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2. Mini-Proceedings of the 'Fourth International Workshop on the Extension Project for the J-PARC Hadron Experimental Facility (HEF-ex 2024)'

Author

Achenbach, P., Aoki, K., Aoki, S., Curceanu, C., Diehl, S., Doi, T., Endo, M., Fujita, M., Fukuda, T., Garcia-Tecocoatzi, H., Geng, L. S., Gunji, T., Hanhart, C., Harada, M., Harada, T., Hayakawa, S., He, B. R., Hiyama, E., Honda, R., Ichikawa, Y., Isaka, M., Jido, D., Jinno, A., Kamada, K., Kamiya, Y., Kong, Y. K., Liu, Z. W., Lu, J. X., Miwa, K., Mizutani, K., Murakami, K., Muto, R., Murase, K., Nagao, S., Nanamura, T., Nanjo, H., Nara, Y., Ohnishi, A., Qiu, J. W., Sakaguchi, A., Sakuma, F., Santopinto, E., Scordo, A., Sekihara, T., Seong, C., Shevchenko, N. V., Stone, J. R., Strakovsky, I., Suzuki, K., Takahashi, H., Takizawa, M., Tamura, H., Tomida, N., Umeya, A., Doce, O. Vázquez, Yamagata-Sekihara, J., Yamamoto, T. O., Xiao, Y., Yin, Z., Yu, Z., and Zou, B. S.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

The mini proceedings of the "Fourth International Workshop on the Extension Project for the J-PARC Hadron Experimental Facility (HEF-ex 2024) [https://kds.kek.jp/event/46965]" held at J-PARC, February 19-21, 2024, are presented. The workshop was devoted to discussing the physics case that connects both the present and the future Hadron Experimental Facility at J-PARC, covering a wide range of topics in flavor, hadron, and nuclear physics related to both experimental and theoretical activities being conducted at the facility.

Published
2024

3. White Paper on Polarized Target Studies with Real Photons in Hall D

Author

Afzal, F., Dalton, M. M., Deur, A., Hurck, P., Keith, C. D., Mathieu, V., Sirca, S., and Yu, Z.

Subjects
Nuclear Experiment
Abstract

This white paper summarizes the Workshop on Polarized Target Studies with Real Photons in Hall D at Jefferson Lab, that took place on 21 February 2024. The Workshop included about 45 participants both online and in person at Florida State University in Tallahassee. Contributions describe the experimental infrastructure available in Hall D and potential physics applications. The rate and detection capabilities of Hall D are outlined, as well as the properties of a circularly polarized photon beam and a polarized target. Possible physics measurements include light and strange quark baryon spectroscopy, the GDH sum rule, proton structure accessed through measurement of Generalized Parton Distributions and modification of nucleon structure within the nuclear medium., Comment: 25 pages, 8 figures

Published
2024

4. Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay

Author

Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative $\overline{\nu}_{e}$ rates and energy spectra variation among the near and far detectors gives $\mathrm{sin}^22\theta_{13} = 0.0759_{-0.0049}^{+0.0050}$ and $\Delta m^2_{32} = (2.72^{+0.14}_{-0.15})\times10^{-3}$ eV$^2$ assuming the normal neutrino mass ordering, and $\Delta m^2_{32} = (-2.83^{+0.15}_{-0.14})\times10^{-3}$ eV$^2$ for the inverted neutrino mass ordering. This estimate of $\sin^2 2\theta_{13}$ is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields $\mathrm{sin}^22\theta_{13}= 0.0833\pm0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.

Published
2024
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5. OzDES Reverberation Mapping Program: Stacking analysis with H$\beta$, Mg II and C IV

Author

Malik, Umang, Sharp, Rob, Penton, A., Yu, Z., Martini, P., Tucker, B. E., Davis, T. M., Lewis, G. F., Lidman, C., Aguena, M., Alves, O., Annis, J., Asorey, J., Bacon, D., Brooks, D., Rosell, A. Carnero, Carretero, J., Cheng, T. -Y., da Costa, L. N., Pereira, M. E. S., De Vicente, J., Doel, P., Ferrero, I., Frieman, J., Giannini, G., Gruen, D., Gruendl, R. A., Hinton, S. R., Hollowood, D. L., James, D. J., Kuehn, K., Marshall, J. L., Mena-Fernández, J., Menanteau, F., Miquel, R., Ogando, R. L. C., Palmese, A., Pieres, A., Malagón, A. A. Plazas, Reil, K., Romer, A. K., Sanchez, E., Schubnell, M., Smith, M., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Weaverdyck, N., and Wiseman, P.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Reverberation mapping is the leading technique used to measure direct black hole masses outside of the local Universe. Additionally, reverberation measurements calibrate secondary mass-scaling relations used to estimate single-epoch virial black hole masses. The Australian Dark Energy Survey (OzDES) conducted one of the first multi-object reverberation mapping surveys, monitoring 735 AGN up to $z\sim4$, over 6 years. The limited temporal coverage of the OzDES data has hindered recovery of individual measurements for some classes of sources, particularly those with shorter reverberation lags or lags that fall within campaign season gaps. To alleviate this limitation, we perform a stacking analysis of the cross-correlation functions of sources with similar intrinsic properties to recover average composite reverberation lags. This analysis leads to the recovery of average lags in each redshift-luminosity bin across our sample. We present the average lags recovered for the H$\beta$, Mg II and C IV samples, as well as multi-line measurements for redshift bins where two lines are accessible. The stacking analysis is consistent with the Radius-Luminosity relations for each line. Our results for the H$\beta$ sample demonstrate that stacking has the potential to improve upon constraints on the $R-L$ relation, which have been derived only from individual source measurements until now., Comment: 20 pages, 15 figures. Accepted by MNRAS

Published
2024
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6. Search for a sub-eV sterile neutrino using Daya Bay's full dataset

Author

An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains $5.55 \times 10^{6}$ reactor \anue candidates identified as inverse beta-decay interactions followed by neutron-capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with $\sin^2 2\theta_{14} \gtrsim 0.01$ can be excluded at 95\% confidence level in the region of $0.01$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.1 $ eV$^2$. This result represents the world-leading constraints in the region of $2 \times 10^{-4}$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.2 $ eV$^2$., Comment: 7 pages, 4 figures, 1 table

Published
2024

8. First measurement of the yield of $^8$He isotopes produced in liquid scintillator by cosmic-ray muons at Daya Bay

Author

Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

Daya Bay presents the first measurement of cosmogenic $^8$He isotope production in liquid scintillator, using an innovative method for identifying cascade decays of $^8$He and its child isotope, $^8$Li. We also measure the production yield of $^9$Li isotopes using well-established methodology. The results, in units of 10$^{-8}\mu^{-1}$g$^{-1}$cm$^{2}$, are 0.307$\pm$0.042, 0.341$\pm$0.040, and 0.546$\pm$0.076 for $^8$He, and 6.73$\pm$0.73, 6.75$\pm$0.70, and 13.74$\pm$0.82 for $^9$Li at average muon energies of 63.9~GeV, 64.7~GeV, and 143.0~GeV, respectively. The measured production rate of $^8$He isotopes is more than an order of magnitude lower than any other measurement of cosmogenic isotope production. It replaces the results of previous attempts to determine the ratio of $^8$He to $^9$Li production that yielded a wide range of limits from 0 to 30\%. The results provide future liquid-scintillator-based experiments with improved ability to predict cosmogenic backgrounds.

Published
2024

9. Charged-current non-standard neutrino interactions at Daya Bay

Author

Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

The full data set of the Daya Bay reactor neutrino experiment is used to probe the effect of the charged current non-standard interactions (CC-NSI) on neutrino oscillation experiments. Two different approaches are applied and constraints on the corresponding CC-NSI parameters are obtained with the neutrino flux taken from the Huber-Mueller model with a $5\%$ uncertainty. For the quantum mechanics-based approach (QM-NSI), the constraints on the CC-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ are extracted with and without the assumption that the effects of the new physics are the same in the production and detection processes, respectively. The approach based on the weak effective field theory (WEFT-NSI) deals with four types of CC-NSI represented by the parameters $[\varepsilon_{X}]_{e\alpha}$. For both approaches, the results for the CC-NSI parameters are shown for cases with various fixed values of the CC-NSI and the Dirac CP-violating phases, and when they are allowed to vary freely. We find that constraints on the QM-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ from the Daya Bay experiment alone can reach the order $\mathcal{O}(0.01)$ for the former and $\mathcal{O}(0.1)$ for the latter, while for WEFT-NSI parameters $[\varepsilon_{X}]_{e\alpha}$, we obtain $\mathcal{O}(0.1)$ for both cases., Comment: 25 pages, 16 figures, 6 tables; 36 pages, format changed, references added

Published
2024

14. Identifying the spin trapped character of the $^{32}$Si isomeric state

Author

Williams, J., Hackman, G., Starosta, K., Lubna, R. S., Choudhary, Priyanka, Srivastava, P. C., Andreoiu, C., Annen, D., Asch, H., Badanage, M. D. H. K. G., Ball, G. C., Beuschlein, M., Bidaman, H., Bildstein, V., Coleman, R., Garnsworthy, A. B., Greaves, B., Leckenby, G., Karayonchev, V., Martin, M. S., Natzke, C., Petrache, C. M., Radich, A., Raleigh-Smith, E., Rhodes, D., Russell, R., Satrazani, M., Spagnoletti, P., Svensson, C. E., Tam, D., Wu, F., Yates, D., and Yu, Z.

