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5. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

Author

Hao, Xiaoxin, Shen, Yichao, Chen, Nan, Zhang, Weijie, Valverde, Elizabeth, Wu, Ling, Chan, Hilda L., Xu, Zhan, Yu, Liqun, Gao, Yang, Bado, Igor, Michie, Laura Natalee, Rivas, Charlotte Helena, Dominguez, Luis Becerra, Aguirre, Sergio, Pingel, Bradley C., Wu, Yi-Hsuan, Liu, Fengshuo, Ding, Yunfeng, Edwards, David G., Liu, Jun, Alexander, Angela, Ueno, Naoto T., Hsueh, Po-Ren, Tu, Chih-Yen, Liu, Liang-Chih, Chen, Shu-Hsia, Hung, Mien-Chie, Lim, Bora, and Zhang, Xiang H.-F.

Published
2023
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6. Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Author

Xu, Zhan, primary, Liu, Fengshuo, additional, Ding, Yunfeng, additional, Pan, Tianhong, additional, Wu, Yi-Hsuan, additional, Liu, Jun, additional, Bado, Igor L., additional, Zhang, Weijie, additional, Wu, Ling, additional, Gao, Yang, additional, Hao, Xiaoxin, additional, Yu, Liqun, additional, Edwards, David G., additional, Chan, Hilda L., additional, Aguirre, Sergio, additional, Dieffenbach, Michael Warren, additional, Chen, Elina, additional, Shen, Yichao, additional, Hoffman, Dane, additional, Dominguez, Luis Becerra, additional, Rivas, Charlotte Helena, additional, Chen, Xiang, additional, Wang, Hai, additional, Gugala, Zbigniew, additional, Satcher, Robert L., additional, and Zhang, Xiang H.-F., additional

Published
2024
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7. Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

Author

Liu, Fengshuo, primary, Ding, Yunfeng, additional, Xu, Zhan, additional, Hao, Xiaoxin, additional, Pan, Tianhong, additional, Miles, George, additional, Rivas, Charlotte Helena, additional, Hoffman, Dane, additional, Edwards, David G, additional, Chen, Elina, additional, Wang, Hi, additional, Chan, Hilda L, additional, Liu, Jun, additional, Wu, Ling, additional, Yu, Liqun, additional, Gao, Yang, additional, Dominguez, Luis Becerra, additional, Dieffenbach, Michael Warren, additional, Aguirre, Sergio, additional, Zhang, Weijie, additional, Chen, Xiang, additional, Wu, Yi-Hsuan, additional, Shen, Yichao, additional, Bado, Igor L, additional, Gugala, Zbigniew, additional, Satcher, Robert L, additional, and Zhang, Xiang, additional

Published
2024
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10. Laparoscopic surgery for ectopic pregnancy: A comparative study on the clinical benefits and impact on tubal patency and reproductive outcomes.

Author

Yu, Juan, Peng, Yan, Yu, Liqun, and Shi, Shutian

Subjects
LAPAROSCOPIC surgery, THERAPEUTICS, CONSERVATIVE treatment, DEMOGRAPHIC characteristics, REPRODUCTIVE health, ECTOPIC pregnancy, SALPINGECTOMY
Abstract

BACKGROUND: Ectopic pregnancy is a major contributor to maternal morbidity and mortality across the globe. OBJECTIVE: This study aims to investigate the clinical benefits of laparoscopic surgery in treating ectopic pregnancy, and its impact on tubal patency and reproductive outcomes. METHODS: A clinical study was conducted to compare laparoscopic and medical conservative treatment for ectopic pregnancy. A total of 206 patients were treated for ectopic pregnancy at our hospital from January 2018 to June 2020. Among them, 46 underwent laparoscopic ipsilateral salpingectomy, 54 underwent laparoscopic ipsilateral salpingostomy with lesion removal, and 106 were treated conservatively with medication. RESULTS: The age range and average age of each group are provided, with no significant differences in these general demographic characteristics (p > 0.05). Both the salpingostomy and medication groups had higher rates of ectopic pregnancy compared to the salpingectomy group, with statistically significant differences (p < 0.05). The comparison of ectopic pregnancy rates between the salpingostomy and medication groups showed no significant difference. Within three years, the salpingostomy group had 10 cases of recurrent ectopic pregnancy, with 2 cases on the same side, while the medication group had 18 cases, with 8 cases on the same side. At 3 months after the normalization of blood β -HCG, the salpingostomy group showed 43 cases of tubal patency (patency rate: 79.63%), while the medication group showed 57 cases (patency rate: 53.77%), with a statistically significant difference between the two groups (p = 0.01). CONCLUSION: Laparoscopic surgery for ectopic pregnancy offers significant clinical benefits over conservative medical treatment, including higher rates of tubal patency and improved reproductive outcomes. These findings support laparoscopic surgery as an effective approach for the management of ectopic pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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22. Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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23. Supplementary Video 1 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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24. Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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25. Supplementary Video 4 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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26. Supplementary Raw Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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27. Supplementary Video 3 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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28. Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions

Author

Hao, Xiaoxin, Shen, Yichao, Liu, Jun, Alexander, Angela, Wu, Ling, Xu, Zhan, Yu, Liqun, Gao, Yang, Liu, Fengshuo, Chan, Hilda L., Li, Che-Hsing, Ding, Yunfeng, Zhang, Weijie, Edwards, David G., Chen, Nan, Nasrazadani, Azadeh, Ueno, Naoto T., Lim, Bora, and Zhang, Xiang H.-F.

Abstract

Solid tumours induce systemic immunosuppression that involves myeloid and T cells. B cell-related mechanisms remain relatively understudied. Here we discover two distinct patterns of tumour-induced B cell abnormality (TiBA; TiBA-1 and TiBA-2), both associated with abnormal myelopoiesis in the bone marrow. TiBA-1 probably results from the niche competition between pre-progenitor-B cells and myeloid progenitors, leading to a global reduction in downstream B cells. TiBA-2 is characterized by systemic accumulation of a unique early B cell population, driven by interaction with excessive neutrophils. Importantly, TiBA-2-associated early B cells foster the systemic accumulation of exhaustion-like T cells. Myeloid and B cells from the peripheral blood of patients with triple-negative breast cancer recapitulate the TiBA subtypes, and the distinct TiBA profile correlates with pathologic complete responses to standard-of-care immunotherapy. This study underscores the inter-patient diversity of tumour-induced systemic changes and emphasizes the need for treatments tailored to different B and myeloid cell abnormalities.

Published
2024
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35. Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, additional, Hao, Xiaoxin, additional, He, Tiancheng, additional, Li, Jiasong, additional, Shen, Yichao, additional, Liu, Kai, additional, Gao, Yang, additional, Liu, Jun, additional, Edwards, David G., additional, Muscarella, Aaron M., additional, Wu, Ling, additional, Yu, Liqun, additional, Xu, Longyong, additional, Chen, Xi, additional, Wu, Yi-Hsuan, additional, Bado, Igor L., additional, Ding, Yunfeng, additional, Aguirre, Sergio, additional, Wang, Hai, additional, Gugala, Zbigniew, additional, Satcher, Robert L., additional, Wong, Stephen T.C., additional, and Zhang, Xiang H.-F., additional

Published
2022
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39. Comparison between BP Neural Network and Multiple Linear Regression Method

Author

Wang, Guoli, Wu, Jianhui, Yin, Sufeng, Yu, Liqun, Wang, Jing, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Zhu, Rongbo, editor, Zhang, Yanchun, editor, Liu, Baoxiang, editor, and Liu, Chunfeng, editor

Published
2010
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41. sj-docx-1-onc-10.1177_11795549221079171 ��� Supplemental material for Complement 4 Aids in the Prediction of Newly Diagnosed Multiple Myeloma Outcome in Patients

Author

Zhang, Lihua, Ling, Xiaosui, Li, Fan, Yang, Tonghua, Shi, Keqian, Zhao, Shixiang, Yu, Liqun, Li, Zengzheng, and He, Haiping

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-onc-10.1177_11795549221079171 for Complement 4 Aids in the Prediction of Newly Diagnosed Multiple Myeloma Outcome in Patients by Lihua Zhang, Xiaosui Ling, Fan Li, Tonghua Yang, Keqian Shi, Shixiang Zhao, Liqun Yu, Zengzheng Li and Haiping He in Clinical Medicine Insights: Oncology

Published
2022
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50. The bone microenvironment invigorates metastatic seeds for further dissemination

Author

Zhang, Weijie, primary, Bado, Igor L., additional, Hu, Jingyuan, additional, Wan, Ying-Wooi, additional, Wu, Ling, additional, Wang, Hai, additional, Gao, Yang, additional, Jeong, Hyun-Hwan, additional, Xu, Zhan, additional, Hao, Xiaoxin, additional, Lege, Bree M., additional, Al-Ouran, Rami, additional, Li, Lucian, additional, Li, Jiasong, additional, Yu, Liqun, additional, Singh, Swarnima, additional, Lo, Hin Ching, additional, Niu, Muchun, additional, Liu, Jun, additional, Jiang, Weiyu, additional, Li, Yi, additional, Wong, Stephen T.C., additional, Cheng, Chonghui, additional, Liu, Zhandong, additional, and Zhang, Xiang H.-F., additional

Published
2021
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