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5. Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy

Author

Yu, Tingdong, primary, He, Yanan, additional, Chen, Haitao, additional, Lu, Xiaokai, additional, Ni, Huijing, additional, Ma, Yimin, additional, Chen, Yumei, additional, Li, Chen, additional, Cao, Run, additional, Ma, Liju, additional, Li, zhiyao, additional, Lei, Yujie, additional, Luo, Xiaomao, additional, and Zheng, Chenhong, additional

Published
2022
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6. Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition

Author

Mo, Shutian, primary, Fang, Dalang, additional, Zhao, Shuqi, additional, Thai Hoa, Pham Thi, additional, Zhou, Caifu, additional, Liang, Tianyi, additional, He, Yongfei, additional, Yu, Tingdong, additional, Chen, Yuanyuan, additional, Qin, Wei, additional, Han, Quanfa, additional, Su, Hao, additional, Zhu, Guangzhi, additional, Luo, Xiaoling, additional, Peng, Tao, additional, and Han, Chuangye, additional

Published
2022
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7. Intraoperative Indocyanine Green Retention Test of Left Hemiliver in Decision-Making for Patients With Hepatocellular Carcinoma Undergoing Right Hepatectomy

Author

Yu, Tingdong, primary, Ye, Xinping, additional, Wen, Zhang, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Han, Chuangye, additional, Huang, Ketuan, additional, Qin, Wei, additional, Liao, Xiwen, additional, Yang, Chengkun, additional, Liu, Zhen, additional, Wang, Xiangkun, additional, Xu, Banghao, additional, Su, Ming, additional, Lv, Zili, additional, Lau, Wan Yee, additional, and Peng, Tao, additional

Published
2021
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8. Genome-wide association study of the TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and infection with hepatitis B virus

Author

Han, Chuangye, primary, Yu, Tingdong, additional, Qin, Wei, additional, Liao, Xiwen, additional, Huang, Jianlu, additional, Liu, Zhengtao, additional, Yu, Long, additional, Liu, Xiaoguang, additional, Chen, Zhiwei, additional, Yang, Chengkun, additional, Wang, Xiangkun, additional, Mo, Shutian, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Li, Jiaquan, additional, Qin, Xue, additional, Gui, Ying, additional, Mo, Zengnan, additional, Li, Lequn, additional, and Peng, Tao, additional

Published
2020
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9. Genome-wide association study of TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and hepatitis B virus infection in Guangxi

Author

Han, Chuangye, primary, Yu, Tingdong, additional, Qin, Wei, additional, Liao, Xiwen, additional, Huang, Jianlu, additional, Liu, Zhengtao, additional, Yu, Long, additional, Liu, Xiaoguang, additional, Chen, Zhiwei, additional, Yang, Chengkun, additional, Wang, Xiangkun, additional, Mo, Shutian, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Mo, Zengnan, additional, and Peng, Tao, additional

Published
2020
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10. Establishment of a prognostic model for predicting short-term disease-free survival in cases of hepatitis B-related hepatocellular carcinoma with the TP53 249Ser mutation in southern China

Author

Qin, Wei, primary, Han, Chuangye, additional, Mai, Rongyun, additional, Yu, Tingdong, additional, Shang, Liming, additional, Ye, Xinping, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Liao, Xiwen, additional, Liu, Zhengtao, additional, Yu, Long, additional, Liu, Xiaoguang, additional, Yang, Chengkun, additional, Wang, Xiangkun, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2020
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11. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms

Author

Zhou, Xin, primary, Liao, Xiwen, additional, Wang, Xiangkun, additional, Huang, Ketuan, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Han, Quanfa, additional, Chen, Zijun, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ruan, Guotian, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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12. Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma

Author

Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Han, Chuangye, Deng, Jianlong, Yu, Tingdong, Yang, Chengkun, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Gong, Yizhen, Liu, Zhengtao, Huang, Jianly, Winkler, Cheryl A., O'Brien, Stephen J., Ye, Xinping, Peng, Tao, Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Han, Chuangye, Deng, Jianlong, Yu, Tingdong, Yang, Chengkun, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Gong, Yizhen, Liu, Zhengtao, Huang, Jianly, Winkler, Cheryl A., O'Brien, Stephen J., Ye, Xinping, and Peng, Tao

