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1. Risk of Cardiovascular Events Associated with Chronic Obstructive Pulmonary Disease and/or Metabolic Syndrome: A Large-Scale Nationwide Population-Based Cohort Study

Author: Noh E, Jeong H, Cho IS, Chang MS, Yu I, Park S, Lee JH, Lee SJ, Lee WY, Yong SJ, and Kim SH
Subjects: cardiovascular event, chronic obstructive pulmonary disease, metabolic syndrome, Diseases of the respiratory system, RC705-779
Abstract: Enkyu Noh,1,&ast; Hyungmin Jeong,1,&ast; In-So Cho,2 Min-Seok Chang,2 Iseul Yu,2 Sunmin Park,2 Ji-Ho Lee,2 Seok Jeong Lee,2 Won-Yeon Lee,2 Suk Joong Yong,2 Sang-Ha Kim2 1Yonsei University Wonju College of Medicine, Wonju, 26426, Korea; 2Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, 26426, Korea&ast;These authors contributed equally to this workCorrespondence: Sang-Ha Kim, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea, 20 Ilsanro, Wonju, 26426, Korea, Tel +82-33-741-0926, Fax +82-33-746-4667, Email sanghakim@yonsei.ac.krPurpose: Chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MetS) are among the most prevalent conditions that might predispose individuals to life-threatening events. We aimed to examine their associations with cardiovascular (CV) events and mortality using a large-scale population dataset from the National Health Information Database in Korea.Patients and Methods: This population-based cohort study enrolled adults aged ≥ 40 years who had undergone more than two health examinations between 2009 and 2011. They were divided into four groups based on the presence of COPD and MetS. Analysis of the outcomes and CV events or deaths was performed from 2014 to 2019. We compared CV event incidence and mortality rates using a multivariate Cox proportional hazards model and Kaplan–Meier curves.Results: Totally, 5,101,810 individuals were included, among whom 3,738,458 (73.3%) had neither COPD nor MetS, 1,193,014 (23.4%) had only MetS, 125,976 (2.5%) had only COPD, and 44,362 (0.9%) had both. The risk of CV events was significantly higher in individuals with both COPD and MetS than in those with either COPD or MetS alone (HRs: 2.4 vs 1.6 and 1.8, respectively; all P < 0.001). Similarly, among those with both COPD and MetS, all-cause and CV mortality risks were also elevated (HRs, 2.9 and 3.0, respectively) compared to the risks in those with either COPD (HRs, 2.6 and 2.1, respectively) or MetS (HRs, 1.7 and 2.1, respectively; all P < 0.001).Conclusion: The comorbidity of MetS in patients with COPD increases the incidence of CV events and all-cause and cardiovascular mortality rates.Keywords: cardiovascular event, chronic obstructive pulmonary disease, metabolic syndrome
Published: 2024

2. Influence of plasticity on the magnetic-field-induced bending deformation in a magneto-active elastomer with superparamagnetic nanoparticles

Author: V. M. Kalita, Yu I. Dzhezherya, S. V. Cherepov, Yu B. Skirta, A. V. Kyryliuk, S. O. Reshetniak, A. V. Bodnaruk, and S. M. Ryabchenko
Subjects: Physics, QC1-999
Abstract: The influence of residual plastic deformation on the bending deformation of a magnetoactive elastomer (MAE) beam with non-coercive superparamagnetic manganite (La0.6Ag0.2Mn1.2O3) nanoparticles induced by a transverse uniform magnetic field has been studied. It was found that the MAE bending induced by the magnetic field switching-on/switching-off is mainly cyclic elastic. Plastic deformation leads to the emergence of residual bending and hysteresis in the field dependence of the bending. It was shown that the residual bending that appears after the first magnetic field switch-on eliminates the uncertainty of the bending direction at the next magnetization. Due to the residual plastic deformation, the bending direction of the superparamagnetic MAE with nanoparticles does not change when the direction of the applied magnetic field is inverted, in contrast to the MAE with microparticles where the uncertainty of the bending direction is eliminated due to the residual magnetization of weakly coercive ferromagnetic microparticles; therefore, the bending direction changes its sign with magnetic field reversion. In the low fields, the bending value for the MAEs with superparamagnetic particles is proportional to the square of the magnetic field strength. Model estimates on the residual deformation influence on the beam bending at beam magnetization reversal were obtained.
Published: 2024
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3. Comparison of Risk of Pneumonia Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study

Author: Choi JH, Jeong KB, Park YH, Yu I, Lee SJ, Lee MK, Kim SH, Lee WY, Yong SJ, and Lee JH
Subjects: inhaled corticosteroid, chronic obstructive pulmonary disease, pneumonia, fluticasone propionate, budesonide, Diseases of the respiratory system, RC705-779
Abstract: Jae-Hwa Choi,1,&ast; Keun-Bae Jeong,1,&ast; You Hyun Park,2 Iseul Yu,1 Seok Jeong Lee,1 Myoung Kyu Lee,1 Sang-Ha Kim,1 Won-Yeon Lee,1 Suk Joong Yong,1 Ji-Ho Lee1 1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea; 2Department of Biostatistics, Yonsei University, Seoul, Korea&ast;These authors contributed equally to this workCorrespondence: Ji-Ho LeeDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, 26426, KoreaTel +82-33-741-0926Fax +82-33-741-0928Email airwayleejh@yonsei.ac.krIntroduction: Inhaled corticosteroids (ICSs) play an important role in lowering the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD). However, ICSs are known to increase the risk of pneumonia. Moreover, previous studies have shown that the incidence rate of pneumonia varies depending on the type of ICS. In this study, the risk of pneumonia according to the type of ICS was investigated in a population-based cohort.Methods: A retrospective cohort study was conducted using claims data of the entire population from the Korean National Health Insurance Service. Patients who were newly diagnosed with COPD and prescribed fluticasone propionate or budesonide were enrolled as study subjects. Cumulative doses of ICSs were classified into categorical variables to analyze the risk of pneumonia within identical ICS doses.Results: A total of 47,473 subjects were identified and allocated as 14,518 fluticasone propionate and 14,518 budesonide users through 1:1 propensity score matching. Fluticasone propionate users were more likely to develop pneumonia than budesonide users (14.22% vs 10.66%, p< 0.0001). The incidence rate per 100,000 person-years was 2,914.77 for fluticasone propionate users and 2,102.90 for budesonide users. The hazard ratio (HR) of pneumonia in fluticasone propionate compared to budesonide was 1.34 (95% CI 1.26– 1.43, p< 0.0001). The risk of pneumonia for fluticasone propionate compared to budesonide increased with higher ICS cumulative doses: 1.06 (0.93– 1.21), 1.41 (1.19– 1.66), 1.41 (1.23– 1.63), and 1.49 (1.33– 1.66) from the lowest to highest quartiles, respectively.Conclusion: ICS types and doses need to be carefully considered during treatment with ICSs in patients with COPD.Keywords: inhaled corticosteroid, chronic obstructive pulmonary disease, pneumonia, fluticasone propionate, budesonide
Published: 2021

4. Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells

Author: Seon-Hee Kim, Eunjung Cho, Yu I. Kim, Chungyong Han, Beom K. Choi, and Byoung S. Kwon
Subjects: Science
Abstract: Lymphodepleting preconditioning is generally required prior to adoptive T cell therapy (ACT). Here the authors show in a preclinical melanoma model that anti-CD4 treatment as a post-conditioning regimen enhances the anti-tumor efficacy of ACT by promoting the expansion of IL-18Rαhi CD8+ T cells.
Published: 2021
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5. Characterization of the optical model of the T2K 3D segmented plastic scintillator detector

Author: Abe, S., Alekseev, I., Arai, T., Arihara, T., Arimoto, S., Babu, N., Baranov, V., Bartoszek, L., Berns, L., Bhattacharjee, S., Blondel, A., Boikov, A. V., Buizza-Avanzini, M., Capó, J., Cayo, J., Chakrani, J., Chong, P. S., Chvirova, A., Danilov, M., Davis, C., Davydov, Yu. I., Dergacheva, A., Dokania, N., Douqa, D., Doyle, T. A., Drapier, O., Eguchi, A., Elias, J., Fedorova, D., Fedotov, S., Ferlewicz, D., Fuji, Y., Furui, Y., Gendotti, A., Germer, A., Giannessi, L., Giganti, C., Glagolev, V., Hu, J., Iwamoto, K., Jakkapu, M., Jesús-Valls, C., Ji, J. Y., Jung, C. K., Kakuno, H., Kasetti, S. P., Kawaue, M., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., Kobayashi, H., Kobayashi, T., Kodama, S., Kolupanova, M., Korzenev, A., Kose, U., Kudenko, Y., Kuribayashi, S., Kutter, T., Lachat, M., Lachner, K., Last, D., Latham, N., Silverio, D. Leon, Li, B., Li, W., Li, Z., Lin, C., Lin, L. S., Lin, S., Lux, T., Mahtani, K., Maret, L., Caicedo, D. A. Martinez, Martynenko, S., Matsubara, T., Mauger, C., McGrew, C., McKean, J., Mefodiev, A., Miller, E., Mineev, O., Moreno, A. L., Muñoz, A., Nakadaira, T., Nakagiri, K., Nguyen, V., Nicola, L., Noah, E., Nosek, T., Okinaga, W., Osu, L., Paolone, V., Parsa, S., Pellegrino, R., Ramirez, M. A., Reh, M., Ricco, C., Rubbia, A., Sakashita, K., Sallin, N., Sanchez, F., Schefke, T., Schloesser, C. M., Sgalaberna, D., Shvartsman, A., Skrobova, N., Speers, A. J., Suslov, I. A., Suvorov, S., Svirida, D., Tairafune, S., Tanigawa, H., Teklu, A., Tereshchenko, V. V., Tzanov, M., Vasilyev, I. I., Wallace, H. T., Whitney, N., Wood, K., Xu, Y. -h., Yang, G., Yershov, N., Yokoyama, M., Yoshimoto, Y., Zhao, X., Zheng, H., Zhu, T., Zilberman, P., and Zimmerman, E. D.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The magnetised near detector (ND280) of the T2K long-baseline neutrino oscillation experiment has been recently upgraded aiming to satisfy the requirement of reducing the systematic uncertainty from measuring the neutrinonucleus interaction cross section, which is the largest systematic uncertainty in the search for leptonic charge-parity symmetry violation. A key component of the upgrade is SuperFGD, a 3D segmented plastic scintillator detector made of approximately 2,000,000 optically-isolated 1 cm3 cubes. It will provide a 3D image of GeV neutrino interactions by combining tracking and stopping power measurements of final state particles with sub-nanosecond time resolution. The performance of SuperFGD is characterized by the precision of its response to charged particles as well as the systematic effects that might affect the physics measurements. Hence, a detailed Geant4 based optical simulation of the SuperFGD building block, i.e. a plastic scintillating cube read out by three wavelength shifting fibers, has been developed and validated with the different datasets collected in various beam tests. In this manuscript the description of the optical model as well as the comparison with data are reported., Comment: 31 pages, 15 figures
Published: 2024

