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Your search keyword '"Yu, Zhongbo"' showing total 1,106 results
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1,106 results on '"Yu, Zhongbo"'

1. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

Author

Zhang, Qianping, Sun, Tiantian, Yu, Fan, Liu, Wei, Gao, Jin, Chen, Jinyu, Zheng, Hao, Liu, Jinming, Miao, Chenjian, Guo, Huanyi, Tian, Wu, Su, Meihui, Guo, Yingjie, Liu, Xi, Pei, Yandong, Wang, Zhuofei, Chen, Shang, Mu, Chenglong, Lam, Sin Man, Shui, Guanghou, Li, Zongjin, Yu, Zhongbo, Zhang, Yan, Chen, Guo, Lu, Congcong, Midgley, Adam C., Li, Changhua, Bian, Xin, Liao, Xudong, Wang, Yong, Xiong, Wei, Zhu, Hongying, Li, Yanjun, and Chen, Quan

Published
2024
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2. Author Correction: PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

Author

Zhang, Qianping, Sun, Tiantian, Yu, Fan, Liu, Wei, Gao, Jin, Chen, Jinyu, Zheng, Hao, Liu, Jinming, Miao, Chenjian, Guo, Huanyi, Tian, Wu, Su, Meihui, Guo, Yingjie, Liu, Xi, Pei, Yandong, Wang, Zhuofei, Chen, Shang, Mu, Chenglong, Lam, Sin Man, Shui, Guanghou, Li, Zongjin, Yu, Zhongbo, Zhang, Yan, Chen, Guo, Lu, Congcong, Midgley, Adam C., Li, Changhua, Bian, Xin, Liao, Xudong, Wang, Yong, Xiong, Wei, Zhu, Hongying, Li, Yanjun, and Chen, Quan

Published
2024
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48. Optimal reliability ensemble averaging approach for robust climate projections over China.

Author

Gao, Yiyan, Yu, Zhongbo, Zhou, Minpei, Ju, Qin, Wen, Lei, and Huang, Tangkai

Subjects
*CLIMATE change, *TWENTY-first century, *TEMPERATURE, *ECOSYSTEMS
Abstract

Accurate simulation and reliable projection of temperature and precipitation over China under climate change is important for proposing adaptation measures for future natural ecosystems. This study proposes a novel method to construct an optimal reliability ensemble averaging (REA) subset from the Coupled Model Intercomparison Project Phase 6 (CMIP6) based on their historical performance in simulating temperature and precipitation across different subregions. The optimal REA ensemble outperforms the multi‐model ensemble mean (MMEM) and single optimal model in reproducing the spatial patterns of historical annual mean temperature and precipitation over China from 1985 to 2014. Under the examined Shared Socioeconomic Pathway scenarios (SSP1‐2.6, SSP2‐4.5 and SSP5‐8.5), the REA projects persistent warming and increased precipitation towards the end of the 21st century, intensifying under higher emissions. Nationwide mean temperature rises of 1.39, 2.69 and 5.05°C, and precipitation increases of 9%, 10% and 20% are projected in the long‐term (2081–2100) relative to 1995–2014 under SSP1‐2.6, SSP2‐4.5 and SSP5‐8.5 scenarios, respectively. Northwestern China and the Tibetan Plateau are expected to experience amplified warming and precipitation increases, respectively. Compared to the MMEM, the REA generally indicates reduced warming but larger precipitation increases, especially over the Tibetan Plateau under higher‐emissions scenarios. The REA exhibits lower projection uncertainty than the MMEM for both temperature and precipitation, primarily attributed to reduced internal variability. The novel optimal framework for REA shows the potential for extracting robust regional climate information applicable to different subregions of China. This study may contribute to new comprehension of future climate change over China. [ABSTRACT FROM AUTHOR]

Published
2024
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49. A DNA Force Circuit for Exploring Protein‐Protein Interactions at the Single‐Molecule Level†.

Author

Ma, Kangkang, Xiong, Luoan, Wang, Zhuofei, Hu, Xin, Qu, Lihua, Zhao, Xuetong, Li, Yao, and Yu, Zhongbo

Subjects
PROTEIN-protein interactions, BIOCONJUGATES, DRUG discovery, MAGNETIC force microscopy, ATOMIC force microscopy, GENETIC code
Abstract

Comprehensive Summary: Protein‐protein interactions (PPIs) play a crucial role in drug discovery and disease treatment. However, the development of effective drugs targeting PPIs remains challenging due to limited methodologies for probing their spatiotemporal anisotropy. Here, we propose a single‐molecule approach using a unique force circuit to investigate PPI dynamics and anisotropy under mechanical forces. Unlike conventional techniques, this approach enables the manipulation and real‐time monitoring of individual proteins at specific amino acids with defined geometry, offering insights into molecular mechanisms at the single‐molecule level. The DNA force circuit was constructed using click chemistry conjugation methods and genetic code expansion techniques, facilitating orthogonal conjugation between proteins and nucleic acids. The SET domain of the MLL1 protein and the tail of histone H3 were used as a model system to demonstrate the application of the DNA force circuit. With the use of atomic force microscopy and magnetic tweezers, optimized assembly procedures were developed. The DNA force circuit provides an exceptional platform for studying the anisotropy of PPIs and holds promise for advancing drug discovery research targeted at PPIs. [ABSTRACT FROM AUTHOR]

Published
2024
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