Subjects
Nuclear Experiment
Abstract

The properties of a nanosecond isomer in $^{32}$Si, disputed in previous studies, depend on the evolution of proton and neutron shell gaps near the `island of inversion'. We have placed the isomer at 5505.2(2) keV with $J^{\pi} = 5^-$, decaying primarily via an $E3$ transition to the $2^+_1$ state. The $E3$ strength of 0.0841(10) W.u. is unusually small and suggests that this isomer is dominated by the $(\nu d_{3/2})^{-1} \otimes (\nu f_{7/2})^{1}$ configuration, which is sensitive to the $N=20$ shell gap. A newly observed $4^+_1$ state is placed at 5881.4(13) keV; its energy is enhanced by the $Z=14$ subshell closure. This indicates that the isomer is located in a `yrast trap', a feature rarely seen at low mass numbers., Comment: Accepted, Physical Review C

Published
2023

15. Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. XIII. Ultraviolet Time Lag of H$\beta$ Emission in Mrk 142

Author

Khatu, V. C., Gallagher, S. C., Horne, K., Cackett, E. M., Hu, C., Pasquini, S., Hall, P., Wang, J. -M., Bian, W. -H., Li, Y. -R., Bai, J. -M., Chen, Y. -J., Du, P., Goad, M., Jiang, B. -W., Li, S. -S., Songsheng, Y. -Y., Wang, C., Xiao, M., and Yu, Z.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We performed a rigorous reverberation-mapping analysis of the broad-line region (BLR) in a highly accreting ($L/L_{\mathrm{Edd}}=0.74-3.4$) active galactic nucleus, Markarian 142 (Mrk 142), for the first time using concurrent observations of the inner accretion disk and the BLR to determine a time lag for the $H\beta$ $\mathrm{\lambda}$4861 emission relative to the ultraviolet (UV) continuum variations. We used continuum data taken with the Niel Gehrels Swift Observatory in the UVW2 band, and the Las Cumbres Observatory, Dan Zowada Memorial Observatory, and Liverpool Telescope in the g band, as part of the broader Mrk 142 multi-wavelength monitoring campaign in 2019. We obtained new spectroscopic observations covering the $H\beta$ broad emission line in the optical from the Gemini North Telescope and the Lijiang 2.4-meter Telescope for a total of 102 epochs (over a period of eight months) contemporaneous to the continuum data. Our primary result states a UV-to-$H\beta$ time lag of $8.68_{-0.72}^{+0.75}$ days in Mrk 142 obtained from light-curve analysis with a Python-based Running Optimal Average algorithm. We placed our new measurements for Mrk 142 on the optical and UV radius-luminosity relations for NGC 5548 to understand the nature of the continuum driver. The positions of Mrk 142 on the scaling relations suggest that UV is closer to the "true" driving continuum than the optical. Furthermore, we obtain $\log(M_{\bullet}/M_{\odot}) = 6.32\pm0.29$ assuming UV as the primary driving continuum., Comment: 35 pages, 12 figures, 11 tables, accepted for publication in ApJ

Published
2023

16. Rapid Detection of SLCO1B1 Polymorphisms Using Duplex Fluorescence Melting Curve Analysis: Implications for Personalized Drug Dosing in Clinical Settings

Author

Yu Z, Shang Z, Huang Q, Wu H, and Patil S

Subjects
slco1b1, melting curve analysis, gene polymorphism, drug delivery, Therapeutics. Pharmacology, RM1-950
Abstract

Zhikang Yu,1,2,* Zifang Shang,1,2,* Qingyan Huang,3 Heming Wu,4 Sandip Patil5,6 1Institute of Basic Medical Sciences, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, 514031, People’s Republic of China; 2Guangdong Engineering Technological Research Center of Clinical Molecular Diagnosis and Antibody Drugs, Meizhou Academy of Medical Sciences, Meizhou, 514031, People’s Republic of China; 3Institute of Cardiovascular Disease, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, Guangdong, 514031, People’s Republic of China; 4Meizhou Municipal Engineering and Technology Research Centre for Molecular Diagnostics of Major Genetic Disorders, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, 514031, People’s Republic of China; 5Department of Hematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, 518038, People’s Republic of China; 6Paediatric Research Institute, Shenzhen Children’s Hospital, Shenzhen, 518038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Heming Wu; Sandip Patil, Email wuheming@mzrmyy.com; sandippatil1309@yahoo.comObjective: The polymorphism of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene exerts a marked influence on drug transport, thus playing a pivotal role in personalized drug dosing. This study endeavours to establish a rapid, precise, and straightforward method for detecting SLCO1B1 genetic variants utilizing Duplex Fluorescence Melting Curve Analysis (DFMCA).Methods: Whole blood samples were collected from 54 individuals from Meizhou People’s Hospital (2023.01– 2023.03), with a mean age of 58.90 years (SD = 7.86), including 28 men and 26 women. DNA was extracted from these samples and subjected to PCR amplification targeting two allelic regions. Primers, fluorescent probes, and corresponding allelic target sequences were designed specifically for two common SLCO1B1 polymorphisms (rs2306283 and rs4149056). The functionality of the fluorescent probes in binding to their respective allelic targets was verified using melting curve analysis, enabling the identification of distinct melting temperatures for different genotypes. Subsequently, DFMCA was employed to differentiate genotypes based on the melting temperature shifts of the corresponding fluorescent probes. The sensitivity, accuracy, and consistency of the method were evaluated, with sequencing validation performed on a subset of samples.Results: DFMCA facilitated the concurrent detection and accurate genotyping of both polymorphisms within 2 hours, demonstrating concordance with sequencing results from randomly selected samples. Importantly, stable detection performance was achieved for human genomic DNA at concentrations ≥ 3.125 ng. In a cohort comprising Han Chinese individuals from southern China, the allele frequencies for rs2306283 (A: 28.7%, G: 71.3%) and rs4149056 (T: 88.89%, C: 11.11%) concurred well with previous studies in the Han Chinese population.Conclusion: The SNP typing system utilizing DFMCA technology presents advantages in terms of speed, ease of use, accuracy, and cost-effectiveness, making it a suitable tool.Keywords: SLCO1B1, melting curve analysis, gene polymorphism, drug delivery

Published
2024

17. ABO Blood Type and Pretreatment Systemic Inflammatory Response Index Associated with Lymph Node Metastasis in Patients with Breast Cancer

Author

Xiong N, Han W, and Yu Z

Subjects
breast cancer, lymph node metastasis, system inflammation response index, abo blood group, Medicine (General), R5-920
Abstract

Nating Xiong,1 Wendao Han,1 Zhikang Yu2,3 1Department of Blood Transfusion, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Institute of Basic Medical Sciences, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 3Guangdong Engineering Technological Research Center of Clinical Molecular Diagnosis and Antibody Drugs, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Zhikang Yu, Institute of Basic Medical Sciences, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China, Email 392244719@qq.comBackground: Lymph node metastasis (LNM) is an important prognostic factor for breast cancer. Inflammatory stimulation can change tumor microenvironment and lead to LNM, but the relationship between LNM and peripheral immunoinflammatory indices has not been clarified in breast cancer.Methods: The clinical information of 1918 patients with breast cancer admitted to Meizhou People’s Hospital from October 2017 to December 2023 were retrospectively analyzed. The relationship of clinicopathological features (age, body mass index (BMI), ABO blood types, family history of cancer, tumor site, disease stage, LNM, distant metastasis, and molecular subtypes) and peripheral immunoinflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) were analyzed.Results: There were 935 (48.7%) patients had no LNM and 983 (51.3%) had LNM. There were statistically significant differences in the distributions of ABO blood groups (p=0.022) and molecular subtypes (p< 0.001) between the two groups. PIV, SII, and SIRI levels in patients with LNM were significantly higher than those without LNM (all p< 0.05). The proportions of LNM in patients with high PIV, SII, and SIRI levels were higher than those with low PIV, SII, and SIRI levels, respectively. Logistic regression analysis showed that non-O blood type (non-O blood type vs O blood type, odds ratio (OR): 1.327, 95% confidence interval (CI): 1.056– 1.667, p=0.015), luminal B subtype (luminal B vs luminal A, OR: 2.939, 95% CI: 2.147– 4.022, p< 0.001), HER2+ subtype (HER2+ vs luminal A, OR: 2.044, 95% CI: 1.388– 3.009, p< 0.001), and high SIRI level (≥ 0.875 vs < 0.875, OR: 1.572, 95% CI: 1.092– 2.265, p=0.015) were independently associated with LNM.Conclusion: Non-O blood type, luminal B and HER2+ subtypes, and high SIRI level (≥ 0.875) have potential role in predicting the status of LNM in breast cancer patients.Keywords: breast cancer, lymph node metastasis, system inflammation response index, ABO blood group

Published
2024

18. Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Locally Advanced Gastric Cancer

Author

Yu Z, Liu H, Li R, Hu L, Xiao C, Gao Y, Li P, Liang W, Zhou S, and Zhao X

Subjects
locally advanced gastric cancer, lymph node metastasis, clinicopathological factors, nomogram., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Zhiyuan Yu,1– 3,&ast; Haopeng Liu,4,&ast; Rui Li,1– 3,&ast; Liai Hu,3 Chun Xiao,5 Yunhe Gao,2 Peiyu Li,1– 3 Wenquan Liang,2 Sixin Zhou,2 Xudong Zhao2 1Medical School of Chinese PLA, Beijing, People’s Republic of China; 2Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3School of Medicine, Nankai University, Tianjin, People’s Republic of China; 4Department of Hepatobiliary Surgery, Zhangqiu District People’s Hospital, Jinan, Shandong Province, People’s Republic of China; 5Department of General Surgery, PLA Rocket Force Characteristic Medical Center, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xudong Zhao; Sixin Zhou, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing, 100853, People’s Republic of China, Email 601489554@qq.com; 35060555@qq.comBackground: The research on lymph node metastasis (LNM) in locally advanced gastric cancer (LAGC) infiltrating the subserous tissue and serous membrane (T3-4a) is significantly inadequate. This study aims to explore the clinicopathological factors related to LNM in stages T3 and T4a LAGC, while also developing predictive nomograms.Methods: After systematic searching and rigorous screening, 1995 T3 and 1244 T4a LAGC cases who underwent surgery without neoadjuvant or perioperative chemotherapy were selected. The risk factors associated with LNM were identified using both univariate and multivariate logistic regression analyses. Subsequently, the independent variables identified through the multivariate analyses were utilized to construct a nomogram.Results: The incidence of LNM in T3 and T4a LAGC was 77.1% (1539/1995) and 83.8% (1043/1244), respectively. The following factors were found to be independently associated with LNM in T3 LAGC: preoperative serum albumin < 41g/L (P=0.007), gastrointestinal obstruction (P< 0.001), tumor location (P=0.040), tumor size > 4cm (P=0.002), mixed (P=0.001) and undifferentiated histological types (P=0.002), presence of lymphovascular invasion (LVI) (P< 0.001) and nerve invasion (P< 0.001). Additionally, in T4a LAGC cases, serum albumin < 39g/L (P=0.004), tumor size > 6cm (P=0.020), mixed (P< 0.001) and undifferentiated histological types (P< 0.001), presence of gastrointestinal hemorrhage (P=0.016), neuroendocrine differentiation (P=0.024), and LVI (P< 0.001) independently influenced the occurrence of LNM.Conclusion: This study identified the risk factors associated with LNM in T3-4a LAGC cases and constructed nomograms, thereby providing valuable guidance for formulating and implementing a multidisciplinary perioperative treatment program.Keywords: locally advanced gastric cancer, lymph node metastasis, clinicopathological factors, nomogram