6. Search for proton decay via $p\rightarrow{e^+\eta}$ and $p\rightarrow{\mu^+\eta}$ with a 0.37 Mton-year exposure of Super-Kamiokande

Author: Collaboration, Super-Kamiokande, Taniuchi, N., Abe, K., Abe, S., Asaoka, Y., Bronner, C., Harada, M., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Noguchi, Y., Pronost, G., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Mirabito, J., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Kim, J. Y., Lee, S. H., Lim, I. T., Moon, D. H., Park, R. G., Yang, B. S., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Feltre, M., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Quilain, B., Fujisawa, C., Horiuchi, S., Kobayashi, M., Liu, Y. M., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Yrey, A. Portocarrero, Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Boschi, T., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Taani, M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Yamamoto, S., Zhong, H., Feng, J., Feng, L., Han, S., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Yanagisawa, C., Hino, Y., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Stowell, P., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Lee, M. W., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Koshiba, M., Eguchi, A., Goto, S., Iwamoto, K., Mizuno, Y., Muro, T., Nakagiri, K., Nakajima, Y., Shima, S., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Marti, Ll., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Asaka, R., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Nakano, Y., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Wu, Y., Xu, B. D., Zhang, A. Q., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., Shibayama, R., Shimamura, R., Suzuki, S., and Wada, K.
Subjects: High Energy Physics - Experiment
Abstract: A search for proton decay into $e^+/\mu^+$ and a $\eta$ meson has been performed using data from a 0.373 Mton$\cdot$year exposure (6050.3 live days) of Super-Kamiokande. Compared to previous searches this work introduces an improved model of the intranuclear $\eta$ interaction cross section, resulting in a factor of two reduction in uncertainties from this source and $\sim$10\% increase in signal efficiency. No significant data excess was found above the expected number of atmospheric neutrino background events resulting in no indication of proton decay into either mode. Lower limits on the proton partial lifetime of $1.4\times\mathrm{10^{34}~years}$ for $p\rightarrow e^+\eta$ and $7.3\times\mathrm{10^{33}~years}$ for $p\rightarrow \mu^+\eta$ at the 90$\%$ C.L. were set. These limits are around 1.5 times longer than our previous study and are the most stringent to date.
Published: 2024

7. First Measurement of Missing Energy Due to Nuclear Effects in Monoenergetic Neutrino Charged Current Interactions

Author: Marzec, E., Ajimura, S., Antonakis, A., Botran, M., Cheoun, M. K., Choi, J. H., Choi, J. W., Choi, J. Y., Dodo, T., Furuta, H., Goh, J. H., Haga, K., Harada, M., Hasegawa, S., Hino, Y., Hiraiwa, T., Hwang, W., Iida, T., Iwai, E., Iwata, S., Jang, H. I., Jang, J. S., Jang, M. C., Jeon, H. K., Jeon, S. H., Joo, K. K., Jung, D. E., Kang, S. K., Kasugai, Y., Kawasaki, T., Kim, E. J., Kim, J. Y., Kim, E. M., Kim, S. Y., Kim, W., Kim, S. B., Kinoshita, H., Konno, T., Kuwata, K., Lee, D. H., Lee, S., Lim, I. T., Little, C., Maruyama, T., Masuda, S., Meigo, S., Monjushiro, S., Moon, D. H., Nakano, T., Niiyama, M., Nishikawa, K., Noumachi, M., Pac, M. Y., Park, B. J., Park, H. W., Park, J. B., Park, J. S., Park, R. G., Peeters, S. J. M., Roellinghoff, G., Rott, C., Ryu, J. W., Sakai, K., Sakamoto, S., Shima, T., Shin, C. D., Spitz, J., Stancu, I., Suekane, F., Sugaya, Y., Suzuya, K., Taira, M., Takeuchi, Y., Wang, W., Waterfield, J., Wei, W., White, R., Yamaguchi, Y., Yeh, M., Yeo, I. S., Yoo, C., Yu, I., and Zohaib, A.
Subjects: High Energy Physics - Experiment
Abstract: We present the first measurement of the missing energy due to nuclear effects in monoenergetic, muon neutrino charged-current interactions on carbon, originating from $K^+ \rightarrow \mu^+ \nu_\mu$ decay-at-rest ($E_{\nu_\mu}=235.5$ MeV), performed with the JSNS$^2$ liquid scintillator based experiment. Towards characterizing the neutrino interaction, ostensibly $\nu_\mu n \rightarrow \mu^- p$ or $\nu_\mu$$^{12}\mathrm{C}$ $\rightarrow \mu^-$$^{12}\mathrm{N}$, and in analogy to similar electron scattering based measurements, we define the missing energy as the energy transferred to the nucleus ($\omega$) minus the kinetic energy of the outgoing proton(s), $E_{m} \equiv \omega-\sum T_p$, and relate this to visible energy in the detector, $E_{m}=E_{\nu_\mu}~(235.5~\mathrm{MeV})-m_\mu~(105.7~\mathrm{MeV}) - E_{vis}$. The missing energy, which is naively expected to be zero in the absence of nuclear effects (e.g. nucleon separation energy, Fermi momenta, and final-state interactions), is uniquely sensitive to many aspects of the interaction, and has previously been inaccessible with neutrinos. The shape-only, differential cross section measurement reported, based on a $(77\pm3)$% pure double-coincidence KDAR signal (621 total events), provides an important benchmark for models and event generators at 100s-of-MeV neutrino energies, characterized by the difficult-to-model transition region between neutrino-nucleus and neutrino-nucleon scattering, and relevant for applications in nuclear physics, neutrino oscillation measurements, and Type-II supernova studies.
Published: 2024

8. Treatment of infected wounds of the abdominal wall after mesh hernia repair

Author: Yaroslav Feleshtynskyi, K D Derkach, V V Smishchuk, O O Dyadyk, and Yu I Beketova
Subjects: wound infection of abdominal wall, mesh heria repair, abdominal hernia alloplasty, ultrasound cavitation, VAC therapy, decamethoxine solution, Medicine
Abstract: Background. An infected wound of the abdominal wall after mesh hernia repair is related to mesh infection, because mesh is situated at the bottom of the wound and granulation tissue doesn’t cover it. Infected mesh wounds have traditionally been treated by surgically removing the mesh which causes prolonged hospitalizations and hernia recurrence. Objective of the study is to increase the efficiency of treatment of wounds infection after mesh heria repair. Маterials and methods. We analyzed the results of wound infection treatment in 72 patients. 37 patients (group I) were treated according to the developed algorithm (ultrasound cavitation, VAC-therapy and decamethoxine solution), 35 (group II) were treated according to the traditional one (ultrasound cavitation, VAC-therapy and chlorhexidine digluconate solution). Results. The number of microbial colonies (CFU) in the wound decreased to lg (2.33 ± 0.51) CFU/ml and lg (1.35 ± 0.49) CFU/ml in group I against lg (4.01 ± 0) CFU/ml and lg (2.93 ± 0.56) CFU/ml in group II. (p < 0.01) The results of morphological examination of the wound edges confirmed more efficient growth of connective tissue in patients of group I (mesh was completely covered with granulation tissue) which improved wound healing. While in group II, mesh explantation was performed in 5 (14.3 %) patients (granulation tissue hasn’t covered mesh completely). The duration of wound healing in patients of group I was 16 ± 1.05 days, compared with 21 ± 1.2 days in group II (p < 0.01). We achieved better results through the use of the developed algorithm in group I, in particular the combination of ultrasound cavitation, VAC therapy and decametoxine solution, which has not only antimicrobial action, but also promotes connective tissue repair in the wound. Conclusion. Developed algorithm for wounds infection treatment after alloplasty, which includes ultrasound cavitation, VAC-therapy and decamethoxine solution, improves treatment outcomes, reduced wound healing time to 16 ± 1.05 days in patients of the main group against 21 ± 1.2 in comparison group, and excludes the possibility of mesh explantation in the main group against 14.3 % in the comparison group.
Published: 2022
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9. First joint oscillation analysis of Super-Kamiokande atmospheric and T2K accelerator neutrino data

