Wk, Wyttenbach, A, Xavier, Rj, Xi, Z, Xia, P, Xiao, G, Xie, Z, Xu, Dz, Xu, J, Xu, L, Xu, X, Yamamoto, A, Yamashina, S, Yamashita, M, Yan, X, Yanagida, M, Yang, D, Yang, E, Yang, Jm, Yang, Sy, Yang, W, Yang, Wy, Yang, Z, Yao, Mc, Yao, Tp, Yeganeh, B, Yen, Wl, Yin, Jj, Yin, Xm, Yoo, Oj, Yoon, G, Yoon, Sy, Yorimitsu, T, Yoshikawa, Y, Yoshimori, T, Yoshimoto, K, You, Hj, Youle, Rj, Younes, A, Yu, L, Yu, Sw, Yu, Wh, Yuan, Zm, Yue, Z, Yun, Ch, Yuzaki, M, Zabirnyk, O, Silva-Zacarin, E, Zacks, D, Zacksenhaus, E, Zaffaroni, N, Zakeri, Z, Zeh HJ, 3rd, Zeitlin, So, Zhang, H, Zhang, Hl, Zhang, J, Zhang, Jp, Zhang, L, Zhang, My, Zhang, Xd, Zhao, M, Zhao, Yf, Zhao, Y, Zhao, Zj, Zheng, X, Zhivotovsky, B, Zhong, Q, Zhou, Cz, Zhu, C, Zhu, Wg, Zhu, Xf, Zhu, X, Zhu, Y, Zoladek, T, Zong, Wx, Zorzano, A, Zschocke, J, Zuckerbraun, B., and Viscomi M. T. (ORCID:0000-0002-9096-4967)
- Abstract
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused o
- Published
- 2012
17. Laryngeal mask airway with inhalational induction and maintenance of sevoflurane anaesthesia and prophylactic dexamethasone for outpatient surgery
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Hsiao, HT, primary, Yang, LC, additional, Yu, SW, additional, Wu, JI, additional, Fong, WP, additional, and Tan, PH, additional
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- 2009
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18. Soft X-ray Studies of Pu Electronic Structure: Past Lessons and Future Directions
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Tobin, James G, primary and Yu, SW, additional
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- 2008
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19. The Utilization of Spin Polarized Photoelectron Spectroscopy as a Probe of Electron Correlation with an Ultimate Goal of Pu
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Tobin, James G, primary, Yu, SW, additional, Chung, B W, additional, Morton, S A, additional, Komesu, T, additional, and Waddill, G D, additional
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- 2008
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20. A non-invariant plane model for the interface in CuAlNi single crystal shape memory alloys
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Zhang, XY, Sun, QP, Yu, SW, Zhang, XY, Sun, QP, and Yu, SW
- Abstract
A non-invariant plane model for the austenite-martensitic (A-M) interface in CuAlNi single crystal shape memory alloys (SMAs) is proposed in this paper. The model is based on the crystallography of martensitic transformation and the recent uniaxial tensile Moire tests on Cu-14\%Al-4.12\%Ni (wt\%) single crystals, The two types of specimens used have the same tensile axis orientation but have different transition temperatures. One exhibits Shape Memory Effect (SME) and the other exhibits Superelasticity (SE). In the case of SME, the plane invariant nature of the A-M interface is well verified by the Moire test. On the contrary, the A-M interface in the case of SE was identified to be a non-invariant plane. A crystallography-based model is proposed to explain the formation of this non-plane-invariant A-M interface in SE and is used to predict the resultant interface structure and the transformation strain of the stress-induced beta(1)-->beta'(1) transformation in CuAlNi. The comparison between the theoretical calculations and the experimental results support the proposed model. (C) 2000 Elsevier Science Ltd. All rights reserved.
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- 2000
21. On the strain jump in shape memory alloys - A crystallographic-based mechanics analysis
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Zhang, XY, Sun, QP, Yu, SW, Zhang, XY, Sun, QP, and Yu, SW
- Abstract
The strain jump across the Austenite-Martensite (A-M) interface in single crystal Cu-14wt\%Al-4.12wt\%Ni Shape Memory Alloys (SMAs) under uniaxial tension was studied in this paper. A crystallographic-based mechanics analysis on the formation and microstructure of the interface was performed. By using the high sensitive Moire interference technique, the full-field deformation patterns during the transformation process were successfully recorded The orientation of the habit plane (A-M interface) and the magnitude of the shape strain; were determined precisely from the Moire fringe patterns. The theoretical predictions on the habit plane normal and the shape strain were compared with the measured results and good agreements were obtained.
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- 1999
22. Diffusion in cementitious materials: II, further investigations of chloride and oxygen diffusion in well-cured OPC and OPC/30%PFA pastes
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Ngala, VT, primary, Page, CL, additional, Parrott, LJ, additional, and Yu, SW, additional
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- 1995
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23. The effect of surgeon empathy and emotional intelligence on patient satisfaction.