Published
2024

19. Mechanisms of Antiphage Defense in Prokaryotes

Author

А. D. Daudova, Yu. Z. Demina, R. O. Abdrakhmanova, G. R. Baeva, T. S. Rubalskaia, A. L. Yasenyavskaya, O. V. Rubalsky, and M. A. Samotrueva

Subjects
bacteriophage, phage infection, drug resistance, lysogeny, pseudolysogeny, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The globalization of the problem of the formation of bacterial strains poly- and pan-resistant to known antimicrobial drugs creates high risks in the healthcare sector. The threat of a return to the «pre-antibiotic» era dictates the need to search for alternative forms of antibacterial therapy. Phage therapy, based on the use of a natural, widely distributed in the environment, accessible antimicrobial agent, is again becoming relevant. The article highlights the mechanisms of antiviral protection of prokaryotes at various stages of interaction between the virus and the target cell. Revealing the secrets of the confrontation between bacteria and viruses, their co-evolution is necessary to increase the effectiveness of phage therapy and develop modern means of overcoming bacterial resistance to antimicrobial agents.

Published
2024
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20. Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy

Author

Peng H, Jiang Q, Mao W, Hu Z, Wang Q, Yu Z, Zhang L, Wang X, Zhuang C, Mai J, Wang Z, and Sun T

Subjects
hcofs, pdt, ros, hypoxia, ferroptosis, cancer cells, Medicine (General), R5-920
Abstract

Hui Peng,1,2,&ast; Qian Jiang,1,&ast; Wenhao Mao,1,3,&ast; Zhonglan Hu,1,&ast; Qi Wang,4 Zhuo Yu,1 Li Zhang,1 Xinyan Wang,5 Chunbo Zhuang,1 Jia Mai,6 Zhiyuan Wang,7 Ting Sun1 1Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 2Center for Clinical Laboratory, General Hospital of the Yangtze River Shipping Wuhan Brain Hospital, Wuhan, Hubei, 430010, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 4Department of Pharmacy, Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng, 475000, People’s Republic of China; 5Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 6Department of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 7Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ting Sun, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China, Email sunting@zzu.edu.cn Zhiyuan Wang, Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China, Email wangzhiy@zzu.edu.cnBackground: The hypoxic tumor microenvironment and single mechanisms severely limit the photodynamic therapy (PDT) efficiency of covalent organic framework (COF) nanoparticles in cancer treatment.Purpose: Here, we propose an iron-loaded, hydrophilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000)-modified hollow covalent organic framework (HCOF), Fe-HCOF-PEG2000, for use in hypoxic PDT and ferroptosis therapy owing to its type I and II photodynamic ability and iron nanoparticle loading property.Results: Fe-HCOF-PEG2000 nanoparticles (Fe-HCOFs-PEG2000) with semiconducting polymers and microporous skeletons allow efficient photophysical properties. Moreover, the iron nanoparticles on Fe-HCOF-PEG2000 caused ferroptosis and further enhanced tumor elimination under normoxic and hypoxic conditions. DSPE-PEG2000 endowed Fe-HCOF-PEG2000 with hydrophilicity, allowing it to circulate and accumulate in organs rich in blood supply, especially tumors. 808 nm NIR activated Fe-HCOF-PEG2000 aggregated in tumors and significantly inhibited tumor growth under hypoxia.Conclusion: To our knowledge, Fe-HCOF-PEG2000 is the leading combination of type I/II PDT and ferroptosis. The strong antitumor effects of this nanomaterial suggest prospects for clinical translation as a tumor nanotherapy drug. Keywords: HCOFs, PDT, ROS, hypoxia, ferroptosis, cancer cells

Published
2024

21. Population Pharmacokinetics of Tigecycline for Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

Author

Song S, Liu J, Su W, Yu H, Feng B, Wu Y, Guo F, and Yu Z

Subjects
tigecycline, population pharmacokinetics, critically ill, continuous renal replacement therapy., Therapeutics. Pharmacology, RM1-950
Abstract

Shuping Song,1,&ast; Jieqiong Liu,2,3,&ast; Wei Su,1 Haitao Yu,4 Binbin Feng,1 Yinshan Wu,1 Feng Guo,1 Zhenwei Yu2 1Intensive Care Unit, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 3Department of Pharmacy, The 903rd Hospital of PLA Joint Logistic Support Force, Hangzhou, People’s Republic of China; 4Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Feng Guo; Zhenwei Yu, Email 3408003@zju.edu.cn; yzw_srrsh@zju.edu.cnBackground: Tigecycline is considered one of the last resorts for treating infections caused by multidrug-resistant bacteria. Continuous renal replacement therapy (CRRT) is widely used in critically ill patients, especially those with acute kidney injury or severe infections. However, pharmacokinetic data for tigecycline in patients receiving CRRT are limited.Methods: This was a single-center prospective clinical study with intensive sampling that included critically ill patients who received tigecycline and CRRT. A population pharmacokinetic (PPK) model was developed and evaluated by goodness-of-fit plots, bootstrap analysis, visual predictive checks, and numerical predictive checks. Pharmacokinetic/pharmacodynamic target attainment and cumulative fraction of response analyses were performed to explore the potential need for dose adjustments of tigecycline in CRRT.Results: In total, 21 patients with 167 concentrations were included. A two-compartment model adequately described the tigecycline concentration–time points, but no covariates were found to adequately explain the viability in the pharmacokinetic parameters of tigecycline. The typical values of CL, Q, V1 and V2 were 4.42 L/h, 34.8 L/h, 30.9 L and 98.7 L, respectively. For most infections, the standard regimen of 50 mg/12 h was deemed appropriate, expect for skin and soft skin tissue infections and community-acquired pneumonia caused by Acinetobacter baumannii and Klebsiella pneumoniae, which required a dosage regimen of 100 mg/12 h or higher.Conclusion: A tigecycline PPK model describing critically ill patients undergoing CRRT was successfully developed. The optimized dosage regimens for various infections are recommended.Keywords: tigecycline, population pharmacokinetics, critically ill, continuous renal replacement therapy

Published
2024

26. NvDEx-100 Conceptual Design Report

Author

Cao, X., Chang, Y., Chen, K., Ciuffoli, E., Duan, L., Fang, D., Gao, C., Ghorui, S. K., Hu, P., Hu, Q., Huang, S., Huang, Z., Lang, L., Li, Y., Li, Z., Liang, T., Liu, J., Lu, C., Mai, F., Mei, Y., Qiu, H., Sun, X., Tang, X., Wang, H., Wang, Q., Xiao, L., Xiao, M., Xin, J., Xu, N., Yang, P., Yang, Y., Yang, Z., Yu, Z., Zhang, D., Zhang, J., Zhao, C., and Zhu, D.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Observing nuclear neutrinoless double beta (0vbb) decay would be a revolutionary result in particle physics. Observing such a decay would prove that the neutrinos are their own antiparticles, help to study the absolute mass of neutrinos, explore the origin of their mass, and may explain the matter-antimatter asymmetry in our universe by lepton number violation. We propose developing a time projection chamber (TPC) using high-pressure 82SeF6 gas and top-metal silicon sensors for read-out in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of 82Se, called the NvDEx experiment. Besides being located at CJPL with the world's thickest rock shielding, NvDEx combines the advantages of the high Qbb (2.996 MeV) of 82Se and the TPC's ability to distinguish signal and background events using their different topological characteristics. This makes NvDEx unique, with great potential for low-background and high-sensitivity 0vbb searches. NvDEx-100, a NvDEx experiment phase with 100 kg of SeF6 gas, is being built, with plans to complete installation at CJPL by 2025. This report introduces 0vbb physics, the NvDEx concept and its advantages, and the schematic design of NvDEx-100, its subsystems, and background and sensitivity estimation.