Author: Super-Kamiokande, collaborations, T2K, Abe, S., Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Amanai, S., Andreopoulos, C., Anthony, L. H. V., Antonova, M., Aoki, S., Apte, K. A., Arai, T., Arihara, T., Arimoto, S., Asada, Y., Asaka, R., Ashida, Y., Atkin, E. T., Babu, N., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Bates, P., Batkiewicz-Kwasniak, M., Beauchêne, A., Berardi, V., Berns, L., Bhadra, S., Bhuiyan, N., Bian, J., Blanchet, A., Blondel, A., Bodur, B., Bolognesi, S., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bubak, A., Avanzini, M. Buizza, Burton, G. T., Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Chalumeau, A., Chen, S., Cherdack, D., Choi, K., Chong, P. S., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cormier, F., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davis, C., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Dharmapal, R., Di Lodovico, F., Lopez, G. Diaz, Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., D'ago, D., Edwards, R., Eguchi, A., Elias, J., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fannon, J. E. P., Fedorova, D., Fedotov, S., Feltre, M., Feng, J., Feng, L., Ferlewicz, D., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fujisawa, C., Fujita, S., Fukuda, Y., Furui, Y., Gao, J., Gaur, R., Giampaolo, A., Giannessi, L., Giganti, C., Glagolev, V., Goldsack, A., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Gorshanov, K., Gousy-Leblanc, V., Grassi, M., Griskevich, N. J., Guigue, M., Hadley, D., Haigh, J. T., Han, S., Harada, M., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Heitkamp, I., Henaff, D., Hill, J., Hino, Y., Hiraide, K., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Horiuchi, S., Hosokawa, K., Hu, Z., Hu, J., Iacob, F., Ichikawa, A. K., Ieki, K., Ikeda, M., Iovine, N., Ishida, T., Ishino, H., Ishitsuka, M., Ishizuka, T., Ito, H., Itow, Y., Izmaylov, A., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, M. C., Jang, J. S., Jenkins, S. J., Jesús-Valls, C., Ji, J. Y., Jia, M., Jiang, J., Jonsson, P., Joshi, S., Jung, C. K., Jung, S., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kanemura, Y., Kaneshima, R., Karpova, S., Kasetti, S. P., Kashiwagi, Y., Kasturi, V. S., Kataoka, Y., Katori, T., Kawamura, Y., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, S. B., King, S., Kiseeva, V., Kisiel, J., Kneale, L., Kobayashi, H., Kobayashi, T., Kobayashi, M., Koch, L., Kodama, S., Kolupanova, M., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kurochka, V., Kutter, T., Kuze, M., Kwon, E., La Commara, M., Labarga, L., Lachat, M., Lachner, K., Lagoda, J., Lakshmi, S. M., LamersJames, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, Y., Lee, S. H., Silverio, D. Leon, Levorato, S., Lewis, S., Li, X., Li, W., Lin, C., Litchfield, R. P., Liu, S. L., Liu, Y. M., Long, K. R., Longhin, A., Moreno, A. Lopez, Lu, X., Ludovici, L., Lux, T., Machado, L. N., Maekawa, Y., Magaletti, L., Mahn, K., Mahtani, K. K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Martens, K., Marti, Ll., Martin, D. G. R., Martin, J. F., Martin, D., Martini, M., Maruyama, T., Matsubara, T., Matsumoto, R., Mattiazzi, M., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J. M., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Menjo, H., Metelko, C., Mezzetto, M., Migenda, J., Mijakowski, P., Miki, S., Miller, E., Minamino, A., Mine, S., Mineev, O., Mirabito, J., Miura, M., Bueno, L. Molina, Moon, D. H., Mori, M., Moriyama, S., Morrison, P., Muñoz, A., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, Y., Nagai, K., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K., Nakamura, K. D., Nakamura, T., Nakanishi, F., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Nguyen, D. T., Nicholson, M., Niewczas, K., Ninomiya, K., Nishijima, K., Nishimori, S., Nishimura, Y., Noguchi, Y., Nosek, T., Nova, F., Novella, P., Nugent, J. C., Odagawa, T., Okazaki, R., Okazawa, H., Okinaga, W., Okumura, K., Okusawa, T., Ommura, Y., Onda, N., Ospina, N., Osu, L., Oyama, Y., O'Flaherty, M., O'Keeffe, H. M., O'Sullivan, L., Périssé, L., Paganini, P., Palladino, V., Paolone, V., Pari, M., Park, R. G., Parlone, J., Pasternak, J., Payne, D., Penn, G. C., de Perio, P., Pershey, D., Pfaff, M., Pickering, L., Pintaudi, G., Pistillo, C., Pointon, B. W., Popov, B., Yrey, A. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Prasad, H., Pronost, G., Prouse, N. W., Pupilli, F., Quilain, B., Quyen, P. T., Raaf, J. L., Radermacher, T., Radicioni, E., Radics, B., Ramirez, M. A., Ramsden, R. M., Ratoff, P. N., Reh, M., Riccio, C., Richards, B., Rogly, R., Rondio, E., Roth, S., Roy, N., Rubbia, A., Russo, L., Rychter, A., Saenz, W., Sakai, S., Sakashita, K., Samani, S., Santos, A. D., Sato, Y., Sato, K., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaikhiev, A., Shi, W., Shiba, H., Shibayama, R., Shigeta, N., Shima, S., Shimamura, R., Shimizu, K., Shinoki, M., Shiozawa, M., Shiraishi, Y., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smy, M. B., Smyczek, D., Sobczyk, J. T., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Stroke, Y., Suslov, I. A., Suvorov, S., Suzuki, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sánchez, F., Tada, T., Tada, M., Tairafune, S., Takagi, Y., Takeda, A., Takemoto, Y., Takeuchi, Y., Takhistov, V., Takifuji, K., Tanaka, H., Tanaka, H. K., Tanigawa, H., Taniuchi, N., Tano, T., Tarrant, A., Tashiro, T., Teklu, A., Terada, K., Tereshchenko, V. V., Thamm, N., Thiesse, M. D., Thompson, L. F., Toki, W., Tomiya, T., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Vargas, D., Varghese, M., Vasseur, G., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Wallace, H. T., Walsh, J. G., Walter, C. W., Wan, L., Wang, X., Wang, Y., Wark, D., Wascko, M. O., Watanabe, E., Weber, A., Wendell, R. A., Wester, T., Wilking, M. J., Wilkinson, C., Wilson, S. T., Wilson, J. R., Wood, K., Wret, C., Wu, Y., Xia, J., Xie, Z., Xu, B. D., Xu, Y. -H., Yamamoto, K., Yamamoto, T., Yamauchi, K., Yanagisawa, C., Yang, G., Yang, B. S., Yang, J. Y., Yankelevich, A., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoo, J., Yoshida, T., Yoshida, S., Yoshimoto, Y., Yoshimura, N., Yoshioka, Y., Yu, M., Yu, I., Zaki, R., Zaldivar, B., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhang, J., Zhang, A. Q., Zhang, B., Zhao, X. Y., Zhong, H., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: The Super-Kamiokande and T2K collaborations present a joint measurement of neutrino oscillation parameters from their atmospheric and beam neutrino data. It uses a common interaction model for events overlapping in neutrino energy and correlated detector systematic uncertainties between the two datasets, which are found to be compatible. Using 3244.4 days of atmospheric data and a beam exposure of $19.7(16.3) \times 10^{20}$ protons on target in (anti)neutrino mode, the analysis finds a 1.9$\sigma$ exclusion of CP-conservation (defined as $J_{CP}=0$) and a preference for the normal mass ordering., Comment: 12 pages, 4 figures
Published: 2024

10. Glycemia normalization in patients with obesity and type 2 diabetes mellitus: bariatric surgery vs pharmacological therapy

Author: I A Sklyanik, E A Shestakova, A V Yurasov, Yu I Yashkov, and M V Shestakova
Subjects: liraglutide, biliopancreatic diversion, gastric bypass, diabetes mellitus, obesity, Medicine
Abstract: Aims. To compare glucose - lowering and weight reduction capacity of bypass operations (gastric bypass (GB), biliopancreatic diversion (BPD) vs GLP-1 agonist liraglutide 3.0 mg (models of maximum incretin effect) for 6 months. Materials and methods. 46 patients with type 2 diabetes and long history (≥10 years) of obesity were divided into 2 groups: surgery - group (n=23) and liraglutide - group (n=23), where liraglutide 3.0 mg in dose - escalation manner was added to baseline glucose - lowering therapy. Anthropometric parameters, HbA1c and insulin resistance (IR) by hyperinsulinemic euglycemic clamp (M-value) were measured before and 16 weeks after the intervention. With the stabilization of glycemia (≤6.5 mmol/l at fasting state, ≤8 mmol/l postprandial) the initial glucose - lowering therapy was canceled. Results and discussion. Both surgery and liraglutide 3.0 mg provided target HbA1c in 16 weeks. Bypass operations led to elimination of glucose - lowering therapy in 82.6% patients due to a more significant weight reduction and decrease in IR. In liraglutide - group previous glucose - lowering therapy was cancelled in 78.3% patients, mainly receiving baseline mono - and two - component therapy. The most significant difference between interventions was achieved in BMI (-8.9 kg in surgery group vs -3.8 kg in liraglutide group, p
Published: 2019
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11. Relationships of arterial hypertension and reduced renal function in a population 25-45 years