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Weng HC, Steed JF, Yu SW, Liu YT, Hsu CC, Yu TJ, and Chen W
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- 2011
24. Clinical evaluation of vertebroplasty for multiple-level osteoporotic spinal compression fracture in the elderly.
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Yu SW, Yang SC, Kao YH, Yen CY, Tu YK, Chen LH, Yu, Shang-Won, Yang, Shih-Chieh, Kao, Yu-Hsien, Yen, Cheng-Yo, Tu, Yuan-Kun, and Chen, Lih-Huei
- Abstract
Introduction: Outstanding results have been achieved using vertebroplasty for the treatment of osteoporotic spinal compression fractures. However, few reports are available in the management of multiple-level compression fractures due to severe osteoporosis. This study prospectively evaluated the clinical and surgical outcomes of patients receiving vertebroplasty due to multiple-level osteoporotic spinal compression fractures.Patients and Methods: Eighteen patients underwent more than four levels of vertebroplasty due to multiple-level osteoporotic spinal compression fracture. All patients received a preoperative magnetic resonance imaging (MRI) check-up to determine which level needed vertebroplasty. Detailed evaluations were made in accordance with the patients' clinical tracking, pre- and postoperative daily activities, Denis pain scale, and Roland-Morris score.Results: After an average follow-up period of 36 months, the group receiving multiple-level vertebroplasty showed significant improvement, as registered on the Denis pain scale, Roland-Morris score, and in the activity of daily living. No major complications occurred during operation or postoperation, except one patient who expired due to suffocation at the rehabilitation center 3 weeks after vertebroplasty.Conclusions: The use of vertebroplasty with cement to treat multiple-level osteoporotic spinal compression fractures in the elderly does have value, and brings good results to patients which were previously unimaginable. Preoperative MRI to evaluate the non-union levels and determine which levels needed vertebroplasty is very important. [ABSTRACT FROM AUTHOR]- Published
- 2008
25. Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
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Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL, Biskup, Saskia, Moore, Darren J, Celsi, Fulvio, and Higashi, Shinji
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- 2006
26. Anti-plane vibration of cracked piezoelectric materials
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Zengtao Chen and Yu, Sw
27. On the dynamic ductile damage and fragmentation in porous metallic materials
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Zengtao Chen and Yu, Sw
28. Neurological picture. Acute middle cerebral artery stroke and an innominate steal from a ruptured brachiocephalic trunk atheroma.
- Author
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Youn SW, Yu SW, Lee NJ, Kim JH, Youn, S W, Yu, S-W, Lee, N J, and Kim, J H
- Published
- 2009
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29. Atrioventricular dissociation after electroconvulsive therapy.
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Yu SW, Vallurupalli S, Arnoldi J, and Holloway R
- Published
- 2011
30. Reconstruction of upper extremity large soft-tissue defects using pedicled latissimus dorsi muscle flaps--technique illustration and clinical outcomes.
- Author
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Ma CH, Tu YK, Wu CH, Yen CY, Yu SW, Kao FC, Ma, Ching-Hou, Tu, Yuan-kun, Wu, Chin-Hsien, Yen, Cheng-Yo, Yu, Shang-Won, and Kao, Feng-Chen
- Abstract
Summary: Reconstruction of large soft-tissue defects of an upper extremity is very challenging due to the unavailability of expendable local muscle. Appropriate soft-tissue restoration is an essential component of such reconstruction treatment protocols, and often requires a vascularised flap to protect the exposed neurovascular and musculotendinous structures. The latissimus dorsi muscle makes an ideal pedicled flap because of its long neurovascular pedicle, large size, ease of mobilisation and expendability. Moreover, the flap provides well-vascularised tissue from a region far from the area of injury. This paper describes the technique for pedicle latissimus dorsi flap transfer and also reports the authors' experience of its application for the acute treatment of massive upper-extremity soft-tissue injuries. 20 patients with large soft-tissue defects over the upper extremity caused by trauma and infection underwent aggressive debridements and immediate soft-tissue reconstruction using a pedicled latissimus dorsi muscle flap. Successful reconstructions were achieved and primary healing of wounds occurred in all patients, with minor complications. The donor site morbidity was minimal. At a mean of 3.6 years' follow-up (range: 1.5-6 years), all functional results were good and the patients were satisfied with their outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2008
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31. Unraveling RNA contribution to the molecular origins of bacterial surface-enhanced Raman spectroscopy (SERS) signals.