Published
2023
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27. Theoretical Domains Framework: A Bibliometric and Visualization Analysis from 2005-2023

Author

Zhou Y, Huang Y, Wang Y, Xu X, Yu Z, and Gu Y

Subjects
theoretical domains framework, bibliometric analysis, visualization, implementation science, Medicine (General), R5-920
Abstract

Yiwen Zhou,1,&ast; Yuyan Huang,1,&ast; Yingwen Wang,2 Xiaofeng Xu,1 Zhuowen Yu,1 Ying Gu3 1Department of Gastroenterology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 201102, People’s Republic of China; 2Centre for Clinical Practice Guideline Production and Evaluation, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 201102, People’s Republic of China; 3Nursing Department, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 201102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Gu, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 201102, People’s Republic of China, Email guying0128@aliyun.com Zhuowen Yu, Department of Gastroenterology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 201102, People’s Republic of China, Email yzw100@126.comBackground: The Theoretical Domains Framework (TDF) is among the most extensively utilised foundational frameworks in implementation science. It was developed from 33 psychological theories, with the latest version identifying 14 domains encompassing 84 theoretical constructs. These domains and constructs capture the complexity of factors that affect behaviours, making the framework a valuable tool for designing and implementing interventions within health and social care settings.Objective: To summarise the development, hot topics, and future trends in TDF-related research and provide implementation practitioners with more information on the application of TDF.Methods: We used TDF as the topic and searched the ISI Web of Science Core Collection, identifying 1382 relevant publications. We used analytical tools such as Excel, Tableau, VOSviewer, and Citespace to conduct a bibliometric analysis of the relevant publication.Results: We identified the United Kingdom as the primary contributor, with University College London as the key institution. Susan Michie ranked highest in total citations. The analysis highlighted cancer and stroke as primary clinic medicine-related topics using TDF. Emerging themes encompass abuse, violence, maternal health, antenatal care, patient involvement, and trauma-informed care et al. “Nurse” and “qualitative research” emerged as recent and enduring hotspots, possibly indicating future research trends.Conclusion: This article represents the first attempt to summarise the TDF using bibliometric analysis. We suggest this method can be used to analyse other theoretical frameworks in scientific implementation of its objectivity and quantifiability. Overall, the application scope of TDF is shifting from public health towards more specialised clinical directions, although its application in the field of public health is continuously expanding. In the future, the number of users of TDF is also expected to expand from implementation scientists to professional technical personnel.Keywords: theoretical domains framework, bibliometric analysis, visualization, implementation science

Published
2024

28. Cross-Lagged Panel Networks of Sleep Inertia Across Its Distinct Change Patterns Among Intern Nurses with Shift Work in China

Author

Ma Z, Fan Y, Yu Z, Wu W, Zhang X, Li H, Zhao S, Li Y, Wang D, and Fan F

Subjects
sleep inertia, change patterns, network structures, intern nurse, shift work, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Zijuan Ma,1,&ast; Yunge Fan,1,&ast; Zhijun Yu,1 Wenxuan Wu,1 Xiangting Zhang,1 Huolian Li,1 Shaochen Zhao,2 Yang Li,3 Yuanyuan Li,4 Dongfang Wang,1 Fang Fan1 1Center for Studies of Psychological Application, School of Psychology, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People’s Republic of China; 2Research Center for Guangdong-Hong Kong-Macao Policing Model Innovation, China People’s Police University, Guangzhou, People’s Republic of China; 3Department of Educational Psychology, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 4Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dongfang Wang; Fang Fan, School of Psychology, South China Normal University, Shipai Road, Guangzhou, 510631, People’s Republic of China, Email wdfpsyc@126.com; fangfan@scnu.edu.cnPurpose: Although experimental psychopathology using PET, EEG, and fMRI is at the forefront of understanding the underlying mechanisms of sleep inertia, many questions concerning causality remain unanswerable due to ethical constraints and the use of small and heterogeneous samples in experimental methods. There is a pressing need for a novel perspective in a large and relatively homogeneous population to fully capture and elucidate longitudinal processes and dynamic causality that culminate in episodes of sleep inertia over time. Therefore, this study aimed to reveal the causal relationships between symptoms of sleep inertia across its distinct patterns.Patients and Methods: A total of 1636 intern nurses participated in the first survey (94.1% validity rate), then 1277 intern nurses were followed up (82.9% tracing rate). Symptoms of sleep inertia were self-reported using the Sleep Inertia Questionnaire. The cross-lagged panel network models were used to examine unique longitudinal relationships between symptoms of sleep inertia across distinct trajectories.Results: Four distinct trajectories of sleep inertia were established. Additionally, we found differences in those symptoms with the highest influence on other symptoms at the subsequent point across the networks of four trajectories, particularly, “Difficulty in concentrating” in the persistent-high group and “Feeling tense” in the deteriorating groups.Conclusion: The current study highlights changes in sleep inertia based on the long-term course over time. Notably, symptoms of “Difficulty in concentrating” and “Feeling tense” are imperative to address these specific symptoms within subpopulations.Keywords: sleep inertia, change patterns, network structures, intern nurse, shift work

Published
2024

29. Development and Validation of Diagnostic Models for Transcriptomic Signature Genes for Multiple Tissues in Osteoarthritis

Author

Gao Q, Ma Y, Shao T, Tao X, Yang X, Li S, Gu J, and Yu Z

Subjects
osteoarthritis, machine learning, immune cells infiltration, diagnostic model, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Qichang Gao,1 Yiming Ma,1 Tuo Shao,1 Xiaoxuan Tao,2 Xiansheng Yang,1 Song Li,1 Jiaao Gu,1 Zhange Yu1 1Department of Spinal Surgery, The 1st Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Radiotherapy, The 3st Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Zhange Yu, Email yuzhange1967@163.comBackground: Progress in research on expression profiles in osteoarthritis (OA) has been limited to individual tissues within the joint, such as the synovium, cartilage, or meniscus. This study aimed to comprehensively analyze the common gene expression characteristics of various structures in OA and construct a diagnostic model.Methods: Three datasets were selected: synovium, meniscus, and knee joint cartilage. Modular clustering and differential analysis of genes were used for further functional analyses and the construction of protein networks. Signature genes with the highest diagnostic potential were identified and verified using external gene datasets. The expression of these genes was validated in clinical samples by Real-time (RT)-qPCR and immunohistochemistry (IHC) staining. This study investigated the status of immune cells in OA by examining their infiltration.Results: The merged OA dataset included 438 DEGs clustered into seven modules using WGCNA. The intersection of these DEGs with WGCNA modules identified 190 genes. Using Least Absolute Shrinkage and Selection Operator (LASSO) and Random Forest algorithms, nine signature genes were identified (CDADC1, PPFIBP1, ENO2, NOM1, SLC25A14, METTL2A, LINC01089, L3HYPDH, NPHP3), each demonstrating substantial diagnostic potential (areas under the curve from 0.701 to 0.925). Furthermore, dysregulation of various immune cells has also been observed.Conclusion: CDADC1, PPFIBP1, ENO2, NOM1, SLC25A14, METTL2A, LINC01089, L3HYPDH, NPHP3 demonstrated significant diagnostic efficacy in OA and are involved in immune cell infiltration.Keywords: osteoarthritis, machine learning, immune cells infiltration, diagnostic model

Published
2024

30. Unveiling Unexpected Selfless Collectivism: Exploring Variances in Moral Beliefs Across Cultural Values

Author

Yang D, Yu Z, and He X

Subjects
collectivism, individualism, moral beliefs, pro-social behavior, selflessness, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Danni Yang, Zhao Yu, Xianyou He Center for Studies of Psychological Application, South China Normal University, Guangzhou, People’s Republic of ChinaCorrespondence: Xianyou He, Email xianyouhe@163.comPurpose: The impact of moral beliefs on individuals’ moral judgments, particularly within the framework of contrasting cultural values such as collectivism and individualism, continues to be a subject of interest. This research delves into whether individuals with distinct values display differences in moral beliefs, with a specific focus on selflessness.Methods: Through experiment 1 and 2, we scrutinize the moral judgments of individuals with diverse values concerning pro-social behaviors driven by selflessness and in-group favoritism. Experiment 3 investigates the underlying mechanisms by examining reward expectations.Results: The findings from experiments 1 and 2 indicate that collectivists exhibit significantly higher moral judgment levels for selfless pro-social behaviors compared to individualists, highlighting a disparity in moral beliefs between the two value systems. Experimental 2 also found that collectivists’ moral judgments rose and fell as rescuers’ selflessness increased or decreased. However, individualist moral judgment did not change significantly with behavioral selflessness. The results reveal that collectivists hold higher reward expectations for selfless behavior, which contributes to their heightened moral judgment of selfless behavior.Conclusion: While it may be assumed that collectivists’ moral beliefs would be dominated by in-group preferences, aligning with the conceptual in-group preference of collectivism, this study unexpectedly found evidence of collectivists’ pursuit of selflessness in their moral beliefs. These findings offer initial evidence of distinct patterns of moral beliefs associated with collectivism and individualism, shedding light on potential reasons that lead collectivists to possess stronger moral beliefs about selflessness.Keywords: collectivism, individualism, moral beliefs, pro-social behavior, selflessness

Published
2024

31. Adequacy of the Dosing and Infusion Time of Ceftazidime/Avibactam for the Treatment of Gram-Negative Bacterial Infections: A PK/PD Simulation Study

Author

Han Y, Zhu J, Liu J, Zheng Y, Liang G, Yang Y, Yu L, Yu Z, and Han G

Subjects
ceftazidime, avibactam, pharmacokinetic/pharmacodynamic, probability of target attainment., Infectious and parasitic diseases, RC109-216
Abstract

Yun Han,1,&ast; Jianping Zhu,1,&ast; Jieqiong Liu,2 Ying Zheng,2 Gang Liang,1 Yi Yang,1 Lingyan Yu,3 Zhenwei Yu,1 Gang Han1 1Research Center for Clinical Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of China; 2The 903rd Hospital of PLA Joint Logistic Support Force, Hangzhou, People’s Republic of China; 3Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhenwei Yu; Gang Han, Email yzw_srrsh@zju.edu.cn; 3199022@zju.edu.cnIntroduction: Recent studies suggested the potential benefits of extended infusion times to optimize the treatment efficacy of ceftazidime/avibactam, which indicated that the current pharmacokinetic/pharmacodynamic (PK/PD) target may not be sufficient, especially for severe infections. The purpose of this study is to assess the adequacy of dosing strategies and infusion durations of ceftazidime/avibactam when applying higher PK/PD targets.Methods: This study utilized published PK parameters to conduct Monte Carlo simulations. Different dosages including the recommended regimen based on renal function were simulated and evaluated by the probability of target attainment (PTA) and cumulative fraction of response (CFR). Different PK/PD targets were set for ceftazidime and avibactam. MIC distributions from various sources were used to calculate the CFR.Results: Multiple PK/PD targets have been set in this study, All recommended dosage could easily achieve the target of 50%fT ≥ MIC (ceftazidime) and 50%fT ≥ CT=1.0 mg/L (avibactam). However, for severe infection patients with normal renal function and augmented renal clearance at the recommended dosage (2000 mg/500 mg, every 8 hours), the infusion duration needs to be extended to 3 hours and 4 hours to achieve the targets of 100%fT ≥ MIC and 100%fT ≥ CT=1.0 mg/L. Only continuous infusion at higher dosages achieved 100%fT ≥ 4×MIC and 100%fT ≥ CT=4.0 mg/L targets to all currently recommended regimens. According to the varying MIC distributions, higher concentrations are needed for Pseudomonas aeruginosa, with the attainment rates vary across different regions.Conclusion: The current recommended dosing regimen of ceftazidime/avibactam is insufficient for severe infection patients, and continuous infusion is suggested.Keywords: ceftazidime, avibactam, pharmacokinetic/pharmacodynamic, probability of target attainment

