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30 results on '"Yu, Mandy Wai Man"'

7. The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents

Author

Chen, Chris Xie, primary, Li, Tim Man Ho, additional, Zhang, Jihui, additional, Li, Shirley Xin, additional, Yu, Mandy Wai Man, additional, Tsang, Chi Ching, additional, Chan, Kate Ching Ching, additional, Au, Chun Ting, additional, Li, Albert Martin, additional, Kong, Alice Pik Shan, additional, Chan, Joey Wing Yan, additional, Wing, Yun Kwok, additional, and Chan, Ngan Yin, additional

Published
2022
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11. Isolated dream‐enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.

Author

Huang, Bei, Zhang, Jihui, Wang, Jing, Chau, Steven Wai Ho, Chan, Joey Wing Yan, Yu, Mandy Wai Man, Li, Shirley Xin, Zhou, Li, Mok, Vincent, Wing, Yun Kwok, and Liu, Yaping

Subjects
RAPID eye movement sleep, BEHAVIOR disorders, SLEEP disorders, TYPE 2 diabetes, EYE movements, ANXIETY disorders
Abstract

Summary: Recurrent dream‐enactment behaviours (DEB) and rapid eye movement (REM) sleep without atonia (RSWA) are two diagnostic hallmarks of REM sleep behaviour disorder (RBD), a specific prodrome of α‐synucleinopathy. Whilst isolated RSWA (without DEB) was suggested as a prodrome of RBD, the implication of 'isolated' recurrent DEB remains under‐investigated. In this cross‐sectional study, we sought to investigate neurodegenerative markers amongst the first‐degree relatives (FDRs, aged >40 years) of patients with RBD who underwent clinical assessment for DEB, neurodegenerative markers, and video‐polysomnography assessment. Isolated recurrent DEB was defined as: (i) three or more episodes of DEB, (ii) had a DEB episode in the past 1 year, and (iii) subthreshold RSWA. We identified 29 FDRs (mean [SD] age 53.4 [8.3] years, 55.2% male) with isolated recurrent DEB and 98 age and sex‐matched FDRs as controls. Isolated DEB was associated with nightmare (27.6% versus 11.2%, p = 0.02), and the DEB group had a higher rate of current smoking (27.6% versus 3.1%, p = 0.006), type 2 diabetes mellitus (24.1% versus 10.2%, p = 0.003), anxiety disorder (24.1% versus 11.2%, p = 0.02), and constipation (hard lump of stool, 31.0% versus 7.1%, p < 0.001) than the control group. The present findings revealed that family relatives of patients with RBD with isolated recurrent DEB have increased risk of RBD and neurodegenerative features, which adds to the emerging data that isolated DEB is a prodromal feature of RBD and α‐synucleinopathy neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study

Author

Wang, Jing, primary, Chau, Steven W H, additional, Lam, Siu Ping, additional, Liu, Yaping, additional, Zhang, Jihui, additional, Chan, Ngan Yin, additional, Cheung, Maxine M S, additional, Yu, Mandy Wai Man, additional, Tsang, Jessie C T, additional, Chan, Joey W Y, additional, Huang, Bei, additional, Li, Shirley X, additional, Mok, Vincent, additional, and Wing, Yun Kwok, additional

Published
2021
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13. Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.

Author

Jing Wang, Chau, Steven W. H., Siu Ping Lam, Yaping Liu, Jihui Zhang, Ngan Yin Chan, Cheung, Maxine M. S., Wai Man Yu, Mandy, Tsang, Jessie C. T., Chan, Joey W. Y., Bei Huang, Li, Shirley X., Mok, Vincent, Yun Kwok Wing, Wang, Jing, Lam, Siu Ping, Liu, Yaping, Zhang, Jihui, Chan, Ngan Yin, and Yu, Mandy Wai Man

Subjects
POLYSOMNOGRAPHY, PARKINSON'S disease, MENTAL depression, DISEASE prevalence, PARASOMNIAS, DISEASE complications
Abstract

Objective: To investigate the prevalence and clinical correlates of video polysomnography (vPSG)-confirmed rapid eye movement sleep behaviour disorder (RBD) in patients with major depressive disorder (MDD).Methods: This is a clinic-based two-phase epidemiological study. In phase 1, patients with MDD were screened by a validated questionnaire, RBD Questionnaire-Hong Kong (RBDQ-HK). In phase 2, a subsample of both the screen-positive (RBDQ-HK >20) and screen-negative patients with MDD underwent further clinical and sleep assessment (vPSG) to confirm the diagnosis of RBD (MDD+RBD). Poststratification weighting method was used to estimate the prevalence of MDD+RBD. The total likelihood ratio and the probability of prodromal Parkinson's disease (PD) were calculated from prodromal markers and risk factors, as per the Movement Disorder Society research criteria.Results: A total of 455 patients with MDD were screened (median age (IQR)=52.66 (15.35) years, 77.58% woman, 43.74% positive). Eighty-one patients underwent vPSG and 12 of them were confirmed MDD+RBD. The prevalence of MDD+RBD was estimated to be 8.77% (95% CI: 4.33% to 16.93%), with possibly male predominance. MDD+RBD were associated with colour vision and olfaction deficit and a higher probability for prodromal PD.Conclusions: Almost 9% of patients with MDD in the psychiatric outpatient clinic has vPSG-confirmed RBD. Comorbid MDD+RBD may represent a subtype of MDD with underlying α-synucleinopathy neurodegeneration. Systematic screening of RBD symptoms and necessity of vPSG confirmation should be highlighted for capturing this MDD subtype with a view to enhance personalised treatment and future neuroprotection to prevent neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder

Author

Feng, Hongliang, primary, Chen, Lauren, additional, Liu, Yaping, additional, Chen, Xinru, additional, Wang, Jing, additional, Yu, Mandy Wai Man, additional, Huang, Bei, additional, Li, Shirley Xin, additional, Chau, Steven Wai Ho, additional, Chan, Joey Wing Yan, additional, Chen, Jie, additional, Mok, Vincent Chung Tong, additional, Wing, Yun Kwok, additional, and Zhang, Jihui, additional

Published
2020
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17. Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow‐up Study

Author

Wang, Jing, primary, Liu, Yaping, additional, Chau, Steven W.H., additional, Zhang, Jihui, additional, Tsang, Jessie, additional, Yu, Mandy Wai Man, additional, Chan, Ngan Yin, additional, Chan, Joey W.Y., additional, Li, Shirley Xin, additional, Huang, Bei, additional, Feng, Hongliang, additional, Mok, Vincent, additional, and Wing, Yun Kwok, additional

Published
2020
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20. Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study

Author

Wang, Jing, Chau, Steven W H, Lam, Siu Ping, Liu, Yaping, Zhang, Jihui, Chan, Ngan Yin, Cheung, Maxine M S, Yu, Mandy Wai Man, Tsang, Jessie C T, Chan, Joey W Y, Huang, Bei, Li, Shirley X, Mok, Vincent, and Wing, Yun Kwok

Abstract

ObjectiveTo investigate the prevalence and clinical correlates of video polysomnography (vPSG)-confirmed rapid eye movement sleep behaviour disorder (RBD) in patients with major depressive disorder (MDD).MethodsThis is a clinic-based two-phase epidemiological study. In phase 1, patients with MDD were screened by a validated questionnaire, RBD Questionnaire-Hong Kong (RBDQ-HK). In phase 2, a subsample of both the screen-positive (RBDQ-HK >20) and screen–negative patients with MDD underwent further clinical and sleep assessment (vPSG) to confirm the diagnosis of RBD (MDD+RBD). Poststratification weighting method was used to estimate the prevalence of MDD+RBD. The total likelihood ratio and the probability of prodromal Parkinson’s disease (PD) were calculated from prodromal markers and risk factors, as per the Movement Disorder Society research criteria.ResultsA total of 455 patients with MDD were screened (median age (IQR)=52.66 (15.35) years, 77.58% woman, 43.74% positive). Eighty-one patients underwent vPSG and 12 of them were confirmed MDD+RBD. The prevalence of MDD+RBD was estimated to be 8.77% (95% CI: 4.33% to 16.93%), with possibly male predominance. MDD+RBD were associated with colour vision and olfaction deficit and a higher probability for prodromal PD.ConclusionsAlmost 9% of patients with MDD in the psychiatric outpatient clinic has vPSG-confirmed RBD. Comorbid MDD+RBD may represent a subtype of MDD with underlying α-synucleinopathy neurodegeneration. Systematic screening of RBD symptoms and necessity of vPSG confirmation should be highlighted for capturing this MDD subtype with a view to enhance personalised treatment and future neuroprotection to prevent neurodegeneration.

Published
2022
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23. Sleep education in Hong Kong

Author

Chan, Ngan Yin, primary, Lam, Siu Ping, additional, Zhang, Jihui, additional, Yu, Mandy Wai Man, additional, Li, Shirley Xin, additional, Li, Albert Martin, additional, and Wing, Yun Kwok, additional

Published
2015
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30. Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease.

Author

Yun Kwok Wing, Shirley Xin Li, Mo, Vincent, Siu Ping Lam, Joshua Tsoh, Anne Chan, Yu, Mandy Wai Man, Lau, Christine Y. K., Jihui Zhang, and Ho, Crover Kwok Wah

Subjects
LETTERS to the editor, RAPID eye movement sleep, PARKINSON'S disease
Abstract

A letter to the editor related to a study revealing that the rapid eye movement sleep behavior disorder (RBD) is an early precursor of the Parkinson's disease, is presented.

Published
2012
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