1. Improvement of Oral Bioavailability and Anti-Tumor Effect of Zingerone Self-Microemulsion Drug Delivery System.
- Author
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Cao, Xia, Zhu, Qin, Wang, Qi-Long, Adu-Frimpong, Michael, Wei, Chun-Mei, Weng, Wen, Bao, Rui, Wang, Ya-Ping, Yu, Jiang-Nan, and Xu, Xi Ming
- Subjects
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BIOAVAILABILITY , *DRUG delivery systems , *ZETA potential , *MEDICAL research - Abstract
This study sought to prepare a self-microemulsion drug delivery system containing zingerone (Z-SMEDDS) to improve the low oral bioavailability of zingerone and anti-tumor effect. Z-SMEDDS was characterized by particle size, zeta potential and encapsulation efficiency, while its pharmacokinetics and anti-tumor effects were also evaluated. Z-SMEDDS had stable physicochemical properties, including average particle size of 17.29 ± 0.07 nm, the zeta potential of -22.81 ± 0.29 mV, and the encapsulation efficiency of 97.96% ± 0.02%. In vitro release studies have shown the release of zingerone released by Z-SMEDDS was significantly higher than free zingerone in different release media. The relative oral bioavailability of Z-SMEDDS was 7.63 times compared with free drug. Meanwhile, the half inhibitory concentration (IC50)of Z-SMEDDS and free zingerone was 8.45 μg/mL and 13.30 μg/mL, respectively on HepG2. This study may provide a preliminary basis for further clinical research and application of Z-SMEDDS. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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