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Objectives: To develop and validate a novel method for quantifying the efficacy of Bevacizumab (Bev) in treating Recurrent Respiratory Papillomatosis (RRP), and to evaluate the clinical outcomes of a three‐dose Bev induction therapy followed by surgical intervention. Methods: Twenty‐one RRP patients treated with a three‐dose Bev regimen were included. A novel efficacy evaluation method using ImageJ software was developed to calculate the standardized lesion volume from laryngoscopic images. This was compared with the Derkay score. Clinical outcomes, including reduction rate, cumulative reduction rate, efficacy grading, recurrence, and adverse reactions, were analyzed. Results: In the study cohort, the reduction rate was significantly higher after the first treatment compared with subsequent treatments. The overall response rate increased from 75% after the first treatment to 100% after the third. Among patients with localized lesions who underwent surgery, 76% experienced recurrence with a mean recurrence time of 114.23 days. Most recurrent lesions were smaller than at baseline. Adverse reactions included increased blood pressure in seven patients, which resolved without intervention. The new method showed a significant positive correlation with the Derkay score. Conclusion: In conclusion, based on the above findings, systemic Bev treatment for RRP is a safe and effective therapeutic approach, though further research is needed. Moreover, the new efficacy evaluation method we developed can significantly aid in studying the effectiveness of Bev treatment for RRP. Level of Evidence: 2 Laryngoscope, 135:257–262, 2025 [ABSTRACT FROM AUTHOR]

Objective: Whether ligation or reconstruction should be performed after radical resection of the tumor and carotid artery in patients with head and neck cancers invading the carotid artery (HNC‐CA) has been controversial. This paper provides a review and meta‐analysis of the efficacy of these 2 modalities. Data Sources: PubMed, Cochrane, Web of Science, Scopus, and Ovid databases were searched through August 2023. Review Methods: Descriptive, graphical, tabular, and quantitative data were extracted. The statistical outcomes (risk difference, RD) were synthesized under a random‐effects model. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐analyses reporting guidelines. Results: A total of 22 papers and 337 patients met the inclusion criteria for the literature review. Statistical analysis showed that the RD of overall survival (OS) rate at 1‐year was 32% (95% confidence interval [CI]: 21%‐42%) for ligation and 70% (95% CI: 65%‐76%) for reconstruction (P <.05). The RD for OS rate at 2‐year was 16% (95% CI: 7%‐26%) for ligation and 39% (95% CI: 30%‐47%) for reconstruction (P <.05). The RD for disease‐free survival rate at 1‐year was 27% (95% CI: 17%‐38%) for ligation and 60% (95% CI: 51%‐70%) for reconstruction (P <.05). There were no statistically significant differences (P >.05) between the 2 surgical modalities in terms of locoregional recurrence rate, carotid blowout rate, surgery‐related complications rate, neurological complications rate, and perioperative mortality rate. Conclusion: This review demonstrates the significant advantage of carotid artery reconstruction surgery in short‐term patient survival, thus making it a recommended option for HNC‐CA patients undergoing radical surgery. [ABSTRACT FROM AUTHOR]

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Background: Laryngeal leukoplakia (LL) is a white lesion with high potential of recurrence and malignant transformation. Currently, CO2 laser has become the primary surgical treatment for LL, and the recurrence and malignant transformation rates after treatment vary widely. Objective: We performed a systematic review and meta‐analysis dedicated to evaluating the rates of recurrence and malignant transformation of LL lesions treated with CO2 laser and exploring relevant risk factors for recurrence or malignant transformation. Methods: Literature searches were conducted on ProQuest, PubMed, Web of Science, Ovid Medline, Embase, and Cochrane databases. Some articles identified through hand searching were included. Results: A total of 14 articles and 1462 patients were included in this review. Pooled results showed that the overall recurrence rate was 15%, and the malignant transformation rate was 3%. Subgroup analysis showed that the dysplasia grade was not a significant risk factor for the recurrence and malignant transformation of LL (P >.05). Conclusions: The results of this systematic review and meta‐analysis suggest that the CO2 laser is a safe and effective surgical instrument for the excision of LL, which yields low rates of recurrence and malignant transformation. The risk factors relevant to recurrence or malignant transformation remain unclear and require further investigation. [ABSTRACT FROM AUTHOR]

This article explores the treatment of arytenoid dislocation, a condition that can cause voice problems. The study emphasizes the importance of accurate preoperative evaluation, including CT scans and electromyography, to determine the severity of the dislocation. The researchers developed a reduction clamp to assist with the surgical procedure, which involved manipulating the arytenoid cartilage. The study concludes that early diagnosis and surgical intervention are crucial for voice recovery in patients with arytenoid dislocation. [Extracted from the article]