- Author
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Chien JY, Gu YC, Chien CC, Chang CL, Cheng HW, Chiu SW, Nee YJ, Tsai HM, Chu FY, Tang HF, Wang YL, and Lin CH
- Subjects
- Purines metabolism, Adenosine Triphosphate metabolism, Spectrum Analysis, Raman methods, RNA, Bacterial genetics, RNA, Bacterial metabolism, Escherichia coli metabolism, Escherichia coli genetics
- Abstract
Surface-enhanced Raman spectroscopy (SERS) is widely utilized in bacterial analyses, with the dominant SERS peaks attributed to purine metabolites released during sample preparation. Although adenosine triphosphate (ATP) and nucleic acids are potential molecular origins of these metabolites, research on their exact contributions remains limited. This study explored purine metabolite release from E. coli and RNA integrity following various sample preparation methods. Standard water washing generated dominant SERS signals within 10 s, a duration shorter than the anticipated RNA half-lives under starvation. Evaluating RNA integrity indicated that the most abundant ribosomal RNA species remained intact for hours post-washing, whereas messenger RNA and transfer RNA species degraded gradually. This suggests that bacterial SERS signatures observed after the typical washing step could originate from only a small fraction of endogenous purine-containing molecules. In contrast, acid depurination led to degradation of most RNA species, releasing about 40 times more purine derivatives than water washing. Mild heating also instigated the RNA degradation and released more purine derivatives than water washing. Notably, differences were also evident in the dominant SERS signals following these treatments. This work provides insights into SERS-based studies of purine metabolites released by bacteria and future development of methodologies., (© 2024. The Author(s).)
- Published
- 2024
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32. Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation.
- Author
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Park I, Choi M, Kim J, Jang S, Kim D, Kim J, Choe Y, Geum D, Yu SW, Choi JW, Moon C, Choe HK, Son GH, and Kim K
- Subjects
- Animals, Mice, Male, Affect physiology, Mice, Knockout, Mice, Inbred C57BL, Transcription Factors metabolism, Transcription Factors genetics, Depression metabolism, Nuclear Receptor Subfamily 1, Group D, Member 1 metabolism, Nuclear Receptor Subfamily 1, Group D, Member 1 genetics, Dorsal Raphe Nucleus metabolism, Serotonin metabolism, Serotonin biosynthesis, Tryptophan Hydroxylase metabolism, Tryptophan Hydroxylase genetics, Circadian Rhythm
- Abstract
Affective disorders are frequently associated with disrupted circadian rhythms. The existence of rhythmic secretion of central serotonin (5-hydroxytryptamine, 5-HT) pattern has been reported; however, the functional mechanism underlying the circadian control of 5-HTergic mood regulation remains largely unknown. Here, we investigate the role of the circadian nuclear receptor REV-ERBα in regulating tryptophan hydroxylase 2 (Tph2), the rate-limiting enzyme of 5-HT synthesis. We demonstrate that the REV-ERBα expressed in dorsal raphe (DR) 5-HTergic neurons functionally competes with PET-1-a nuclear activator crucial for 5-HTergic neuron development. In mice, genetic ablation of DR 5-HTergic REV-ERBα increases Tph2 expression, leading to elevated DR 5-HT levels and reduced depression-like behaviors at dusk. Further, pharmacological manipulation of the mice DR REV-ERBα activity increases DR 5-HT levels and affects despair-related behaviors. Our findings provide valuable insights into the molecular and cellular link between the circadian rhythm and the mood-controlling DR 5-HTergic systems., (© 2024. The Author(s).)
- Published
- 2024
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33. Oxysulfonylation of Alkynes with Sodium Sulfinates to Access β-Keto Sulfones Catalyzed by BF 3 ·OEt 2 .
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Yu SW, Chen ZJ, Li HQ, Li WX, Li Y, Li Z, and Wang ZY
- Abstract
An efficient and operationally simple method for the synthesis of β-keto sulfones through the BF
3 ·OEt2 -promoted reaction of alkynes and sodium sulfinates is developed. With its facile and selective access to the targets, it features good functional group compatibility, mild conditions, easily available starting materials, and good yields. Notably, the reaction does not require metal catalysts or chemical reagents with pungent odors.- Published
- 2024
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34. Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells.
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Choe S, Jeong H, Choi J, and Yu SW
- Subjects
- Animals, Mice, Inbred C57BL, Autophagy physiology, Chronic Disease, Autophagy-Related Protein 7 metabolism, Autophagy-Related Protein 7 genetics, Anxiety pathology, Anxiety physiopathology, Male, Adult Stem Cells pathology, Autophagic Cell Death, Memory physiology, Mice, Neural Stem Cells metabolism, Neural Stem Cells pathology, Hippocampus pathology, Stress, Psychological pathology
- Abstract
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous results show that chronic restraint stress causes cognitive deficits and mood dysregulation by inducing autophagic death of adult hippocampal neural stem cells (NSCs). However, it is unknown whether other models of psychological stress also induce autophagic death of adult hippocampal NSCs. Here, we show that chronic unpredictable stress (CUS) for 10 days impaired memory function and increased anxiety in mice. Immunohistochemical staining with SOX2 and KI67 revealed a significant reduction in the number of NSCs in the hippocampus following exposure to CUS. However, these deficits were prevented by NSC-specific, inducible conditional deletion of Atg7. These findings suggest that autophagic death of adult hippocampal NSCs is a critical pathogenic mechanism underlying stress-induced brain disorders., (© 2024. The Author(s).)