Author: N A Kovalkova, Yu I Ragino, L V Scherbakova, A D Hudyakova, D V Denisova, and M I Voevoda
Subjects: epidemiological study, arterial hypertension, glomerular filtration rate, renal function, cardiometabolic risk factors, Medicine
Abstract: Aim. To study relationships of reduced renal function with hypertension and other cardiometabolic risk factors in persons aged 25-45 years. Materials and methods. A cross-sectional population study of one of the typical district of Novosibirsk (Russia) was performed during 2013-2016 years. The study included 468 men and 606 women aged 25-45 years. Blood pressure (BP), waist circumference (WC), blood lipids, glucose, creatinine were measured. Glomerular filtration rate (GFR) was calculated with the formula CKD-EPI. Hypertension was registered if blood pressure (BP) was ≥140/90 mm Hg, reduced kidney function - at GFR
Published: 2019
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12. Modern radiation therapy in part of treatment primary mediastinal (thymic) B-large cell lymphoma (results of 131 patients treated at N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation)

Author: O P Trofimova, I Z Zavodnova, G S Tumyan, Yu I Pryamikova, N V Volkova, O S Zaichenko, and A V Nazarenko
Subjects: primary mediastinal b-cell lymphoma, treatment, prognostic factors, radiotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background. For many decades of the twentieth century, radiation therapy has played a leading role in the treatment of patients with lymphoproliferative diseases, which are highly susceptible to ionizing radiation by neoplasms. But due to the effective development of chemotherapy, the discovery and rapid introduction of targeted drugs into practice, the role of radiation treatment in various types of lymphomas becomes less defined in many clinical situations. Primary mediastinal (thymic) B-cell lymphoma (PMBCL) belongs to the primary extranodal tumors and originate from a thymic medullary B cell. The disease has specific morphoimmunological and genetic characteristics that allows it to be identified from the others similar in manifestations lymphoproliferative diseases. The standard of treatment for PMBCL is immunochemotherapy with subsequent irradiation of a residual tumor in the mediastinum. Currently, the benefits of one chemotherapy regimen over the other ones have not been shown in controlled studies. Aim. To study the modern approaches to the chemoradiotherapy in PMBCL patients with an attempt to "individualize" them depending on various prognostic factors. Methods. The study conducted a thorough analysis of the treatment results of 131 patients with PMBCL who were treated in the N.N.Blokhin National Medical Research Center of Oncology from 2005 to 2017. More than half of the patients were women (58%), the median age was 30 years. At different historical periods, the treatment of PMBCL was applied according to different chemotherapy regimens: MACOP-B+R - 55 (42%), R-CHOP - 40 (30.5%), R-DA-EPOCH - 36 (27.5%); 99 patients received radiation therapy. Results. The efficacy of treatment in the whole group of PMBCL patients was high: remission was achieved in 87% of patients, 3-year progression-free survival was 78%, and overall survival was 88%. With a median follow-up of 37 months, 17 (13%) of 131 patients had a relapse or progression of the disease within 13 months from the start of treatment; no late relapses were detected. Treatment of this group was ineffective: the 12-month overall survival did not exceed 37%. In the group of 99 patients with immunochemoradiotherapy, high rates of 3-year overall survival and progression-free survival (with a median of 37 months) were achieved - 91% and 88%, respectively. It has been shown that intensive immunochemotherapy regimens (R-MACOP-B, R-EPOCH) do not differ in efficacy and have statistically significant advantages over the standard R-CHOP regimen. Positron emission tomography (PET) is an important prognostic tool in the treatment of patients with PMBCL: 3-year progression-free survival in the PET-negative group was 92% compared with 26% in the PET-positive group. The frequency of radiation damage to the lungs during conventional and 3D conformal radiation therapy was analyzed. Conclusion. The algorithm of optimal treatment for PMBCL patients was determined based on clinical factors, the drug treatment program, the degree of regression of the tumor and its metabolic activity, volume and method of irradiation.
Published: 2018
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13. The structural-size effect, aging time, and pressure-dependent functional properties of Mn-containing perovskite nanoparticles

Author: Su, Danyang, Liedienov, N. A., Kalita, V. M., Fesych, I. V., Xu, Wei, Bodnaruk, A. V., Dzhezherya, Yu. I., Li, Quanjun, Liu, Bingbing, and Levchenko, G. G.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Soft Condensed Matter, Condensed Matter - Strongly Correlated Electrons
Abstract: The properties of nanoparticles are determined by their size and structure. When exposed to external pressure P, their structural properties can change. The improvement or degradation of the properties of the samples depending on time is particularly interesting. The knowledge of the influence of structural-size effect, aging time, and pressure on the behavior of the compounds is essential for fundamental and applied purposes.Therefore, the first attempts have been made to shed light on how the functional properties of the Mn-containing perovskites change depending on them. The nanoparticles of different sizes, from 20 to 70 nm, have been obtained. After 3 years, their structural properties underwent significant changes, including an increase in particle size, bandwidth, and microstrains, as well as a reduction in dislocation density.The greatest change in the structure is observed for the smallest nanoparticles. The phase transition temperatures increase with nanoparticle size, time, and pressure. The aging time has the strongest influence on the changing Curie temperature for the smallest and most magnetically inhomogeneous nanoparticles with dTc/dP = 100 K / GPa. Conversely, the structural-size effect and external pressure have the greatest influence on the biggest and most magnetically uniform nanoparticles with dTc/dP = 91 and 16 K / GPa, respectively. After 3 years, the biggest nanoparticles demonstrate the most stable phase transition temperatures with improved magnetocaloric parameters near room temperature. These structural-size effect, aging time, and pressure are powerful instruments to tune the phase transition temperatures and magnetocaloric effect of the nanoparticles. These outcomes may have implications for the whole class of perovskites and could initiate a new mainstream., Comment: 57 pages, 33 figures
Published: 2024
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14. Development of a data overflow protection system for Super-Kamiokande to maximize data from nearby supernovae

Author: Mori, M., Abe, K., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Edwards, R., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Bronner, C., Feng, J., Hu, J. R., Hu, Z., Kawaune, M., Kikawa, T., LiCheng, F., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Valls, C. J., Xia, J., Kuze, M., Izumiyama, S., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Hadley, D., Nicholson, M., Flaherty, M. O', Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment
Abstract: Neutrinos from very nearby supernovae, such as Betelgeuse, are expected to generate more than ten million events over 10\,s in Super-Kamokande (SK). At such large event rates, the buffers of the SK analog-to-digital conversion board (QBEE) will overflow, causing random loss of data that is critical for understanding the dynamics of the supernova explosion mechanism. In order to solve this problem, two new DAQ modules were developed to aid in the observation of very nearby supernovae. The first of these, the SN module, is designed to save only the number of hit PMTs during a supernova burst and the second, the Veto module, prescales the high rate neutrino events to prevent the QBEE from overflowing based on information from the SN module. In the event of a very nearby supernova, these modules allow SK to reconstruct the time evolution of the neutrino event rate from beginning to end using both QBEE and SN module data. This paper presents the development and testing of these modules together with an analysis of supernova-like data generated with a flashing laser diode. We demonstrate that the Veto module successfully prevents DAQ overflows for Betelgeuse-like supernovae as well as the long-term stability of the new modules. During normal running the Veto module is found to issue DAQ vetos a few times per month resulting in a total dead time less than 1\,ms, and does not influence ordinary operations. Additionally, using simulation data we find that supernovae closer than 800~pc will trigger Veto module resulting in a prescaling of the observed neutrino data., Comment: 28 pages, 18 figures. Submitted to PTEP
Published: 2024
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15. Evaluation of the performance of the event reconstruction algorithms in the JSNS$^2$ experiment using a $^{252}$Cf calibration source

Author: Lee, D. H., Cheoun, M. K., Choi, J. H., Choi, J. Y., Dodo, T., Goh, J., Haga, K., Harada, M., Hasegawa, S., Hwang, W., Iida, T., Jang, H. I., Jang, J. S., Joo, K. K., Jung, D. E., Kang, S. K., Kasugai, Y., Kawasaki, T., Kim, E. J., Kim, J. Y., Kim, S. B, Kim, W., Kinoshita, H., Konno, T., Lim, I. T., Little, C., Marzec, E., Maruyama, T., Masuda, S., Meigo, S., Moon, D. H., Nakano, T., Niiyama, M., Nishikawa, K., Pac, M. Y., Park, H. W., Park, J. S., Park, R. G., Peeters, S. J. M., Rott, C., Sakai, K., Sakamoto, S., Shima, T., Spitz, J., Suekane, F., Sugaya, Y., Suzuya, K., Takeuchi, Y., Yamaguchi, Y., Yeh, M., Yeo, I. S., Yoo, C., and Yu, I.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: JSNS$^2$ searches for short baseline neutrino oscillations with a baseline of 24~meters and a target of 17~tonnes of the Gd-loaded liquid scintillator. The correct algorithm on the event reconstruction of events, which determines the position and energy of neutrino interactions in the detector, are essential for the physics analysis of the data from the experiment. Therefore, the performance of the event reconstruction is carefully checked with calibrations using $^{252}$Cf source. This manuscript describes the methodology and the performance of the event reconstruction.
Published: 2024