Abstract

Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients. Methods: All of the RNA- and miRNA-sequencing datasets of HCC were obtained from TCGA, and dysregulated RNAs between HCC tumors and the adjacent normal liver tissues were investigated by DESeq and edgeR algorithm. Survival analysis was used to confirm underlying prognostic indicators. Results: In the present study, we constructed a ceRNA network based on 16 differentially expressed genes (DEGs), 7 differentially expressed microRNAs and 34 differentially expressed long non-coding RNAs (DELs). Among these dysregulated RNAs, three DELs (AP002478.1, HTR2A-AS1, and ERVMER61-1) and six DEGs (enhancer of zeste homolog 2 [EZH2], kinesin family member 23 [KIF23], chromobox 2 [CBX2], centrosomal protein 55 [CEP55], cell division cycle 25A [CDC25A], and claspin [CLSPN]) were used for construct a prognostic signature for HCC overall survival (OS), and performed well in HCC OS (adjusted P<0.0001, adjusted hazard ratio = 2.761, 95% confidence interval = 1.838-4.147). Comprehensive survival analysis demonstrated that this prognostic signature may be act as an independent prognostic indicator of HCC OS. Functional assessment of these dysregulated DEGs in the ceRNA network and gene set enrichment of this prognostic signature suggest that both were enriched in the biological processes and pathways of the cell cycle, cell division and cell proliferation. Conclusions: Our current study constructed a ceRNA network for HCC, and developed a prognostic signature that may act as an independent indicator for HCC OS., QC 20190624

Published
2019
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13. Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

Author

Huang, Ketuan, Liao, Xiwen, Han, Chuangye, Wang, Xiangkun, Yu, Tingdong, Yang, Chengkun, Liu, Xiaoguang, Yu, Long, Chen, Zhiwei, Qin, Wei, Zhu, Guangzhi, Su, Hao, Liu, Zhengqian, Zeng, Xianmin, Zhou, Xin, Lu, Sicong, Huang, Jianlv, Liang, Yu, Liu, Zhengtao, Deng, Jianlong, Ye, Xinping, Peng, Tao, Huang, Ketuan, Liao, Xiwen, Han, Chuangye, Wang, Xiangkun, Yu, Tingdong, Yang, Chengkun, Liu, Xiaoguang, Yu, Long, Chen, Zhiwei, Qin, Wei, Zhu, Guangzhi, Su, Hao, Liu, Zhengqian, Zeng, Xianmin, Zhou, Xin, Lu, Sicong, Huang, Jianlv, Liang, Yu, Liu, Zhengtao, Deng, Jianlong, Ye, Xinping, and Peng, Tao

Abstract

Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC., QC 20190325

Published
2019
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14. Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma

Author

Liao, Xiwen, Yu, Tingdong, Yang, Chengkun, Huang, Ketuan, Wang, Xiangkun, Han, Chuangye, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Deng, Jianlong, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Liu, Junqi, Gong, Yizhen, Liu, Zhengtao, Huang, Jianlv, Lu, Lei, Ye, Xinping, Peng, Tao, Liao, Xiwen, Yu, Tingdong, Yang, Chengkun, Huang, Ketuan, Wang, Xiangkun, Han, Chuangye, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Deng, Jianlong, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Liu, Junqi, Gong, Yizhen, Liu, Zhengtao, Huang, Jianlv, Lu, Lei, Ye, Xinping, and Peng, Tao