- Published
- 2024
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35. The first specific probe for pyrrolidine with multifunction by the interaction mechanism of atomic economic reaction.
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Cao XY, Huang Y, Chen SH, Yu SW, Chen ZJ, Li ZH, Zeng Y, Chen N, Cao L, and Wang ZY
- Abstract
Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as the first specific fluorescent probe for PyD. Only by adding PyD to probe 1, there is blue fluorescence at 455 nm, and the color of the solution changes from colorless to yellow. The detection limit is 1.12 × 10
-6 M, and the response time is less than 5 min. Meanwhile, probe 1 can also sense the gaseous PyD and detect PyD in actual water samples. Moreover, due to the low biological toxicity, probe 1 can detect the exogenous PyD in zebrafish. The preliminary mechanism shows that probe 1 and PyD undergo a combination-type chemical reaction to generate a new substance 1-PyD. Therefore, the 100% atom utilization reaction enables probe 1 to exhibit specific adsorption and removal of PyD., Competing Interests: The authors declare no competing interests., (© 2024 The Author(s).)- Published
- 2024
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36. First 100 total hip arthroplasties performed by a young surgeon using the direct anterior approach: learning curve and complications.
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Li YW, Yu SW, Yeh JH, Ma CH, Yen CY, and Tu YK
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- Humans, Retrospective Studies, Learning Curve, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Hip methods, Surgeons, Fractures, Bone surgery
- Abstract
Introduction: Most of the reported discussions about the learning curve for the direct anterior approach (DAA) in total hip arthroplasty (THA) have been by experienced surgeons. The study's aim was to describe the learning curve, short-term outcomes, complications, and adaptations to the DAA used in the first 100 THA cases experienced by a young surgeon who had received DAA training for trauma surgeries., Materials and Methods: This retrospective study summarizes the first 100 consecutive cases experienced by a young surgeon who performed the unilateral DAA for THA between 2019 and 2021. Cumulative sum (CUSUM) analysis was performed to evaluate the learning curve on the basis of operative time and overall complications. The demographics data, short-term outcomes, and complications of the first 50 and second 50 cases were compared., Results: The CUSUM curve declined after 49 and 55 cases, measured by operative time and overall complications, respectively. The median operative time (104 vs. 80 min) and intraoperative fluoroscopic time (38 vs. 12 s) increased significantly in the first 50 cases compared with the times in the second 50 cases. Complications tended to occur in the first 50 cases (12% vs. 6%), and the overall rate was 9%. Major complications all occurred in the first 50 cases, with a rate of 4%. Only one case, which involved a complicated periprosthetic fracture around the stem that extended to the tip, required the intervention of a senior surgeon., Conclusions: Even after receiving training on the DAA for trauma surgeries, the young surgeon experienced a steep learning curve and more complications in the first 50 cases. The DAA for THA is a technically demanding procedure and may require guidance from an experienced surgeon to manage unexpected complications., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2024
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37. The Phylogenetic Relationship of Lamiinae (Coleoptera: Cerambycidae) Using Mitochondrial Genomes.
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Li K, Yu SW, Hu H, Feng YF, Storey KB, Ma Y, Zhang JY, and Yu DN
- Subjects
- Animals, Phylogeny, Bayes Theorem, Mitochondria genetics, Genome, Mitochondrial, Coleoptera genetics
- Abstract
Lamiinae is the largest subfamily of the Cerambycidae (longhorn beetles), with approximately 21,863 described species. Previous phylogenetic studies of Lamiinae showed that this subfamily was monophyletic, but the relationship between the tribes of Lamiinae is still controversial. Partial molecular data and species morphological characteristics are not sufficient to resolve species phylogenetic studies perfectly. At the same time, the full mitochondrial genome contains more comprehensive genetic data. Benefiting from the development of next-generation sequencing (NGS), mitochondrial genomes can be easily acquired and used as reliable molecular markers to investigate phylogenetic relationships within Cerambycidae. Using NGS technology, we obtained 11 mitochondrial genome sequences of Lamiinae species. Based on this newly generated mitochondrial genome dataset matrix, we reconstructed the phylogeny of Lamiinae. The Bayesian Inference and Maximum Likelihood analyses strongly support the monophyly of four tribes (Lamiini, Batocerini, Mesosini, and Saperdini), whereas the tribe Acanthocinini was identified as paraphyletic. Other mitochondrial structural features were also observed: the start codon in the nad1 gene of all 11 mitochondrial genomes is TTG; 17-22 bp intergenic spacers (IGS) with a 'TACTA' motif were found between trnS2 and nad1. Moreover, two long IGS were found in Mesosa myops and Batocera sp. Tandem repeats were found in the IGS of Batocera sp.
- Published
- 2023
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38. [Correlation between drug-induced liver injury in rats caused by Xianling Gubao oral preparation and extraction process].