16. Pulse Shape Discrimination in JSNS$^2$

Author: Dodo, T., Cheoun, M. K., Choi, J. H., Choi, J. Y., Goh, J., Haga, K., Harada, M., Hasegawa, S., Hwang, W., Iida, T., Jang, H. I., Jang, J. S., Joo, K. K., Jung, D. E., Kang, S. K., Kasugai, Y., Kawasaki, T., Kim, E. J., Kim, J. Y., Kim, S. B., Kim, W., Kinoshita, H., Konno, T., Lee, D. H., Lim, I. T., Little, C., Marzec, E., Maruyama, T., Masuda, S., Meigo, S., Moon, D. H., Nakano, T., Niiyama, M., Nishikawa, K., Pac, M. Y., Park, H. W., Park, J. S., Park, R. G., Peeters, S. J. M., Rott, C., Sakai, K., Sakamoto, S., Shima, T., Shin, C. D., Spitz, J., Suekane, F., Sugaya, Y., Suzuya, K., Takeuchi, Y., Yamaguchi, Y., Yeh, M., Yeo, I. S., Yoo, C., and Yu, I.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: JSNS$^2$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) is an experiment that is searching for sterile neutrinos via the observation of $\bar{\nu}_{\mu} \rightarrow \bar{\nu}_e$ appearance oscillations using neutrinos with muon decay-at-rest. For this search, rejecting cosmic-ray-induced neutron events by Pulse Shape Discrimination (PSD) is essential because the JSNS$^2$ detector is located above ground, on the third floor of the building. We have achieved 95$\%$ rejection of neutron events while keeping 90$\%$ of signal, electron-like events using a data driven likelihood method., Comment: arXiv admin note: text overlap with arXiv:2111.07482, arXiv:2308.02722
Published: 2024

17. Calibration and characterization of the RED-100 detector at the Kalinin nuclear power plant

Author: Akimov, D. Yu., Aleksandrov, I. S., Kurbonova, F. B. Ata, Belov, V. A., Bolozdynya, A. I., Etenko, A. V., Galavanov, A. V., Gusakov, Yu. V., Khromov, A. V., Konovalov, A. M., Kornoukhov, V. N., Kovalenko, A. G., Kozlova, E. S., Koskin, Yu. I., Kumpan, A. V., Lukyashin, A. V., Pinchuk, A. V., Razuvaeva, O. E., Rudik, D. G., Shakirov, A. V., Simakov, G. E., Sosnovtsev, V. V., and Vasin, A. A.
Subjects: Physics - Instrumentation and Detectors
Abstract: RED-100 is a two-phase Xe detector designed and built for the study of coherent elastic neutrino-nucleus scattering CEvNS of reactor antineutrinos. A comprehensive calibration was performed in order to obtain important parameters of the detector during its exposition at the Kalinin Nuclear Power Plant (Tver, Russia). This paper describes the analysis of calibration data, position and energy reconstruction procedures, and evaluation of the efficiency of electron extraction from the liquid xenon to the gas phase.
Published: 2024

18. Measurements of the charge ratio and polarization of cosmic-ray muons with the Super-Kamiokande detector

Author: Kitagawa, H., Tada, T., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the results of the charge ratio ($R$) and polarization ($P^{\mu}_{0}$) measurements using the decay electron events collected from 2008 September to 2022 June by the Super-Kamiokande detector. Because of its underground location and long operation, we performed high precision measurements by accumulating cosmic-ray muons. We measured the muon charge ratio to be $R=1.32 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at $E_{\mu}\cos \theta_{\mathrm{Zenith}}=0.7^{+0.3}_{-0.2}$ $\mathrm{TeV}$, where $E_{\mu}$ is the muon energy and $\theta_{\mathrm{Zenith}}$ is the zenith angle of incoming cosmic-ray muons. This result is consistent with the Honda flux model while this suggests a tension with the $\pi K$ model of $1.9\sigma$. We also measured the muon polarization at the production location to be $P^{\mu}_{0}=0.52 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at the muon momentum of $0.9^{+0.6}_{-0.1}$ $\mathrm{TeV}/c$ at the surface of the mountain; this also suggests a tension with the Honda flux model of $1.5\sigma$. This is the most precise measurement ever to experimentally determine the cosmic-ray muon polarization near $1~\mathrm{TeV}/c$. These measurement results are useful to improve the atmospheric neutrino simulations., Comment: 29 pages, 45 figures
Published: 2024
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19. Second gadolinium loading to Super-Kamiokande

Author: Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesus-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Suzuki, S., Scovell, P. R., Meehan, E., Bandac, I., Pena-Garay, C., Perez, J., Gileva, O., Lee, E. K., Leonard, D. S., Sakakieda, Y., Sakaguchi, A., Sueki, K., Takaku, Y., and Yamasaki, S.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The first loading of gadolinium (Gd) into Super-Kamiokande in 2020 was successful, and the neutron capture efficiency on Gd reached 50\%. To further increase the Gd neutron capture efficiency to 75\%, 26.1 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was additionally loaded into Super-Kamiokande (SK) from May 31 to July 4, 2022. As the amount of loaded $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was doubled compared to the first loading, the capacity of the powder dissolving system was doubled. We also developed new batches of gadolinium sulfate with even further reduced radioactive impurities. In addition, a more efficient screening method was devised and implemented to evaluate these new batches of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$. Following the second loading, the Gd concentration in SK was measured to be $333.5\pm2.5$ ppm via an Atomic Absorption Spectrometer (AAS). From the mean neutron capture time constant of neutrons from an Am/Be calibration source, the Gd concentration was independently measured to be 332.7 $\pm$ 6.8(sys.) $\pm$ 1.1(stat.) ppm, consistent with the AAS result. Furthermore, during the loading the Gd concentration was monitored continually using the capture time constant of each spallation neutron produced by cosmic-ray muons,and the final neutron capture efficiency was shown to become 1.5 times higher than that of the first loaded phase, as expected., Comment: 34 pages, 13 figures, submitted to Nuclear Inst. and Methods in Physics Research, A
Published: 2024
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20. Performance of SK-Gd's Upgraded Real-time Supernova Monitoring System

Author: Kashiwagi, Y., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointn, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Among multi-messenger observations of the next galactic core-collapse supernova, Super-Kamiokande (SK) plays a critical role in detecting the emitted supernova neutrinos, determining the direction to the supernova (SN), and notifying the astronomical community of these observations in advance of the optical signal. On 2022, SK has increased the gadolinium dissolved in its water target (SK-Gd) and has achieved a Gd concentration of 0.033%, resulting in enhanced neutron detection capability, which in turn enables more accurate determination of the supernova direction. Accordingly, SK-Gd's real-time supernova monitoring system (Abe te al. 2016b) has been upgraded. SK_SN Notice, a warning system that works together with this monitoring system, was released on December 13, 2021, and is available through GCN Notices (Barthelmy et al. 2000). When the monitoring system detects an SN-like burst of events, SK_SN Notice will automatically distribute an alarm with the reconstructed direction to the supernova candidate within a few minutes. In this paper, we present a systematic study of SK-Gd's response to a simulated galactic SN. Assuming a supernova situated at 10 kpc, neutrino fluxes from six supernova models are used to characterize SK-Gd's pointing accuracy using the same tools as the online monitoring system. The pointing accuracy is found to vary from 3-7$^\circ$ depending on the models. However, if the supernova is closer than 10 kpc, SK_SN Notice can issue an alarm with three-degree accuracy, which will benefit follow-up observations by optical telescopes with large fields of view., Comment: 38 pages, 29 figures, 6 tables
Published: 2024

21. Magnetoactive elastomer based on superparamagnetic nanoparticles with Curie point close to room temperature

Author: Yu I. Dzhezherya, Wei Xu, S.V. Cherepov, Yu B. Skirta, V.M. Kalita, A.V. Bodnaruk, N.A. Liedienov, A.V. Pashchenko, I.V. Fesych, Bingbing Liu, and G.G. Levchenko
Subjects: Magnetoactive elastomer, Superparamagnetic nanoparticles, Magneto-rheological effect, Magnetoelastic properties, Magnetization, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: A magnetoactive elastomer (MAE) consisting of single-domain La0.6Ag0.2Mn1.2O3 nanoparticles with a Curie temperature close to room temperature (TC = 308 K) in a silicone matrix has been prepared and comprehensively studied. It has been found that MAE particles are magnetized superparamagnetically with a low coercivity below 10 Oe at room temperature and above. The influence of magnetic anisotropy on the appearance of torque is justified. A coupling between magnetization and magnetoelasticity has also been established. The mechanisms of the appearance of magnetoelasticity, including the effect of MAE rearrangement and MAE compression by magnetized particles, have been revealed. It has been found that the magnetoelastic properties of MAE have critical features near TC. The magnetoelastic properties of MAE disappear at T > TC and are restored at T
Published: 2021
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22. Dynamics of Neurovisceral Interactions in Individual and Phylogenetic Development: Analysis of Heart Rate Variability