Abstract

Objective: Our study is aim to explore potential key biomarkers and pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using genome-wide expression profile dataset and methods. Methods: Dataset from the GSE14520 is used as the training cohort and The Cancer Genome Atlas dataset as the validation cohort. Differentially expressed genes (DEGs) screening were performed by the limma package. Gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), gene ontology, the Kyoto Encyclopedia of Genes and Genomes, and risk score model were used for pathway and genes identification. Results: GSEA revealed that several pathways and biological processes are associated with hepatocarcinogenesis, such as the cell cycle, DNA repair, and p53 pathway. A total of 160 DEGs were identified. The enriched functions and pathways of the DEGs included toxic substance decomposition and metabolism processes, and the P450 and p53 pathways. Eleven of the DEGs were identified as hub DEGs in the WGCNA. In survival analysis of hub DEGs, high expression of PRC1 and TOP2A were significantly associated with poor clinical outcome of HBV-related HCC, and shown a good performance in HBV-related HCC diagnosis. The prognostic signature consisting of PRC1 and TOP2A also doing well in the prediction of HBV-related HCC prognosis. The diagnostic and prognostic values of PRC1 and TOP2A was confirmed in TCGA HCC patients. Conclusions: Key biomarkers and pathways identified in the present study may enhance the comprehend of the molecular mechanisms underlying hepatocarcinogenesis. Additionally, mRNA expression of PRC1 and TOP2A may serve as potential diagnostic and prognostic biomarkers for HBV-related HCC., QC 20191107

Published
2019
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15. Prognostic value of Kinesin‐4 family genes mRNA expression in early‐stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy

Author

Han, Quanfa, primary, Han, Chuangye, additional, Liao, Xiwen, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Li, Guanghui, additional, Han, Bowen, additional, Zhu, Guangzhi, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Liu, Junqi, additional, Su, Hao, additional, Shang, Liming, additional, Peng, Tao, additional, and Ye, Xinping, additional

Published
2019
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16. Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Liao, Xiwen, additional, Yu, Tingdong, additional, Gong, Yizhen, additional, Zhang, Linbo, additional, Huang, Jianlu, additional, Yang, Chengkun, additional, Han, Chuangye, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Qin, Wei, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Liu, Junqi, additional, Han, Quanfa, additional, and Peng, Tao, additional

Published
2019
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17. Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Zhou, Xin, additional, Liu, Junqi, additional, Liu, Zhengqian, additional, Zhang, Linbo, additional, Gong, Yizhen, additional, Huang, Jianlu, additional, Yu, Long, additional, Wang, Qiaoqi, additional, Yang, Chengkun, additional, Liao, Xiwen, additional, Yu, Tingdong, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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18. Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Author

Zhou, Xin, primary, Liao, Xiwen, additional, Wang, Xiangkun, additional, Huang, Ketuan, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Liu, Junqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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20. Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma

Author

Han, Quanfa, primary, Wang, Xiangkun, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Li, Guanghui, additional, Han, Bowen, additional, Huang, Ketuan, additional, Zhu, Guangzhi, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Su, Hao, additional, Shang, Liming, additional, Gong, Yizhen, additional, Song, Xiaowei, additional, Peng, Tao, additional, and Ye, Xinping, additional

Published
2019
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21. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus‐related hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Gong, Yizhen, additional, Deng, Teng, additional, Zhang, Linbo, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yang, Chengkun, additional, Huang, Jianlu, additional, Wang, Qiaoqi, additional, Song, Xiaowei, additional, Zhang, Tengfang, additional, Yu, Tingdong, additional, Zhu, Guangzhi, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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22. Genome-Wide Profiling Reveals the Landscape of Prognostic Alternative Splicing Signatures in Pancreatic Ductal Adenocarcinoma

Author

Yang, Chengkun, primary, Wu, Qiongyuan, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Liao, Xiwen, additional, Huang, Jianlu, additional, Zhu, Guangzhi, additional, Gong, Yizhen, additional, Han, Chuangye, additional, Su, Hao, additional, Qin, Wei, additional, and Peng, Tao, additional

Published
2019
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25. Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma

Author

Zhou, Xin, primary, Wang, Xiangkun, additional, Huang, Ketuan, additional, Liao, Xiwen, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Liu, Junqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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28. Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy

Author

Wang, Xiangkun, primary, Liao, Xiwen, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Yu, Tingdong, additional, Yu, Long, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Zeng, Xianmin, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Qin, Wei, additional, Su, Hao, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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29. Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

Author

Huang, Ketuan, primary, Liao, Xiwen, additional, Han, Chuangye, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Chen, Zhiwei, additional, Qin, Wei, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Liu, Zhengqian, additional, Zeng, Xianmin, additional, Zhou, Xin, additional, Lu, Sicong, additional, Huang, Jianlv, additional, Liang, Yu, additional, Liu, Zhengtao, additional, Deng, Jianlong, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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30. Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Liao, Xiwen, additional, Huang, Ketuan, additional, Zeng, Xianmin, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Yu, Long, additional, Wang, Qiaoqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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31. Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma

Author

Liao, Xiwen, primary, Wang, Xiangkun, additional, Huang, Ketuan, additional, Han, Chuangye, additional, Deng, Jianlong, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Rui, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Zeng, Xianmin, additional, Han, Bowen, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Gong, Yizhen, additional, Liu, Zhengtao, additional, Huang, Jianlv, additional, Winkler, Cheryl A, additional, O'Brien, Stephen J., additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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32. Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma

Author

Liao, Xiwen, primary, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Han, Chuangye, additional, Huang, Rui, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Han, Bowen, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Liu, Junqi, additional, Gong, Yizhen, additional, Liu, Zhengtao, additional, Huang, Jianlv, additional, Lu, Lei, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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33. Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study

Author

Yang, Chengkun, primary, Han, Chuangye, additional, Wang, Xiangkun, additional, Liao, Xiwen, additional, Liu, Xiaoguang, additional, Qin, Wei, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Lu, Sicong, additional, Chen, Zhiwei, additional, Yu, Tingdong, additional, Liu, Zhen, additional, Huang, Ketuan, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, and Peng, Tao, additional

Published
2018
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34. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.

Author

Zhou, Xin, Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Yang, Chengkun, Yu, Tingdong, Han, Chuangye, Zhu, Guangzhi, Su, Hao, Han, Quanfa, Chen, Zijun, Huang, Jianlv, Gong, Yizhen, Ruan, Guotian, Ye, Xinping, and Peng, Tao

Subjects
PHOSPHOLIPASE C, PANCREATIC enzymes, PROPORTIONAL hazards models
Abstract

The purpose of this investigation was to explore the prognostic value of phospholipase C delta (PLCD) genes in early stage pancreatic ductal adenocarcinoma (PDAC) and its potential molecular mechanisms. The prognostic value of PLCD genes in early stage PDAC was assessed using the Kaplan‐Meier method and multivariate Cox proportional hazards regression model. Genome‐wide correlation analysis was performed on PLCD3 to identify the highly correlated genes in the transcriptome. Then, PLCD3 and these correlated genes together underwent a bioinformatics analysis to elucidate the potential molecular biological functions of PLCD3 in PDAC. PLCD1 and PLCD3 are significantly overexpressed in PDAC. In PDAC patients, PLCD3 is overexpressed in certain groups of people with a history of alcoholism (P =.032). High expression of PLCD3 was found to be associated with lower overall survival (OS) of patients with early stage PDAC (P =.020; adjusted P =.016). A combination of PLCD3 and clinical variables was able to better predict the outcome of patients with early stage PDAC. These clinical variables are histological grade (P =.001; adjusted P =.001), targeted molecular therapy (P <.001; adjusted P <.001), radiation therapy (P =.002; adjusted P =.039), and residual resection (P =.001; adjusted P =.002). The bioinformatics analysis revealed that PLCD3 is associated with angiogenesis, intracellular signal transduction, and regulation of cell proliferation. In conclusion, PLCD3 may be a potential prognostic biomarker for early stage PDAC. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways associated with TP53 expression status in HBV-related hepatocellular carcinoma

Author

Liao, Xiwen, primary, Yu, Long, additional, Liu, Xiaoguang, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Qin, Wei, additional, Yang, Chengkun, additional, Zhu, Guangzhi, additional, Su, Hao, additional, and Peng, Tao, additional

Published
2018
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40. Marker of proliferation Ki-67 expression is associated with transforming growth factor beta 1 and can predict the prognosis of patients with hepatic B virus-related hepatocellular carcinoma

Author

Yang, Chengkun, primary, Su, Hao, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Zhu, Guangzhi, additional, Wang, Xiangkun, additional, Winkler, Cheryl A, additional, O'Brien, Stephen J, additional, and Peng, Tao, additional

Published
2018
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42. Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Survival in Patients with Hepatocellular Carcinoma

Author

Liao, Xiwen, primary, Yang, Chengkun, additional, Huang, Rui, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Huang, Ketuan, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Wang, Xiangkun, additional, Qin, Wei, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2018
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43. Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Author