- Author
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Peng XY, Zhang L, Yu SW, Zhai YQ, and Guo ZJ
- Subjects
- Rats, Male, Animals, Rats, Sprague-Dawley, Liver pathology, Tablets, Body Weight, Plant Extracts, Chemical and Drug Induced Liver Injury etiology, Chemical and Drug Induced Liver Injury pathology, Fatty Liver, Phenols
- Abstract
In light of the liver injury risk associated with the oral administration of Xianlin Gubao oral preparation, this study compared the differences in liver injury induced by two different extraction processes in rats and explored the correlation between hepatotoxicity and extraction process from the perspective of the differences in the content of the relevant components. Thirty male Sprague-Dawley(SD) rats were randomly divided into a normal group, tablet extract groups of different doses, and capsule extract groups of different doses, with 6 rats in each group. Each group received continuous oral administration for 4 weeks. The assessment of liver injury caused by different extracts was conducted by examining rat body weight, liver function blood biochemical indicators, liver coefficient, and liver pathological changes. In addition, a high-performance liquid chromatography(HPLC) method was established to simultaneously determine the content of icariin, baohuoside I, and bakuchiol in the extracts to compare the differences in the content of these three components under the two extraction processes. The results showed that both extracts caused liver injury in rats. Compared with the normal group, the tablet extract groups, at the studied dose, led to slow growth in body weight, a significant increase in triglyceride levels(P<0.05), a significant decrease in liver-to-brain ratio(P<0.05), and the appearance of hepatic steatosis. The capsule extract groups, at the studied dose, resulted in slow growth in body weight, a significant increase in aspartate aminotransferase levels(P<0.05), a significant decrease in body weight, liver weight, and liver-to-brain ratio(P<0.05), and the presence of hepatic steatosis and inflammatory cell infiltration. In comparison, the capsule extraction process had a higher risk of liver injury. Furthermore, based on the completion of the liquid chromatography method, the content of icariin and baohuoside Ⅰ in the capsule extract groups was 0.83 and 0.81 times that in the tablet extract groups, respectively, while the bakuchiol content in the capsule extract group was 29.80 times that in the tablet extract groups, suggesting that the higher risk of liver injury associated with the capsule extraction process may be due to its higher bakuchiol content. In summary, the differences in rat liver injury caused by the two extracts are closely related to the extraction process. This should be taken into consideration in the formulation production and clinical application.
- Published
- 2023
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39. New insights into the electronic structure of α -U and δ -Pu.
- Author
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Kutepov AL, Tobin JG, Yu SW, Chung BW, and Roussel P
- Abstract
This work presents the results of a theoretical study of the electronic structure of two actinide metals, α -U and δ -Pu. We compare our ab-initio results obtained with the recently developed self-consistent Vertex corrected GW approach with previously published experimental measurements such as photo-electron spectroscopy, for the occupied density of states, and bremsstralung isochromat spectroscopy (BIS) and inverse photo-electron spectroscopy (IPES), for the unoccupied density of states. Our ab-initio approach includes all important relativistic effects (it is based on Dirac's equation) and it represents the first application of the Vertex corrected GW approach in the physics of actinides. Overall, our theoretical results are in good agreement with the experimental data, which supports the level of approximations which our theoretical method is based upon. By comparing our vertex corrected GW results with our results obtained with less sophisticated approaches (local density approximation and self-consistent GW) we differentiate the strength of correlation effects in Uranium and Plutonium. Also, our theoretical results allow us to elucidate the subtle differences between the previously published experimental BIS and IPES data on the unoccupied density of states in α -U., (© 2023 IOP Publishing Ltd.)
- Published
- 2023
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40. Trace water in a BF 3 ·OEt 2 system: a facile access to sulfinyl alkenylsulfones from alkynes and sodium sulfinates.
- Author
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Yu SW, Chen ZJ, Chen ZH, Chen SH, Yang K, Xu WJ, and Wang ZY
- Abstract
A highly efficient and operationally simple method for the synthesis of β-sulfinyl alkenylsulfones through a BF
3 ·OEt2 -promoted reaction of alkynes and sodium sulfinates is developed, successfully avoiding the complicated anhydrous treatment before the reaction and greatly simplifying the reaction conditions. As a facile and selective route to the targets, it features good functional group compatibility, mild conditions, easily available starting materials, and excellent yields. Notably, the trace water in solvent plays a key role in promoting the reaction, which provides a more practical pathway for the utilization of the BF3 ·OEt2 catalytic system.- Published
- 2023
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41. Presenilin 2 N141I Mutation Induces Hyperimmunity by Immune Cell-specific Suppression of REV-ERBα without Altering Central Circadian Rhythm.