Published
2024

32. A Nomogram Based on Clinicopathological Characteristics for Estimating the Risk of Brain Metastasis from Advanced Gastric Cancer: A Multi-Center Retrospective Clinical Study

Author

Zhang L, Yu Z, Zhang Y, Wang H, Cheng J, and Shi C

Subjects
brain metastasis, gastric cancer, nomogram, risk factors, Therapeutics. Pharmacology, RM1-950
Abstract

Li Zhang,1,2 Zimu Yu,3 Yunfeng Zhang,1 Hengyu Wang,4,5 Juntao Cheng,6 Chao Shi1 1Department of Oncology, Gaoxin Branch Of The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2First School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330031, People’s Republic of China; 3Medical College of Zhengzhou University, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China; 4Queen Mary College, Nanchang University, Nanchang, 330031, People’s Republic of China; 5School of Biological and Biomedical Sciences, Queen Mary University of London, London, UK; 6Peking University First Hospital, Peking University, Beijing, 100034, People’s Republic of ChinaCorrespondence: Chao Shi, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 151 7049 8679, Email ndyfy4540@ncu.edu.cnPurpose: Although brain metastasis (BM) from gastric cancer (GC) is relatively uncommon, its incidence has been increasing owing to advancements in treatment modalities. Unfortunately, patients diagnosed with BM from gastric cancer have poor life expectancy. Our study aims to establish a predictive model for brain metastasis in advanced gastric cancer patients, thus enabling the timely diagnosis of brain metastasis.Patients and Methods: The clinicopathological features of a cohort which included 40 GC patients with brain metastasis, 32 of whom from the First Affiliated Hospital of Nanchang University, 2 from Gaoxin Branch of the First Affiliated Hospital of Nanchang University, remaining 6 from Anyang District Hospital, and 80 non-metastatic advanced GC patients from the First Affiliated Hospital of Nanchang University between 2018 and 2022. Data were retrospectively analyzed.Results: Age, tumor size, differentiation, lymph node grade, tumor location, Lauren classification, liver metastasis, carbohydrate antigen 199 (CA199), lactate dehydrogenase (LDH), and human epidermal growth factor receptor 2 (Her-2) were associated with BM. A nomogram integrated with nine risk factors (tumor size, differentiation, lymph node grade, tumor location, Lauren classification, liver metastasis, CA-199, LDH, and Her-2) showed good performance (Area Under Curve 0.95, 95% CI: 0.91– 0.98).Conclusion: We developed and validated a nomogram that achieved individualized prediction of the possibility of BM from GC. This model enables personalized imaging review schedules for timely brain metastasis detection in advanced gastric cancer patients.Keywords: brain metastasis, gastric cancer, nomogram, risk factors

Published
2024

33. Survival Benefit of Synchronous Lenvatinib Combined PD-1 Inhibitors for Advanced Hepatocellular Carcinoma Beyond Oligometastasis

Author

Xu K, Xiang C, Yu Z, Li J, and Liu C

Subjects
lenvatinib, pd-1 inhibitor, hepatocellular carcinoma beyond oligometatases, simultaneous, prognosis., Immunologic diseases. Allergy, RC581-607
Abstract

Kaiwu Xu,1 Cailing Xiang,1 Zhige Yu,1 Jia Li,2 Changjun Liu2 1Department of Gastrointestinal Surgery, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan Province, 410005, People’s Republic of China; 2Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan Province, 410005, People’s Republic of ChinaCorrespondence: Changjun Liu, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), 61 Jiefang West Road, Changsha, Hunan Province, 410005, People’s Republic of China, Tel +86-0731-83928052, Email liuchangjun712@163.comPurpose: Strategies therapy for hepatocellular carcinoma (HCC) beyond oligometastasis are limited. The optimal sequence of systemic treatment for advanced HCC is not yet clear. Our study aims to evaluate the effectiveness of simultaneous lenvatinib combined PD-1 inhibitor on advanced HCC beyond oligometastasis.Patients and Methods: A total of 232 patients were enrolled in our retrospective study. Patients divided into three groups. (a) Lenvatinib plus simultaneous PD-1 inhibitor (Simultaneous group, n=58); (b) patients received PD-1 inhibitor before the tumor progression with continued lenvatinib administration (Before PD group, n=77); (c) patients received PD-1 inhibitor after the tumor progression (After PD group, n=97). To analyze overall survival (OS) and progression-free survival (PFS) among the three groups.Results: The estimated 6-, 12-, 18- and 24-mon OS for Simultaneous group patients were 100%, 93.1%, 63.4%, 48.3%, whereas the OS rates were 100%, 78%, 36.3%, 23.6% in Before PD group, and 99%, 61.2%, 22.1%, 7.5% in After PD group. The OS rates were obviously improved with the use of simultaneous PD-1 inhibitor among the three groups (P < 0.001). The estimated 3-, 6-, 9- and 12-month PFS rates for patients were 89.6%, 44.8%, 24.6%, 6% in After PD group, 90.9%, 59.7%, 27.3%, 12.4% in Before PD group and 98.3%, 81%, 51.7%, 39.7% in Simultaneous group, respectively. PFS rate was significantly different among the three groups (P < 0.001).Conclusion: Synchronous administration of lenvatinib and PD-1 inhibitors improved survival rate significantly. The synchronous combination could represent a promising strategy in HCC beyond oligometastasis.Keywords: lenvatinib, PD-1 inhibitor, hepatocellular carcinoma beyond oligometastasis, simultaneous, prognosis

Published
2024

34. Periductal Mastitis, a Disease with Distinct Clinicopathological Features from Granulomatous Lobular Mastitis

Author

Zhou F, Liu L, Wang F, Yu L, Xiang Y, Zheng C, Huang S, Yang Z, and Yu Z

Subjects
etiology, granulomatous lobular mastitis, immunology, pathology, periductal mastitis, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Fei Zhou,1,2 Liyuan Liu,1,2 Fei Wang,1,2 Lixiang Yu,1,2 Yujuan Xiang,1,2 Chao Zheng,1,2 Shuya Huang,1,2 Zhen Yang,1 Zhigang Yu1,2 1Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 2Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, Shandong, 250033, People’s Republic of ChinaCorrespondence: Zhigang Yu, Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, People’s Republic of China, Tel +86-531-85875048, Email yzg@medmail.com.cnPurpose: Periductal mastitis (PDM) is a chronic inflammatory lesion of the breast with an unknown etiology, and it is difficult for clinicians to differentiate it from granulomatous lobular mastitis (GLM), although they have different treatment strategies and prognosis. This study aimed to investigate the differences in their clinicopathologic features to inform treatment strategies.Patients and Methods: Between 2011 and 2020, 121 patients diagnosed with PDM and 57 patients with GLM were retrospective analysis. Patient data were extracted on demographics, clinical presentation, pathologic characteristics, treatments and clinical response. Histopathological evaluations were performed on core needle biopsy specimens. Immunohistochemical stains using antibodies against CD3, CD4, CD8, CD20, and CD138 was performed to define immune cell infiltration.Results: PDM patients had a higher median age compared to GLM patients (38 vs 32, p< 0.001). PDM was primarily located in the areolar area, while GLM predominantly affected the peripheral quadrant of the breast (56.20% vs 75.44%, p< 0.001). Histopathologically, more ductal dilatation (90.08% vs 3.51%, p< 0.001), ductal wall thickening (47.93% vs 1.75%, p< 0.001), and ductal rupture (44.63% vs 5.26%, p< 0.001) were observed in PDM. GLM presented with significantly more granuloma (94.74% vs 10.74%, p< 0.001), microabscess (68.42% vs 28.93%, p< 0.001), and lipid vacuole (40.35% vs 8.26%, p< 0.001) formation than PDM. Immunohistochemical analysis revealed a significant presence of CD20+ B lymphocytes in PDM and a higher prevalence of CD8+ T lymphocytes in GLM, indicating differing immune responses. Treatment outcomes varied, with PDM patients responding well to surgery and anti-mycobacterial therapy, while GLM patients showed favorable responses to steroid therapy.Conclusion: PDM is a specific entity with a similar clinical presentation but distinct histopathological features and immune profiles to GLM. Further research is needed to elucidate the pathogenesis and optimize therapeutic approaches for these breast inflammatory conditions.Keywords: etiology, granulomatous lobular mastitis, immunology, pathology, periductal mastitis

Published
2024

35. Machine Learning Tools to Assist the Synthesis of Antibacterial Carbon Dots

Author

Bian Z, Bao T, Sun X, Wang N, Mu Q, Jiang T, Yu Z, Ding J, Wang T, and Zhou Q

Subjects
carbon dots, machine learning, antibacterial, minimum inhibitory concentration, classification algorithms, Medicine (General), R5-920
Abstract