Liao, Xiwen, primary, Liu, Xiaoguang, additional, Yang, Chengkun, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Han, Chuangye, additional, Huang, Ketuan, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Huang, Rui, additional, Yu, Long, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2018
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44. Genome-scale analysis to identify prognostic markers in patients with early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Author

Liao,Xiwen, Huang,Ketuan, Huang,Rui, Liu,Xiaoguang, Han,Chuangye, Yu,Long, Yu,Tingdong, Yang,Chengkun, Wang,Xiangkun, Peng,Tao, Liao,Xiwen, Huang,Ketuan, Huang,Rui, Liu,Xiaoguang, Han,Chuangye, Yu,Long, Yu,Tingdong, Yang,Chengkun, Wang,Xiangkun, and Peng,Tao

Abstract

Xiwen Liao,1,* Ketuan Huang,1,* Rui Huang,2 Xiaoguang Liu,1,3 Chuangye Han,1 Long Yu,1,4 Tingdong Yu,1 Chengkun Yang,1 Xiangkun Wang,1 Tao Peng1 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, 2Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 3Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 4Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China *These authors contributed equally to this work Background: Molecular analysis is a promising source of clinically useful prognostic biomarkers. The aim of this investigation was to identify prognostic biomarkers for patients with early-stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy.Methods: An RNA sequencing dataset of PDAC was obtained from The Cancer Genome Atlas. Survival analysis and weighted gene co-expression network analysis were used to investigate the prognostic markers of early-stage PDAC after pancreaticoduodenectomy.Results: Using whole genome expression level screening, we identified 1,238 markers that were related to the prognosis of PDAC after pancreaticoduodenectomy, and identified 9 hub genes (ARHGAP30, HCLS1, CD96, FAM78A, ARHGAP15, SLA2, CD247, GVINP1, and IL16) using the weighted gene co-expression network analysis approach. We also constructed a signature comprising the 9 hub genes and weighted by the regression coefficient derived from a multivariate Cox proportional hazards regression model to divide patients into a high-risk group, with increased risk of death, and a low-risk group, with significantly improved overall survival (adjusted P=0.026, adjusted HR =0.513, 95% CI =0.285–0.924). The prognostic signature of the 9 genes demonstrated good performance for predicting 1-year overall survival (area under the respective receiver operating charact

Published
2017

45. NLRCandNLRXgene family mRNA expression and prognostic value in hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Yang, Chengkun, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Huang, Ketuan, additional, Yu, Long, additional, Qin, Wei, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Liu, Xiaoguang, additional, Ye, Xinping, additional, Chen, Bin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
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47. Prognostic value of Notch receptors in postsurgical patients with hepatitis B virus‐related hepatocellular carcinoma

Author

Yu, Tingdong, primary, Han, Chuangye, additional, Zhu, Guangzhi, additional, Liao, Xiwen, additional, Qin, Wei, additional, Yang, Chengkun, additional, Liu, Zhen, additional, Su, Hao, additional, Liu, Xiaoguang, additional, yu, Long, additional, Liu, Zhengtao, additional, Lu, Sicong, additional, Chen, Zhiwei, additional, Liang, Yu, additional, Huang, Jianlu, additional, Qin, Xue, additional, Gui, Ying, additional, Li, Jiaquan, additional, and Peng, Tao, additional

Published
2017
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48. PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

Author

Liao, Xiwen, primary, Han, Chuangye, additional, Qin, Wei, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Yu, Tingdong, additional, Lu, Sicong, additional, Su, Hao, additional, Liu, Zhen, additional, Chen, Zhiwei, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, Dong, Jiahong, additional, Li, Lequn, additional, Qin, Xue, additional, Ye, Xinping, additional, Xiao, Kaiyin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
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49. ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma

Author

Zhu, Guangzhi, primary, Liao, Xiwen, additional, Han, Chuangye, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Qin, Wei, additional, Lu, Sicong, additional, Su, Hao, additional, Chen, Zhiwei, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Shang, Liming, additional, Ye, Xinping, additional, Li, Lequn, additional, Qin, Xue, additional, Xiao, Kaiyin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
Full Text
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