Author: Bakhchina, A. V., Sozinova, I. S., and Alexandrov, Yu. I.
Published: 2024
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23. Plasma Diagnostics in T-15MD Divertor: Tasks, Problems, and Implementation Possibilities

Author: Vukolov, K. Yu., Andreenko, E. N., Buzmakov, M. Yu., Neverov, V. S., Orlovskiy, I. I., Tolpegina, Yu. I., and Fedorov, D. A.
Published: 2024
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24. Features of Magnetic Susceptibility of a Ferrofluid with a Non-Magnetic Filler

Author: Dikansky, Yu. I., Gladkikh, D. V., Dorozhko, D. S., and Kurnev, A. V.
Published: 2024
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25. Features of the Formation of a Labyrinthine Structure in Thin Layers of Magnetic Fluids in a Constant Electric Field

Author: Beketova, E. S., Mkrtchyan, V. D., and Dikanskii, Yu. I.
Published: 2024
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26. Improvement in the physical properties of poly(lactic acid)/thermoplastic starch blends using oligo(lactic acid)-grafted starch

Author: Shibasaki, Kazuki, Hsu, Yu-I, and Uyama, Hiroshi
Published: 2024
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27. Peculiarities of Clay Mineral Formation in Pleistocene Sediments Under Specific Tectonomagmatic and Hydrothermal Conditions of the Central Hill (Escanaba Trough, Gorda Ridge, Pacific Ocean): Communication 1. Hole ODP 1038B

Author: Kurnosov, V. B., Sakharov, B. A., Konovalov, Yu. I., Savichev, A. T., Morozov, I. A., and Korshunov, D. M.
Published: 2024
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28. Role of the Serotonergic System in Functional Recovery after Spinal Cord Injury

Author: Konovalova, S. P., Sysoev, Yu. I., Vetlugina, A., Arsentiev, K. A., and Musienko, P. E.
Published: 2024
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29. Possibility of Using a Composition with Lipid Transfer Protein Ns-LTP1 in Therapy of Ulcerative Colitis

Author: Oshchepkova, Yu. I., Amanlikova, D. A., and Rakhmonova, G. G.
Published: 2024
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30. Microstructure and Thermoelastic Martensitic Transformation in Ni-Low and -Rich Ni–Ti–Hf–Nb Hightemperature Shape Memory Alloys

Author: Eftifeeva, A. S., Timofeeva, E. E., Panchenko, E. Yu., Zherdeva, M. V., Kurlevskaya, I. D., Fatkullin, I. D., Tagiltsev, A. I., Yanushonyte, E. I., and Chumlyakov, Yu. I.
Published: 2024
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31. Thermal and Cyclic Stability of Two-Way Shape Memory Effect in Ni44Fe19Ga27Co10 Single Crystals

Author: Timofeeva, E. E., Dmitrienko, M. S., Panchenko, E. Yu., Zherdeva, M. V., Tokhmetova, A. B., Tagiltsev, A. I., Fatkullin, I. D., and Chumlyakov, Yu. I.
Published: 2024
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32. Mass Spectrometric Study of the Interaction of Y2O3 with Carbon at High Temperatures

Author: Folomeikin, Yu. I., Stolyarova, V. L., and Lopatin, S. I.
Published: 2024
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33. The influence of antyhypertensive therapy of valsartan and fixed combination with hydrochlorothiazide use on pulse-wave velocity and central arterial pressure in patients with arterial hypertension of 1-2 grades in international VICTORY clinical trial

Author: I E Chazova, T V Martynyuk, R Accetto, Yu N Sirenko, J Vincelj, Jr Widimsky, B Barbič-Žagar, M V Arhipov, Yu I Grinshtein, O D Ostroumova, A S Galjavich, O P Rotar, L A Haisheva, and S V Nedogoda
Subjects: валсартан, гидрохлоротиазид, артериальная гипертония, скорость пульсовой волны, центральное артериальное давление, клиническое исследование victory, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Objective - to explore influence of valsartan monotherapy use and its use in combination with hydrochlorothiazide (HCTZ) on pulse-wave velocity (PWV) and central arterial pressure (CAP) in patients with arterial hypertension (AH) of 1-2 grades in international VICTORY clinical trial. Materials and methods. The international multicenter prospective randomized clinical study VICTORY that lasted for 16 weeks included patients with 1-2 grades AH. In patients who previously received antihypertensive therapy a 7 days washout period was carried out. All patients started their therapy with 80 mg valsartan (Valsacor®, KRKA, Slovenia); in Russia the starter dose of Valsacor®, KRKA was 160 mg in previously treated patients that did not influence the study results. If after 4 weeks of treatment BP was more than 140/90 mm hg (more than 130/80 mm hg in high risk patients or in diabetes mellitus patients) the dose of valsartan was increased to 160 mg (320 mg in Russia) or diuretic in fixed combination with valsartan was added (160 mg valsartan/12.5 mg HCTZ): Valsacor® H 160 (KRKA, Slovenia). If target BP after 8 weeks of treatment was not reached valsartan dose was increased to 320 mg or fixed combination of valsartan and diuretic (160 mg/12.5 mg) was used. If target BP after 12 weeks of treatment was not reached - valsartan and diuretic 320 mg/12.5 mg were used. PWV and CAP (SphygmoCor®, AtCorMedical) were assessed at baseline and after 16 weeks of treatment. The primary endpoints were assessment of the impact of studied medications on aortic stiffness, aortic augmentation index and comparison of absolute medians of reached central and peripheral BP reduction with baseline value. Results. Of 365 patients included in the study 74 were included in PWV and CAP study subgroup. Valsartan and its combination with HCTZ were effective in CBP reduction. The mean absolute reduction of central systolic and diastolic BP after 16 weeks of treatment was 19.7±12.9 mm hg and 13.9±8.5 mm hg, respectively (р
Published: 2018
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34. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Author: Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh, Sunhee Hwang, Yu I. Kim, Sang H. Park, Kwang H. Kim, Don G. Lee, Ho S. Oh, Sangeun Lee, Young H. Kim, Beom K. Choi, and Byoung S. Kwon
Subjects: Science
Abstract: Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
Published: 2018
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35. Fast reconstruction of programmable interferometers with intensity-only measurements

Author: Bantysh, B. I., Chernyavskiy, A. Yu., Fldzhyan, S. A., and Bogdanov, Yu. I.
Subjects: Quantum Physics
Abstract: Programmable linear optical interferometers are promising for classical and quantum applications. Their integrated design makes it possible to create more scalable and stable devices. To use them in practice, one has to reconstruct the whole device model taking the manufacturing errors into account. The inability to address individual interferometer elements complicates the reconstruction problem. A naive approach is to train the model via some complex optimization procedure. A faster optimization-free algorithm has been recently proposed [Opt. Express 31, 16729 (2023)]. However, it requires the full transfer matrix tomography while a more practical setup measures only the fields intensities at the interferometer output. In this paper, we propose the modification of the fast algorithm, which uses additional set of interferometer configurations in order to reconstruct the model in the case of intensity-only measurements. We show that it performs slightly worse than the original fast algorithm but it is more practical and still does not require intensive numerical optimization.
Published: 2024
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36. Solar neutrino measurements using the full data period of Super-Kamiokande-IV

Author: Collaboration, Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, R., Wang, X., Yoshida, S., Bravo-Berguno, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Blaszczyk, F. d. M., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Yankelevich, A., Ganezer, K. S., Hill, J., Jang, M. C., Kim, J. Y., Lee, S., Lim, I. T., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Rogly, R., Quilain, B., Santos, A., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Matsuno, S., Iovine, N., Choi, K., Cao, S., Anthony, L. H. V., Litchfield, R. P., Prouse, N., Marin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Langella, A., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Bhuiyan, N., Burton, G. T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Sedgwick, S. Molina, Ramsden, R. M., Taani, M., Xie, Z., Zsoldos, S., Abe, KE., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Yamamoto, S., Zhong, H., Ashida, Y., Feng, J., Feng, L., Hayashino, T., Hirota, S., Hu, J. R., Hu, Z., Jiang, M., Kawaue, M., Kikawa, T., Mori, M., Nakamura, KE., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Pritchard, A., Tarrant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Murase, M., Ninomiya, K., Niwa, T., Tsukada, M., Yoshioka, Y., Frankiewicz, K., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jiang, J., Jia, M., Jung, C. K., Palomino, J. L., Santucci, G., Shi, W., Vilela, C., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Hino, Y., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Sakuda, M., Tada, T., Tano, T., Xu, C., Yamaguchi, R., Ishizuka, T., Kuno, Y., Barr, G., Barrow, D., Cook, L., Samani, S., Simpson, C., Wark, D., Holin, A. M., Nova, F., Jung, S., Yang, B., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Choi, Y., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairahune, S., Nishijima, K., Eguchi, A., Iwamoto, K., Nakagiri, K., Nakajima, Y., Ogawa, N., Shima, S., Watanabe, E., Yokoyama, M., Calland, R. G., Fujita, S., Jesus-Valls, C., Junjie, X., Ming, T. K., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Izumiyama, S., Kuze, M., Matsumoto, R., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Ohta, K., Ommura, Y., Shinoki, M., Shigeta, N., Suganuma, T., Yamaguchi, K., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Berkman, S., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., Suzuki, S., and Wada, K.
Subjects: High Energy Physics - Experiment
Abstract: An analysis of solar neutrino data from the fourth phase of Super-Kamiokande~(SK-IV) from October 2008 to May 2018 is performed and the results are presented. The observation time of the data set of SK-IV corresponds to $2970$~days and the total live time for all four phases is $5805$~days. For more precise solar neutrino measurements, several improvements are applied in this analysis: lowering the data acquisition threshold in May 2015, further reduction of the spallation background using neutron clustering events, precise energy reconstruction considering the time variation of the PMT gain. The observed number of solar neutrino events in $3.49$--$19.49$ MeV electron kinetic energy region during SK-IV is $65,443^{+390}_{-388}\,(\mathrm{stat.})\pm 925\,(\mathrm{syst.})$ events. Corresponding $\mathrm{^{8}B}$ solar neutrino flux is $(2.314 \pm 0.014\, \rm{(stat.)} \pm 0.040 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$, assuming a pure electron-neutrino flavor component without neutrino oscillations. The flux combined with all SK phases up to SK-IV is $(2.336 \pm 0.011\, \rm{(stat.)} \pm 0.043 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$. Based on the neutrino oscillation analysis from all solar experiments, including the SK $5805$~days data set, the best-fit neutrino oscillation parameters are $\rm{sin^{2} \theta_{12,\,solar}} = 0.306 \pm 0.013 $ and $\Delta m^{2}_{21,\,\mathrm{solar}} = (6.10^{+ 0.95}_{-0.81}) \times 10^{-5}~\rm{eV}^{2}$, with a deviation of about 1.5$\sigma$ from the $\Delta m^{2}_{21}$ parameter obtained by KamLAND. The best-fit neutrino oscillation parameters obtained from all solar experiments and KamLAND are $\sin^{2} \theta_{12,\,\mathrm{global}} = 0.307 \pm 0.012 $ and $\Delta m^{2}_{21,\,\mathrm{global}} = (7.50^{+ 0.19}_{-0.18}) \times 10^{-5}~\rm{eV}^{2}$., Comment: 47 pages, 61 figures
Published: 2023
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37. Metabolic Characteristics of the Amphipod Gammarus oceanicus (Crustacea: Amphipoda) Exposed to Octylphenol (4t-Op)