Zirui Bian,1,&ast; Tianzhe Bao,2,&ast; Xuequan Sun,3,4 Ning Wang,1 Qian Mu,5 Ting Jiang,6 Zhongxiang Yu,6 Junhang Ding,2 Ting Wang,7 Qihui Zhou2 1Department of Bone, Huangdao District Central Hospital, Qingdao, People’s Republic of China; 2Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, People’s Republic of China; 3Weifang Eye Institute, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, People’s Republic of China; 4Zhengda Guangming International Eye Research Center, Qingdao Zhengda Guangming Eye Hospital, Qingdao University, Qingdao, People’s Republic of China; 5Department of Biomaterials, LongScience Biological (Qingdao) Co, LTD, Qingdao, People’s Republic of China; 6Heart Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao University, Qingdao, People’s Republic of China; 7Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qihui Zhou; Junhang Ding, Tel +86-17660670299, Email qihuizhou@uor.edu.cn; dingjunhang@uor.edu.cnIntroduction: The emergence and rapid spread of multidrug-resistant bacteria (MRB) caused by the excessive use of antibiotics and the development of biofilms have been a growing threat to global public health. Nanoparticles as substitutes for antibiotics were proven to possess substantial abilities for tackling MRB infections via new antimicrobial mechanisms. Particularly, carbon dots (CDs) with unique (bio)physicochemical characteristics have been receiving considerable attention in combating MRB by damaging the bacterial wall, binding to DNA or enzymes, inducing hyperthermia locally, or forming reactive oxygen species.Methods: Herein, how the physicochemical features of various CDs affect their antimicrobial capacity is investigated with the assistance of machine learning (ML) tools.Results: The synthetic conditions and intrinsic properties of CDs from 121 samples are initially gathered to form the raw dataset, with Minimum inhibitory concentration (MIC) being the output. Four classification algorithms (KNN, SVM, RF, and XGBoost) are trained and validated with the input data. It is found that the ensemble learning methods turn out to be the best on our data. Also, &epsiv;-poly(L-lysine) CDs (PL-CDs) were developed to validate the practical application ability of the well-trained ML models in a laboratory with two ensemble models managing the prediction.Discussion: Thus, our results demonstrate that ML-based high-throughput theoretical calculation could be used to predict and decode the relationship between CD properties and the anti-bacterial effect, accelerating the development of high-performance nanoparticles and potential clinical translation. Keywords: carbon dots, machine learning, antibacterial, minimum inhibitory concentration, classification algorithms

Published
2024

36. Issues and Solutions in Psychiatric Clinical Trial with Case Studies

Author

Chen X, Chen J, Zhao X, Mu R, Tan H, and Yu Z

Subjects
clinical efficacy assessment, clinical trials, mental health, research design, statistical analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Xiaochen Chen,1,&ast; Jun Chen,2,&ast; Xue Zhao,2 Rongji Mu,1 Hongsheng Tan,1 Zhangsheng Yu1,3 1Clinical Research Institute & School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hongsheng Tan, Clinical Research Institute & School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China, Email tanhs@shsmu.edu.cn Zhangsheng Yu, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 210240, People’s Republic of China, Email yuzhangsheng@sjtu.edu.cnAbstract: The coronavirus disease-2019 pandemic resulted in a major increase in depression and anxiety disorders worldwide, which increased the demand for mental health services. However, clinical interventions for treating mental disorders are currently insufficient to meet this growing demand. There is an urgent need to conduct scientific and standardized clinical research that are consistent with the features of mental disorders in order to deliver more effective and safer therapies in the clinic. Our study aimed to expose the challenges, complexities of study design, ethical issues, sample selection, and efficacy evaluation in clinical research for mental disorders. The reliance on subjective symptom presentation and rating scales for diagnosing mental diseases was discovered, emphasizing the lack of clear biological standards, which hampers the construction of rigorous research criteria. We underlined the possibility of psychotherapy in efficacy evaluation alongside medication treatment, proposing for a multidisciplinary approach comprising psychiatrists, neuroscientists, and statisticians. To comprehend mental disorders progression, we recommend the development of artificial intelligence integrated evaluation tools, the use of precise biomarkers, and the strengthening of longitudinal designs. In addition, we advocate for international collaboration to diversity samples and increase the dependability of findings, with the goal of improving clinical research quality in mental disorders through sample representativeness, accurate medical history gathering, and adherence to ethical principles.Keywords: clinical efficacy assessment, clinical trials, mental health, research design, statistical analysis

Published
2024

37. Intrinsic minimum average variance estimation for sufficient dimension reduction with symmetric positive definite matrices and beyond

Author

Chen, B., Dai, S., and Yu, Z.

Subjects
Statistics - Methodology
Abstract

In this paper, we target the problem of sufficient dimension reduction with symmetric positive definite matrices valued responses. We propose the intrinsic minimum average variance estimation method and the intrinsic outer product gradient method which fully exploit the geometric structure of the Riemannian manifold where responses lie. We present the algorithms for our newly developed methods under the log-Euclidean metric and the log-Cholesky metric. Each of the two metrics is linked to an abelian Lie group structure that transforms our model defined on a manifold into a Euclidean one. The proposed methods are then further extended to general Riemannian manifolds. We establish rigourous asymptotic results for the proposed estimators, including the rate of convergence and the asymptotic normality. We also develop a cross validation algorithm for the estimation of the structural dimension with theoretical guarantee Comprehensive simulation studies and an application to the New York taxi network data are performed to show the superiority of the proposed methods., Comment: 35 pages, 4 tables, 2 figures

Published
2023

38. Reactor neutrino physics potentials of cryogenic pure-CsI crystal

Author

Wang, L., Li, G. d., Yu, Z. Y., Liang, X. H., Wang, T. A., Liu, F., Sun, X. L., Guo, C., Zhang, X., Yu, L., and Chen, Y. D.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This paper presents a world-leading scintillation light yield among inorganic crystals measured from a 0.5~kg pure-CsI detector operated at 77 Kelvin. Scintillation photons were detected by two 2-inch Hamamatsu SiPM arrays equipped with cryogenic front-end electronics. Benefiting the light yield enhancement of pure-CsI at low temperatures and the high photon detection efficiency of SiPM, a light yield of 30.1 photoelectrons per keV energy deposit was obtained for X-rays and $\gamma$-rays with energies from 5.9~keV to 59.6~keV. Instrumental and physical effects in the light yield measurement are carefully analyzed. This is the first stable cryogenic operation of kg-scale pure-CsI crystal readout by SiPM arrays at liquid nitrogen temperatures for several days. The world-leading light yield opens a door for the usage of pure-CsI crystal in several fields, particularly in detecting the coherent elastic neutrino-nucleus scattering of reactor neutrinos. The potential of using pure-CsI crystals in neutrino physics is discussed in the paper., Comment: 10 pages, 16 figures

Published
2022

39. Upper limits on the isotropic diffuse flux of cosmic PeV photons from Carpet-2 observations

Author

Dzhappuev, D. D., Afashokov, Yu. Z., Dzaparova, I. M., Dzhatdoev, T. A., Gorbacheva, E. A., Karpikov, I. S., Khadzhiev, M. M., Klimenko, N. F., Kudzhaev, A. U., Kurenya, A. N., Lidvansky, A. S., Mikhailova, O. I., Petkov, V. B., Podlesnyi, E. I., Pozdnukhov, N. A., Romanenko, V. S., Rubtsov, G. I., Troitsky, S. V., Unatlokov, I. B., Vaiman, I. A., Yanin, A. F., and Zhuravleva, K. V.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Isotropic diffuse gamma-ray flux in the PeV energy band is an important tool for multimessenger tests of models of the origin of high-energy astrophysical neutrinos and for new-physics searches. So far, this flux has not yet been observed. Carpet-2 is an air-shower experiment capable of detecting astrophysical gamma rays with energies above 0.1 PeV. Here we report the upper limits on the isotropic gamma-ray flux from Carpet-2 data obtained in 1999-2011 and 2018-2022. These results, obtained with the new statistical method based on the shape of the muon-number distribution, summarize Carpet-2 observations as the upgraded installation, Carpet-3, starts its operation., Comment: 5 pages, 3 figures, JETPL.cls; V2: references added, version accepted by JETP Letters

Published
2022
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40. Precision measurement of reactor antineutrino oscillation at kilometer-scale baselines by Daya Bay

Author

Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Ding, X. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

We present a new determination of the smallest neutrino mixing angle ${\theta}_{13}$ and the mass-squared difference ${\Delta}{\rm m}^{2}_{32}$ using a final sample of $5.55 \times 10^{6}$ inverse beta-decay (IBD) candidates with the final-state neutron captured on gadolinium. This sample was selected from the complete data set obtained by the Daya Bay reactor neutrino experiment in 3158 days of operation. Compared to the previous Daya Bay results, selection of IBD candidates has been optimized, energy calibration refined, and treatment of backgrounds further improved. The resulting oscillation parameters are ${\rm sin}^{2}2{\theta}_{13} = 0.0851 \pm 0.0024$, ${\Delta}{\rm m}^{2}_{32} = (2.466 \pm 0.060) \times 10^{-3}{\rm eV}^{2}$ for the normal mass ordering or ${\Delta}{\rm m}^{2}_{32} = -(2.571 \pm 0.060) \times 10^{-3} {\rm eV}^{2}$ for the inverted mass ordering., Comment: 7 pages, 3 figures, 1 table, 10 supplementary files

Published
2022

41. OzDES Reverberation Mapping Program: H$\beta$ lags from the 6-year survey

Author

Malik, Umang, Sharp, Rob, Penton, A., Yu, Z., Martini, P., Lidman, C., Tucker, B. E., Davis, T. M., Lewis, G. F., Aguena, M., Allam, S., Alves, O., Andrade-Oliveira, F., Asorey, J., Bacon, D., Bertin, E., Bocquet, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Carollo, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., Pereira, M. E. S., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Everett, S., Ferrero, I., Frieman, J., García-Bellido, J., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Marshall, J. L., Mena-Fernández, J., Menanteau, F., Miquel, R., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Pieres, A., Malagón, A. A. Plazas, Raveri, M., Rodriguez-Monroy, M., Romer, A. K., Sanchez, E., Scarpine, V., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Taylor, G., Tucker, D. L., Weaverdyck, N., and Wilkinson, R. D.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Reverberation mapping measurements have been used to constrain the relationship between the size of the broad-line region and luminosity of active galactic nuclei (AGN). This $R-L$ relation is used to estimate single-epoch virial black hole masses, and has been proposed for use to standardise AGN to determine cosmological distances. We present reverberation measurements made with H$\beta$ from the six-year Australian Dark Energy Survey (OzDES) Reverberation Mapping Program. We successfully recover reverberation lags for eight AGN at $0.12