- Author
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Nam H, Kim B, Lee Y, Choe HK, and Yu SW
- Abstract
Circadian rhythm is a 24-hour cycle of behavioral and physiological changes. Disrupted sleep-wake patterns and circadian dysfunction are common in patients of Alzheimer Disease (AD) and are closely related with neuroinflammation. However, it is not well known how circadian rhythm of immune cells is altered during the progress of AD. Previously, we found presenilin 2 ( Psen2 ) N141I mutation, one of familial AD (FAD) risk genes, induces hyperimmunity through the epigenetic repression of REV-ERBα expression in microglia and bone marrow-derived macrophage (BMDM) cells. Here, we investigated whether repression of REV-ERBα is associated with dysfunction of immune cell-endogenous or central circadian rhythm by analyses of clock genes expression and cytokine secretion, bioluminescence recording of rhythmic PER2::LUC expression, and monitoring of animal behavioral rhythm. Psen2 N141I mutation down-regulated REV-ERBα and induced selective over-production of IL-6 (a well-known clock-dependent cytokine) following the treatment of toll-like receptor (TLR) ligands in microglia, astrocytes, and BMDM. Psen2 N141I mutation also lowered amplitude of intrinsic daily oscillation in these immune cells representatives of brain and periphery. Of interest, however, the period of daily rhythm remained intact in immune cells. Furthermore, analyses of the central clock and animal behavioral rhythms revealed that central clock remained normal without down-regulation of REV-ERBα. These results suggest that Psen2 N141I mutation induces hyperimmunity mainly through the suppression of REV-ERBα in immune cells, which have lowered amplitude but normal period of rhythmic oscillation. Furthermore, our data reveal that central circadian clock is not affected by Psen2 N141I mutation.
- Published
- 2023
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42. [Clinical characteristics and follow-up analysis of 12 patients of acute phosphine poisoning].
- Author
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Zhang Q, Yang SL, Yu SW, and Ye Q
- Subjects
- Humans, Follow-Up Studies, Lung, Phosphines poisoning, Poisoning diagnosis, Central Nervous System Diseases chemically induced, Respiratory Tract Diseases chemically induced
- Abstract
Objective: To investigate the clinical characteristics of patients with acute phosphine poisoning, and to follow up and evaluate the prognosis of patients. Methods: In May 2022, 12 patients with phosphine poisoning by respiratory inhalation in Beijing Chao-Yang Hospital of Capital Medical University were analyzed. The patients were treated with symptomatic support therapy. Three months later, patients were re-evaluated the symptoms of poisoning, pulmonary function and magnetic resonance imaging (MRI) of the brain to understand the prognosis of the phosphine poisoning. Results: The main symptoms of 12 patients were respiratory and central nervous system symptoms with hypoxia. The symptoms of poisoning improved after treatment. Follow-up found that the patients had different degrees of residual symptoms. Pulmonary function showed increased airway resistance. Airway challenge test was positive in some patients. MRI of the head of some patients showed small ischemic focus in bilateral frontal lobes. Conclusion: Acute phosphine poisoning may cause persistent damage to the respiratory system and central system, and residual symptoms after 3 months.
- Published
- 2023
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- View/download PDF
43. [Evaluation of right ventricular function using two-dimensional speckle tracking echocardiography and analysis of the risk factors for right ventricular dysfunction in patients with silicosis].
- Author
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Jiang W, Yu SW, Lyu XZ, and Song YG
- Subjects
- Humans, Middle Aged, Aged, Ventricular Function, Right, Echocardiography, Risk Factors, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right etiology, Silicosis complications, Silicosis diagnostic imaging
- Abstract
Objective: To evaluate the right ventricular function using two-dimensional speckle tracking echocardiography (2-D STE) and analyze the associated risk factors of right ventricular dysfunction in patients with silicosis. Methods: All 104 patients with silicosis treated in the Department of Occupational Medicine and Toxicology in Beijing Chao-Yang Hospital, Capital Medical University from May 2021 to September 2022 were enrolled in this study in October 2022. The clinical information of patients such as general data, arterial blood gas analysis and pulmonary function test were collected. The right ventricular function of patients was evaluated by 2-D STE-derived right ventricular free wall longitudinal strain (RVFWLS) and conventional echocardiographic-derived parameters, including right ventricular fractional area change (RVFAC), tricuspid annular plane systolic excursion (TAPSE) and doppler tissue imaging-derived tricuspid lateral annular systolic velocity (S'), respectively. Based on their RVFWLS, the patients were divided into right ventricular dysfunction group and normal right ventricular function group. Risk factors for right ventricular dysfunction in patients with silicosis were analyzed using binary logistic regression analysis. Results: A total of 104 silicosis patients were enrolled, with aneverage age (65.52±11.18) years old, among whom including 57 cases diagnosed with stage Ⅰ/Ⅱ silicosis and 47 cases diagnosed with stage Ⅲ silicosis. 26 (25.00%) patients concurrent right ventricular dysfunction. The abnormal rates of RVFAC, TAPSE and S' in patients were 16.35% (17 cases), 21.15% (22 cases) and 6.73% (7 cases), respectively. The RVFAC and TAPSE in right ventricular dysfunction group were lower than those in normal right ventricular function group, and the incidence of pulmonary arterial systolic pressure ≥36 mmHg was higher than that in normal right ventricular function group ( P <0.05). Logistic regression analysis showed that arterial partial pressure of oxygen ( OR =0.932, 95% CI : 0.885-0.981, P =0.007) was the protective factor, and the forced expiratory volume in 1 second (FEV(1)) /forced vital capacity (FVC) ratio<70% ( OR =5.484, 95% CI : 1.049-28.662, P =0.044) and stage Ⅲ silicosis ( OR =6.343, 95% CI : 1.698-23.697, P =0.007) were the risk factors for silicosis patients concurrent right ventricular dysfunction. Conclusion: The incidence of right ventricular dysfunction is higher in patients with stage Ⅲ silicosis than that in patients with stage Ⅰ/Ⅱ silicosis. Using 2-D STE can help the early detection of silicosis with right ventricular dysfunction. Hypoxemia, airflow limitation and the stage Ⅲ silicosis are the risk factors for silicosis patients concurrent right ventricular dysfunction.