Author: Berezina, N. A., Gubelit, Yu. I., Bakina, L. G., Egorova, A. V., and Kholodkevich, S. V.
Published: 2024
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38. Peculiarities of Clay Mineral Formation in Pleistocene Sediments Under Specific Tectonomagmatic and Hydrothermal Conditions of the Central Hill (Escanaba Trough, Gorda Ridge, Pacific Ocean): Communication 2. Holes ODP 1038A and 1038H

Author: Kurnosov, V. B., Sakharov, B. A., Konovalov, Yu. I., Savichev, A. T., Morozov, I. A., and Korshunov, D. M.
Published: 2024
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39. Associations between metabolic syndrome and reduced lung function in young people

Author: N A Kovalkova, Yu I Ragino, N Yu Travnikova, D V Denisova, L V Shcherbakova, and M I Voevoda
Subjects: metabolic syndrome, lung function, associations, Medicine
Abstract: Aim. To reveal possible associations between metabolic syndrome (MS) and reduced lung function. Subjects and methods. In 2013—016, a cross-sectional survey was conducted in 908 Novosibirsk dwellers, which included spirometry to evaluate external respiratory function (ERF). For the detection of MS, the investigators used the 2009 All-Russian Research Society of Cardiologists criteria: waist circumference (WC) > 80 cm for women and >94 cm for men in combination with two of the following criteria: blood pressure (BP) ≥130/85 mm Hg, triglycerides (TG) ≥1.7 mmol/l, high-density lipoproteins (HDL) cholesterol
Published: 2017
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40. Microcirculatory parameters in compensated and decompensated type 2 diabetes mellitus

Author: O V Suchkova, Yu I Gurfinkel, and M L Sasonko
Subjects: digital nail-fold capillaroscopy, blood microcirculation, type 2 diabetes mellitus, glycated hemoglobin, capillary tortuosity, remodeling rate, narrowed arterial capillary segment, Medicine
Abstract: Aim. To reveal the features of microcirculatory parameters in compensated and decompensated type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 196 patients with T2DM were examined and divided into 2 groups: 1) 52 patients (40.4% of men) aged 52.8±8.7 years with compensated T2DM (glycated hemoglobin (HbA1с), 6.3±0.5%); 2) 68 patients (38.2% of men) aged 52.8±8.1 years with decompensated T2DM (HbA1с, 9.4±1.7%). Both patient groups had concomitant hypertension (its prevalence, degree, stage of hypertension were comparable). A control group consisted of 76 volunteers (40.8% of men) aged 52.2±8.7 years with normal carbohydrate metabolism and without signs of cardiovascular disease (HbA1с, 5.3±0.49%). Capillary blood flow in the finger nail-fold area was investigated in all the participants. A digital optical capillaroscope with image-processing software was used to obtain quantitative blood microcirculatory parameters. The diameters of arterial and venous capillary segments were measured, by calculating the remodeling rate. The degree of capillary tortuosity, network density, and polymorphism and the size of the perivascular zone (PZ) were estimated. Blood rheological properties and capillary blood flow velocity were also investigated. Results. The decompensated T2DM group compared to the compensated T2DM group was found to have a narrowing of the arterial capillary segment diameter (8.4±2.0 µm; p=0.009) and an increase in remodeling rates (1.47±0.22; p=0.000). The tendency of the PZ size to be larger in patients with decompensated T2DM compared to those with compensated T2DM (p=0.080) and the increase in this indicator compared to the control group (p=0.001) reflect the presence of edema syndrome in Group 2, as laboratory confirmed by a statistically significantly elevated sodium level (p=0.000; p=0.006). The enlarged venous capillary segment demonstrates involvement of the venous component in microcirculatory disorders in T2DM. The reduction in the density of the capillary network and the increase in capillary tortuosity and polymorphism, which were also observed in the patients of both groups versus the control group, are referred to as disorders that are characteristic of T2DM. Conclusion. In decompensated T2DM, capillary bed structural and functional changes are found as a narrowing of the arterial capillary segment, an increase in the rate of remodeling, and enlargement of the PZ. Digital capillaroscopy opens up new possibilities for assessing the magnitude of changes in the microcirculatory system in DM and can simultaneously evaluate the efficiency of treatment, by monitoring the status of the microvasculature.
Published: 2017
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41. Irreversible electroporation of locally advanced unresectable pancreatic cancer

Author: Yu I Patyutko, A N Polyakov, N E Kudashkin, D V Podluzhnyi, and O V Chistyakova
Subjects: locally advancesd pancreatic cancer, irreversible electroporation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Aim: to improve the results of treatment of patients with locally advancesd pancreatic cancer. Matherials and methods. From February 2015 till June 2017 there was performed 6 irreversible electroporations of unresectable pancreatic cancers, one of which was combined with palliative gastropanreatoduodenectomy. The median tumor size was 41.7 mm (range from 22 to 65 mm). The median quantity of treated areas was 2.3 (1-5). Perioperative treatment was routinely used. Results. Two patients had complications. One died on the 21st day from the pancreonecrosis with parapancreatic abscesses. Autopsy showed there was no evidence of tumor cells in the site of electroporation performed. In the other case there were revealed several foci of destruction around the area of electroporation which required sanation under the endoscopic US-guidance. In different periods of observation (1-, 3-, 4 and 12 month) four patients were alive without sign of progression. One patient died in 13 month from progression. Conclusion: irreversible electroporation - is one of the effective local treatment methods for the patiemts with unresectable nonmetastatic pancreatic cancer. To increase treatment results it is recommended to combine electroporation with chemoor radiotherapy.
Published: 2017

42. METABOLISM AND CHEMILUMINESCENT ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH DIFFERENT SENSITIVITY TO ACETYLSALICYLIC ACID IN ACUTE CORONARY SYNDROME

Author: I Yu Grinshtein, A A Savchenko, Yu I Grinshtein, and I I Gvozdev
Subjects: acute coronary syndrome, neutrophils, respiratory explosion, enzyme activity, Medicine
Abstract: Objective: to study the features of the chemiluminescent state and the activity of NAD (P) -depen- dent dehydrogenases in neutrophilic granulocytes of blood in patients with different sensitivity to acetylsalicylic acid (ACA) in acute coronary syndrome (ACS).Materials and methods: The study included 53 patients with ACS. Evaluation of resistance or sensitivity to ASA was performed in vitro by incubating platelet-rich plasma with adenosine diphosphate and ASA to determine the level of aggregation. The state of respiratory explosion of neutrophils was investigated by the method of chemiluminescence. The activity of enzymes in neutrophils was studied by the bioluminescent method.Results of the study: In patients with ACS-resistant ACS, the rate of synthesis of primary and secondary active forms of oxygen was reduced, and the index of luminol-dependent activation of neutrophils was reduced. The intensity of substrate stimulation of glycolysis and oxidation of glucose by the pentose phosphate pathway is increased.Conclusion: With resistance to ASA in patients with ACS, there are abnormalities in the metabolism and functional activity of neutrophils, which is of interest in studying the intercellular relationships of thrombus formation.
Published: 2017
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43. The results of the international clinical study VICTORY: efficacy and safety of antihypertensive monotherapy with valsartan (Valsacor®) and its fixed combination with hydrochlorothiazide (Valsacor® H) in routine clinical practice in patients with grade 1 and grade 2 hypertension