Published
2022
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43. The Prevalence and Risk Factors of Sexual Dysfunction in the Elderly in Southern China

Author

Yu Z, Niu J, and Wang C

Subjects
epidemiology, sexual dysfunction, elderly, prevalence, risk factor, Medicine (General), R5-920
Abstract

Zhenzhen Yu,1 Jianping Niu,1 Chen Wang2 1Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, People’s Republic of China; 2Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, People’s Republic of ChinaCorrespondence: Chen Wang, Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Zhenhai Road No. 55, Siming District, Xiamen, Fujian, 361000, People’s Republic of China, Email wangchen1986xm@163.com Jianping Niu, Department of Neurology, The Second Affiliated Hospital of Xiamen medical college, Shengguang Road No. 566, Jimei District, Xiamen, Fujian, 361000, People’s Republic of China, Email 549872685@qq.comObjective: This study aims to evaluate the epidemiological features of sexual dysfunction in people aged more than 65 years in parts of China, and to investigate the independent significant risk factors.Methods: According to the population distribution of five communities in Xiamen and Chongqing, we have randomly enrolled 2403 people more than 65 years-of-age. We collected data information through a questionnaire survey. Then demonstrated the current condition of sexual dysfunction in the samples by statistical analysis, and multivariable logistic regression was used to disclose the risk factors of sexual dysfunction in the older adults.Results: According to this study, about 10.48% of the elderly had sexual dysfunctions of different degrees and duration. The proportion of men was about twice that of women (14.5% of males and 7.3% of females). During the course of the disease, 3.19% (43/1344) of women and 3.31% (35/1059) of men had more than 15 years duration of sexual dysfunction. In severity, 5.7% (77/1344) of women and 7.0% (74/1059) of men had very severe sexual dysfunction. There were statistically significant differences in BMI, smoking, drinking history, hypertension, depression incidence or median (p< 0.05). Alcohol consumption history [OR = 1.711, 95% CI: 1.124– 2.604, p = 0.012] and depression [OR = 2.107, 95% CI: 1.109– 4.356, p =0.044] were independent risk factors for sexual dysfunction.Conclusion: The prevalence of sexual dysfunction was low among elderly in the southern part of China. But the course of the disease is long and the degree of the disease is very severe. Elderly with a history of drinking and depression are more prone to sexual dysfunction.Keywords: epidemiology, sexual dysfunction, elderly, prevalence, risk factor

Published
2024

44. The Relationship Between Psychological Conditions and Gastrointestinal Symptoms of Medical Students During the COVID-19 Pandemic

Author

Su Y, Lu N, Wang P, Li Q, Wen H, Zhang J, Fan L, Li J, Yu Z, Cui M, and Zhang M

Subjects
covid-19, health lockdown, gastrointestinal symptoms, anxiety, depression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Yuanyuan Su,1,* Ning Lu,2,* Pei Wang,3,* Qian Li,2 Hua Wen,2 Jie Zhang,2 Ling Fan,2 Jie Li,2 Zhaoxiang Yu,4 Manli Cui,2 Mingxin Zhang2 1Department of General Medicine, the People’s Hospital of Yubei District of Chongqing, Chongqing, People’s Republic of China; 2Department of Gastroenterology, the First Affiliated Hospital of Xi’an Medical College, Xi’an, Shaanxi, People’s Republic of China; 3Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, People’s Republic of China; 4Department of General Surgery, the First Affiliated Hospital of Xi’an Medical College, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Manli Cui, The First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, Email cuiml1587@163.com; Mingxin Zhang, The First Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, Email zmx3115@xiyi.edu.cn.Objective: This study aims to explore the nexus between students’ psychological well-being and the manifestation of gastrointestinal symptoms (GISs) amid the health lockdown enforced in Xi’an, focusing on the student populace of Xi’an Medical College and Shaanxi University of Traditional Chinese Medicine.Materials and methods: A survey encompassing psychological parameters and GISs was administered to a randomized cohort of 1327 college students drawn from Xi’an Medical College and Shaanxi University of Traditional Chinese Medicine. The survey instrument was developed utilizing the Questionnaire Star platform. Subsequent to data collection, analysis was performed using GraphPad Prism 9 and SPSS 22.0.Results: Comparative analysis revealed statistically significant disparities (P < 0.05) in various GISs between the periods during and preceding the health lockdown, encompassing symptoms such as nausea/vomiting, acid reflux, postprandial fullness/early satiety, anorexia, decreased appetite, bloating, abdominal discomfort, abdominal pain, diarrhea, and constipation. Notably, the mean score for Generalized Anxiety Disorder 7 (GAD-7) was 3.31± 3.92, indicating mild anxiety, while the mean score for Patient Health Questionnaire-2 (PHQ-2) was 1.15± 1.28, suggesting mild depression. Detailed evaluation of anxiety revealed prevalence rates of 34% among respondents, with 34.2% of these individuals reporting concurrent GISs, while among those evaluated for depression (38.8% of the sample), 44.2% reported concurrent GISs. Furthermore, multiple linear regression analysis unveiled a negative correlation between GISs during the health lockdown and lifestyle scores, while positive correlations were observed with GISs preceding the lockdown, anxiety, and depression. The formulated multiple linear regression equation for GISs during the health lockdown is delineated as follows: 14.693– 0.342 life style + 0.725GISs before health lockdown + 0.218anxiety + 0.564 depression.Conclusion: This investigation underscores the substantial impact of anxiety and depression on the student body, accentuating their role in precipitating GISs during health lockdown situations. The psychological well-being of medical students during exigent circumstances such as natural disasters warrants heightened attention, necessitating proactive measures aimed at emotional regulation to mitigate the onset of GISs.Keywords: COVID-19, health lockdown, gastrointestinal symptoms, anxiety, depression

Published
2024

45. A Novel Network Pharmacology Strategy Based on the Universal Effectiveness-Common Mechanism of Medical Herbs Uncovers Therapeutic Targets in Traumatic Brain Injury

Author

Yu Z, Ding R, Yan Q, Cheng M, Li T, Zheng F, Zhu L, Wang Y, Tang T, and Hu E

Subjects
traditional chinese medicine, medicinal plants, luteolin, azd3759, epidermal growth factor receptor, astrocyte, Therapeutics. Pharmacology, RM1-950
Abstract

Zhe Yu,1– 3 Ruoqi Ding,1– 3 Qiuju Yan,1– 3 Menghan Cheng,1– 3 Teng Li,1– 4 Fei Zheng,5 Lin Zhu,1– 4 Yang Wang,1– 4 Tao Tang,1– 4 En Hu1– 4 1Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2NATCM Key Laboratory of TCM Gan, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 3Center for Interdisciplinary Research in Traditional Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 4Xiangya Hospital, Central South University, Nanchang, Jiangxi, 330004, People’s Republic of China; 5The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410008, People’s Republic of ChinaCorrespondence: En Hu; Ruoqi Ding, Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China, Email znxyhe@csu.edu.cn; ruoqi_ding@outlook.comPurpose: Many herbs can promote neurological recovery following traumatic brain injury (TBI). There must lie a shared mechanism behind the common effectiveness. We aimed to explore the key therapeutic targets for TBI based on the common effectiveness of the medicinal plants.Material and methods: The TBI-effective herbs were retrieved from the literature as imputes of network pharmacology. Then, the active ingredients in at least two herbs were screened out as common components. The hub targets of all active compounds were identified through Cytohubba. Next, AutoDock vina was used to rank the common compound-hub target interactions by molecular docking. A highly scored compound-target pair was selected for in vivo validation.Results: We enrolled sixteen TBI-effective medicinal herbs and screened out twenty-one common compounds, such as luteolin. Ten hub targets were recognized according to the topology of the protein-protein interaction network of targets, including epidermal growth factor receptor (EGFR). Molecular docking analysis suggested that luteolin could bind strongly to the active pocket of EGFR. Administration of luteolin or the selective EGFR inhibitor AZD3759 to TBI mice promoted the recovery of body weight and neurological function, reduced astrocyte activation and EGFR expression, decreased chondroitin sulfate proteoglycans deposition, and upregulated GAP43 levels in the cortex. The effects were similar to those when treated with the selective EGFR inhibitor.Conclusion: The common effectiveness-based, common target screening strategy suggests that inhibition of EGFR can be an effective therapy for TBI. This strategy can be applied to discover core targets and therapeutic compounds in other diseases.Keywords: traditional Chinese medicine, medicinal plants, luteolin, AZD3759, epidermal growth factor receptor, astrocyte

Published
2024

46. Whole Genome Sequence Analysis of Two Oxacillin-Resistant and mecA-Positive Strains of Staphylococcus haemolyticus Isolated from Ear Swab Samples of Patients with Otitis Media

Author

Liu Z, Wang L, Sun J, Zhang Q, Peng Y, Tang S, Zhang L, Li X, Yu Z, and Zhang T

Subjects
staphylococcus haemolyticus, ear swabs, meca, antimicrobial resistance plasmid, whole genome sequence, Infectious and parasitic diseases, RC109-216
Abstract