- Published
- 2023
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44. Surfactants Used in Colloidal Synthesis Modulate Ni Nanoparticle Surface Evolution for Selective CO 2 Hydrogenation.
- Author
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Wei X, Johnson G, Ye Y, Cui M, Yu SW, Ran Y, Cai J, Liu Z, Chen X, Gao W, Bean PJL, Zhang W, Zhao TY, Perras FA, Crumlin EJ, Zhang X, Davis RJ, Wu Z, and Zhang S
- Abstract
Colloidal chemistry holds promise to prepare uniform and size-controllable pre-catalysts; however, it remains a challenge to unveil the atomic-level transition from pre-catalysts to active catalytic surfaces under the reaction conditions to enable the mechanistic design of catalysts. Here, we report an ambient-pressure X-ray photoelectron spectroscopy study, coupled with in situ environmental transmission electron microscopy, infrared spectroscopy, and theoretical calculations, to elucidate the surface catalytic sites of colloidal Ni nanoparticles for CO
2 hydrogenation. We show that Ni nanoparticles with phosphine ligands exhibit a distinct surface evolution compared with amine-capped ones, owing to the diffusion of P under oxidative (air) or reductive (CO2 + H2 ) gaseous environments at elevated temperatures. The resulting NiPx surface leads to a substantially improved selectivity for CO production, in contrast to the metallic Ni, which favors CH4 . The further elimination of surface metallic Ni sites by designing multi-step P incorporation achieves unit selectivity of CO in high-rate CO2 hydrogenation.- Published
- 2023
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- View/download PDF
45. [Current status of public health system in Guangdong-Hong Kong-Macao Greater Bay Area and improvement suggestion].
- Author
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Liu T, Wang J, Yu SW, Chen ZQ, Zhu QJ, Yang SF, Ma WJ, and Liang XF
- Subjects
- Humans, China, Hong Kong, Macau, Public Health
- Abstract
Guangdong-Hong Kong-Macao Greater Bay Area (GBA) has three public health systems under different systems, which plays an important role in the construction of the public health system in China. Further strengthening the construction of the public health system in the GBA will play an important reference role in the optimization and upgrade of China's public health system in the future. Based on the key consulting project of "research on the strategy of the modern public health system and capacity building in China" by Chinese Academy of Engineering, this paper deeply analyzes the current status and existing problems of public health system construction in GBA and suggests to improve and innovate the mechanisms of collaborative prevention and control of public health risks, resource coordination and joint research and result sharing, information sharing and exchange, personnel training and team building in order to comprehensively improve the capacity of public health system in GBA, and promote the construction of Healthy China.
- Published
- 2023
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- View/download PDF
46. Distinct Signaling Pathways for Autophagy-Driven Cell Death and Survival in Adult Hippocampal Neural Stem Cells.
- Author
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Jeong SH, An HK, Ha S, and Yu SW
- Subjects
- Glycogen Synthase Kinase 3 beta metabolism, Cell Death, Signal Transduction, Autophagy, Insulin metabolism, Insulin, Regular, Human, Hippocampus metabolism, Apoptosis, Neural Stem Cells metabolism
- Abstract
Autophagy is a cellular catabolic process that degrades and recycles cellular materials. Autophagy is considered to be beneficial to the cell and organism by preventing the accumulation of toxic protein aggregates, removing damaged organelles, and providing bioenergetic substrates that are necessary for survival. However, autophagy can also cause cell death depending on cellular contexts. Yet, little is known about the signaling pathways that differentially regulate the opposite outcomes of autophagy. We have previously reported that insulin withdrawal (IW) or corticosterone (CORT) induces autophagic cell death (ACD) in adult hippocampal neural stem (HCN) cells. On the other hand, metabolic stresses caused by 2-deoxy-D-glucose (2DG) and glucose-low (GL) induce autophagy without death in HCN cells. Rather, we found that 2DG-induced autophagy was cytoprotective. By comparing IW and CORT conditions with 2DG treatment, we revealed that ERK and JNK are involved with 2DG-induced protective autophagy, whereas GSK-3β regulates death-inducing autophagy. These data suggest that cell death and survival-promoting autophagy undergo differential regulation with distinct signaling pathways in HCN cells.