Author: I E Chazova, T V Martynyuk, R Accetto, Yu Sirenko, J Vincelj, Jr JWidimsky, B Barbič-Žagar, M V Arhipov, Yu I Grinshtein, O D Ostroumova, A S Galjavich, O P Rotar', L A Haisheva, and S V Nedogoda
Subjects: hypertension, combined antihypertensive therapy, valsartan, hydrochlorothiazide, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Objective. The VICTORY study aimed to evaluate effectiveness and safety of monotherapy with valsartan (Valsacor®) and its fixed combination with hydrochlorothiazide (Valsacor® H) in clinical practice in patients with stage 1 and stage 2 hypertension. Materials and methods. In the prospective, randomized, open-label, international multicentre study involved 356 patients with grade 1 and grade 2 hypertension from 5 countries, including 130 patients from Russia. In Russia the study was conducted in 7 cities, in 8 clinical centers. The patients, who were receiving antihypertensive therapy at the moment of screening, underwent a 7 days wash-out period. The starter dose of valsartan (Valsacor®, KRKA, Slovenia) was 80 mg (except for Russia where 160 mg of Valsacor® were given at the first visit, what did not influence the study results). After 4 weeks of treatment in case of blood pressure (BP) >140/90 or 130/80 mm Hg the dose was increased to 160 mg (in Russia - to 320 mg) or combined therapy with Valsacor® H (KRKA, Slovenia) was prescribed. In 4 weeks the dose of valsartan was increased to 320 or 160/12.5 mg in case of previous dose insufficiency. If target BP levels were not reached in the next 4 weeks, the dose was increased to 320/12.5 mg. The primary endpoints included evaluation of antihypertensive effect of valsartan and its fixed combination with hydrochlorothiazide on BP levels; evaluation of the drugs’ influence on aortal stiffness; comparison of absolute average means of achieved decrease in central and peripheral BP compared with baseline; evaluation of the impact on aortic augmentation index. The secondary endpoints included comparison of primary endpoints when using mono and combined therapy; evaluation and comparison of the effect on erectile function in men by questionnaires at baseline and after 16 weeks of treatment; evaluation of adverse events frequency. Results. Data on 365 patients - 196 (54.0%) female and 169 (46.0%) male aged 54.6±12.0 years were analyzed. Mean initial value of systolic (SBP) and diastolic BP (DBP) were 156.6±8.9 and 95.6±6.0 mm Hg, respectively and 130.1±8.2 and 80.9±5.8 mm Hg, respectively after 16 weeks of treatment. The mean absolute decrease of SBP and DBP was 26.6±10.4 and 14.8±7.6 mm Hg. The decrease of SBP and DBP was statistically significant in all treatment periods (p
Published: 2017

44. Impact of shock-wave therapy on the clinical and functional status of patients with coronary heart disease

Author: S T Matskeplishvili, B M Borbodoeva, E U Asymbekova, A Z Rakhimov, N K Akhmedyarova, K B Kataeva, and Yu I Buziashvili
Subjects: coronary heart disease, stable angina, myocardial revascularization, cardiac shock-wave therapy, therapeutic angiogenesis, echocardiography, exercise echocardiography, tissue doppler echocardiography, Medicine
Abstract: Aim. To study of the impact of shock-wave therapy (SWT) on the functional status of patients with coronary heart disease (CHD). Subjects and methods. Thirty-four CHD patients (including 33 men) with left ventricular (LV) asynergic segments, as evidenced by echocardiography (EchoCG), were examined. Their mean age was 60.1±1.76 years. All the patients received a SWT cycle according to the standard scheme. The patient examination protocol involved EchoCG, dobutamine EchoCG, treadmill exercise EchoCG, and tissue Doppler EchoCG, which were performed at baseline, immediately and one month after the end of a SWT cycle. Results. Following a SWT cycle, all the patients were noted to have a significant decrease in mean angina pectoris and heart failure functional classes and in the frequency of daily intake of nitrates. EchoCG showed that at baseline the LV ejection fraction (EF) was 51.1±1.02%; end- diastolic volume index, 71.5±3.6 ml/m2; end-systolic volume index, 34.4±2.2 ml/m2. According to exercise EchoCG, the tolerance threshold was 6.4±0.1 Меts (Bruce protocol); the total exercise time of 5.05±0.23 min was achieved in an average of 75.2±1.32%. Immediately and one month after a SWT cycle, there was an increment in EF from 51.1±1.02 to 55±0.8 and 57±1.7%, respectively; a substantial increase in the tolerance threshold to 8.17±0.24 and 9.45±0.34 Меts, as compared to the baseline values. The exercise time increased up to 6.41±0.17 and 7.7±0.29 min immediately and one month after SWT, respectively. The increment in EF in response to exercise was 8.54±2.12, 14±1.5, and 16±1.2% at baseline, immediately and one month after SWT, respectively. Moreover, myocardial relaxation and diastolic function improved. Conclusion. Shock-wave therapy in patients with CHD is accompanied by their improved functional status, which is manifested by increased tolerance threshold and exercise duration, a rise in rest and exercise LV EF, better relaxation of LV, and its diminished stiffness.
Published: 2017
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45. Prevalence of external respiratory dysfunction in young people

Author: N A Kovalkova, N Yu Travnikova, Yu I Ragino, and M I Voevoda
Subjects: external respiratory function, ventilation disorders, screening, spirometry, Medicine
Abstract: Aim. To investigate the prevalence of impaired external respiration function (ERF) in young Novosibirsk dwellers. Subjects and methods. A cross-sectional population-based survey in one of the typical districts of Novosibirsk was conducted at the Research Institute of Internal and Preventive Medicine in 2013—2015. ERF was examined by spirometry in accordance with the guidelines. The best indicators of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio were selected and three reproducible attempts were made to evaluate ERF. Spirometry was carried out in 787 respondents (358 males and 429 females) for the entire period. The results were interpreted according to the guidelines of the European Respiratory Society, the American Thoracic Society, and the Russian Respiratory Society. Results. The prevalence of a FEV1/FVC of
Published: 2017
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46. THE PROBLEM OF CLASSIFICATION OF THE MODERN BROADCASTING: THE ESSENTIAL CHARACTERISTICS OG THE FORMAT 'TALK SHOW'

Author: P V Gulenko and Yu I Dolgova
Subjects: ток-шоу, шоу, жанр, формат, телевидение, телевизионные разговоры, Literature (General), PN1-6790
Abstract: The ambiguity of the term “talk show” in the practice and theory of television journalism, difficulties in defining television programs like “talk shows” require to discover the essential format`s characteristics by which we could easily find out the broadcast of this type. The article analyzes the definitions of the concept in Russian and foreign dictionaries and also in the scientific literature.The author investigates contentious issues in the definition of the term and essential characteristics of talk show: identification the genre of the conversation which takes place in the studio; the role of a live studio audience in talk; the border of the format. Besides, the term “talk show” is correlated to such categories as “format” and “genre”. The author raises the question about the correctness of the understanding of “talk shows” like the current genre of TV journalism. Finally, on systematizes distinctive characteristics of talk shows, highlighted by different researchers, and offers the list of essential characteristics of the broadcast of this type.
Published: 2016

47. Iranian Religious and Political Influence in Persian Gulf Countries (Bahrain, Saudi Arabia and Kuwait)

Author: Yu I Ilyina
Subjects: Бахрейн, ислам, исламское правление, исламская революция, Иран, Кувейт, политическое влияние, религия, Саудовская Аравия, шиизм, Political science
Abstract: This article is focuses on evolution of Iranian political influence in Persian Gulf countries. It examines theological and political aspects of such influence and its consequences for the region. The author analyses origins of the transnational Shia movements such as “Harakat ar-Risala” and “ad-Dawa” linked with traditional Shia institutions at Najaf and Kerbela, and its ambiguous relationships with post-revolution Iranian elite. In the same way, not all of Shias of Persian Gulf was “fascinated” by “Islamic revolution” in Iran and became admirers of R. Khomeini’s conception of “vilayat-e-faqih”. In addition, the author traces history of local political Shia movements, that are, in fact, more influential on domestic politics of Gulf countries that mythical “Iran’s hand”.
Published: 2016

48. Maximalist and Minimalist Approach to Islam in Iranian Religious-Political Thought of Second Half of the 20th Century

Author: Yu I Ilyina
Subjects: ислам, исламское правление, исламская революция, максимализм, минимализм, религия, религиозная философия, шиизм, Political science
Abstract: This article focuses on evolution of Iranian religious political thought of the second half of the 20th century. The author uses philosophic notions of “minimalist” and “maximalist” approach to the role of religion in social and political processes with the aim to classify different ideological conceptions that were born at that time and exist nowadays.
Published: 2016

49. Computer Simulation of Properties and Structure of Crystalline 1,6-closo-Carborane (С2B4)n

Author: Zaitsev, S. A., Zaitseva, Yu. I., Getmanskiy, I. V., and Minyaev, R. M.
Published: 2024
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50. Orientation Dependence of Cyclic Stability of Superelasticity of Ti50.2Ni49.8 Alloy Single Crystals under Compression

Author: Kireeva, I. V., Chumlyakov, Yu. I., Vyrodova, A. V., Saraeva, A. A., Pobedennaya, Z. V., and Marchenko, E. S.
Published: 2024
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