Zhao Liu,1,&ast; Ling Wang,2,&ast; Jiabing Sun,1,&ast; Qinghuan Zhang,3 Yue Peng,1 Susu Tang,1 Limei Zhang,4 Xiaobin Li,4,5 Zhijian Yu,1 Tao Zhang6 1Department of Otolaryngology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, People’s Republic of China; 2Department of Obstetrics, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, 519000, People’s Republic of China; 3Department of Clinical Laboratory, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, 519000, People’s Republic of China; 4Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, People’s Republic of China; 5Zhuhai Precision Medical Center, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, People’s Republic of China; 6Department of Otolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Zhang; Zhijian Yu, Email 18045681156@163.com; yzjent@163.comObjective: Staphylococcus haemolyticus can cause a series of infections including otitis media (OM), and the oxacillin-resistant S. haemolyticus has become a serious health concern. This study aimed to investigate the genomic characteristics of two strains of oxacillin-resistant and mecA-positive S. haemolyticus isolated from the samples of ear swabs from patients with OM and explore their acquired antibiotic resistance genes (ARGs) and the mobile genetic elements (MGEs).Methods: Two oxacillin-resistant S. haemolyticus strains, isolated from ear swab samples of patients with OM, underwent antimicrobial susceptibility evaluation, followed by whole-genome sequencing. The acquired ARGs and the MGEs carried by the ARGs, harbored by the genomes of two strains of S. haemolyticus were identified.Results: The two strains of oxacillin-resistant S. haemolyticus (strain SH1275 and strain SH9361) both carried the genetic contexts of mecA with high similarity with the SCCmec type V(5C2& 5) subtype c. Surprisingly, the chromosomal aminoglycoside resistance gene aac(6’)-aph(2”) harbored by S. haemolyticus strain SH936 was flanked by two copies of IS 256, forming the IS 256-element (IS 256-GNAT-[aac(6’)-aph(2”)]-IS 256), which was widely present in strains of both Staphylococcus and Enterococcus genus. Furthermore, the two strains of oxacillin-resistant and MDR S. haemolyticus were found to harbor antimicrobial resistance plasmids, including one 26.9-kb plasmid (pSH1275-2) containing msr(A)–mph(C)) and qacA, one mobilizable plasmid pSH1275-3 harboring vga(A)LC, one plasmid (pSH9361-1) carrying erm(C), and one plasmid (pSH9361-2) carrying qacJ.Conclusion: The systematic analysis of whole-genome sequences provided insights into the mobile genetic elements responsible for multi-drug resistance in these two strains of oxacillin-resistant and mecA-positive S. haemolyticus, which will assist clinicians in devising precise, personalized, and clinical therapeutic strategies for treating otitis media caused by multi-drug resistant S. haemolyticus.Keywords: Staphylococcus haemolyticus, ear swabs, mecA, antimicrobial resistance plasmid, whole genome sequence

Published
2024

47. Coronary Artery Fistula and Severe Coronary Artery Stenosis: A Case Report and an Insight for Potential Pathogenesis of Coronary Artery Atherosclerosis

Author

Liu J, Yu Z, and Wang G

Subjects
coronary artery fistulae, atherosclerosis, pathogenesis, plaque healing, endothelial injury, Medicine (General), R5-920
Abstract

Jinchun Liu,1 Zhijun Yu,2,3 Guohua Wang2 1Department of Medicine, Henan Vocational College of Nursing, Anyang, Henan Province, 455000, People’s Republic of China; 2Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226019, People’s Republic of China; 3Department of Thoracic Surgery, Nantong Second People’s Hospital, Nantong, Jiangsu, 226001, People’s Republic of ChinaCorrespondence: Guohua Wang, Email wgh036@hotmail.comAbstract: Coronary artery fistulae (CAF) are a rare anomaly characterized by abnormal connections between a coronary artery and a cardiac chamber or a great vessel, with most patients remaining asymptomatic. Despite being predisposed to severe complications like heart failure, patients with CAF infrequently experience severe stenosis in the coronary artery. This study delineates a case involving a 46-year-old male presenting with a fistula bridging the right coronary artery (RCA) and right atrium (RA), manifesting a pronounced 99% stenosis at the right extremity of the coronary artery proximal to the fistula. Concurrently, the individual exhibits six conventional risk factors: age over 40, male gender, hypertension, diabetes, smoking, and hypertriglyceridemia. Following pharmaceutical intervention, the patient was discharged and subjected to extended follow-up. This case highlights the dual processes of “accelerating damage” and “retarding renewal” in the progression of atherosclerosis. Factors such as shear stress, smoking, and hypertension are posited to expedite endothelial cell damage, while aging and diabetes may impede the renewal and repair of these cells. Together with the concept of secondary atherosclerotic plaque healing, this case prompts the introduction of a “Double Endothelial Healings” hypothesis, proposing a potential pathogenetic mechanism for coronary artery atherosclerosis.Keywords: coronary artery fistulae, atherosclerosis, pathogenesis, plaque healing, endothelial injury

Published
2024

48. Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

Author

Guo Y, Yu Z, Tu H, Zheng B, Li J, and Liu Y

Subjects
very preterm birth, very low birth weight infant, vitamin d, 4 weeks of age, outcome, Pediatrics, RJ1-570
Abstract

Yanping Guo,1 Zhangbin Yu,2 Huiying Tu,2 Biying Zheng,1 Jiamin Li,1 Ying Liu1 1Department of Pediatrics, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Department of Neonatology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Yanping Guo; Ying Liu, Tel +86-15919990131 ; +86-13902992158, Email guoyanping1223@163.com; 13902992158@139.comBackground and Objectives: To examine the correlation between the concentration of vitamin D (VD) in venous blood at approximately 4 weeks of age (± 4 weeks of age) and neonatal outcomes in preterm infants (birth weight < 1500 g or gestational age < 32 weeks) in two neonatal intensive care units (NICUs) located in Shenzhen, China.Methods and Study Design: Preterm infants were split into two groups based on their VD concentration at ± 4 weeks of age: VD insufficiency (VDI) group (≤ 20 ng/mL) and VD sufficient (VDS) group (> 20 ng/mL). Binary logistic regression analysis was used to examine relationships between outcomes and VDI.Results: Of 230 infants in total, 119 (51.7%) were assigned to the VDI group and 111 to the VDS group (48.3%). No correlation was found between serum VD at ± 4 weeks of age and gestational age (p> 0.05). The starting point of the two groups for oral VD intake did not differ significantly (p> 0.05). At ± 4 weeks of age, oral VD dose (P< 0.05) was greater in the VDS group. Gestational diabetes mellitus was associated with VDI (OR=1.94, 95% CI 1.01– 3.75, p=0.047) after controlling for this risk. Following correction for gestational age and oral VD dosage at ± 4 weeks old, VDI was also linked to a significant risk of retinopathy of prematurity (OR=2.00, 95% CI 1.08– 3.68, p< 0.027).Conclusion: Preterm newborns (gestational age < 32 weeks or birth age < 1500 g) in NICUs in Shenzhen, China continue to have significantly high VDI. Higher VDI is associated with gestational diabetes mellitus and retinopathy of prematurity.Keywords: very preterm birth, very low birth weight infant, vitamin D, 4 weeks of age, outcome

Published
2024

49. Topological valley crystals in a photonic Su-Schrieffer-Heeger (SSH) variant

Author

Yu, Z., Lin, H., Zhou, R., Li, Z., Mao, Z., Peng, K., Liu, Y., and Shi, X.

Subjects
Physics - Optics
Abstract

Progress on two-dimensional materials has shown that valleys, as energy extrema in a hexagonal first Brillouin zone, provides a new degree of freedom for information manipulation. Then valley Hall topological insulators supporting such-polarized edge states on boundaries were set up accordingly. In this paper, a two-dimensional valley photonic crystal composed of six tunable dielectric triangular pillars in unit cells is proposed in the photonic sense of a deformed Su-Schrieffer-Heeger (SSH) model. We reveal the vortex nature of valley states and establish the selection rules for valley polarized states. Based on the valley topology, a rhombus-shaped beam splitter waveguide is designed to verify the valley-chirality selection above. Our numerical results entail that this topologically protected edge states still maintain robust transmission at sharp corners, henceforth providing a feasible idea for valley photonic devices in THz regime.

Published
2022
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50. OzDES Reverberation Mapping Program: Hβ lags from the 6-yr survey

Author

Malik, U, Sharp, R, Penton, A, Yu, Z, Martini, P, Lidman, C, Tucker, BE, Davis, TM, Lewis, GF, Aguena, M, Allam, S, Alves, O, Andrade-Oliveira, F, Asorey, J, Bacon, D, Bertin, E, Bocquet, S, Brooks, D, Burke, DL, Rosell, A Carnero, Carollo, D, Kind, M Carrasco, Carretero, J, Costanzi, M, da Costa, LN, Pereira, MES, De Vicente, J, Desai, S, Diehl, HT, Doel, P, Everett, S, Ferrero, I, Frieman, J, García-Bellido, J, Gerdes, DW, Gruen, D, Gruendl, RA, Gschwend, J, Hinton, SR, Hollowood, DL, Honscheid, K, James, DJ, Kuehn, K, Marshall, JL, Mena-Fernández, J, Menanteau, F, Miquel, R, Ogando, RLC, Palmese, A, Paz-Chinchón, F, Pieres, A, Malagón, AA Plazas, Raveri, M, Rodriguez-Monroy, M, Romer, AK, Sanchez, E, Scarpine, V, Sevilla-Noarbe, I, Smith, M, Soares-Santos, M, Suchyta, E, Swanson, MEC, Tarle, G, Taylor, G, Tucker, DL, Weaverdyck, N, and Wilkinson, RD

Subjects
Nuclear and Plasma Physics, Physical Sciences, galaxies: active, galaxies: nuclei, quasars: emission lines, quasars: general, quasars: supermassive black holes, Astronomical and Space Sciences, Astronomy & Astrophysics, Astronomical sciences, Particle and high energy physics, Space sciences
Abstract

Reverberation mapping measurements have been used to constrain the relationship between the size of the broad-line region and luminosity of active galactic nuclei (AGN). This R-L relation is used to estimate single-epoch virial black hole masses, and has been proposed to use to standardize AGN to determine cosmological distances. We present reverberation measurements made with Hβ from the 6-yr Australian Dark Energy Survey (OzDES) Reverberation Mapping Program. We successfully recover reverberation lags for eight AGN at 0.12 < z < 0.71, probing higher redshifts than the bulk of Hβ measurements made to date. Our fit to the R-L relation has a slope of α = 0.41 ± 0.03 and an intrinsic scatter of σ = 0.23 ± 0.02 dex. The results from our multi-object spectroscopic survey are consistent with previous measurements made by dedicated source-by-source campaigns, and with the observed dependence on accretion rate. Future surveys, including LSST, TiDES, and SDSS-V, which will be revisiting some of our observed fields, will be able to build on the results of our first-generation multi-object reverberation mapping survey.

Published
2023

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