- Published
- 2023
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47. Pu 5f Occupation in Plutonium Dioxide.
- Author
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Tobin JG and Yu SW
- Abstract
An actinide N
4,5 branching ratio analysis of PuO2 and UO2 has been performed, including measurements with a scanning transmission electron microscope at the Advanced Light Source. It is shown that the 5f occupation of the Pu in plutonium dioxide is n = 5. This is contrary to recent results from another technique.- Published
- 2023
- Full Text
- View/download PDF
48. Non-iridium-based electrocatalyst for durable acidic oxygen evolution reaction in proton exchange membrane water electrolysis.
- Author
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Wu ZY, Chen FY, Li B, Yu SW, Finfrock YZ, Meira DM, Yan QQ, Zhu P, Chen MX, Song TW, Yin Z, Liang HW, Zhang S, Wang G, and Wang H
- Abstract
Iridium-based electrocatalysts remain the only practical anode catalysts for proton exchange membrane (PEM) water electrolysis, due to their excellent stability under acidic oxygen evolution reaction (OER), but are greatly limited by their high cost and low reserves. Here, we report a nickel-stabilized, ruthenium dioxide (Ni-RuO
2 ) catalyst, a promising alternative to iridium, with high activity and durability in acidic OER for PEM water electrolysis. While pristine RuO2 showed poor acidic OER stability and degraded within a short period of continuous operation, the incorporation of Ni greatly stabilized the RuO2 lattice and extended its durability by more than one order of magnitude. When applied to the anode of a PEM water electrolyser, our Ni-RuO2 catalyst demonstrated >1,000 h stability under a water-splitting current of 200 mA cm-2 , suggesting potential for practical applications. Density functional theory studies, coupled with operando differential electrochemical mass spectroscopy analysis, confirmed the adsorbate-evolving mechanism on Ni-RuO2 , as well as the critical role of Ni dopants in stabilization of surface Ru and subsurface oxygen for improved OER durability., (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2023
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49. Effect of support on the performance of PtRu-based catalysts in oxidative steam reforming of ethanol to produce hydrogen.
- Author
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Tang CW, Liu CH, Yu SW, and Wang CB
- Abstract
Oxidative steam reforming of ethanol (OSRE) to produce hydrogen has been investigated over a series of supported PtRu catalysts, with different supports. Bimetallic PtRu-based catalysts were prepared by the impregnation method using H
2 PtCl6 and RuCl3 as precursors. Six supports (reducible oxides of ZrO2 , CeO2 , and Co3 O4 , and irreducible oxides of ZnO, Al2 O3 , and NiO) were chosen to fabricate bimetallic catalysts. The catalytic performance of the OSRE reaction in the series of PtRu-based samples was evaluated using a fixed-bed flow reactor under atmospheric pressure. In front reaction, the catalyst was pre-activated by reduction under 200°C for 3 h. The gas hourly space velocity was adjusted at 66,000 h-1 , and the optimal molar ratios of the H2 O/EtOH and O2 /EtOH feeds were 4.9 and 0.44, respectively. The results indicated that the PtRu supported on the ZrO2 and CeO2 exhibited superior catalytic performance in the OSRE reaction under a low temperature (a TR of approximately 320°C) for producing the main products of H2 and CO2 with lower CO and CH4 by-products. Also, it was quite stable during a long time evaluation; the maximum YH2 maintained at 4.5-4.2, and the CO distribution approached 3.3-3.5 mol% around 84 h test at 340°C over the PtRu/ZrO2 catalyst., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Tang, Liu, Yu and Wang.)- Published
- 2022
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50. Response of China's electricity consumption to climate change using monthly household data.
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Hou JJ, Liu LC, Dong ZY, Wang Z, Yu SW, and Zhang JT
- Subjects
- Poverty, China, Climate Change, Meteorology
- Abstract
Intensifying climate change significantly impacts residential electricity consumption, especially in developing countries, such as China, that are experiencing rapid income growth. By combining meteorological and monthly household consumption survey data, this study explores the response function of residential electricity consumption to temperature in China from a micro perspective. Future residential electricity demands and related CO
2 emissions are then forecast under different climate scenarios. Overall, the response function is U-shaped, and one additional day above 34 °C will increase monthly residential electricity consumption by 2.11%. Global warming will more likely increase the electricity burden on low-income groups. There will be notable seasonal changes in electricity demand in the future, and the largest increase will occur in August. The total demand for residential electricity caused by temperature change will show a fluctuating growth trend, from 0.8% and 1% in 2025 to 2% and 2.9% in 2060 under the RCP4.5 scenario and RCP8.5 scenario, respectively; meanwhile, this demand will be accompanied by a cumulative increase in carbon dioxide emissions., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2022
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